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Article

2,023 Views

10 Pages

Copaiba Oleoresin Improves Weight Gain and IL-10 Concentration, with No Impact on Hepatic Histology, in Liver Cirrhosis

Maiara Taffarel,
Bianca Sulzbacher da Silva,
Angélica Macedo Borgês Paulino,
Luciana Ortega Telles,
Sabrina Trigueiro Mendonça,
Cintia Vieira dos Santos,
Morenna Alana Giordani,
André Ferreira Nascimento,
Danilo Henrique Aguiar and
Valéria Dornelles Gindri Sinhorin
+ 3 authors

Biology2024, 13(11), 853;https://doi.org/10.3390/biology13110853

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23 October 2024

Copaifera sp. is a native tree in the Amazon region. Copaiba oleoresin has components such as sesquiterpenes, which have anti-inflammatory and antioxidant potential. Liver cirrhosis is the end stage of liver disease with limited therapeutic options....

Article

21 Citations

4,995 Views

14 Pages

Safety and Effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on Inflammation and Tissue Repair of Oral Wounds in Rats

María Olimpia Paz Alvarenga,
Leonardo Oliveira Bittencourt,
Paulo Fernando Santos Mendes,
Julia Turra Ribeiro,
Osmar Alves Lameira,
Marta Chagas Monteiro,
Carlos Augusto Galvão Barboza,
Manoela Domingues Martins and
Rafael Rodrigues Lima

Int. J. Mol. Sci.2020, 21(10), 3568;https://doi.org/10.3390/ijms21103568

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18 May 2020

In traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in ora...

Article

6 Citations

2,265 Views

17 Pages

Solid Lipid Nanoparticles Based on Babassu Oil and Copaiba Oleoresin: A Promising Approach for Prostate Cancer Therapy

Michael Jackson Ferreira da Silva,
Alisson Mendes Rodrigues,
Maria Célia Pires Costa,
Adriana Leandro Camara,
Lucio Mendes Cabral,
Eduardo Ricci Junior,
Daniel Figueiredo Vanzan,
Ana Paula dos Santos Matos,
Thiago da Silva Honorio and
Antonio Carlos Romão Borges

Nanomaterials2024, 14(12), 1014;https://doi.org/10.3390/nano14121014

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12 June 2024

Solid lipid nanoparticles (SLNs) represent promising nanostructures for drug delivery systems. This study successfully synthesized SLNs containing different proportions of babassu oil (BBS) and copaiba oleoresin (COPA) via the emulsification–ul...

Article

1 Citations

1,450 Views

21 Pages

Probing the Physicochemical, Nanomorphological, and Antimicrobial Attributes of Sustainable Silk Fibroin/Copaiba Oleoresin-Loaded PVA Films for Food Packaging Applications

Daniel S. Santos,
Robert S. Matos,
Erveton P. Pinto,
Samuel B. Santos,
Henrique D. da Fonseca Filho,
Rodrigo Prioli,
Irlon M. Ferreira and
Tiago M. Souza

Polymers2025, 17(3), 375;https://doi.org/10.3390/polym17030375

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30 January 2025

We explore the development of biodegradable poly(vinyl alcohol) (PVA) films loaded with silk fibroin (SF) functionalized with copaiba oleoresin (SFCO) for potential use in active food packaging. The films were characterized, showing significant impro...

Review

200 Citations

29,272 Views

24 Pages

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

Lidiam Maia Leandro,
Fabiano De Sousa Vargas,
Paula Cristina Souza Barbosa,
Jamilly Kelly Oliveira Neves,
José Alexsandro Da Silva and
Valdir Florêncio Da Veiga-Junior

Molecules2012, 17(4), 3866-3889;https://doi.org/10.3390/molecules17043866

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30 March 2012

Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes...

Article

9 Citations

5,199 Views

13 Pages

Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats

Vinicius Ruan Neves dos Santos,
João Victor da Silva Motta,
Deborah Ribeiro Frazão,
Railson de Oliveira Ferreira,
Deiweson Souza-Monteiro,
Daiane Claydes Baia-da-Silva,
Paulo Fernando Santos Mendes,
Leonardo Oliveira Bittencourt,
João Daniel Mendonça de Moura and
Osmar Alves Lameira
+ 4 authors

Molecules2022, 27(19), 6255;https://doi.org/10.3390/molecules27196255

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23 September 2022

Several studies have investigated the effects of natural products in the treatment of diseases. Traditional Amazonian populations commonly use copaiba due to its well-known anti-inflammatory, antibacterial, and healing properties. In this study, we a...

Review

107 Citations

11,391 Views

33 Pages

Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology

Rafaela Da Trindade,
Joyce Kelly Da Silva and
William N. Setzer

Int. J. Mol. Sci.2018, 19(5), 1511;https://doi.org/10.3390/ijms19051511

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18 May 2018

The oleoresin of Copaifera trees has been widely used as a traditional medicine in Neotropical regions for thousands of years and remains a popular treatment for a variety of ailments. The copaiba resins are generally composed of a volatile oil made...

Article

100 Citations

10,509 Views

9 Pages

Antimicrobial Evaluation of Diterpenes from Copaifera langsdorffii Oleoresin Against Periodontal Anaerobic Bacteria

Ariana B. Souza,
Maria G. M. de Souza,
Maísa A. Moreira,
Monique R. Moreira,
Niege A. J. C. Furtado,
Carlos H. G. Martins,
Jairo K. Bastos,
Raquel A. dos Santos,
Vladimir C. G. Heleno and
Sergio Ricardo Ambrosio
+ 1 author

Molecules2011, 16(11), 9611-9619;https://doi.org/10.3390/molecules16119611

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18 November 2011

The antimicrobial activity of four labdane-type diterpenes isolated from the oleoresin of Copaifera langsdorffii as well as of two commercially available diterpenes (sclareol and manool) was investigated against a representative panel of microorganis...

Article

30 Citations

6,901 Views

18 Pages

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Jonas Gabriel de Oliveira Pinheiro,
Emanuella De Aragão Tavares,
Sofia Santos da Silva,
Juliana Félix Silva,
Yasmim Maria Barbosa Gomes de Carvalho,
Magda Rhayanny Assunção Ferreira,
Adriano Antunes de Souza Araújo,
Euzébio Guimarães Barbosa,
Matheus De Freitas Fernandes Pedrosa and
Luiz Alberto Lira Soares
+ 3 authors

Int. J. Mol. Sci.2017, 18(11), 2388;https://doi.org/10.3390/ijms18112388

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18 November 2017

Complexation with cyclodextrins (CDs) is a technique that has been extensively used to increase the aqueous solubility of oils and improve their stability. In addition, this technique has been used to convert oils into solid materials. This work aims...

Article

10 Citations

3,254 Views

14 Pages

Evaluation of Resin-Based Material Containing Copaiba Oleoresin (Copaifera Reticulata Ducke): Biological Effects on the Human Dental Pulp Stem Cells

Roberta Souza D’Almeida Couto,
Maria Fernanda Setubal Destro Rodrigues,
Leila Soares Ferreira,
Ivana Márcia Alves Diniz,
Fernando de Sá Silva,
Talita Christine Camilo Lopez,
Rafael Rodrigues Lima and
Márcia Martins Marques

Biomolecules2020, 10(7), 972;https://doi.org/10.3390/biom10070972

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28 June 2020

The purpose of this study was to analyze in vitro the biological effects on human dental pulp stem cells triggered in response to substances leached or dissolved from two experimental cements for dental pulp capping. The experimental materials, based...

Feature Paper
Review

10 Citations

8,068 Views

17 Pages

Toxicological Effects of Copaiba Oil (Copaifera spp.) and Its Active Components

Camila Castanho Cardinelli,
Josiane Elizabeth Almeida e Silva,
Rayssa Ribeiro,
Valdir F. Veiga-Junior,
Elisabete Pereira dos Santos and
Zaida Maria Faria de Freitas

Plants2023, 12(5), 1054;https://doi.org/10.3390/plants12051054

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27 February 2023

Vegetable oils are among the most important traditional resources of Amazonia. Oleoresins are a type of oil that have interesting characteristics and highly bioactive properties with pharmacological potential. Oleoresins produced in the trunks of Cop...

Article

1 Citations

1,386 Views

11 Pages

Skin Tear Treatment with Copaifera multijuga Hayne in Polymeric Hydrogel: A Randomized Clinical Trial

Camila Castanho Cardinelli,
Jéssica Teixeira Gâmba Passos,
Valdir Florêncio Veiga-Junior,
Beatriz Guitton Renaud Baptista de Oliveira,
Elisabete Pereira dos Santos,
Guilherme Guilhermino Neto,
Karina Chamma Di Piero and
Zaida Maria Faria de Freitas

Pharmaceuticals2024, 17(12), 1691;https://doi.org/10.3390/ph17121691

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15 December 2024

A double-blind, randomized, and controlled clinical trial with therapeutic intervention was performed at a university hospital in Rio de Janeiro to evaluate whether the addition of Copaifera multijuga Hayne oleoresin to a carboxypolymethylene hydroge...

Communication

30 Citations

7,545 Views

10 Pages

Antifungal Activity of Copaifera langsdorffii Desf Oleoresin against Dermatophytes

Danielle C. Zimmermam-Franco,
Edilene B. Bolutari,
Hudson C. Polonini,
Antônio Márcio R. Do Carmo,
Maria Das Graças A. M. Chaves and
Nádia R. B. Raposo

Molecules2013, 18(10), 12561-12570;https://doi.org/10.3390/molecules181012561

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11 October 2013

Dermatophytoses are mycoses that affect keratinized tissues in both humans and animals. The aim of this study was to investigate the antifungal activity of the oleoresin extracted from Copaifera langsdorffii Desf. against the strains Microsporum cani...

Communication

21 Citations

4,415 Views

13 Pages

Anti-Inflammatory Potential of the Oleoresin from the Amazonian Tree Copaifera reticulata with an Unusual Chemical Composition in Rats

José Sousa de Almeida Júnior,
Éden Bruno Sousa da Silva,
Tânia Mara Pires Moraes,
Aline Aparecida München Kasper,
Adilson Sartoratto,
Leopoldo Clemente Baratto,
Elaine Cristina Pacheco de Oliveira,
Euzebio Oliveira,
Lauro Euclides Soares Barata and
Antonio Humberto Hamad Minervino
+ 1 author

Vet. Sci.2021, 8(12), 320;https://doi.org/10.3390/vetsci8120320

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10 December 2021

Copaifera reticulata Ducke is a popularly known species known as copaíba that is widely spread throughout the Amazon region. The tree yields an oleoresin which is extensively used in local traditional medicine mainly as an anti-inflammatory and antin...

Article

503 Views

15 Pages

Advancing the Chemical Characterization of Eperua oleifera Duke Oleoresin: A UHPLC-HRMS-Based Approach

Rayssa Ribeiro,
Gabriel Reis Alves Carneiro,
Gustavo Ramalho Cardoso dos Santos,
Márcio Vinícius da Silva Gomes,
Henrique Marcelo Gualberto Pereira,
Monica Costa Padilha and
Valdir F. Veiga-Junior

Plants2025, 14(18), 2893;https://doi.org/10.3390/plants14182893

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18 September 2025

Eperua oleifera Ducke (Fabaceae), commonly known as copaíba-jacaré, is traditionally used for therapeutic purposes, like Copaifera oleoresins. Previous GC-MS studies reported its chemical composition as mainly composed of diterpenic aci...