Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.2
4.8
Journals
Nutrients
Special Issues
Trace Elements in Aging and Age-Related Pathologies: From Mechanisms to...
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Trace Elements in Aging and Age-Related Pathologies: From Mechanisms to Dietary Interventions

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 3907

Special Issue Editor

Dr. Francesco Piacenza

E-Mail Website
Guest Editor
Experimental Animal Models for Aging Unit, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy
Interests: nutrition; inflammation; aging; trace elements; mineral; epigenetic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Trace elements play a crucial role in maintaining the health of aging individuals by supporting metabolic and physiological processes. The regulation of the bioavailability of each trace element is essential for the proper functioning of living cells, and this regulation is called metallostasis. Metal uptake, storage, and efflux processes work in tandem to maintain an optimal amount of trace elements.

The levels of trace elements change in various tissues during aging, but the cause of these changes is still debated. It is unclear if these changes are due to malnutrition or if they are the cause or consequence of other age-related alterations, such as immune or inflammatory responses.

To understand the mechanisms that underlie changes in trace elements, epigenetic modifications such as DNA methylation, histone modification, and non-coding RNA expression can be evaluated. These modifications play a critical role in regulating metal uptake, storage, and efflux processes, contributing to metallostasis.

Further research could explore the impact of dietary habits, interventions, or supplementation on epigenetic modifications and their effects on metallostasis and the health of older adults with age-related diseases.

This Special Issue aims to collect a series of original research and review articles that address the role of trace elements and minerals in aging and age-related pathologies. The manuscripts must focus on mechanisms that contribute to the maintenance of metallostasis in healthy aging, changes in metallostasis in older adults with single or multiple age-related diseases, the contribution of changes in tissue distribution of trace elements to healthspan in older adults, and changes in trace elements that could be targeted for diagnostic, preventive, or therapeutic purposes. Special emphasis will be given to articles that address these topics.

Suggested potential topics may include the following: metallomics or selected trace elements (zinc, copper, iron, selenium, iodine, chromium, boron, fluoride, manganese and molybdenum) in age-related pathologies; mechanisms of metallostasis failure in age-related chronic pathologies; impact of dietary habits, dietary intervention or supplementation with trace elements in aging and age-related pathologies, new therapeutic or diagnostic tools targeting trace elements; trace elements and multimorbidity; impact of epigenetic alterations on metallostasis.

Dr. Francesco Piacenza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • trace elements
  • minerals
  • metallomics
  • aging
  • age-related disease
  • metallostasis
  • healthspan
  • epigenetic

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 2194 KiB  
Article
Postprandial Micronutrient Variability and Bioavailability: An Interventional Meal Study in Young vs. Old Participants
by Denny Pellowski, Paula Kusch, Thorsten Henning, Bastian Kochlik, Maria Maares, Amy Schmiedeskamp, Gabriele Pohl, Monika Schreiner, Susanne Baldermann, Hajo Haase, Tanja Schwerdtle, Tilman Grune and Daniela Weber
Nutrients 2024, 16(5), 625; https://doi.org/10.3390/nu16050625 - 23 Feb 2024
Viewed by 1842
Abstract
This study explores age- and time-dependent variations in postprandial micronutrient absorption after a micronutrient-rich intervention meal within the Biomiel (bioavailability of micronutrients in elderly) study. Comprising 43 healthy participants, the study compares young (n = 21; mean age 26.90 years) and old (n [...] Read more.
This study explores age- and time-dependent variations in postprandial micronutrient absorption after a micronutrient-rich intervention meal within the Biomiel (bioavailability of micronutrients in elderly) study. Comprising 43 healthy participants, the study compares young (n = 21; mean age 26.90 years) and old (n = 22; mean age 66.77 years) men and women, analyzing baseline concentrations and six-hour postprandial dynamics of iron (Fe), copper (Cu), zinc (Zn), selenium (Se), iodine (I), free zinc (fZn), vitamin C, retinol, lycopene, β-carotene, α-tocopherol, and γ-tocopherol, along with 25(OH) vitamin D (quantified only at baseline). Methodologically, quantifications in serum or plasma were performed at baseline and also at 90, 180, 270, and 360 min postprandially. Results reveal higher baseline serum Zn and plasma lycopene concentrations in the young group, whereas Cu, Se, Cu/Zn ratio, 25(OH) vitamin D, α-tocopherol, and γ-tocopherol were higher in old participants. Postprandial variability of Zn, vitamin C, and lycopene showed a strong time-dependency. Age-related differences in postprandial metabolism were observed for Se, Cu, and I. Nevertheless, most of the variance was explained by individuality. Despite some limitations, this study provides insights into postprandial micronutrient metabolism (in serum/plasma), emphasizing the need for further research for a comprehensive understanding of this complex field. Our discoveries offer valuable insights for designing targeted interventions to address and mitigate micronutrient deficiencies in older adults, fostering optimal health and well-being across the lifespan. Full article
(This article belongs to the Special Issue Trace Elements in Aging and Age-Related Pathologies: From Mechanisms to Dietary Interventions)
►▼ Show Figures

Figure 1

12 pages, 509 KiB  
Article
Blood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adults
by Esther García-Esquinas, Adrián Carballo-Casla, Rosario Ortolá, Mercedes Sotos-Prieto, Pablo Olmedo, Fernando Gil, Elena Plans-Beriso, Pablo Fernández-Navarro, Roberto Pastor-Barriuso and Fernando Rodríguez-Artalejo
Nutrients 2023, 15(22), 4750; https://doi.org/10.3390/nu15224750 - 10 Nov 2023
Cited by 2 | Viewed by 1570
Abstract
Background: Selenium is an essential trace element with an antioxidant and anti-inflammatory capacity that has been associated in experimental studies with beneficial effects on appetite control, the regulation of the gut microbiota, and control of the anabolic–catabolic balance. The main aim of the [...] Read more.
Background: Selenium is an essential trace element with an antioxidant and anti-inflammatory capacity that has been associated in experimental studies with beneficial effects on appetite control, the regulation of the gut microbiota, and control of the anabolic–catabolic balance. The main aim of the present study was to evaluate the association between circulating selenium concentrations and the risk of developing undernutrition in older adults. Methods: This was a cohort study with 1398 well-nourished community-dwelling individuals aged ≥ 65 years residing in Spain in 2017, who were followed for a mean of 2.3 years. Whole blood selenium was measured at baseline using inductively coupled plasma-mass spectrometry. Undernutrition was assessed at baseline and at follow-up, and defined as having at least one of the three GLIM phenotypic criteria (involuntary weight loss, a low body mass index, and a reduced muscle mass) and at least one of the two etiologic criteria (reduced food consumption or nutrient assimilation and inflammation/disease burden). Results: During the follow-up, 142 participants (11%) developed moderate undernutrition and 113 (8.8%) severe undernutrition. The standardized relative risks of moderate and severe undernutrition at the 75th percentile of Se levels versus the 25th were 0.90 and 0.70, respectively. In dose–response analyses, the risk of severe undernutrition decreased linearly with increasing selenium concentrations. This association was independent of protein intake or diet quality and was stronger among participants with a diagnosis of a musculoskeletal disorder. Conclusions: The results suggest that an adequate dietary selenium status is needed to prevent undernutrition in older adults. Also, this may open the door for clinical trials with selenium supplementation, at doses considered as safe, to prevent undernutrition. Full article
(This article belongs to the Special Issue Trace Elements in Aging and Age-Related Pathologies: From Mechanisms to Dietary Interventions)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop