Search Results (121)

To improve the energy efficiency and indoor environmental quality of rural dwellings in China’s cold regions, this study selected a typical rural dwelling in Linyi, Shandong Province, as a case study. Integrating field measurements with parametric simulations, the Orthogonal Experimental Design method was employed to systematically evaluate the impacts of 12 envelope design parameters on building energy demand (ED_tot, ED_H, ED_C), thermal comfort (PNT_ave), daylight performance (UDI_ave), and economic outcomes (retrofit cost and return on investment, ROI). Three sets of orthogonal experiments with varying value ranges (Case 1–3) were conducted. The results revealed that U-Window and SHGC are the most critical factors influencing energy demand and thermal comfort, while light transmittance (Trans) exerts the greatest influence on daylighting. The economic analysis demonstrated that window material is the primary determinant of retrofit costs, whereas building depth and the south window-to-wall ratio (WWR-South) significantly affect ROI. Additional range and variance analyses quantified the significance of each parameter and revealed nonlinear influence patterns. This research provides data support and decision-making references for the energy-efficient retrofit and multi-objective optimization of rural dwellings in cold regions, offering strong practical implications. Full article

Glazed façades play a decisive role in building energy performance, particularly in high-radiation equatorial climates. This study examines the thermal behavior and economic feasibility of three glazing systems—10 mm monolithic clear glass, laminated solar-control glass, and selective double glazing—applied to the Plataforma Gubernamental Norte, the largest institutional building in Ecuador. Dynamic simulations using DesignBuilder with the EnergyPlus engine assessed solar gains, HVAC demand, and operative temperatures, complemented by a sensitivity analysis of SHGC, U-value, and Tvis. Results indicate that selective double glazing reduced annual HVAC consumption by 78.21% (110.6 MWh), while laminated glazing achieved a 55.40% reduction. SHGC and U-value emerged as the most influential parameters, whereas Tvis had no impact on energy loads. Despite strong technical performance, the economic analysis revealed payback periods exceeding 235 years under Ecuador’s subsidized tariff (USD 0.10/kWh), compared to the 18–25 years commonly observed in Europe. This highlights the “efficiency paradox”: advanced glazing solutions deliver significant energy savings but remain financially unfeasible in subsidy-driven contexts. The findings underscore the need for policy reforms to better align façade design strategies with energy resilience, an issue particularly relevant after Ecuador’s 2024 electricity crisis and ongoing debates on subsidy elimination. Full article

School buildings in hot-humid climates encounter considerable difficulties in balancing energy use and thermal comfort due to this environment, necessitating optimized design strategies to reduce energy consumption while enhancing occupant comfort. This study presents sustainable design strategies for educational structures in hot-humid regions, aiming to optimize energy efficiency and thermal comfort for environmental preservation and occupant welfare. The present work introduces a multi-objective optimization framework for window design in school buildings situated in hot-humid climates, targeting a balance between Energy Use Intensity (EUI) and Thermal Comfort Time Ratio (TCTR). Exploring multi-objective optimization through NSGA-II genetic algorithms, the study conducts Sobol sensitivity analysis for parameter assessment and applies Gaussian Process Regression (GPR) for effective model validation, identifying optimal window configurations that reduce energy consumption while enhancing thermal comfort. It finds that the Window-to-Wall Ratio (WWR) and Solar Heat Gain Coefficient (SHGC) are the most significant factors, with WWR and SHGC accounting for 28.1% and 23.7% of the variance in EUI and TCTR, respectively. The results reveal a non-linear trade-off between the objectives, with the Balanced Solution offering a practical compromise: a 6.7% decrease in energy use and a 14.3% enhancement in thermal comfort. The study examined various ranges of window parameters, including WWR (0.1–0.50), SC (0.20–0.80), K (1.0–2.5 W·m⁻²·K⁻¹), SHGC (0.1–0.4), Shading width (0.3–2.0 m), and Shading angle (0°–90°). The recommended compromise, known as the Balanced Solution, suggests optimal values as follows: WWR = 0.40, SC = 0.30, SHGC = 0.40, K = 1.2 W·m⁻²·K⁻¹, Shading width = 1.22 m, and Shading angle = 28°. The GPR model exhibited high predictive precision, with R² values of 0.91 for EUI and 0.95 for TCTR, underscoring the framework’s effectiveness. This research offers actionable insights for designing energy-efficient and comfortable school buildings in hot-humid climates, enriching sustainable architectural design knowledge. Full article

Essential oils (EOs) are natural mixtures of volatile compounds characterized by beneficial pharmacological effects. The repeated inhalation of EOs in olfactory training (OT) has been demonstrated to improve the sense of smell in patients with olfactory deficits. We conducted a conjunct evaluation of the chemical composition, sensory profile, and bioactivity in cell models of commercial EOs of rose (EO1), eucalyptus (EO2), lemon (EO3), and clove (EO4) used for OT (StimuScent^®, Dos Medical, Sense Trading BV, Groningen, The Netherlands). Citronellol, 1,8-cineole, limonene, and eugenol emerged as the most abundant volatile compounds in EO1, EO2, EO3, and EO4, respectively, by GC-MS analysis. Some differences emerged (using a Likert-type scale) in the perception of EO’s odor dimensions (pleasantness, intensity, and familiarity in subjects with hyposmia (n = 8) compared to controls (n = 22). Cytotoxicity assays (24 h of incubation) demonstrated the anticancer effects of EOs (5–100 μg/mL) on SH-SY5Y neuroblastoma cells (the order of potency was EO3 > EO4 > EO2 > EO1), while all EOs showed lower effects on the viability/morphology of human skin HaCaT keratinocytes. SH-SY5Y cancer cells grown for six days with different EOs (at 50 μg/mL) showed evident signs of toxicity and apoptosis. Marked changes in cell morphology (structure/number of processes) were evidenced in clove EO-treated cells. EO’s sensory properties/bioactivity were also related to the in silico physicochemical/pharmacokinetic properties of the main EO components. Our results provide new insights into a more targeted EO application for OT. Full article

Urbanization in China and the proliferation of high-rise office buildings have led to increased demand for daylighting and thermal comfort. These requirements often result in reliance on active systems, including heating, cooling, and artificial lighting, which increase energy consumption. Existing studies have often focused on individual cases or room-scale models, which makes it difficult to generalize findings to the design of various high-rise office building types. Therefore, in this study, parametric prototype building models for high-rise office buildings were developed based on surveys of completed and under-construction projects. These surveys reflected actual design practices and were used to support systematic performance evaluation and typology-level optimization. Building performance was simulated using Grasshopper and Honeybee to generate large-scale datasets, and stacking ensemble learning models were used as surrogate predictors for energy use, daylighting, and thermal comfort. Multi-objective optimization was conducted using the non-dominated sorting genetic algorithm III (NSGA-III), followed by strategy formulation. The results revealed the following: (1) the proposed prototype model establishes clear parameter ranges for geometry, envelope design, and thermal performance, offering reusable models and data; (2) the stacking ensemble model outperforms individual models, improving the coefficient of determination (R²) by 0.5–16.1%, with mean squared error (MSE) reductions of 4.4–70.6%, and mean absolute error (MAE) reductions of 2.8–45.8%; (3) space length, aspect ratio, usable area ratio, window U-value, and solar heat gain coefficient (SHGC) were identified as primary performance drivers; and (4) optimized solutions reduced energy use by 3.79–11.81% and enhanced daylighting comfort by 40.16–50.32% while maintaining thermal comfort. The proposed framework provides localized, data-driven guidance for early-stage performance optimization in high-rise office building design. Full article

Oxidative stress is a biological imbalance that contributes to cellular damage and is a major driver of aging and age-related disorders, prompting the search for natural antioxidant agents. Our study is a phytochemical, electrochemical, and biological characterization of the antioxidant potential of aqueous extracts from aerial parts of A. occidentale—leaves, bark, fruit, and cashew nuts—traditionally used in folklore medicine. Extracts were analyzed using FT-IR spectroscopy, GC × GC-TOFMS, polyphenol quantification, and antioxidant capacity assays (ABTS, FRAP, DPPH). Biological activity was tested in different mice and human cell lines (SH-SY5Y, MEF, ARPE-19, and HLECs). Aqueous extracts from the leaves and bark of A. occidentale exhibited significantly higher antioxidant activity compared to those from the fruit and cashew nut. These extracts showed elevated polyphenol content and strong performance in antioxidant capacity assays. In vitro, leaf and bark extracts enhanced cell viability under H₂O₂-induced oxidative stress, preserved mitochondrial membrane potential, and upregulated cytoprotective genes (HMOX1, NQO1, GCLC, and GCLM) in multiple cell lines. In contrast, fruit and nut extracts showed minimal antioxidant activity and no significant gene modulation. Our findings underscore the therapeutic potential of A. occidentale leaf and bark extracts as effective natural antioxidants and support their further development as candidates for phytotherapeutic interventions. Full article

Background and Objectives: This study investigated changes in quality of life (QOL), depression, and menopausal symptoms after surgical menopause, and the efficacy of hormone replacement therapy (HRT) in gynecological cancer survivors (GCS). Materials and Methods: Participants undergoing gynecologic cancer surgery (N = 155) were divided into those who received HRT after surgical menopause (SH, N = 47), those after surgical menopause (SM, N = 54), and those after natural menopause (NM, N = 54). QOL, depression, and menopausal symptoms were assessed using the Functional Assessment of Cancer Therapy-General (FACT-G), Center for Epidemiologic Studies Depression Scale (CES-D), and Endocrine Symptoms Subscale-19 (ESS-19), respectively. Assessments were conducted before and at 6 and 12 months after surgery. Results: In SH and SM, FACT-G and CES-D were worst before surgery, gradually improved by 6 months, and remained stable for the following 6 months. FACT-G and CES-D showed an inverse relationship. ESS-19 did not change in SH and SM for 12 months. Among the items on the ESS-19, worsened vasomotor symptoms (VMSs), assessed with ES1, showed more improvement in SH than in SM, while worsened arthralgia assessed with BRM1 was maintained in SM. Multivariate analysis showed that HRT was not independently correlated with changes in QOL and depression status. Conclusions: In GCS, the prevalence of depression was highest at cancer disclosure along with declining QOL. QOL gradually improved by 6 months after surgery in SH and SM, but not in NM. Although menopausal HRT is known to alleviate VMS, anxiety, and depression, its efficacy for cancer-related emotional distress and the associated decline in QOL seems limited. Full article

Hemp essential oils are rich in bioactive compounds, including terpenes and cannabinoids, yet standardized analytical methods for their simultaneous quality control are limited. This study aimed to (i) validate a static headspace gas chromatography–mass spectrometry (SHS-GC-MS) method for simultaneous quantification of 20 terpenes and 2 cannabinoids and (ii) apply it to fingerprint essential oils from four hemp strains, including local (HRDI2, HRDI5) and internationally cultivated (Charlotte’s Angel, Cherry Wine) varieties. The method met AOAC validation criteria, with detection limits of 0.025–0.5 µg/mL for terpenes and 1 µg/mL for cannabinoids. Quantitation limits ranged from 0.1–1 µg/mL for terpenes and 5 µg/mL for cannabinoids. Intraday precision (%RSD) ranged from 0.27–11.00%, while interday precision ranged from 3.14–13.89%. The method recoveries ranged from 85.12–115.47%. Precision and recovery confirmed the method’s reliability. Multivariate statistical analysis identified 82 metabolites, revealing distinct chemical fingerprints among strains, and emerged as newly identified chemotype markers, supporting chemotype classification. This work demonstrates, for the first time, a solvent-free, automatable SHS-GC-MS approach for simultaneous terpene and cannabinoid profiling in hemp essential oils, enabling both qualitative and quantitative characterization and supporting regulatory compliance for the development of standardized phytopharmaceutical products. Full article

This study initially examined the thermal comfort of rural residents in southern Jiangsu, analyzing their tolerance levels and expected temperature ranges during winter and summer. Subsequently, Design Builder 7.02.004 software was utilized to simulate the energy consumption of typical residential buildings. Furthermore, an orthogonal test method was employed to investigate the significant relationships among seven factors influencing building energy consumption in both winter and summer. These factors include external wall heat transfer coefficient, roof heat transfer coefficient, external window heat transfer coefficient, external window solar heat gain coefficient (SHGC), window-to-wall-area ratio, air tightness, and building orientation. Finally, based on the findings from the thermal comfort study, recommended passive design parameters for near-zero-energy residential buildings in southern Jiangsu were proposed. This provides valuable references for the future construction efforts of such buildings within this region. Full article

Based on the resource conservation requirements of GB/T 50378-2019 “Green Building Evaluation Standard”, this study constructed a BIM–Ecotect collaborative analysis model and proposed a “four-dimensional integration” green performance optimization method. Taking a high-rise office building in Wuhan as an example, a LOD 300-level Revit building information model was established, and a multidisciplinary collaborative analysis was achieved through gbXML data interaction. The lighting simulation results show that the average natural lighting coefficient of the office area facing south is 2.4 (the standard 85%), while in the meeting room area, due to the optimized design of the curtain wall, the average natural lighting coefficient has increased to 2.6 (the standard 92%). In terms of energy-saving renovation, a three-dimensional collaborative design strategy was adopted. Through the optimization of the envelope structure, the cooling load of the air conditioning system was reduced by 25.3%, and the heat load was reduced by 23.6% (the u value of the exterior wall was reduced by 56.3%, the SHGC of the exterior windows was reduced by 42.9%, and the thermal resistance of the roof was increased by 150%). The ventilation optimization adopts the CFD flow field reverse design, adjusting the window opening rate of the exterior windows from 15% to 20% to form a turbulent diffusion effect. Therefore, the air change rate in the office area reached 2.5 times per hour, and the CO₂ concentration decreased by up to 27.1% at most. The innovative adoption of the “composite sound insulation curtain wall” technology in acoustic environment control has increased the indoor noise compliance rate by 27 percentage points (from 65% to 92%). The above research data indicate that digital collaborative design can achieve an overall energy-saving rate of over 20% for buildings, providing a replicable technical path for enhancing the performance of green buildings. Full article

The flavor profile of white tea emerges from the natural biochemical composition of its tender leaves, a delicate balance profoundly shaped by seasonal growing conditions and tea cultivars. However, the effects of harvest seasons on biochemical and volatile compounds in white teas in southwestern China have not been fully analyzed at present. This study investigated the sensory characteristics, biochemical components, and volatile compounds of ‘Sanhua1951’ spring white tea (SH-S), ‘Sanhua1951’ autumn white tea (SH-A), ‘Fudingdabai’ spring white tea (FD-S), and ‘Fudingdabai’ autumn white tea (FD-A). The results showed that the sensory quality (appearance, taste, and aroma) scores of spring tea were higher than those of autumn tea. Spring teas exhibited significantly higher epigallocatechin, soluble sugar, and amino acid levels than autumn teas (p < 0.05), whereas autumn teas contained greater contents of epicatechin gallate, catechin, caffeine, and polyphenols (p < 0.05), which were responsible for the differences in taste quality observed between samples with different harvest seasons. A total of 90 volatile compounds in four groups were identified through HS-SPME–GC–MS analysis, and spring white teas contained higher contents of and variability in volatile compounds than autumn white teas. According to the OPLS-DA model, 52 and 57 differential volatile compounds (VIP > 1, p < 0.05, and fold change ≥ 2 or ≤0.5) were identified in SH-S vs. SH-A and FD-S vs. FD-A, including (Z)-linalool oxide, (E)-linalool oxide, styrene, phenylethyl alcohol, (Z)-citral, etc. The odor active value (OAV) results indicated that 30 key differential volatile compounds (OAV > 1) were determined in four groups, among which β-ionone, 5,6-epoxy-β-ionone, linalool, and (E)-linalool oxide exhibited particularly high OAVs and contributed more pekoe aroma and floral sensory characteristics. Notably, (E)-linalool oxide, (Z)-jasmone, and δ-cadinene were identified in each cultivar. These findings suggest their potential as seasonal markers, paving the way for the development of white tea ’Sanhua1951’ and ’Fudingdabai’. Full article

This study investigated specific winemaking procedures that could increase fermentation esters and volatile thiols in Chardonnay wine during fermentation. These compounds together are known to cause tropical fruit aromas. Two levels of pre-fermentative skin contact (10 °C for 18 h) (yes/no), two levels of β-lyase addition (40 μL/L) (yes/no), and three levels of fermentation gradient temperature, FG0 (constant 13 °C), FG1 (started at 20 °C and after 96 h dropped to 13 °C), and FG2 (started at 20 °C and after ~11.5 °Brix dropped to 13 °C), were evaluated using laboratory-scale ferments in a full factorial design. Esters and the volatile thiols, 3-sulfanylhexan-1-ol (3SH), 3-sulfanylhexyl acetate (3SHA), and 4-methyl-4-sulfanylpentan-2-one (4MSP), were quantified using gas and liquid chromatography methods, respectively. The combination of skin contact and FG1 or FG2 resulted in the greatest levels of esters and thiols in Chardonnay wine. The fermentation gradient was shown to be efficient in reducing volatile compounds normally lost due to evaporation during fermentation. With these different processing techniques, it will be possible for winemakers to achieve different wine qualities depending on their chosen wine style. Full article

This study employs Design Builder software to evaluate advanced glazing technologies for enhancing the thermal performance of residential buildings in Jeddah, Saudi Arabia. Recognizing the energy inefficiencies caused by adopting Western architectural styles unsuited to local climatic conditions, and given that buildings consume 44% of national energy, we conducted a systematic parametric analysis to isolate the effects of key glazing parameters. The study examines six polycarbonate (PC) configurations and three critical comparative cases: (1) a selective double-glazed unit representing a new baseline glazing; (2) a low-U configuration to isolate thermal insulation effects; and (3) a low-SHGC configuration to evaluate solar heat gain mitigation independently. These controlled comparisons address a critical research gap by decoupling the traditionally confounded impacts of U-value and SHGC in hot climates. The simulations reveal that the 36 mm aerogel glazing (U = 0.9 W/m²·K, SHGC = 0.3) reduces cooling demand by 48.6% annually compared to single-pane glazing while maintaining indoor temperatures at 30.09 °C versus 38.43 °C at baseline. Notably, the findings demonstrate that 87% of these savings derive from SHGC reduction, with only 3.02 percentage points attributable to U-value improvements. The selective DGU benchmark delivers 85% of aerogel’s benefits at 40% lower cost, establishing it as a practical solution for most applications. These findings provide evidence-based guidance for Saudi Vision 2030’s sustainability goals, emphasizing that while aerogel glazing excels in extreme solar exposures, strategic SHGC optimization in conventional glazing can achieve the most energy savings in hot climates. Full article

This study investigates the potential reuse of Prunus spinosa (blackthorn) seeds, a food industry by-product. Traditionally discarded, these seeds are now being explored for their bioactive compounds. In this work, seeds were used as raw material for supercritical CO₂ extraction. Two distinct extracts were obtained at low and high pressure (SFE90 and SFE200) and both extracts presented an aqueous phase (WE90 and WE200). SFE90 analysis by GC/MS allowed us to identify benzaldehyde and fatty acids (mainly oleic and linoleic acids). The fatty acid profile of SFE200, determined by HPLC-DAD/ELSD, showed that oleic and linoleic acids were predominant in supercritical oil. The phytochemical composition of the water extracts, analyzed via LC-DAD-ESI-MS, revealed that higher pressure enhanced the recovery of specific flavonols and anthocyanins, while lower pressure preserved various polyphenolic subclasses. WE90 was rich in 3-feruloylquinic acid and cyanidin-3-O-rutinoside, whereas WE200 was rich in caffeic acid hexoside 2 and dihydro-o-coumaric acid glucoside. Benzaldehyde was individuated in WE90 and WE200 by HPLC-DAD analysis. Cytotoxicity assays demonstrated that WE90, WE200 and SFE200 had anticancer effects on SH-SY5Y neuroblastoma cells, while all extracts did not remarkably affect the viability and morphology of human skin keratinocytes (HaCaT cells). These results suggest that P. spinosa seed extracts have potential nutraceutical and pharmaceutical applications. Full article

Cathinones, a class of synthetic new psychoactive substances (NPSs), continue to emerge and pose public threats. Government control efforts often lead to the emergence of new isomers, which have adverse repercussions on NPSs identification and risk prediction. This work reports on the synthesis and structural characterization of twenty chloro-cathinones, including different isomers, to create analytical data to facilitate their identification in forensic and clinical contexts. Additionally, the potential of these cathinones to cause neuronal damage was evaluated. In vitro cytotoxicity was assessed using a differentiated human neuroblastoma cell line (SH-SY5Y) as a dopaminergic neuronal model. The tested cathinones showed LC₅₀ values from 0.6 to 2.5 mM, with 4-CBC being the most cytotoxic. The most toxic cathinones increase reactive oxygen species levels and/or cause mitochondrial membrane potential depolarization. Furthermore, this study explored, for the first time, the effect of cathinones on the cholinergic system through acetylcholinesterase (AChE) inhibition. All tested cathinones inhibited AChE with IC₅₀ values between 0.1 and 2 mM. Molecular docking analysis revealed that the most inhibitory cathinones interacted with the CASs and PASs in AChE’s active gorge. These findings provide valuable insights into the effects of cathinones, highlighting potential health risks and structural features that may influence their toxicity towards the cholinergic system and neuronal damage. Full article