Search Results (2)

Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that are not translated into proteins. Their expression is tissue-specific, with the vast majority involved in the regulation of cellular processes and functions. Many human diseases, including cancer, have been shown to be associated with deregulated lncRNAs, rendering them potential therapeutic targets and biomarkers for differential diagnosis. The expression of lncRNAs in the nervous system varies in different cell types, implicated in mechanisms of neurons and glia, with effects on the development and functioning of the brain. Reports have also shown a link between changes in lncRNA molecules and the etiopathogenesis of brain neoplasia, including glioblastoma multiforme (GBM). GBM is an aggressive variant of brain cancer with an unfavourable prognosis and a median survival of 14–16 months. It is considered a brain-specific disease with the highly invasive malignant cells spreading throughout the neural tissue, impeding the complete resection, and leading to post-surgery recurrences, which are the prime cause of mortality. The early diagnosis of GBM could improve the treatment and extend survival, with the lncRNA profiling of biological fluids promising the detection of neoplastic changes at their initial stages and more effective therapeutic interventions. This review presents a systematic overview of GBM-associated deregulation of lncRNAs with a focus on lncRNA fingerprints in patients’ blood. Full article

A floating storage and regasification unit (FSRU) terminal has been planned to be constructed in Saros Bay (Türkiye). This study presents the ground improvement method using jet grouting to prevent the liquefaction of marine sediments in the project area. An approach for performance assessment of jet column construction is also discussed. The study site has a liquefiable ground level with a thickness changing between 2 m and 8 m. Jet grout columns with an 80 cm diameter were constructed under the sea level, which varied between 4 m and 18 m for ground improvement. The main issue is controlling the quality and performance of these jet columns. Therefore, a practical quality control procedure containing observational, mechanical, and geophysical methods for offshore grouting operations was proposed. The factor of safety values against liquefaction varied between 0.04 and 0.29 for natural conditions, while the minimum factor of safety after jet column constructions was obtained as 1.01. The results of the numerical analyses showed that the constructed terminal has sufficient performance against liquefaction. Consequently, the results of these methods have demonstrated that the jet grout applications performed by following this procedure are a suitable and effective improvement method for offshore soils. Full article