Optimisation of In Vitro Models of the Blood-Brain Barrier towards Recapitulation of In Vivo Responses
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: closed (20 May 2021) | Viewed by 168
Special Issue Editor
2. National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland
Interests: vascular biology; blood brain barrier; nanomaterials; nanoparticles; endocrinology; inflammation; macrovasculature; microvasculature; endothelium; tight junctions; shear stress; hemodynamics
Special Issue Information
Dear Colleagues,
The blood–brain barrier is a complex, yet dynamic interface which is pivotal in maintaining homeostasis of the brain in humans. This highly organised and regulated structure is fundamental for survival; yet, this barrier, which evolved to protect humans, ironically prevents the successful delivery of neurotherapeutics to the brain. With the incidence of neurological disorders increasingly rapidly, the pharmaceutical industry has been tasked with developing innovative strategies which not only overcome the obstacle this barrier presents, but also are effective therapeutics, equally safe and high in quality. As such, appropriate models which accurately reflect the sophisticated physiology of this human neurovascular unit towards improvements to the drug delivery pipeline in this area are continuously sought.
Recent advancements in three-dimensional modelling, microfluidics, and cell culture have overcome many of the limitations of these approaches, and efforts towards the development of new neurotherapeutics have seen an improvement in drugs’ efficacy, quality, and safety as a result. This Special Issue is intended to highlight the recent advancements in approaches to blood–brain barrier modelling and how such approaches have been used to test and validate the translational potential of drug candidates for neurological diseases which pose a significant risk to the global population. Topics of interest of this Special Issue include, but are not limited to, the following: lab-on-a-chip, spheroids, three-dimensional cell culture, microfluidics, selective targeting, nanotherapeutics, translational evidence.
Dr. Keith Rochfort
Guest Editor
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Keywords
- lab-on-a-chip
- spheroids
- three-dimensional cell culture
- pluripotent stem cells
- microfluidics
- hemodynamics
- cell junctions
- active Transporters
- selective targeting
- nanotherapeutics
- translational evidences
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