Development of Polymer-Encapsulated, Amine-Functionalized Zinc Ferrite Nanoparticles as MRI Contrast Agents
Abstract
:1. Introduction
2. Results
2.1. Preparation and Characterization of the Amine-Functionalized ZnFe2O4 Samples
2.2. Results of the In Vitro MRI Measurements
2.3. In Vivo MRI Measurement
3. Materials and Methods
3.1. Materials
3.2. Characterization Techniques
3.3. Synthesis of the Amine-Functionalized Zinc Ferrite Nanoparticles
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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(nm) | Mean | SD | Min. | Max. | P90 | P95 |
---|---|---|---|---|---|---|
ZnFe2O4-NH2 Refl. | 47 | 14 | 18 | 88 | 64 | 66 |
ZnFe2O4-NH2 MW | 63 | 20 | 33 | 123 | 88 | 105 |
Synthesis Method | Ms (emu/g) | Mr (emu/g) | Hc (Oe) | Crystallite Size XRD (nm) | Particle Size EM (nm) | Reference |
---|---|---|---|---|---|---|
Solvothermal | 18.35 | 0 | 0 | 9 ± 2 | 47 ± 17 | This work |
16.99 | 0 | 0 | 12 ± 2 | 63 ± 20 | ||
Solvothermal | 60.4 | 0.83 | 9.9 | 25.3 | 150 ± 25 | [47] |
60.3 | 0.18 | 0.2 | 15.8 | 130 ± 30 | ||
52 | 1.31 | 22.0 | 20.4 | 120 ± 30 | ||
43.2 | 0.35 | 2.1 | 15.1 | 300 ± 50 | ||
Solvothermal | 66.71 | 0.42 | 3.67 | 12.2 | 345.2 | [48] |
58.46 | 0.30 | 3.15 | 11.1 | 340.8 | ||
66.52 | 0.38 | 3.52 | 10.0 | 312.8 | ||
Solvothermal | 66.71 | 0 | 0 | 12.9 | 345.2 | [49] |
81.34 | 5.2 | 34.60 | 40.7 | 150.6 | ||
76.65 | 7.5 | 51.24 | 24.5 | 110.6 | ||
Solvothermal (reflux) | 50.4 | 0 | 0 | 11 | 10 | [65] |
Ball milling | 30 | 0 | 0 | 16 | n.d. | [66] |
Hydrothermal | 10 | 2 | 100 | 26 | n.d. | [67] |
Sol–gel | 12.9 | 3.4 | 352.1 | 22 | n.d. | [68] |
Microwave combustion | 2.6 | 0.01 | 7.5 | 37.6 | n.d. | [69] |
Microemulsion | 1.49 | negl. | negl. | 15.3 | n.d. | [70] |
Thermal decomposition | 43 | negl. | negl. | 9.8 | 9.8 | [71] |
Coprecipitation | 2.51 | 0.44 | 69.83 | 34 | 30–50 | [72] |
2.31 | 0.22 | 60.59 | 36.3 |
(mL/mg/ms) | r1 | r2 | r2* |
---|---|---|---|
ZnFe2O4-NH2 Refl. | 0.007 | 1.113 | 1.562 |
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Ilosvai, Á.M.; Forgách, L.; Kovács, N.; Heydari, F.; Szigeti, K.; Máthé, D.; Kristály, F.; Daróczi, L.; Kaleta, Z.; Viskolcz, B.; et al. Development of Polymer-Encapsulated, Amine-Functionalized Zinc Ferrite Nanoparticles as MRI Contrast Agents. Int. J. Mol. Sci. 2023, 24, 16203. https://doi.org/10.3390/ijms242216203
Ilosvai ÁM, Forgách L, Kovács N, Heydari F, Szigeti K, Máthé D, Kristály F, Daróczi L, Kaleta Z, Viskolcz B, et al. Development of Polymer-Encapsulated, Amine-Functionalized Zinc Ferrite Nanoparticles as MRI Contrast Agents. International Journal of Molecular Sciences. 2023; 24(22):16203. https://doi.org/10.3390/ijms242216203
Chicago/Turabian StyleIlosvai, Ágnes M., László Forgách, Noémi Kovács, Fatemeh Heydari, Krisztián Szigeti, Domokos Máthé, Ferenc Kristály, Lajos Daróczi, Zoltán Kaleta, Béla Viskolcz, and et al. 2023. "Development of Polymer-Encapsulated, Amine-Functionalized Zinc Ferrite Nanoparticles as MRI Contrast Agents" International Journal of Molecular Sciences 24, no. 22: 16203. https://doi.org/10.3390/ijms242216203