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Connexons Coupling to Gap Junction Channel: Potential Role for Extracellular Protein Stabilization Centers
- László Héja,
- Ágnes Simon,
- Zsolt Szabó and
- Julianna Kardos
Connexin (Cx) proteins establish intercellular gap junction channels (Cx GJCs) through coupling of two apposed hexameric Cx hemichannels (Cx HCs, connexons). Pre- and post-GJ interfaces consist of extracellular EL1 and EL2 loops, each with three cons...