Search Results (1,964)

The internal architecture of deep-water channels is highly complex. Previous research has primarily emphasized the sedimentary processes governing channel migration, yet the linkage between sediment-source mechanisms and migration patterns—particularly their vertical evolution—remains insufficiently understood. Drawing on 3D seismic data, well logs, and core analyses, this study delineates the channel architecture within the deep-water succession of the Niger Delta Basin. Furthermore, by correlating high-frequency sea-level fluctuations with the formation timing of structural units, we explore how sea-level changes influence the spatial distribution and evolutionary dynamics of submarine fan systems. This study investigated the bottom-up evolution of two channel-lobe systems—the East Channel System (ECS) and West Channel System (WCS) within the stratigraphic succession, identifying two principal channel migration styles: expansive migration and downstream migration. In the ECS, migration was primarily characterized by a combination of downstream and expansive patterns. In contrast, the WCS displayed intermittent downstream migration, accompanied by some irregular migration. Correlation of sea-level variation curves with corresponding core photographs indicates that the ECS developed during a fourth-order sea-level. Its lower lobe and upper channel intervals each correspond to two complete five-stage sea-level cycles. In this system, debris flows and high-density turbidity currents produced stronger lateral erosion and channel migration, giving rise to the expansive migration style. Conversely, the WCS formed during a four-stage sea-level rise, with its lobe and channel sections likewise corresponding to two complete five-stage sea-level cycles. Here, sedimentation dominated by high- and low-density turbidity currents promoted enhanced erosion and migration along the flow direction, resulting in the predominance of downstream migration patterns. The ECS and WCS together constitute a complete three-tiered stratigraphic sequence representing two lobe–channel systems. This configuration deviates to some extent from the conventional understanding of the spatial distribution of debris flows, lobate channels, main channels, and deep-sea mud deposits. Consequently, during intervals of frequent sea-level fluctuation, deep-water sedimentary components within the continental slope region can partially record the signals of fourth- and even fifth-order sea-level variations, facilitated by a stable tectonic framework and favorable sediment preservation conditions. These findings offer valuable insights for reconstructing regional sedimentary processes and interpreting sea-level evolution. Full article

Automated valet parking (AVP) is a key component of autonomous driving systems. Its functionality and reliability need to be thoroughly tested before road application. Current testing technologies are limited by insufficient scenario coverage and lack of comprehensive evaluation indices. This study proposes an AVP testing and evaluation framework using OnSite (Open Naturalistic Simulation and Testing Environment) and Unity3D platforms. Through scenario construction based on field-collected data and model reconstruction, a testing scenario library is established, complying with industry standards. A simplified kinematic model, balancing simulation accuracy and operational efficiency, is applied to describe vehicle motion. A multidimensional evaluation system is developed with completion rate as a primary index and operation performance as a secondary index, which considers both parking efficiency and accuracy. Over 500 AVP algorithms are tested on the OnSite platform, and the testing results are evaluated through the Unity3D platform. The performance of the top 10 algorithms is analyzed. The evaluation platform is compared with CARLA simulation platform and field vehicle testing. This study finds that the framework provides an effective tool for AVP testing and evaluation; a variety of high-level AVP algorithms are developed, but their flexibility in complex dynamic scenarios has limitations. Future research should focus on exploring more sophisticated learning-based algorithms to enhance AVP adaptability and performance in complex dynamic environment. Full article

Background/Objectives: Acute bacterial endocarditis (ABE) is a frequent situation and continues to be a challenge. Mitral valve involvement during acute bacterial endocarditis is often the result of the spread of the endocarditic process from the adjacent aortic valve. Mitral involvement, on the other hand, could also be an expression of the initial localization of the bacteria. The best option for treating mitral ABE is still a matter of debate. Recent reports have shown satisfactory results with mitral reconstructive techniques in the treatment of mitral ABE. In this study, we present a comprehensive review of our 10-year institutional experience in the surgical management of acute mitral endocarditis with a focus on technical considerations, outcomes, and the durability of mitral valve repair in this high-risk population. Methods: We queried the institutional database, cross-referencing patients admitted with a diagnosis of “acute bacterial endocarditis” with patients undergoing surgical procedures for “valvular disease” at our division. Out of 1136 valvular procedures listed in our PACS database, 180 patients were admitted with a diagnosis of active acute endocarditis, and 46 included treatment of the mitral valve. We analyzed and compared short- and long-term follow-up (ranging from 3 to 141 months with a mean of 42 ± 38 months) of these 46 patients, dividing them into two groups: mitral valve repair (MVr) and mitral valve replacement (MVR). Results: 18 (40%) patients underwent reconstructive treatment of the mitral valve, and 28 (60%) underwent mitral valve replacement. Cumulative in-hospital mortality was 10% (5 pts, all from the MVR group), however, with no difference between the two groups. A shorter time gap from diagnosis to surgery (<10 days) was the only predictive factor for early mortality. A further 11 patients died during follow-up (2 from group A and 9 from group B). Long-term survival, on the other hand, was negatively influenced by MV surgical replacement (p = 0.0178), older patients’ age (>60 years), and urgent surgical procedures. Finally, patients with MVr also experienced a favorable postoperative event-free curve for endocarditis recurrence (p = 0.0260) and time elapsed before recurrence (p = 0.0438). Conclusions: Mitral valve repair in the case of active endocarditis could be a treatment associated with more favorable outcomes, providing that a complete eradication of infective tissue can be accomplished. Conservative treatment, when feasible, seems to offer favorable cumulative long-term outcomes. Full article

Developing bone substitutes that are mechanically strong, highly biocompatible and capable of controlled degradation is crucial for successful bone regeneration. Magnesium phosphate cements (MPCs) and calcium magnesium phosphate cements (CMPCs) offer higher strength and solubility than established calcium phosphate cements (CPCs). This study aimed to evaluate the in vivo degradation, osteoregeneration and biocompatibility of 3D powder-printed Mg3d (Mg₃(PO₄)₂) and Mg275d (Ca_0.25Mg_2.75(PO₄)₂) scaffolds with alkaline post-treatment, using structurally identical TCP (Ca₃(PO₄)₂) scaffolds as the control. The scaffolds were implanted into the lateral femoral condyle of adult female Zika rabbits and analysed up to 6, 12 and 24 weeks using radiography, microCT, histology, EDX and SEM. All materials demonstrated good biocompatibility. Mg3d and Mg275d scaffolds degraded significantly faster than the TCP scaffolds, with nearly complete degradation after 12 weeks. A cell-rich reconstruction zone formed during degradation, which was subsequently replaced by new bone. The degradation rate of the scaffolds corresponded closely to bone regeneration. Notably, the Mg3d and Mg275d scaffolds supported the faster formation of mature lamellar bone compared to the TCP scaffolds. These results indicate that magnesium phosphate (MgP)-based scaffolds represent a promising alternative to conventional calcium phosphate (CP)-based bone substitutes, given their rapid and almost complete degradation and their effective support of bone regeneration. Full article

Grapes (Vitis spp.) are a globally significant fruit crop with a long history of cultivation and substantial cultivar diversity. Their high genetic differentiation and complex evolutionary history make them a valuable system for studying plant evolution. The chloroplast genome, known for its structural conservation and uniparental inheritance, offers a reliable molecular marker for phylogenetic reconstruction. In this study, we sequenced and assembled the complete chloroplast genomes of nine representative grape cultivars, analyzed their phylogenetic relationships, and compared structural variations. All chloroplast genomes displayed a typical quadripartite structure, with high conservation in genomic architecture, gene order and content, codon usage, and simple sequence repeats (SSRs). However, additional sequence comparisons revealed seven regions with high variation, including the genes rbcL and ndhF, and the intergenic regions rps16-trnQ, ndhC-trnV, accD-psaI, ndhF-rpl32, and trnL-ccsA. At the same time, seven natural variation sites were identified in the amino acid sequences of rbcL and ndhF. Additionally, the study’s maximum likelihood (ML) phylogenetic trees and photosynthetic index measurements suggest that developmental characteristics of grape photosynthesis may be related to the evolutionary origins of different populations. This phylogenetic classification not only elucidates the evolutionary origins of these germplasm resources but also provides a foundation for molecular-assisted breeding by identifying distinct genetic groups. Full article

Reconstruction of large and complex hard tissue defects remains a major clinical challenge, as conventional autografts and allografts are often limited in availability, biological compatibility, and long-term efficacy, particularly for extensive defects or poor bone quality. Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a potent osteoinductive factor capable of initiating the complete cascade of bone formation. However, its clinical use is restricted by dose-dependent complications such as inflammation, ectopic ossification, and osteolysis. This review synthesizes current evidence on the safety profile of rhBMP-2 and examines strategies to enhance its therapeutic index. Preclinical and clinical data indicate that conventional collagen-based carriers frequently cause rapid burst release and uncontrolled diffusion, aggravating adverse outcomes. It is noteworthy that low doses of rhBMP-2 (0.5–0.7 mg/level in anterior cervical discectomy and fusion (ACDF) or 0.5–1.0 mg/level in transforaminal lumbar interbody fusion (TLIF)) provide the optimal balance of efficacy and safety. Advanced biomaterial-based platforms, such as bioceramic–polymer composites, injectable hydrogels, and 3D-printed scaffolds, enable spatially and temporally controlled release while maintaining osteogenic efficacy. Molecular delivery approaches, including chemically modified messenger RNA (cmRNA) and regional gene therapy, provide transient, site-specific rhBMP-2 expression with reduced dosing and minimal systemic exposure. By integrating mechanistic insights with translational advances, this review outlines a framework for optimizing rhBMP-2-based regenerative protocols, emphasizing their potential role in multidisciplinary strategies for reconstructing complex hard tissue defects. Full article

Terpenes are the largest category of specialised metabolites. Aerobic endospore-forming bacteria (AEFB), a diverse group of microorganisms, can thrive in various habitats and produce specialised metabolites, including terpenes. This study investigates the potential for terpene biosynthesis in 10 AEFB strain whole-genome sequences by performing a bioinformatics analyses to identify genes associated with these isoprene biosynthesis pathways. Specifically, we focused on the sequences coding for enzymes in the methylerythritol-phosphate (MEP) pathway and the polyprenyl synthase family, which play crucial roles in synthesising terpene precursors together with terpene synthases. A comparative analysis revealed the unique genetic architecture of these biosynthetic gene clusters (BGCs). Our results indicated that some strains possessed the complete genetic machinery required to produce terpenes such as squalene, hopanoids, and carotenoids. We also reconstructed phylogenetic trees based on the amino acid sequences of terpene synthases, which aligned with the phylogenetic relationships inferred from the whole-genome sequences, suggesting that the production of terpenes is an ancestor property in AEFB. Our findings highlight the importance of genome mining as a powerful tool for discovering new biological activities. Furthermore, this research lays the groundwork for future investigations to enhance our understanding of terpene biosynthesis in AEFB and the potential applications of these Brazilian environmental strains. Full article

The present article focuses on the assessment of the potential advantages and disadvantages of the utilisation of modern building inventory technologies in crisis situations, using a case study of Ukraine, currently engulfed in armed conflict. The following methods are described in detail: laser scanning, 360-degree camera images, and photo series. The authors conducted an in-depth SWOT/TOWS analysis, adapted to the specifics of the post-conflict environment, with a view to the future reconstruction of damaged buildings. The originality of the study lies in the use of a modified, quantitative version of the conventional SWOT analysis, supplemented with a weighting and rating system, which allowed for a more accurate assessment of the effectiveness of various technologies, including laser scanning. While the study focuses on the Ukrainian context, the authors emphasise that the developed methodology is universal and can be successfully applied to other critical areas, such as regions affected by earthquakes, floods, fires, or technological disasters. A modified SWOT/TOWS analysis can serve as a valuable tool in crisis management and infrastructure reconstruction during emergencies, providing the data necessary for making rational and effective decisions regarding the use of modern technologies in construction. The analysis revealed that, of the analysed inventory strategies, only laser scanning technology fits the so-called “maxi-maxi” strategy, a scenario in which both internal resources and external capabilities are maximised. The remaining two strategies were designated as “maxi-mini,” signifying that their implementation is associated with elevated levels of risk despite their inherent advantages. It is imperative to acknowledge the existence of substantial external threats that persist. Nevertheless, this does not constitute a complete rejection of the concept. This study examines armed conflict as a research context for a selection of buildings in Ukraine. The analysis was constrained to the three most prevalent methods: The use of TLS, SfM, and 360-degree cameras is also a key component of the methodology. Full article

Pott’s Puffy Tumor (PPT) is a rare but potentially life-threatening complication of frontal sinusitis, characterized by subperiosteal abscess formation and frontal bone osteomyelitis. Although predominantly seen in adolescents, adult cases are increasingly recognized. Early diagnosis is essential to prevent severe orbital and intracranial sequelae. We present two patients with distinct clinical features: a 31-year-old female with chronic frontal sinusitis complicated by sequestrated bone extrusion through a cutaneous fistula, and a 16-year-old male with an acute presentation of subperiosteal abscess, nasal polyp-related obstruction of the osteomeatal complex (OMC), and orbital cellulitis. Both patients underwent combined surgical and medical management, including broad-spectrum intravenous antibiotics, functional endoscopic sinus surgery, and external drainage. In the adult, necrotic bone was excised, and the anterior frontal wall was reconstructed with titanium mesh to restore sinus anatomy and drainage, while in the adolescent, early abscess drainage and polyp removal ensured frontal recess patency and prevented osteomyelitis. Postoperative follow-up demonstrated complete resolution without recurrence. These cases highlight that PPT can occur in both acute and chronic settings of chronic rhinosinusitis with nasal polyps, emphasizing the importance of prompt imaging, multidisciplinary evaluation, and individualized surgical strategies to optimize outcomes and minimize life-threatening complications. Full article

Background: Multilocular mesothelial inclusion cysts—also known as benign multicystic mesothelioma (BMM)—are rare, typically arising in the peritoneal cavity. Pericardial involvement is extremely uncommon and can pose diagnostic and therapeutic challenges due to their recurrent and infiltrative nature. Accurate diagnosis and surgical strategy are critical for management and recurrence prevention. Methods: We present the case of a 36-year-old woman with a prior history of malignant melanoma who developed recurrent multilocular cystic masses of the pericardium. Initial imaging with echocardiography, cardiac magnetic resonance (CMR), and computed tomography (CT) revealed multilocular pericardial cysts. Surgical resection was performed under cardiopulmonary bypass (CPB), but complete excision was limited due to epicardial infiltration. Histopathology confirmed a benign mesothelial origin. One year later, recurrence prompted a second surgical intervention with total pericardiectomy and Gore-Tex patch reconstruction. Results: Postoperative recovery was uneventful in both instances. Follow-up imaging at 6 and 12 months demonstrated no significant recurrence. Histological analysis confirmed benign cysts lined with mesothelial cells, positive for calretinin and WT-1. This represents one of the first documented living cases of pericardial BMM managed with staged surgery and total pericardiectomy. Conclusions: Pericardial BMM is a rare, benign, but potentially recurrent lesion. In cases of extensive or recurrent disease, total pericardiectomy may offer definitive treatment. Multimodal imaging, histopathological evaluation, and personalized surgical planning are essential for effective management. Full article

The automatic reconstruction of existing buildings has gained momentum through the integration of Building Information Modeling (BIM) into architecture, engineering, and construction (AEC) workflows. This study presents a hybrid methodology that combines deep learning with surface-based techniques to automate the generation of 3D models and 2D floor plans from unstructured indoor point clouds. The approach begins with point cloud preprocessing using voxel-based downsampling and robust statistical outlier removal. Room partitions are extracted via DBSCAN applied in the 2D space, followed by structural segmentation using the RandLA-Net deep learning model to classify key building components such as walls, floors, ceilings, columns, doors, and windows. To enhance segmentation fidelity, a density-based filtering technique is employed, and RANSAC is utilized to detect and fit planar primitives representing major surfaces. Wall-surface openings such as doors and windows are identified through local histogram analysis and interpolation in wall-aligned coordinate systems. The method supports complex indoor environments including Manhattan and non-Manhattan layouts, variable ceiling heights, and cluttered scenes with occlusions. The approach was validated using six datasets with varying architectural characteristics, and evaluated using completeness, correctness, and accuracy metrics. Results show a minimum completeness of 86.6%, correctness of 84.8%, and a maximum geometric error of 9.6 cm, demonstrating the robustness and generalizability of the proposed pipeline for automated as-built BIM reconstruction. Full article

The accurate diagnosis of acoustic defects and the precise assessment of the performance of building components are highly dependent on massive amounts of sampling data. In this study, we try to combine the compressed sensing theory with the nearfield acoustic holographic sound insulation measurement method and introduce a noise reduction algorithm so as to realize the sound pressure distribution accuracy similar to that of the conventional sampling under low-density data conditions. Numerical simulation results show that the reconstruction error of the method proposed in this paper is only 8.21% higher than that of the complete sampling under the condition of 20% sampling rate, and the reconstruction error is only 2.50% higher than that of the complete sampling under the condition of 40% sampling rate. The reconstruction error under 50% sampling rate and 6.65 dB SNR is only 4.81% higher than the complete sampling, which is basically consistent with the numerical simulation; the sound insulation is only 1 dB lower than that measured by the sound pressure method, and the acoustic defects of the components can basically be identified. The results of this study have a positive significance in simplifying the process of sound insulation measurement in most scenarios. Full article

State-of-the-art historical global burned area (BA) products largely rely on MODIS data, offering long temporal coverage but limited spatial resolution. As a result, small fires and complex landscapes remain underrepresented in global fire history reconstructions. By contrast, Landsat provides the only continuous satellite record extending back to the 1980s, with substantially finer resolution. However, its use at a global scale has long been hindered by infrequent revisit times, cloud contamination, massive data volumes, and processing demands. We compared MODIS FireCCI51 with the only existing Landsat-based global product, GABAM, in a mountainous region characterized by frequent, small-scale fires. GABAM detected a higher number of burn scars, including small events, with higher Producer’s Accuracy (0.68 vs. 0.08) and similar User’s Accuracy (0.85 vs. 0.83). These results emphasize the value of Landsat for reconstructing past fire regimes in complex landscapes. Crucially, recent advances in cloud computing, data cubes, and processing pipelines now remove many of the former barriers to exploiting the Landsat archive globally. A more systematic integration of Landsat data into MODIS-based routines may help produce more complete and accurate databases of historical fire activity, ultimately enabling improved understanding of long-term global fire dynamics. Full article

Background and Objectives: The sacrum is formed by five fused vertebrae and connects the lumbar spine to the coccyx. It has four pairs of foramina for sacral nerves and shows important anatomical variations. This study aims to analyze the frequency of atypical sacral morphology in the Korean population using 3D reconstruction of postmortem computed tomography (PMCT) images, and to provide a systematic classification and morphological characterization. Materials and Methods: A total of 29 PMCT datasets (10 males, 19 females) from the National Forensic Service were used to generate 3D sacral models with Mimics software for the analysis of atypical sacral morphology. Key morphometric parameters, including sacral width (SW), sacral length (SL), sacral foramina distances (SFD1, SFD2), sacral vertebral heights (SH1, SH2), sacral curvature (SC), and sacral index (SI), were measured. Sacral foramina were categorized into three groups based on completeness, and auricular surfaces were classified into three types according to their vertical position. Results: Median values for sacral dimensions were as follows: SW 95.3 mm, SL 118.6 mm, SFD1 36.1 mm, SFD2 28.8 mm, SH1 28.0 mm, SH2 29.7 mm, SC 0.92, and SI 0.78. Sacral foramina variations were identified in 12 of 29 cases (41.4%) as incomplete, including one case with an incomplete upper opening. No significant sex-based differences were found in foramen or auricular surface types, although females showed higher values for SW and SI (SW: 97.2 mm, SI: 0.86). Correlation analysis revealed positive associations between SL and both stature (r = 0.635) and weight (r = 0.645), and negative correlations between SI and stature (r = −0.663), SL (r = −0.921), and SC (r = −0.845). Two cases (6.8%) exhibited sacralization, while the remaining 25 cases had the configuration of five lumbar vertebrae and six sacral segments. Conclusions: Our findings support the notion that atypical segmentation patterns are more prevalent than sacralization. Atypical sacral morphology was observed in 29 cases (19.8%), most commonly involving a normal lumbar spine with six sacral segments. These findings highlight the relevance of sacral variation in clinical and anatomical contexts. Full article

Background: Thrushes (family Turdidae) are ecologically important passerine birds widely distributed across the Northern Hemisphere. However, the phylogenetic placement of several East Asian congeners, including Turdus pallidus, remains insufficiently resolved due to the limited resolution of partial mitochondrial or nuclear markers used in previous studies. Methods: In this work, we sequenced and annotated the complete mitochondrial genome of T. pallidus (16,739 bp) using high-throughput Illumina sequencing. The mitogenome exhibited the typical circular architecture and contained 37 genes (13 protein-coding genes, 22 tRNAs, and 2 rRNAs), with an overall GC content of 47.32%. Results: Most protein-coding genes initiated with the standard ATG codon, although lineage-specific deviations such as GTG in COX1 and ND2 were identified, and incomplete stop codons (T– or TA–) were observed, consistent with post-transcriptional polyadenylation. The 22 tRNA genes displayed typical cloverleaf secondary structures, except for trnS(AGN), which lacked a DHU arm, while rRNA genes were 977 bp (12S, 48.52% GC) and 1590 bp (16S, 44.65% GC), showing conserved stem regions but variable loop regions. Codon usage analysis revealed a strong bias toward A/T-ending codons, with a total of 3798 codons and an effective number of codons (ENC) of ~40, indicating moderate codon bias shaped by both mutational pressure and translational selection. Comparative analysis of evolutionary rates demonstrated that conserved genes such as COX1 and CYTB are suitable for resolving deeper relationships, whereas rapidly evolving genes like ATP8 provide resolution among closely related taxa. Conclusions: Phylogenetic reconstructions based on 13 mitochondrial protein-coding genes robustly supported the monophyly of Turdidae and recovered T. pallidus as most closely related to T. obscurus. Overall, this study provides a novel mitogenomic resource for T. pallidus, enhances phylogenetic resolution within Turdus, and underscores the value of complete mitochondrial genomes for molecular identification, conservation management, and avian evolutionary studies. Full article