Indole Derivatives as Targeted Melatonin and Serotonin Receptor Ligands
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 23 February 2025 | Viewed by 72
Special Issue Editors
Interests: medicinal chemistry; melatonin receptor ligands; natural products; anticancer activity; indole-based biologically active molecules; glutathione
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Indole derivatives and relative bioisosteres, including other condensed heteroaryl scaffolds or simplified derivatives with a flexible chain, represent the principal strategy to design compounds with melatonergic or serotonergic activity through structure–activity relationship studies.
In this Special Issue, we want to highlight the newest findings in the discovery of synthetic or natural products with potential bioactivity in target-mediated interaction with melatonin or serotonin receptors. This activity may be complemented by the intrinsic reactivity of compounds due to their antioxidant and radical-scavenging properties or the introduction of a second moiety, resulting in a dual-target or multi-target engagement.
We invite you to share recent advancements in the drug design and discovery, synthesis and characterization of new melatonergic or serotonergic compounds containing an indole moiety or a bioisostere replacement. Such new molecules could introduce a novel series, expand our knowledge of already-proposed scaffolds or elucidate new biological activities for known melatonergic or serotonergic agents.
Advancements in methodologies related to this topic are also encouraged for submission, including, but not limited to, synthetic methodologies and green chemistry approaches, the pharmacological characterization and bioanalytical profiling of compounds, molecular modeling and structure–activity relationship rationalization.
Dr. Michele Retini
Dr. Gian Marco Elisi
Guest Editors
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Keywords
- melatonin receptors
- serotonin receptors
- medicinal chemistry
- natural products
- drug design
- antioxidant activity
- multi-target compounds
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