Search Results (177)

The widespread production and application of per- and polyfluoroalkyl substances (PFASs) have created a global environmental and public health crisis. This review aimed to consolidate the foundational knowledge on PFASs by synthesizing research on their environmental fate, human health impact, analytical methods, and regulatory status and by highlighting their critical challenges. A comprehensive literature search focusing on publications from the last five years (2020–2025) was conducted using global scientific databases (e.g., PubMed, Web of Science) and regulatory reports (e.g., EPA, ECHA). The persistent and pervasive nature of PFASs stems from the highly stable carbon–fluorine (C-F) bond, leading to their widespread release from diverse industrial and consumer products into water, soil, and air. Key outcomes reveal significant analytical challenges in their detection, including sample matrix complexity, widespread laboratory contamination, and a lack of standards for the vast number of specific compounds. Critical research gaps were identified, particularly the limited data on PFAS concentrations in air and dust, the need for standardized analytical methods and reporting units, and the urgent necessity for developing scalable, sustainable remediation strategies. The ongoing environmental contamination and associated health risks necessitate continued, focused interdisciplinary research to improve detection, risk assessment, and the effective management of this complex class of pollutants. Full article

Public cooperation is crucial for the police to successfully perform their duties. Yet marginalised and vulnerable groups facing uncertainty about their societal status often significantly mistrust the police. Migrant populations experiencing forced labour are marginalised and uncertain groups that face significant challenges for police in gaining trust and cooperation, especially since many have escaped conflict or authoritarian regimes, or experienced trauma and exploitation prior to encountering police in democratic contexts. This paper examines the potential role of policing agencies in Anglophone countries in addressing forced labour in migrant communities. Whilst recognising that police are not ideal first responders to this issue, the paper acknowledges that they often represent the first visible state response with the legal authority to support or detain individuals. This paper reviews the literature on forced labour and migration and presents a conceptual argument, applying procedural justice as a theoretical framework to assess its potential for improving the policing of forced labour, particularly among newly arrived migrants still establishing social relationships, bonds, and capital. The paper concludes by arguing that procedural justice may help police earn the trust and confidence of migrant populations experiencing forced labour and help address labour exploitation, although this trust-building remains hampered by the concomitant harms caused by crimmigration systems. Full article

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important DNA repair enzyme and its functioning is considered as one of the possible reasons for tumor resistance to topoisomerase 1 (TOP1) poisons such as topotecan. Thus, TDP1 inhibitors in combination with topotecan may improve the effectiveness of anticancer therapy. TDP1 acts somehow in a phospholipase manner, depleting the phosphodiester bond between lipophilic tyrosine residue and 3′ end of DNA; therefore, lipophilic molecules bearing aromatic substituents can interact with TDP1 and even possess high inhibitory activity, which is evidenced by data from the literature. Previously, we identified lipophilic nucleoside derivative (compound 6d, IC₅₀ = 0.82 µM) as an effective inhibitor of the purified enzyme TDP1 that enhances the cytotoxic, DNA-damaging, and antitumor effects of topotecan. However, the role of TDP1 inhibition in this synergistic effect remained not fully understood. In the present study, we have tested the hypothesis of a TDP1-dependent mechanism of action for compound 6d, showing that it sensitizes wild-type A549 lung cancer cells, but not TDP1 knockout cells, to the cytotoxic effects of topotecan. The sensitizing effect was absent in non-cancerous HEK293A cells regardless of TDP1 status. Additionally, we analyzed the effect of compound 6d and topotecan on the expression level of TOP1 and TDP1 to determine whether the observed synergy was due to direct TDP1 inhibition and/or changes in regulation of these enzymes. The data obtained shows that compound 6d did not affect TDP1 gene expression level in HEK293A and A549 WT cells. Thus, compound 6d most probably does not suppress the transcription or mRNA stability of TDP1, and the synergistic action of 6d with topotecan is related to TDP1 inhibtion. Full article

β-glucosidase is a kind of enzyme that can hydrolyze β-glucosidase bonds, and it plays a key role in many fields, such as lignocellulose degradation and wine brewing. The global β-glucosidase market is currently estimated to be USD 40 billion, and more is expected in the future. This trend is mainly due to the demand for enzymes in biofuel processing. At present, β-glucosidase is mainly derived from microorganisms, animals, plants and so on. It has received great attention due to its ease of production, catalytic efficiency and versatility, which have promoted its biotechnology potential in different industries. With the increasing demand for β-glucosidases, various cost-effective methods are being explored to discover, redesign and enhance their production and functional properties. Therefore, this paper reviews the latest progress in the application of β-glucosidase in industry. In this regard, the focus is on the use of recombinant technology, protein engineering and immobilization technology to improve the industrial applicability of the enzyme. In addition, the application status of β-glucosidase in production and life was analyzed. Full article

In traditional scallion cultivation, the bare-root transplanting method—which involves direct seeding, seedling raising in the field, and lifting—is commonly adopted to minimize seedling production costs. However, during the mechanized transplanting of bare-root scallion seedlings, practical problems such as severe seedling damage and poor planting uprightness exist. In this paper, the Hertz–Mindlin with Bonding contact model was used to establish the scallion seedling model. Combined with the Plackett–Burman experiment, steepest ascent experiment, and Box–Behnken experiment, the bonding parameters of scallion seedlings were calibrated. Furthermore, the accuracy of the scallion seedling model parameters was verified through the stress–strain characteristics observed during the actual loading and compression process of the scallion seedlings. The results indicate that the scallion seedling normal/tangential contact stiffness, scallion seedling normal/tangential ultimate stress, and scallion Poisson’s ratio significantly influence the mechanical properties of scallion seedlings. Through optimization experiments, the optimal combination of the above parameters was determined to be 4.84 × 10⁹ N/m, 5.64 × 10⁷ Pa, and 0.38. In this paper, the flexible planting components of scallion seedlings were taken as the research object. Flexible protrusions were added to the planting disc to reduce the damage rate of scallion seedlings, and an EDEM-ADAMS coupling interaction model between the planting components and scallion seedlings was established. Based on this model, optimization and verification were carried out on the key components of the planting components. Orthogonal experiments were conducted with the contact area between scallion seedlings and the disc, rotational speed of the flexible disc, furrow depth, and clamping force on scallion seedlings as experimental factors, and with the uprightness and damage status of scallion seedlings as evaluation criteria. The experimental results showed that when the contact area between scallion seedlings and the disc was 255 mm², the angular velocity was 0.278 rad/s, and the furrow depth was 102.15 mm, the performance of the scallion planting mechanism was optimal. At this point, the uprightness of the scallion seedlings was 94.80% and the damage rate was 3%. Field experiments were carried out based on the above parameters. The results indicated that the average uprightness of transplanted scallion seedlings was 93.86% and the damage rate was 2.76%, with an error of less than 2% compared with the simulation prediction values. Therefore, the parameter model constructed in this paper is reliable and effective, and the designed and improved transplanting mechanism can realize the upright and low-damage planting of scallion seedlings, providing a reference for the low-damage and high-uprightness transplanting operation of scallions. Full article

As modern industrialization accelerates, traditional metallic materials face challenges in meeting critical surface protection requirements. Constrained by their physicochemical properties, these materials exhibit significant performance degradation. This leads to frequent peeling of surface coatings on critical components. Polyetheretherketone (PEEK) is a high-performance semi-crystalline thermoplastic used in advanced engineering applications. Its composite coating systems have emerged as a promising alternative to metallic coatings. This paper systematically reviews the recent advances in coating preparation techniques for PEEK composites. The current status of the use of mainstream preparation methods such as thermal spray technology, rapid prototyping and electrophoretic deposition is highlighted. The strengths and weaknesses of each method are also compared. Critical parameters including substrate roughness, temperature, and substrate elasticity are systematically examined. The effects of these variables are evaluated with respect to critical performance indicators, including porosity levels and interfacial bonding strength of PEEK composite coatings. A comparative investigation was carried out on different reinforcement materials. Their interfacial interactions with the matrix are examined in detail at the microscopic level. The impact of these modification strategies on coating performance was comprehensively evaluated. Full article

Considering the growing demand for modern facility agriculture, it is essential to develop non-destructive technologies for assessing lettuce nutritional status. To overcome the limitations of traditional methods, which are destructive and time-consuming, this study proposes a multimodal non-destructive nitrogen detection method for lettuce based on multi-source imaging. The approach integrates terahertz time-domain spectroscopy (THz-TDS) and near-infrared hyperspectral imaging (NIR-HSI) to achieve rapid and non-invasive nitrogen detection. Spectral imaging data of lettuce samples under different nitrogen gradients (20–150%) were simultaneously acquired using a THz-TDS system (0.2–1.2 THz) and a NIR-HSI system (1000–1600 nm), with image segmentation applied to remove background interference. During data processing, Savitzky–Golay smoothing, MSC (for THz data), and SNV (for NIR data) were employed for combined preprocessing, and sample partitioning was performed using the SPXY algorithm. Subsequently, SCARS/iPLS/IRIV algorithms were applied for THz feature selection, while RF/SPA/ICO methods were used for NIR feature screening, followed by nitrogen content prediction modeling with LS-SVM and KELM. Furthermore, small-sample learning was utilized to fuse crop feature information from the two modalities, providing a more comprehensive and effective detection strategy. The results demonstrated that the THz-based model with SCARS-selected power spectrum features and an RBF-kernel LS-SVM achieved the best predictive performance (R² = 0.96, RMSE = 0.20), while the NIR-based model with ICO features and an RBF-kernel LS-SVM achieved the highest accuracy (R² = 0.967, RMSE = 0.193). The fusion model, combining SCARS and ICO features, exhibited the best overall performance, with training accuracy of 96.25% and prediction accuracy of 95.94%. This dual-spectral technique leverages the complementary responses of nitrogen in molecular vibrations (THz) and organic chemical bonds (NIR), significantly enhancing model performance. To the best of our knowledge, this is the first study to realize the synergistic application of THz and NIR spectroscopy in nitrogen detection of facility-grown lettuce, providing a high-precision, non-destructive solution for rapid crop nutrition diagnosis. Full article

Social behaviour plays a crucial role in the dynamics of parasitic infections in wild bird populations. The red-billed chough (Pyrrhocorax pyrrhocorax), a corvid undergoing notable population declines, shows contrasting social structures linked to reproductive status: non-breeding individuals aggregate in communal roosts during winter, whereas breeding pairs often maintain territorial pair-bonds and roost at nesting sites. This study tested whether differences in sociality (communal roosting vs. territorial pairs) affect intestinal parasite infections. Fresh faecal samples were collected during winter in central Spain and analysed using flotation and McMaster techniques to detect and quantify coccidian oocysts and helminth eggs. The results revealed a relatively high positive rate of Isospora (36.2%, n = 116) and a low positive rate of helminths (9.5%, n = 116) among communally roosting non-breeders, while no parasites were detected in samples from territorial pairs. One communal roost in the Southern Plateau showed higher coccidian positive rate, possibly influenced by structural features that facilitate faecal contact. Although sample size for pairs was limited, the absence of parasites in this group suggests reduced infection risk, likely reflecting superior condition and immune defences rather than differences in exposure alone. These findings highlight the value of non-invasive parasite monitoring as an early-warning tool in wildlife health assessments and stress the importance of considering social behaviour and environmental heterogeneity into conservation strategies for threatened species. Full article

The integration of composite materials into commercial aviation has transformed the industry by providing superior performance benefits, including enhanced fuel efficiency, reduced emissions, and improved structural integrity. With a significant shift towards aircraft featuring high contents of composite materials, the focus has also turned to the challenges associated with the end-of-life management of these materials. Unlike metals, composites are notoriously difficult to recycle due to the strong bonding between fibres and resin, creating significant environmental and economic challenges. The methodology employed—consisting of an extensive literature review that prioritises a holistic approach—aims to provide an overview of the status of composite recyclability in aviation. With this, the report investigates the durability of composites under operational conditions, the associated environmental factors, and their impact on the recycling potential. The dismantling processes for decommissioned aircraft are analysed to identify strategies that preserve material integrity for effective recycling. Established recycling methods are critically evaluated alongside innovative approaches. The study highlights the limitations of current techniques in terms of costs, energy consumption, and material degradation while exploring emerging technologies that aim to overcome these barriers. It is concluded that currently available techniques do not possess the industrial maturity required to handle the amount of composite materials being employed in aviation. Moreover, there is a clear discontinuity between the developments in the usage of composites and their end-of-life recycling, which can cause serious environmental and economic challenges in future years. By combining information regarding composite usage and aircraft retirements, assessing the environmental and economic implications of composite recycling as well as available techniques, and proposing pathways for improvement, this research underscores the importance of adopting sustainable practices in aviation. The findings aim to contribute to the development of a circular economy within the aerospace sector, ensuring the long-term viability and environmental responsibility of future composite-intensive aircraft designs. This is performed by calling for a multi-stakeholder strategy to drive recycling readiness and facilitate the evolution towards a circular economy in aviation, leading to more sustainable design, production, and dismantlement of aircraft in the future. Full article

Background: Understanding the multifactorial determinants of human longevity remains a major scientific challenge. Certain regions of the world—so-called “longevity hotspots”—exhibit a notably high prevalence of centenarians; one such region is the province of Ourense, in north-western Spain. Objectives: This study aimed to analyse, for the first time, the nutritional factors associated with healthy longevity among centenarians, as well as those linked to longevity irrespective of health status, in the province of Ourense. Methods: A cross-sectional, retrospective, observational, mixed-methods study was conducted. A population of 261 individuals aged 100 or over residing in Ourense was identified. A sample of 156 participants was included in the quantitative analysis; from this sample, 25 centenarians were selected for in-depth qualitative analysis through personal interviews. Results: Dietary patterns aligned with the Southern European Atlantic Diet (SEAD), combined with strong social bonds and a culture of self-sufficiency, appear to be key contributors to exceptional longevity in this population. Conclusions: Remarkable longevity in Ourense is associated with a combination of factors: adherence to an SEAD-style dietary pattern, an active and uncomplicated lifestyle, and strong social support networks. Full article

Consanguinity is the marriage of two related persons. This type of marriage is one of the main pillars when it comes to recessive hereditary diseases, birth defects, infertility, miscarriages, abortion, and infant deaths. Intermarriage continues to be a common practice in various communities in North Africa, the Middle East, and West and South Asia, as well as among migrants from Europe and North America, even though in more and more countries it has become illegal. Even if security and stability are some of the motivations for consanguineous marriage, studies show that women often suffer physical and verbal abuse from their husbands. However, because of the blood bond, tolerance for these habits is much higher. In addition, it seems that the divorce rate is much lower because separation would affect the entire state of the family. The choice of partner is significantly influenced by variables such as limited access to education and financial resources. Illiterate people coming from poor rural areas are much more likely to choose consanguineous marriage to maintain wealth in the family. The lack of medical knowledge about the negative effects of consanguinity leads to an increased rate of abortions, infant deaths, and births of children with congenital birth defects. Today, because of the process of urbanization and increased levels of knowledge, the younger generation is becoming increasingly less receptive to this particular form of marriage. In addition, as education has become more accessible to women, they have become more independent and eager to fulfill their own goals and not the wishes of the family. In conclusion, contrary to the many apparent advantages of consanguineous marriage, partners should put genetic risks first, as medical problems bring with them increased costs in the medical system and also within the family, leading to even lower economic status and consequently perpetuation of this type of marriage. Full article

Strong emotional bonds within families are foundational to children’s academic, psychological, and social development. While family cohesion is widely recognized as a protective factor across these domains, there remains a need to understand the specific mechanisms and interventions that foster such cohesion, particularly in diverse socioeconomic and cultural contexts. This systematic review examines global evidence on factors influencing family cohesion and evaluates intervention strategies designed to strengthen familial relationships. Drawing on 41 peer-reviewed studies published between 2015 and 2023, this review adheres to PRISMA guidelines and applies the Mixed Methods Appraisal Tool (MMAT) to assess methodological quality. The findings are organized around four core dimensions of family cohesion—emotional bonding, adaptability, communication, and support—and highlight both common patterns and culturally specific mechanisms. Studies were drawn from a range of settings including North America, sub-Saharan Africa, Latin America, East and Southeast Asia, and Europe, enabling a cross-cultural analysis of how family cohesion operates under different social, cultural, and economic conditions. Intervention strategies are reviewed separately following the synthesis of correlations, with attention to their effectiveness, cultural relevance, and contextual adaptability. Community-based programs, trauma-informed therapies, and parenting interventions emerge as key approaches, though their success has varied by regional and structural context. Studies consistently demonstrate that higher family cohesion correlates with improved academic outcomes, as supportive home environments promote motivation, reduce stress, and enhance learning. Mental health benefits are also evident, with cohesive and adaptable families mitigating risks of anxiety and depression through open communication and emotional availability. Social competence is fostered through observed and practiced interpersonal skills within family settings. Socioeconomic status emerges as both a challenge and a moderating factor, with lower-SES families facing greater barriers to cohesion but also displaying notable resilience when supported through external interventions. Effective strategies identified include family therapy, parenting education, community-based programs, culturally sensitive approaches, and socioeconomic policy supports. Family cohesion and adaptability are critical to nurturing children’s academic success, emotional well-being, and social development. This review contributes to a more culturally nuanced and policy-relevant understanding of family cohesion by integrating empirical findings across global contexts and identifying both shared and differentiated pathways to resilience. The results inform future program design and suggest priorities for cross-cultural family research and intervention development. Full article

Brachycephalic dogs remain highly popular despite the well-documented health problems associated with their conformation. The aim of this study was to investigate differences in the bonding between humans and dogs, behavioral characteristics, awareness of clinical breed-related ailments, and purchasing intentions among Italian brachycephalic dog owners (BDOs) and non-brachycephalic dog owners (NBDOs). A questionnaire, including the DORS and C-BARQ scales, was administered to 320 BDOs and 408 NBDOs. Despite the occurrence of breed-related disorders, 81% of BDOs rated their dog’s health status as good to excellent. Most BDOs were aware of the prevalence of these disorders in the broader brachycephalic dog population. Character and appearance were the main motivations for choosing these breeds. Owners’ satisfaction with specific aspects of ownership, such as veterinary costs and behavior, generally met expectations. Mean scores of perceived emotional closeness (PEC) and dog–owner interaction (DOI) were significantly higher among BDOs compared to NBDOs, while the perceived cost (PC) mean score was higher among NBDOs. The C-BARQ scores for trainability, excitability, and separation-related behaviors were significantly higher in BDOs than in NBDOs. Despite the growing awareness of health issues, the popularity of brachycephalic breeds persists. Scientific evidence may support a revision of brachycephalic breed standards, prioritizing animal welfare while preserving desirable aesthetic traits, promoting more ethical breeding. Full article

Background: According to the One Health concept, the physical proximity between pets and their owners facilitates the interspecies spread of bacteria including those that may harbor numerous antimicrobial resistance genes (ARGs). Methods: A shotgun sequencing metagenomic data-based bacteriome and resistome study of 1830 canine saliva samples was conducted considering the subsets of ARGs with higher public health risk, ESKAPE pathogen relatedness (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species), and survey results on the physical and behavioral characteristics of the participating dogs. Results: A total of 318 ARG types achieved sufficiently high detection rates. These ARGs can affect 31 antibiotic drug classes through various resistance mechanisms. ARGs against tetracyclines, cephalosporins, and, interestingly, peptides appeared in the highest number of samples. Other Critically Important Antimicrobials (CIAs, WHO), such as aminoglycosides, fluoroquinolones, or macrolides, were among the drug classes most frequently affected by ARGs of higher public health risk and ESKAPE pathogen-related ARGs of higher public health risk. Several characteristics, including coat color, sterilization status, size, activity, or aggressiveness, were associated with statistically significant differences in ARG occurrence rates (p < 0.0500). Conclusions: Although the oral microbiome of pet owners is unknown, the One Health and public health implications of the close human–pet bonds and the factors potentially underlying the increase in salivary ARG numbers should be considered, particularly in light of the presence of ARGs affecting critically important drugs for human medicine. Full article

Fiber-reinforced resin composites (FRRCs) are widely used in several fields such as construction, automotive, aerospace, and power. Basalt fiber (BF) has been increasingly used to replace artificial fibers such as glass fiber and carbon fiber in the production of BF-reinforced resin matrix composites (BFRRCs). This preference stems from its superior properties, including high temperature resistance, chemical stability, ease of manufacturing, cost-effectiveness, non-toxicity, and its natural, environmentally friendly characteristics. However, the chemical inertness of BF endows it with poor compatibility, adhesion, and dispersion in a resin matrix, leading to poor adhesion and a weak BF–resin interface. The interfacial bonding strength between BF and resin is an important parameter that determines the service performance of BFRRC. Therefore, the interfacial bonding strength between them can be improved through fiber modification, resin–matrix modification, mixed enhancers, etc., which consequently upgrade the mechanical properties, thermodynamic properties, and durability of BFRRC. In this review, first, the production process and properties of BFs are presented. Second, the mechanical properties, thermodynamic properties, and durability of BFRRC are introduced. Third, the modification effect of the non-destructive surface-modification technology of BF on BFRRC is presented herein. Finally, based on the current research status, the future research direction of BFRRC is proposed, including the development of high-performance composite materials, green manufacturing processes, and intelligent applications. Full article