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Article

17 Citations

3,092 Views

26 Pages

Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies

Virginia Pontecorvi,
Mattia Mori,
Francesca Picarazzi,
Susi Zara,
Simone Carradori,
Amelia Cataldi,
Andrea Angeli,
Emanuela Berrino,
Paola Chimenti and
Alessia Ciogli
+ 3 authors

Int. J. Mol. Sci.2022, 23(14), 7950;https://doi.org/10.3390/ijms23147950

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19 July 2022

Human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms IX and XII are overexpressed in solid hypoxic tumors, and they are considered as prognostic tools and therapeutic targets for cancer. Based on a molecular simplification of the well-known coumarin s...

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Article

26 Citations

8,432 Views

13 Pages

Interactions of β-Conglycinin (7S) with Different Phenolic Acids—Impact on Structural Characteristics and Proteolytic Degradation of Proteins

Jing Gan,
Hao Chen,
Jiyuan Liu,
Yongquan Wang,
Satoru Nirasawa and
Yongqiang Cheng

Int. J. Mol. Sci.2016, 17(10), 1671;https://doi.org/10.3390/ijms17101671

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2 October 2016

p-Coumalic acid (PCA), caffeic acid (CA), gallic acid (GA) and chlorogenic acid (CGA) are the major phenolic acids that co-exist with soy protein components in foodstuffs. Surprisingly, there are only a handful of reports that describe their interact...

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Article

13 Citations

4,139 Views

17 Pages

Transcriptional Stages of Conidia Germination and Associated Genes in Aspergillus flavus: An Essential Role for Redox Genes

Chong Li,
Sifan Jia,
Shahid Ali Rajput,
Desheng Qi and
Shuai Wang

Toxins2022, 14(8), 560;https://doi.org/10.3390/toxins14080560

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18 August 2022

Aflatoxin is a threatening mycotoxin primarily present in the agricultural environment, especially in food and feedstuff, and poses significant global health risks. Aflatoxins are produced mainly by Aspergillus flavus. Conidia germination is the firs...

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