Galleria mellonella as an Alternative Pleiotropic In Vivo Model for Microbiological Research: From Host–Microbial Interaction to Clinical Translation
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2980
Special Issue Editors
Interests: innate immunity; infection; alternative animal model; antibiotic therapy; bacterial genomics
Interests: clinical microbiology; antimicrobial resistance; host-microbe interaction; human immunology; inflammation; autoimmunity
Special Issue Information
Dear Colleagues,
New global rules and greater ethical awareness imply increasingly stringent controls on the use of vertebrates in “in vitro” studies. This condition has increased the costs and time required to obtain the appropriate authorizations. In recent years, new alternative models have been proposed, e.g., lepidoptera, gastropods, and nematodes, as mini-host models for human-pathogenic microorganisms. The moth larva Galleria mellonella is now widely used in pre-clinical research as an alternative animal model to mammals. The reasons for its success lie both in the numerous similarities with the “standard” models, such as the presence of a humoral and cellular immune system, and in the peculiar characteristics of this species, such as the size of the larvae, ease of breeding, and the ability to survive at 37 °C.
This Special Issue, “Galleria mellonella as an Alternative Pleiotropic In Vivo Model for Microbiological Research: From Host–Microbial Interaction to Clinical Translation” aims to assemble a collection of research articles and reviews that explore the extensive potential applications of this animal model in microbiological research. New scientific evidence on the cellular mechanisms involved in innate immunity, host–microbe interaction, microbial virulence factors, and antimicrobial resistance along with their possible impact on the clinical area are welcome.
Dr. Giulio Petronio Petronio
Dr. Roberto Di Marco
Dr. Laura Pietrangelo
Guest Editors
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Keywords
- alternative animal model
- innate immunity
- infection
- antimicrobial resistance
- host–microbe interaction
- antibiotic therapy
- clinical translation
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