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Micromachines
Special Issues
Recent Advances in Biosensors for Biomedical Applications
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Recent Advances in Biosensors for Biomedical Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (16 December 2019) | Viewed by 4182

Special Issue Editors

Dr. Sanela Martic

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Guest Editor
Forensic Science Department, Trent University, Peterborough, ON K9L 0G2, Canada
Interests: sensors; forensic science; electrochemistry; disease biomarkers; protein sensors; electrocatalysis
Special Issues, Collections and Topics in MDPI journals
Dr. Moloud Ahmadi

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Guest Editor
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada
Interests: cancer; brain tumors; biomarkers; stem cell; regenerative medicine; gene therapy; CRISPR
Dr. Md Nazmul Islam

E-Mail
Guest Editor
Department of Bioengineering, Imperial College London, South Kensington, London SW7 2AZ, UK
Interests: electrochemical sensors; molecular diagnostics; non-coding RNAs

Special Issue Information

Dear Colleagues,

The development of biosensors has revolutionized over the last decade and has significantly contributed to the advancement of medical technology that has led to the invention of powerful analytical tools. The integration of various strategies ranging from electrochemical, electromechanical, and optical biosensors has offered great tools for modern biosensor discoveries. Importantly, biosensors can have tremendous medical applications in disease diagnosis and drug discovery, leading to the early diagnosis of a disease and its subsequent treatment. Moreover, biosensors have acquired paramount importance in other areas such as food safety standards, defense, security, and environmental monitoring. Accordingly, the demand for using biosensors for various applications has progressively increased during last decade.

In light of this, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on development of biosensors and their utilization for various biochemical and biomedical applications.

Dr. Sanela Martic
Dr. Moloud Ahmadi
Dr. Md Nazmul Islam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biosensors
  • Biomarkers
  • Cancer
  • Drug discovery
  • Food safety

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Published Papers (1 paper)

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Research

12 pages, 1574 KiB  
Article
Chitosan Stabilized Silver Nanoparticles for the Electrochemical Detection of Lipopolysaccharide: A Facile Biosensing Approach for Gram-Negative Bacteria
by Muhammad Imran, Christopher J. Ehrhardt, Massimo F. Bertino, Muhammad R. Shah and Vamsi K. Yadavalli
Micromachines 2020, 11(4), 413; https://doi.org/10.3390/mi11040413 - 14 Apr 2020
Cited by 35 | Viewed by 3781
Abstract
Negatively charged lipopolysaccharide (LPS), a major endotoxin and component of the outer membrane of several Gram-negative bacteria, provides a useful biomarker for the indirect detection of these pathogens. For instance, Escherichia coli (E. coli) is a pathogenic bacterium that causes infections [...] Read more.
Negatively charged lipopolysaccharide (LPS), a major endotoxin and component of the outer membrane of several Gram-negative bacteria, provides a useful biomarker for the indirect detection of these pathogens. For instance, Escherichia coli (E. coli) is a pathogenic bacterium that causes infections in almost all age groups, and has been implicated in food and water contamination. Current diagnostic and detection methods tend to be labor-intensive or expensive, necessitating the need for an easy, sensitive, rapid, and low-cost method. We report on the synthesis and use of positively charged chitosan stabilized silver nanoparticles (Chi-AgNPs) as a sensitive electrochemical nanobiosensor for the detection of LPS. Chi-AgNPs were synthesized through a facile, single step protocol, and characterized for size, charge, and morphology. Glassy carbon electrodes modified with Chi-AgNPs resulted in an enhancement of signal in the presence of both LPS and E. coli. Detection was accomplished over a large concentration range (several orders of magnitude) of 0.001–100 ng/mL and 10–107 CFU/mL. The biosensors can reliably detect LPS and E. coli at very low concentrations. Chi-AgNPs have potential as low cost, sensitive nanobiosensors for Gram-negative bacteria due to strong electrostatic interaction with LPS present in their outer membranes. Full article
(This article belongs to the Special Issue Recent Advances in Biosensors for Biomedical Applications)
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