Search Results (282)

Background and Objectives: Cancer cachexia is a debilitating metabolic syndrome highly prevalent in colorectal cancer (CRC), characterized by progressive skeletal muscle wasting. The myostatin–FOXO signaling pathway contributes to this process by activating the E3 ubiquitin ligases MuRF-1 and Atrogin-1. Exercise is a promising non-pharmacological strategy, but its effects on this pathway in CRC cachexia remain unclear. This review aimed to synthesize preclinical evidence on the impact of exercise on the myostatin–FOXO axis. Materials and Methods: A comprehensive search was performed in PubMed/MEDLINE, Scopus, Web of Science, and Science Direct from inception through August 2025. Eligible studies included murine CRC models (C26 or Apc^Min/+) exposed to aerobic, resistance, or combined exercise interventions, with outcomes assessing myostatin, FOXO, MuRF-1, or Atrogin-1. Study quality was appraised using the CAMARADES 10-item checklist. Results: eleven studies met the criteria, with quality scores ranging from 6 to 8. Aerobic exercise, particularly voluntary wheel running, most consistently reduced MuRF-1 expression and systemic inflammation, whereas resistance and eccentric training exerted stronger inhibitory effects on FOXO and Atrogin-1. Myostatin was directly measured in two studies, yielding inconsistent results. Resistance and eccentric training promoted anabolic signaling (e.g., mTORC1), whereas aerobic protocols improved oxidative capacity. Variability in exercise type, intensity, and duration contributed to heterogeneity across findings. Conclusions: Exercise attenuates skeletal muscle catabolism in CRC-induced cachexia, mainly through modulation of the myostatin–FOXO pathway and downstream ligases. However, limited direct data on myostatin and methodological heterogeneity underscore the need for standardized protocols and translational studies. This review provides the first focused synthesis of exercise-mediated regulation of this pathway in CRC cachexia. Full article

This study investigated the acute effects of different rest intervals between sets of isometric conditioning activity (ICA) on countermovement jump (CMJ) performance. Fifteen resistance-trained males completed four conditions: three ICA protocols with 1, 2, or 3 min rest intervals between sets and a control condition (CTRL). ICA was performed in the half-squat position at a 90° knee angle against an immovable barbell, with each protocol consisting of three sets of short maximal voluntary isometric contractions (3 × 3 s per set). CMJ performance was assessed before and at 3, 6, 9, and 12 min after ICA or CTRL. The results showed no significant effects of the ICA or rest interval on CMJ height or relative peak power. However, independent of rest duration, ICA induced transient alterations in jump mechanics, characterized by decreased stiffness at 9 min and reduced eccentric peak velocity at 6–12 min post-ICA. Similar fluctuations were observed in the CTRL condition, suggesting that these changes may reflect time-dependent variability rather than specific potentiation effects. In conclusion, the studied ICA protocols did not enhance CMJ height or power output, and the length of the rest interval did not influence the outcomes, indicating limited applicability of this approach in resistance-trained males. Full article

We provide an automated characterization of human retinal cells, i.e., RPE’s based on the non-invasive AO-TFI retinal imaging and PR’s based on the non-invasive AO-FI retinal imaging on a large-scale study involving 171 confirmed healthy eyes from 104 participants of 23 to 80 years old. Comprehensive standard checkups based on SD-OCT and Fondus imaging modalities were carried out by Ophthalmologists from the Luzerner Kantonsspital (LUKS) to confirm the absence of retinal pathologies. AO imaging imaging was performed using the Cellularis^® device and each eye was imaged at various retinal eccentricities. The images were automatically segmented using a dedicated software and RPE and PR cells were identified and morphometric characterizations, such as cell density and area were computed. The results were stratified based on various criteria, such as age, retinal eccentricity, visual acuity, etc. The automatic segmentation was validated independently on a held-out set by five trained medical students not involved in this study. We plotted cell density variations as a function of eccentricity from the fovea along both nasal and temporal directions. For RPE cells, no consistent trend in density was observed between 0° to 9° eccentricity, contrasting with established histological literature demonstrating foveal density peaks. In contrast, PR cell density showed a clear decrease from 2.5° to 9°. RPE cell density declined linearly with age, whereas no age-related pattern was detected for PR cell density. On average, RPE cell density was found to be ≈6313 cells/mm² ($\pm \sigma =757$), while the average PR cell density was calculated as ≈10,207 cells/mm² ($\pm \sigma =1273$). Full article

This study investigated the adaptations induced by a 7-week training protocol combining strength and power training with regular soccer training in young elite soccer players, considering their maturity level. Thirty-five participants were categorized into three training groups according to their maturation status. They were classified based on their relative age and peak height velocity (PHV) as: Pre-PHV, Mid-PHV, and Post-PHV. Each group engaged in a 7-week program, combining their regular soccer training with two resistance sessions per week (one strength and one power session). Before and after the training program, the following tests were conducted: eccentric hamstring strength using the Nordic Hamstring Exercise (NHE), countermovement jump (CMJ), sprint with split times at 10 and 30 m, and Change of Direction and Acceleration Test (CODAT). The Pre-PHV group exhibited significant improvements in sprint performance (p < 0.02), while the Mid-PHV and Post-PHV groups showed enhanced performance in CODAT (p = 0.01 and p = 0.05, respectively). Notably, the Post-PHV group displayed improvements in the NHE (p < 0.05), but also experienced a decline in sprint performance (p < 0.01). The training protocol produced substantial enhancements in 10 and 30 m sprint times for the Pre-PHV and Mid-PHV groups relative to the Post-PHV group (p < 0.02), while the Post-PHV group achieved greater advancements in NHE compared to the Pre-PHV group (p < 0.01). No significant differences were found between Pre-PHV and Mid-PHV groups across all assessed parameters (p > 0.01). These findings demonstrated that the same strength training program led to different adaptations depending on the participants’ maturation status; therefore, this aspect should be carefully considered when designing training programs for young soccer players. Full article

Background/Objectives: Sports tendinopathy management has traditionally focused on mechanical loading protocols, yet emerging evidence suggests metabolic factors significantly influence clinical outcomes and tissue adaptation responses. The aim was to systematically evaluate the impact of metabolic factors on sports tendinopathy outcomes and assess the effectiveness of advanced rehabilitation approaches that extend beyond traditional mechanical loading protocols. Methods: A comprehensive search across academic papers from Semantic Scholar corpus identified studies investigating metabolic influences and advanced rehabilitation strategies in sports tendinopathy. Inclusion criteria encompassed athletes and active individuals with chronic tendinopathy, interventions targeting metabolic factors or advanced rehabilitation techniques, and validated outcome measures. Risk of bias was assessed using RoB 2 for randomized trials and ROBINS-I for observational studies. Evidence certainty was evaluated using GRADE methodology. Results: Forty studies met inclusion criteria, comprising 5 randomized controlled trials, 9 systematic reviews, and 5 cohort studies. Metabolic syndrome significantly impaired eccentric exercise outcomes in Achilles tendinopathy (F[1,54] = 24.45, p < 0.001). Collagen-derived peptide supplementation combined with eccentric training demonstrated superior pain reduction at rest compared to exercise alone (p < 0.05). Advanced rehabilitation strategies including criteria-based progression, neuroplastic training, and staged loading protocols showed improvements in patient-reported outcomes and functional scores, with some approaches demonstrating superiority over traditional eccentric protocols. Conclusions: Metabolic factors negatively influence sports tendinopathy rehabilitation outcomes, while advanced rehabilitation approaches incorporating metabolic considerations show promise for enhancing treatment effectiveness. Integration of metabolic assessment and targeted interventions may optimize tendinopathy management beyond mechanical loading alone. Full article

Recently, there has been growing interest in optimizing exercise protocols in sports training and rehabilitation, with particular attention to eccentric quasi-isometric (EQI) contractions, which involve maintaining joint position until isometric failure and then resisting the subsequent eccentric phase. Evidence directly comparing EQI with other contraction modes remains scarce. This quasi-randomized controlled trial examined the short-term effects of EQI versus isokinetic heavy–slow resistance (IHSR) exercises on ankle plantar flexors, focusing on pain, range of motion (RoM), and strength performance. Thirty-two physically active participants were allocated to EQI (n = 16) or IHSR (n = 16) groups and assessed at baseline, immediately post-exercise, and 24 and 48 h later. Both groups performed three exercise sets with 3 min breaks. The protocols were designed to approximate matched loading, based on preliminary testing. Nevertheless, the EQI group achieved a significantly greater total impulse (p = 0.028), a shorter time under tension (p = 0.001), and lower effort scores (p < 0.001). Group × time analysis revealed less decline in maximal voluntary isometric contraction torque (p = 0.002; η² = 0.16), as well as lower general (p < 0.001; η² = 0.32) and activity-related pain (p < 0.001; η² = 0.32) in the EQI group, with no significant differences in dorsiflexion RoM (p = 0.893). In conclusion, EQI produced a higher torque impulse while inducing less fatigue and post-exercise pain than IHSR, suggesting it may be a more efficient loading strategy for the ankle plantar flexors. The results contribute to the understanding of contraction-specific efficiency, and may inform the design of future training and rehabilitation protocols targeting the ankle plantar flexors. Full article

Background/Objectives: This study examined the effects of a six-week eccentric–reactive training program on neuromechanical markers of lateral explosiveness, asymmetry, and stretch-shortening cycle (SSC) efficiency in elite male youth table tennis players. Fourteen national-level athletes (mean age = 16.6 years) were assigned to either an experimental group (EG, n = 7) or a control group (CG, n = 7). EG performed flywheel squats and lateral depth jumps three times per week, while CG maintained regular training. Pre- and post-intervention testing included countermovement jumps, reactive strength index (RSI_DJ), force asymmetry, time-to-stabilization, SSC efficiency, and energy transfer ratio (ETR), measured via force plates, EMG, and inertial sensors. Methods: Multi-dimensional statistical analysis revealed coordinated improvements in explosive power and movement efficiency following eccentric training that were not visible when examining individual measures separately. Athletes in the training group showed enhanced neuromechanical control and developed more efficient movement patterns compared to controls. The analysis successfully identified distinct performance profiles and demonstrated that the training program improved explosive characteristics in elite table tennis players. Results: Univariate ANOVAs showed no significant Group × Time effects for RSI_DJ, ETR, or SSC_Eff, although RSI_DJ displayed a moderate effect size in EG (d = 0.47, 95% CI [0.12, 0.82], p = 0.043). In contrast, MANOVA confirmed a significant multivariate Group × Time interaction (p = 0.013), demonstrating integrated neuromechanical adaptations. Regression analysis indicated lower baseline CMJ and RSI_DJ predicted greater RSI improvements. Conclusions: In conclusion, eccentric–reactive training promoted multidimensional neuromechanical adaptations in elite racket sport athletes, supporting the use of integrated monitoring and targeted eccentric loading to enhance lateral explosiveness and efficiency. Full article

Hamstring injuries are frequent in sports, often linked to eccentric overloading during sprinting. While eccentric strengthening, like Nordic curls and hip extensions, is common, the impact of exercise symmetry (unilateral vs. bilateral) on neuromuscular control remains unclear. This study aimed to investigate regional/task-specific neuromuscular strategies during unilateral and bilateral eccentric loading of the same exercises. Twenty-five healthy and physically active young men (age: 24.52 ± 3.82 years; height: 175.53 ± 5.44 cm; weight: 72.06 ± 7.44 kg) were recruited based on physical activity screening, with the exclusion criteria including recent lower limb injuries. Participants performed unilateral and bilateral curls and extensions with surface electromyography on hamstrings, gluteus maximus, and trunk stabilisers. Parameters like root mean square and median frequency were extracted and statistically compared. Unilateral execution generally elicited higher muscle activation, particularly in middle hamstring regions (30.65% to 38.38% in RMS, r = −0.84 to −0.77, p_FDR < 0.001). Frequency differences revealed region-specific neuromuscular strategies. Intra-hamstring comparisons revealed significantly higher median frequencies in the BF50 and ST30 regions at their respective anatomical locations (dz = −1.90 to 1.34, all p_FDR < 0.001). These findings suggest that exercise symmetry and anatomical specialisation jointly shape neuromuscular control, with implications for designing eccentric training to reduce injury risk. Full article

Optimizing the neuromechanical determinants of explosive performance remains a key objective in sports science. This study compared the effects of an eight-week movement-pattern-based training program (MPT) with an isometric strength training protocol (ITG) on countermovement jump (CMJ) mechanics in competitive track and field athletes. Thirty-four athletes (19 men, 15 women) with ≥7 years of training experience were randomly allocated to the MPT or ITG. Pre- and post-intervention assessments were conducted using dual force plates to evaluate jump height, musculotendinous stiffness, concentric and eccentric impulses, contraction time, eccentric-to-concentric force ratio, and rate of force development (RFD). The MPT elicited significant gains in stiffness (Δ = +840.94 ± 1302.21 N/m; p = 0.002), maintained concentric peak force, and reduced contraction time (Δ = –64.53 ± 190.32 ms; p = 0.01), suggesting improved elastic efficiency and neuromuscular timing. Conversely, ITG was associated with reductions in concentric peak force (Δ = –66.18 ± 77.45 N; p = 0.003) and stiffness (Δ = –691.94 ± 1414.41 N/m) and an increase in the eccentric-to-concentric force ratio (Δ = +1.99%; p = 0.006). The RFD changes were inconsistent across both groups. These findings indicate that dynamic multi-joint training confers superior neuromechanical adaptations compared to isolated isometric loading. From a performance perspective, programming strategies should prioritize movement-specific dynamic tasks to enhance the explosive qualities critical for sprinting, jumping, and multidirectional field sports. Full article

The purpose of this study was threefold: (a) to analyze differences in mean force, impulse, mean concentric and eccentric velocity, and peak concentric velocity across six repetitions of the flywheel deadlift exercise, with a particular focus on the first repetition initiated from zero momentum; (b) to explore relationships between these kinetic and kinematic variables and one-repetition maximum (1-RM) performance in the free-weight deadlift; (c) to examine the effects of different flywheel inertial loads on the relationships among mean force (MF), impulse, time under tension (TUT), and velocity, with the aim of identifying the most valid and reliable parameter for flywheel load prescription. Thirteen resistance-trained men (24.7 ± 5.0 y; 82.2 ± 11.7 kg; 1-RM deadlift: 174 ± 24 kg) performed six repetitions of the flywheel deadlift against six inertial loads (0.025 to 0.145 kg∙m²) on a kBox 5 device. Results showed that although the first repetition had 25–30% lower mean concentric velocity and 7–11% lower mean force compared to subsequent repetitions (p < 0.001), it exhibited 4–8% higher impulse due to the 14–20% longer time under tension. MF, velocity, and impulse in the first repetition showed moderate-to-strong correlations with 1-RM (r = 0.58 to 0.85, p < 0.05), particularly at the two higher inertia loads. MF plateaued at moderate inertia loads, while impulse and TUT increased linearly with increasing inertial load and demonstrated the strongest and most consistent relationships with inertial load (r = 0.99 ± 0.01 and 0.97 ± 0.02, p < 0.001), enabling individualized flywheel training prescription. This study highlights the distinct value of the first repetition in flywheel deadlifts and its practical value for both assessment and training. Also, it suggests that impulse and TUT may be used as simple and practical flywheel exercise prescription variables. Full article

This study aimed to evaluate the impact of an 8-week reverse Nordic exercise training (RNET) program on physical fitness in male youth soccer players. A total of 35 players participated in the study and were divided into two groups: the RNET group (n = 19, age 16.39 ± 0.46 years) and the active control group (CG: n = 16, age 16.53 ± 0.48 years). To assess fitness changes, participants were tested on linear sprint speed (5, 10, and 20 m sprints), change-of-direction (CiD) speed (505-CiD), vertical jump (countermovement jump [CMJ]), horizontal jump (standing long jump [SLJ]), drop jump (20 cm drop jump [DJ-20]), and repeated sprint ability (RSA). Significant group-by-time interactions were observed (effect size, [ES] = 0.70 to 1.37), with substantial improvements in the RNET group across linear sprint, CiD, and jumping performances (ES = 0.61 to 1.47), while no significant changes were noted in the CG. However, no significant group-by-time interactions were observed for RSA parameters. Individual response analysis revealed that 63–89% of RNET group exhibited improvements exceeding the smallest worthwhile change (SWC_0.2) threshold. These results suggest that the RNET program is both effective and safe for enhancing physical fitness in male youth soccer players. Full article

Background: High-performance tennis exposes players to repetitive high-load strokes and abrupt directional changes, which substantially increase musculoskeletal injury risk. This systematic review synthesized evidence on epidemiology, risk factors, and physiotherapy-led preventive strategies in elite adolescent and adult players. Methods: Following a PROSPERO-registered protocol, MEDLINE, Web of Science, and Scopus were searched (2011–2024) for observational studies reporting epidemiological outcomes in high-performance tennis. Methodological quality was appraised with NIH tools, and certainty of evidence was graded with GRADE. Results: Thirty-seven studies met inclusion criteria: 16 in adolescents, 18 in adults, and 3 mixed. Incidence ranged from 2.1 to 3.5 injuries/1000 h in juniors and 1.25 to 56.6/1000 h in adults. Seasonal prevalence was 46–54% in juniors and 30–54% in professionals. Lower-limb trauma (48–56%) predominated, followed by lumbar (12–39%) and shoulder overuse syndromes. Across age groups, abrupt increases in the acute-to-chronic workload ratio (≥1.3 in juniors; ≥1.5 in adults) were the strongest extrinsic predictor of injury. Intrinsic contributors included reduced glenohumeral internal rotation, scapular dyskinesis, and poor core stability. Three prevention clusters emerged: (1) External load control, four-week “ramp-up” strategies reduced injury incidence by up to 21%; (2) Kinetic-chain conditioning, core stability plus eccentric rotator-cuff training decreased overuse by 26% and preserved shoulder mobility; and (3) Technique/equipment adjustments, grip-size personalization halved lateral epicondylalgia, while serve-timing modifications reduced shoulder torque. Conclusions: Injury risk in high-performance tennis is quantifiable and preventable. Progressive load management targeted kinetic-chain conditioning, and tailored technique/equipment modifications represent the most effective evidence-based safeguards for adolescent and adult elite players. Full article

Unaccustomed eccentric exercise is well established to induce exercise-induced muscle damage (EIMD), characterized by transient strength loss, delayed onset muscle soreness (DOMS), reduced range of motion, and proprioceptive disturbances. While limb dominance has been proposed as a potential modulator of susceptibility to EIMD, evidence remains inconclusive. This exploratory study aimed to compare alterations in muscle damage indices between dominant and non-dominant knee extensors 48 h after eccentric isokinetic exercise. Eighteen physically active young women (23 ± 2 years) completed two eccentric exercise sessions (5 × 15 maximal contractions at 60°/s), one per limb, with sessions separated by 24–30 days. For all participants, testing was conducted during the early follicular phase. Muscle strength (isometric and eccentric peak torque), DOMS (palpation and pain pressure threshold), range of motion, fatigue index, and position sense were assessed pre- and 48 h post-exercise. Significant reductions in isometric and eccentric peak torque, increased DOMS, impaired position sense, and altered fatigue index were observed 48 h post-exercise in the exercised limb (p < 0.001), with no differences between dominant and non-dominant limbs across all indices. These findings demonstrate that limb dominance does not influence the magnitude of EIMD in knee extensors of young women. Practical implications include equal consideration of both limbs in eccentric training, rehabilitation, and injury prevention programs. Full article

The TT genotype of the ACTN-3 polymorphism (rs1815739) has been previously associated with lower sprinting and jumping performance, higher frequency and severity of muscle injuries and eccentric muscle damage in professional football players. This study examined the influence of rs1815739 polymorphism on maximal running speed (MRS) during official matches in elite football players. MRS was collected, using a Global Position System (GPS) at high sampling frequencies (50 Hz), from 45 footballers of the same team during 26 official matches (707 match observations). A buccal swab was used to extract genomic DNA, and an RFLP PCR technique was used to determine the ACTN-3 genotype. The main finding of the present study was that CC players showed significantly higher MRS than TT players (CC = 33.1 ± 1.3 km·h⁻¹; CT = 32.7 ± 1.6 km·h⁻¹; TT = 31.5 ± 1.9 km·h⁻¹, p = 0.041). Moreover, the players harboring a copy of the C allele showed a trend toward higher MRS than TT genotype (CC + CT = 32.9 ± 1.5 km·h⁻¹ vs. TT = 31.5 ± 1.9 km·h⁻¹, p = 0.06). We found, for the first time, an association between the ACTN-3 polymorphism and match-play MRS in elite football players. Our results bring new knowledge to the literature regarding the advantage conferred by the C allele (CC and CT genotypes) of the ACTN-3 polymorphism on sprint performance in football providing perspectives for modulating the speed training program in relation to ACTN-3 genotypes, enhancing performance avoiding muscle lesions. Full article

Objectives: The lat pulldown machine is one of the most versatile pieces of equipment for back strengthening, allowing variations in grip and load. However, there are significant gaps in the literature regarding the relationship between exercise modality and specific muscle activation. Methods: This study examined the electromyographic (EMG) activity of major back muscles during seven lat pulldown exercise variants that differed in grip type, width, and trunk inclination. Forty male subjects, with at least 5 years of resistance training experience, performed five repetitions of lat pulldown exercise using 70% of their repetition maximum. Prior to the surface EMG analysis, maximal voluntary contraction (MVC) tests were performed for each muscle group analysed, specifically the latissimus dorsi, posterior deltoid, brachial biceps, middle and lower trapezium, and infraspinatus. The normalised root mean square of the EMG (NrmsEMG) activity for each muscle was recorded during full, concentric, and eccentric movements. Results: Multivariate analysis of variance (MANOVA) showed no significant difference in the NrmsEMG muscle activation across the different lat pulldown exercise variations (all p > 0.05). A significant difference was found in the posterior deltoid where the wide-pronated grip with a 30° trunk inclination showed greater EMG activation compared to the wide pronated grip (p = 0.011) and wide neutral grip (p = 0.017). Conclusions: These findings suggest that grip variations may not significantly alter latissimus dorsi recruitment, challenging the assumption that grip effectiveness targets this muscle. The results highlight the need for individualised approaches to exercise selection, given the variability in muscle activation patterns observed. Full article