Search Results (15,754)

Composite interphase spacers are essential components in ultra-high-voltage (UHV) transmission lines to suppress conductor galloping. This study investigates the first reported case of a core-rod fracture in a 500 kV composite spacer and elucidates its degradation mechanism through multi-scale characterization, electrical testing combined and electric field and mechanical simulation. Macroscopic inspection and industrial computed tomography (CT) show that degradation initiated at the unsheltered high-voltage sheath–core interface and propagated axially, accompanied by continuous interfacial cracks and void networks whose volume ratio gradually decreased along the spacer. Material characterizations indicate moisture-driven glass-fiber hydrolysis, epoxy oxidation, and progressive interfacial debonding. Leakage current test further indicates humidity-sensitive conductive paths in the degraded region, confirming the presence of moisture-activated interfacial channels. Electric-field simulations under two shed configurations demonstrated that local field intensification was concentrated within 20–30 cm of the HV terminal, where the sheath and core surface fields increased by approximately 9.3% and 5.5%. Mechanical modeling demonstrates a pronounced bending-induced stress concentration at the same end region. The combined effects of moisture ingress, electrical stress, mechanical loading, and chemical degradation lead to the decay-like fracture. Improving sheath hydrophobicity, enhancing interfacial bonding, and optimizing end-fitting geometry are recommended to mitigate such failures and ensure the long-term reliability of UHV composite interphase spacers. Full article

Rapid and specific detection of toxic Novichok agents (A230, A232, A234) is crucial for forensic investigations and the prevention of chemical weapon misuse. While A232 and A234 are relatively stable, A230 is less stable and primarily undergoes hydrolysis via P–F bond cleavage. This product indicates the presence of the Novichok core but does not indicate the agent’s prior existence. In this study, a method with high sensitivity for determining the presence of the minor A230 hydrolysis product—namely methylphosphonofluoridic acid (MPFA), which is generated via P-N bond cleavage—in environmental matrices was established. 2-[(Dimethylamino)methyl]phenol (2-DMAMP) was found to be effective for the derivatization of MPFA in water. The derivatization protocol after optimization involved adding 2-DMAMP followed by agitating for 72 h at 50 °C before LC–MS/MS analysis. The derivatized MPFA, analyzed by ESI–MS/MS, showed two main fragment ions with m/z values of 185.0 and m/z 107.0. The approach was applied to tap water, aqueous soil extract, and saline samples. While intact MPFA exhibited reduced detectability due to strong matrix effects, derivatization enhanced its stability and minimized interferences, resulting in its significantly higher detection sensitivity. The detection of MPFA provides a clear indication that the toxic Novichok compound was present prior to hydrolysis. Full article

Remediating complex-contaminated soils demands the synergistic optimization of efficiency, cost-effectiveness, and carbon emission reduction. Currently, ultra-high-temperature thermal desorption technology is mature in terms of principle and laboratory-scale performance; however, ongoing efforts are focusing on achieving stable, efficient, controllable, and cost-optimized operation in large-scale engineering applications. To address this gap, this study aimed to (1) verify the energy efficiency and economic benefits of removing over 98% of target pollutants at a 7.5 × 10⁴ m³ contaminated site and (2) elucidate the mechanisms underlying parallel scale–technology dual-factor cost reduction and energy–carbon–cost optimization, thereby accumulating case experience and data support for large-scale engineering deployment. To achieve these objectives, a “thermal stability–chemical oxidizability” classification criterion was developed to guide a parallel remediation strategy, integrating ex situ ultra-high-temperature thermal desorption (1000 °C) with persulfate-based chemical oxidation. This strategy was implemented at a 7.5 × 10⁴ m³ large-scale site, delivering robust performance: the total petroleum hydrocarbon (TPH) and pentachlorophenol (PCP) removal efficiencies exceeded 99%, with a median removal rate of 98% for polycyclic aromatic hydrocarbons (PAHs). It also provided a critical operational example of a large-scale engineering application, demonstrating a daily treatment capacity of 987 m³, a unit remediation cost of 800 CNY·m⁻³, and energy consumption of 820 kWh·m⁻³, outperforming established benchmarks reported in the literature. A net reduction of 2.9 kilotonnes of CO₂ equivalent (kt CO₂e) in greenhouse gas emissions was achieved, which could be further enhanced with an additional 8.8 kt CO₂e by integrating a hybrid renewable energy system (70% photovoltaic–molten salt thermal storage + 30% green power). In summary, this study establishes a “high-temperature–parallel oxidation–low-carbon energy” framework for the rapid remediation of large-scale multi-contaminant sites, proposes a feasible pathway toward developing a soil carbon credit mechanism, and fills a critical gap between laboratory-scale success and large-scale engineering applications of ultra-high-temperature remediation technologies. Full article

Kinases, which make up 20% of the druggable genome, are thought to be essential signaling enzymes. Protein phosphorylation is induced by protein kinases. Proliferation, the cell cycle, apoptosis, motility, growth, differentiation, and other biological processes are all regulated by kinases. Their dysregulation disrupts several cellular functions, leading to a variety of illnesses, the most important of which is cancer. As a result, kinases are thought to be crucial targets in a number of malignancies and other diseases. Researchers from all over the world are hard at work developing inhibitors using various chemical structures. The scaffolds of imidazole and benzimidazole provide a versatile structure for a variety of physiologically active substances. Moreover, they serve as specialized scaffolding for the creation of target-specific pharmaceuticals to address various diseases. This article seeks to illustrate the application of imidazole and benzimidazole frameworks in the formulation of inhibitors that target various tyrosine kinases, including fibroblast growth factor receptors (FGFRs), c-Met kinase, epidermal growth factor receptors (EGFRs), vascular endothelial growth factor receptors (VEGFRs), and FMS-like tyrosine kinase 3 (FLT3), from 2020 to the present. The major structure–activity correlations (SARs) of imidazole and benzimidazole derivatives were examined, and, also, a docking study highlighted the varied interactions occurring inside the active site of tyrosine protein kinases. The objective of this effort is to consolidate the fundamental structural information necessary for the synthesis of imidazole- or benzimidazole-based tyrosine kinase inhibitors with enhanced efficacy. Full article

COVID-19 has resulted in over 777 million confirmed cases and more than 7 million deaths globally. While vaccination offers protection for individuals with a functional immune system, immunocompromised populations will not generate sufficient responses, highlighting the critical need for new antiviral treatments. Here we evaluated four highly conserved anti-COVID siRNAs targeting the ORF1a-Nsp1, Membrane, and Nucleocapsid regions by identifying their antiviral efficacy in vitro and investigated the direct delivery of naked siRNAs to the respiratory tract of mice via intranasal instillation to provide proof-of-concept evidence of their in vivo antiviral activity. Dose-response analysis of siRNAs revealed a range of IC50 0.02 nM to 0.9 nM. Intranasal administration of naked anti-COVID siRNA-18 in a K18-hACE2 transgenic SARS-CoV-2 mouse model was capable of reducing viral mRNA levels and disease severity. While anti-COVID siRNA-30 induced modest interferon-stimulated gene expression in vitro and immune cell infiltration in vivo, these effects were markedly reduced by 2′-O-methyl-AS456 chemical modification, which preserved antiviral efficacy against SARS-CoV-2 while minimizing off-target immune activation. These results demonstrate the feasibility of direct respiratory siRNA administration for in vivo viral suppression and highlight the benefit of using conserved target sequences and chemical modification to enhance therapeutic safety and efficacy. Full article

Pinus koraiensis, as a keystone tree species, possesses immense economic and ecological value. However, the present cultivation of high-quality seedlings in Pinus koraiensis plantations remains hindered by prohibitively high costs and inadequate technological advancements. Additionally, the species’ prolonged growth cycle and low yield, when compounded by issues such as excessive harvesting, may result in supply constraints. Plant growth regulators (PGRs), a class of naturally occurring or synthetically derived chemical compounds, are capable of modulating plant development and physiology. These regulators exert notable effects by enhancing root proliferation, facilitating lignification, influencing plant architecture, and augmenting yield. Owing to their operational simplicity and relatively low cost, PGR applications hold substantial promise for cultivating Pinus koraiensis seedlings with superior traits. In this study, four-year-old Pinus koraiensis seedlings were employed to evaluate the impacts of three PGRs (paclobutrazol, chlormequat chloride, and diethyl aminoethyl hexanoate), alongside varied application methods (dosage and frequency), on the growth, physiological, and photosynthetic parameters of the seedlings. The findings revealed that treatment with 1.5 g/L paclobutrazol produced the most pronounced effects across a range of indicators. Specifically, this treatment markedly enhanced growth traits (e.g., branch diameter, new shoot length, lateral branch length, aboveground fresh and dry weights, root fresh and dry weights, lateral root dry weight, and number of second-order roots), physiological attributes (e.g., increased superoxide dismutase and peroxidase activities, elevated lignin content, and reduced relative conductivity and malondialdehyde levels), and photosynthetic metrics (e.g., elevated net photosynthetic rate, stomatal conductance, transpiration rate, and maximum net photosynthetic rate), thereby constituting the optimal treatment combination. Full article

To ensure the quality and efficient access of the population to plant-derived resources, research on the sustainable cultivation of medicinal species is of great importance, and the present study aimed to evaluate the influence of poultry litter-based organic fertilization and seasonality on plant growth, soil health (quality), and secondary metabolism of Cuphea carthagenensis. Plants were cultivated during the summer and autumn/winter seasons in a randomized design with five poultry litter application rates (0, 10, 20, 30, and 40 t ha⁻¹) and three replications per plot field (1 × 2 m). The parameters evaluated included soil health, plant biomass, nutrient content, extract yield from the aerial parts, and chemical composition. In the summer, soil bioindicators (microbial biomass carbon and basal respiration) increased with the addition of poultry litter, although plant biomass was not affected by the season. Plant nutrient levels, particularly N and P, increased under poultry litter application rates of 30 t ha⁻¹ and higher. Under these conditions, the highest extract yield from the aerial parts was obtained at a rate of 40 t ha⁻¹. During autumn/winter, poultry litter increased significantly soil microbial biomass carbon, plant biomass, and N and P contents, resulting in an 11.07% increase in extract yield at a rate of 20 t ha⁻¹. Phytochemical analysis of the extracts identified 29 compounds, predominantly quercetin derivatives. Overall, the findings demonstrate that the sustainable cultivation of C. carthagenensis under organic fertilization enhances soil health, plant biomass, and extract yield. These findings highlight the potential of organic nutrient management as a promising strategy for advancing sustainable medicinal plant production and meeting societal demands for natural bioactive resources. Full article

This study presents a custom-built, portable multispectral imaging (MSI) system integrated with computer vision for sodium nitrite detection via the Griess reaction on paper-based substrates. The MSI system was used to investigate the absorption characteristics of sodium nitrite at concentrations from 0 to 10 ppm across nine spectral bands spanning 360–940 nm on para-aminobenzoic acid (PABA) and sulfanilamide (SA) substrates. Upon forming azo dyes with N-(1-naphthyl) ethylenediamine (NED), the PABA and SA substrates exhibited strong absorption near 545 nm and 540 nm, respectively, as measured by a spectrometer. This agrees with the 550 nm MSI images, in which higher sodium nitrite concentration regions appeared darker due to increased absorption. A concentration-correlation analysis was conducted for each spectral band. The normalized difference index (NDI), constructed from the most and least correlated bands at 550 nm and 940 nm, showed a stronger correlation with sodium nitrite concentration than the single best-performing band for both substrates. The NDI increased the coefficient of determination (R²) by approximately 19.32% for PABA–NED and 19.89% for SA–NED. This improvement was further confirmed under varying illumination conditions and through comparison with a conventional smartphone RGB imaging approach, in which the MSI-based NDI showed substantially superior performance. The enhancement is attributed to improved contrast, illumination normalization by the NDI, and the narrower spectral bands of the MSI compared with RGB imaging. In addition, the NDI framework enabled effective image segmentation, classification, and visualization, improving both interpretability and usability and providing a practical guideline for developing more robust models with larger training datasets. The proposed MSI system offers strong advantages in portability, sub-minute acquisition time, and operational simplicity, enabling rapid, on-site, and non-destructive chemical analysis. Full article

Neuroplasticity refers to the nervous system’s ability to modify its structure and function in response to intrinsic and extrinsic stimuli. Impairments in this capacity are associated with various neurological disorders, underscoring the need for therapies that preserve or enhance neuronal plasticity. Medicinal plants offer a promising source of bioactive compounds with neuroplastic properties and neuroprotective potential. In this work, we report the chemical and neuroplastic properties of Tillandsia usneoides, a medicinal native plant from America. Ethanolic extracts (EtOH) of leaves and stems, along with subfractionated ethyl acetate (EtOAc) and hydroethanolic (H₂O:EtOH) extracts, were analyzed using High-Performance Thin-Layer Chromatography (HPTLC) and Ultra-Performance Liquid Chromatography coupled with a Diode Array Detector (UPLC-DAD), revealing the presence of 14 phenolic acids, 6 flavonoids, and triterpene. Additionally, functional analysis using Sholl analysis showed that the EtOAc fraction of Tillandsia usneoides significantly enhanced structural plasticity in vitro, increasing both dendritic branching and dendrite length at concentrations between 0.03 and 1 μg mL⁻¹, likely through the activation PI3K/Akt and ERK1/2 signaling pathways. Together, our results suggest that Tillandsia usneoides contains bioactive polar metabolites capable of inducing neuronal structural plasticity. Full article

This study evaluates the effect of chemical treatments on the short-beam shear strength, vibrational, and acoustic performance of banana-fibre-reinforced carbon–Kevlar hybrid composites. Banana fibres were treated with 5% NaOH and 0.5% KMnO₄ to improve fibre surface characteristics and interfacial bonding within a sandwich laminate of carbon–Kevlar intraply skins and banana fibre core fabricated by hand lay-up and compression moulding. Short-beam shear strength (SBSS) increased from 14.27 MPa in untreated composites to 17.65 MPa and 19.52 MPa with KMnO₄ and NaOH treatments, respectively, due to enhanced fibrematrix adhesion and removal of surface impurities. Vibrational analysis showed untreated composites had low stiffness (7780.23 N/m) and damping ratio (0.00716), whereas NaOH treatment increased stiffness (9480.51 N/m) and natural frequency (28.68 Hz), improving rigidity and moderate damping. KMnO₄ treatment yielded the highest damping ratio (0.0557) with reduced stiffness, favouring vibration energy dissipation. Acoustic tests revealed KMnO₄-treated composites have superior sound transmission loss across low to middle frequencies, peaking at 15.6 dB at 63 Hz, indicating effective acoustic insulation linked to better mechanical damping. Scanning electron microscopy confirmed enhanced fibre impregnation and fewer defects after treatments. These findings highlight the significant role of chemical surface modification in optimising structural integrity, vibration control, and acoustic insulation in sustainable banana fibre/carbon–Kevlar hybrids. The improved multifunctional properties suggest promising applications in aerospace, automotive, and structural fields requiring lightweight, durable, and sound-mitigating materials. Full article

Additive manufacturing (AM) offers opportunities to advance the design and function of ceramic tooling in high temperature actinide pyrochemistry. In technical ceramics such as alumina, conventional forming techniques often restrict design flexibility and can limit experimental progress. In this study, we investigate the use of vat photopolymerization (VP) with commercial resins to fabricate large-scale alumina crucibles, reaching dimensions up to 125 mm, which is significantly larger than typically reported for dense VP ceramics. Notably, these additively manufactured components are produced using consumer-grade hardware, which limits process control, but offers significant upside in scalability and accessibility. Using microscopy and X-ray computed tomography, the VP alumina parts have high bulk densities above 95%, but also the prevalence of AM-induced artifacts and surface defects. Mechanical testing showed these defects to significantly reduce flexural strength and compromise part reliability. Electrorefining trials under sustained exposure to molten salts and metals reveal mixed results, with the AM material exhibiting high chemical compatibility, but mechanical failures due to the reduced strength were prevalent. Our findings illustrate both the promise and current limitations of AM ceramics for actinide chemistry, and point toward future improvements in process optimization, design strategies, and part screening to enhance performance and reliability. Full article

Flow capacitive deionization (FCDI) technology holds significant promise for cost-effective and energy-efficient desalination; however, its practical application is hindered by limited electrode stability and desalination performance. In this study, we propose a novel composite strategy that combines chemical surface modification with surfactant-assisted dispersion to enhance electrode performance in FCDI systems. We observed that the dispersion stability and capacitance of the flow electrodes were significantly improved after oxidation (AC-O) or amination (AC-N) of activated carbon (AC). To further investigate the underlying ion adsorption mechanisms, we performed Density Functional Theory (DFT) simulations. The simulations revealed that oxidative modification (AC-O) enhances chloride ion adsorption through stronger electrostatic and van der Waals interactions, while amination (AC-N) is more effective for sodium ion adsorption. Subsequently, surfactants (sodium dodecyl sulfate, SDS; cetyltrimethylammonium bromide, CTAB) were used to prepare stable and high-performance flow electrodes. Electrochemical characterization and desalination tests in a 1000 mg·L⁻¹ saline solution demonstrated that the AC-O/SDS composite exhibited excellent dispersion stability (>7 d) and significantly enhanced conductivity and specific capacitance, increasing by factors of 2.48 and 2.50, respectively, compared to unmodified AC. This optimized electrode achieved a desalination efficiency of 74.37% and a desalination rate of 6.2542 mg·L⁻¹·min⁻¹, outperforming the unmodified electrode by a factor of 5.72. Our findings provide a robust, sustainable approach for fabricating advanced flow electrodes and offer valuable insights into electrode structure optimization, opening new possibilities for the application of FCDI technology in water treatment and material sciences. Full article

In intensive vegetable production systems, long-term reliance on chemical fertilizers often leads to soil degradation and microbial imbalance, highlighting the need for sustainable biotillage strategies. In this study, a long-term field experiment examined how vegetable–earthworm co-cultivation (VE) combined with different fertilization regimes affects vegetable yield, soil physicochemical properties, and microbial communities. VE significantly improved vegetable yield, with full chemical fertilization (VE_IF100) and a 30% reduction in chemical fertilizer supplemented with organic fertilizer (VE_IF70) increasing yields by 30.86% and 26.02%, respectively, relative to full fertilization without earthworms (CK_IF100). VE also moderated soil pH toward neutrality. VE_IF100 decreased the soil C/N ratio, whereas VE_IF70 increased it and enhanced available hydrolyzable nitrogen, indicating a more balanced nutrient transformation. Microbial analysis revealed that VE_IF100 reduced bacterial abundance while strongly increasing fungal abundance, decreasing the bacteria-to-fungi ratio from 3.51 to 0.53. In contrast, VE_IF70 restored the bacteria-to-fungi ratio to 1.65 and increased fungal diversity, with the Shannon and Chao1 indices exceeding those in VE_IF100. Bacterial genera associated with nutrient cycling and plant growth promotion (e.g., Brevundimonas, Anaeromyxobacter) were enriched under VE_IF70, while fungal taxa with antagonistic and biocontrol potential (e.g., Chaetomium, Arthrobotrys) also increased. Redundancy analysis identified the soil C/N ratio (ranging from 5.94 to 8.60 across treatments) as a key driver of both bacterial and fungal community structures, whereas pH exerted a stronger influence on fungi. Random forest analysis indicated that the annual total vegetable yield was primarily driven by fertilization and available phosphorus in VE systems, whereas pH and bacterial abundance were the main drivers in CK systems. Overall, earthworm inoculation combined with partial organic fertilizer substitution improved soil conditions, reshaped microbial communities, and maintained high yield, demonstrating a practical strategy for sustainable vegetable production. Full article

This study investigates the effect of sodium-silicate-based chemical surface modification of polypropylene (PP) fibers on the mechanical and fresh-state properties of cementitious composites. The proposed method introduces silanol and siloxane groups onto the PP surface through a radical-assisted chlorination route, aiming to enhance fiber–matrix interfacial bonding. Modified fibers increased the polycarboxylate ether (PCE) demand by 100% compared to the control mixture, while unmodified PP fibers caused a 58% increase at equivalent workability. The incorporation of PP fibers resulted in limited changes in compressive strength (1-7%), whereas silicate-modified fibers led to notable late-age flexural strength gains of 10% (28 days) and 17% (56 days). Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy (SEM-EDX) and Fourier Transform Infrared Spectroscopy (FTIR) analyses confirmed successful surface functionalization, while the heterogeneous silicate deposition still contributed positively to interfacial transition zone (ITZ) performance. Overall, sodium-silicate-modified PP fibers improve flexural behavior and interfacial bonding in cement-based systems, offering a promising approach for enhanced mechanical performance and sustainability. Full article

The growing demand for reliable orthopedic implants has driven extensive research into biomaterials and metal alloys for the development of bone scaffolds. This review summarizes current progress in improving scaffold performance by optimizing mechanical strength, biocompatibility, and bone integration. Key studies on material choice, modeling methods, manufacturing techniques, and surface treatments are discussed, with a special focus on titanium-based alloys due to their favorable mechanical and biological properties. Computational tools, particularly finite element modeling, are increasingly used alongside experimental findings to illustrate mechanical behavior and to guide design of structures that more closely resemble natural bone. Both additive and traditional manufacturing routes are considered, emphasizing how porosity, geometry, and fabrication parameters affect mechanical stability and tissue response. Surface modification approaches, both physical and chemical can enhance cell attachment and antimicrobial function. Overall, this paper shows how combining materials science, mechanical analysis, and biological testing helps develop bone scaffolds that offer durable mechanical support and clinical outcomes. Full article