Search Results (440)

This study comprehensively explores the environmental implications of two feeding strategies in pig farming, focusing on three scenarios: Brazilian tables (BT-2017), NRC (NRC-2012), and AGPIC (AGPIC-2021). The comparison involves conventional phase-feeding (CON) and the daily fit model (DFM). The five-phase system provided the same diet to all pigs within a group during each proposed phase. In contrast, the DFM adjusted the diet based on the nutritional requirements of pigs, anticipating subsequent diets through daily adjustments. We employed a cradle-to-gate approach, with the functional unit defined as one barrow with an initial body weight of 20.61 ± 0.85 kg, raised to 138.94 ± 0.90 kg over a 120-day growing-finishing period. Input data were sourced from observed commercial records from pig farms in Brazil, including over 1,000,000 data points from pigs raised under standard industry conditions. We evaluated the impact of the life cycle by considering factors such as acidification, climate change, ecotoxicity, eutrophication, land use, resource use, and water use. The OpenLCA software (version 1.11.0) and the Environmental Footprint 3.0 impact assessment method were used. Our results indicate that the DFM consistently outperforms the CON strategy in terms of reducing environmental impacts. Among the three scenarios, BT-2017 results in higher environmental impact reductions compared with NRC-2012 and AGPIC-2021. This is due to the higher concentration of corn and soybean meal in diets. Notable reductions include in relation to land use-related climate change impacts (12.55%), freshwater eutrophication (6.21%), mineral and metal resource depletion (6.11%), and fossil resource use (4.88%). These findings highlight that even modest adjustments to feeding strategies can effectively reduce the environmental footprint of pig farming. Full article

Murrah Cave is one of a series of cave and rockshelters in the Lower Pecos Canyonlands (far eastern Trans-Pecos) that contain evidence of late Quaternary cultures, fauna, and flora. Excavated in 1937, many faunal and floral specimens from Murrah Cave remain undescribed. Among those materials are a coracoid of a Pied-billed Grebe (Podilymbus podiceps), seeds, and charcoal. The major cultural occupation now is dated between 1000 and 600 ¹⁴C yr B.P. based on textiles. Charcoal dates, however, cluster earlier at around 2500 ¹⁴C yr B.P. with one date at 4800 ¹⁴C yr B.P. The Pied-billed Grebe represents the first occurrence in the Quaternary fossil record for the Trans-Pecos. The floral taxa are found in the Trans-Pecos Canyonlands today, part of the Chihuahuan Desert vegetation community, with some being the first known presence in the Lower Pecos Canyonlands. Two short-term mesic periods begin around 2500 ¹⁴C yr B.P. and 700 ¹⁴C yr B.P. denoted by the return of modern bison and expansion of the grasslands. These brief periods of increased moisture do not fundamentally alter the desert vegetation community. The floral and avian records highlight the potential available data within and the usefulness of old collections in contributing to modern studies. Full article

The interplay between the environmental exposome and the cancer genome remains a critical gap in precision oncology. While somatic mutational signatures—genomic fossils imprinted by exposures such as ultraviolet radiation; tobacco smoke; and industrial pollutants—are well characterised for their etiological significance; their functional impact on therapeutic efficacy remains largely unexplored. We hypothesised that these environmental genomic scars induce distinct pharmacogenomic vulnerabilities and resistance mechanisms that vary by geographical exposure patterns. This study employs two complementary analytical frameworks. First, a linear regression-based pharmacogenomic screen across four datasets (GDSC1, GDSC2, CTRP, CCLE; 1001 cell lines, 31 cancer types) identified 608 statistically significant (p < 0.01) mutational signature–drug interactions, revealing that UV-associated signature SBS7a is associated with broad-spectrum therapeutic resistance, including to BRAF inhibitors (PLX-4720, p < 10⁻⁴), while pollution-driven oxidative stress (SBS18) is associated with sensitivity to p38 MAPK inhibition (VX-702, r = −0.45, p < 10⁻⁹). Second, an XGBoost predictive model trained exclusively on 33,679 GDSC2 records using a 1265-feature matrix integrating 40 SBS signatures, drug chemistry descriptors, proteomic features, and two satellite-derived environmental variables (NASA PM_2.5 and UV)—achieved R² = 0.7973 on a 20% holdout set (grouped cross-validation R² = 0.7296). SHAP analysis revealed that satellite-derived PM_2.5 (Zone_PM25) ranked 7th of 1265 features, exceeding all 40 individual SBS mutational signatures. Synthesising these findings with satellite-derived atmospheric data, we constructed an exploratory spatially interpolated risk surface spanning 122 nations, generating the hypothesis that uniform drug efficacy assumptions may not apply globally. These findings suggest that a patient’s environmental exposure history may constitute a measurable pharmacogenomic variable. This exploratory framework warrants validation in independent datasets and with individual-level geographic data before clinical application. Full article

The excessive generation and improper disposal of Construction and Demolition Waste (CDW) represent one of the main environmental challenges in the sector. However, its potential for reuse and recycling enables the mitigation of these impacts through sustainable practices. In this context, the present study aimed to estimate reference values for the Federal District, Brazil, regarding the environmental impacts associated both with the transportation stage of CDW—from its point of origin to the processing facility—and with the operations involved in its conversion into recycled aggregates, through the application of a simplified Life Cycle Assessment approach. The analysis focused on quantifying the consumption of electricity, water, and fossil fuels, as well as carbon dioxide emissions and the generation of contaminant residues throughout the analyzed process. The system boundary adopted corresponds to a “cradle-to-gate” scope, with a declared unit of 1 tonne of recycled aggregate. Additionally, a survey of scientific studies providing life cycle inventory data related to aggregate production was conducted, enabling a consistency analysis with the data obtained in this study. Primary data related to the recycled aggregate production process were collected through direct field observations, in situ measurements, and the analysis of operational records from the studied facility. For the year 2024, the environmental indicators obtained showed that the production of 1 tonne of recycled aggregate required 1.23 kWh of electricity, 5.65 L of water, and 2.14 L of diesel, in addition to resulting in emissions of 6.64 kg CO₂ eq and the generation of 2.3 kg of contaminant waste. Full article

The accelerated deployment of hydrogen technologies is widely discussed as a pathway to mitigate climate change and reduce environmental pollution associated with fossil fuel use. In this context, intermediate-temperature proton-exchange membranes that operate in the 120–200 °C window, similar to the one characterizing liquid-acid PAFC systems (much larger in their power range), are sought as a bridge between low-temperature PFSA-based PEMFCs and low-temperature PCFs, thus combining reduced sensitivity to external humidification with solid-electrolyte handling. This Part I review surveys phosphate- and silicate-based glassy proton conductors as single-anion baseline matrices and organizes the literature around a mechanistic screening framework that links processing fingerprints—particularly sol–gel hydrolysis/condensation conditions, aging, drying, and thermal treatment—to pore architecture, hydration state, and the dominant proton-transport regime. Across both families, conductivity is governed by coupled variables: network chemistry (acidic site density and connectivity), water activity (RH), and microstructure-controlled percolation and retention. Reported σ values can arise from fundamentally different regimes, ranging from hopping-dominated transport supported by dense hydrogen-bond networks and proton-bearing groups to carrier-assisted, water-mediated transport in connected porosity, with distinct humidity dependence and stability implications. Accordingly, the review treats σ(T,RH) and activation energy together with hydration/porosity indicators as primary screening metrics, and it records missing durability and device-level information—chemical stability (hydrolysis and leaching/acid migration), mechanical robustness and cycling response, and current/power density where available—as explicit knowledge gaps. While substantial progress has been achieved within single-anion phosphate and silicate glasses, particularly through engineered acidity and microstructural control, most systems remain limited by hydration drift under gradients, thermal/humidity cycling stability, and electrode/electrolyte interfacial constraints when evaluated against intermediate-temperature membrane requirements. These conclusions establish a quantitative baseline and comparison rules for Part II, which will assess mixed-network, composite, and hybrid strategies designed to decouple conductivity from water-retention and durability trade-offs. Full article

Trackways preserve sequential records of animal locomotion and provide some of the most direct evidence of locomotor behaviour in the vertebrate fossil record. Alternating short–long pace lengths have historically been used to infer gait irregularities such as limping or lateral limb preference, but these interpretations typically lack statistical validation, treating mean asymmetry as sufficient grounds for behavioural conclusions without first establishing whether observed differences exceed normal locomotor variability. This study introduces a quantitative framework that addresses this gap by applying Welch’s t-test to pace and stride length measurements, establishing statistical confirmation of asymmetry as a prerequisite for behavioural interpretation. The framework is demonstrated on nine dinosaurian trackways drawn from published data. While all had previously been interpreted as asymmetric, seven exhibited statistically significant pace asymmetry (p < 0.05) and two did not exceed the range of normal variation. Stride length showed no significant asymmetry in any trackway, confirming that pace-level metrics are more sensitive to limb bias than stride-based measures. This framework provides an objective, reproducible standard for evaluating asymmetry claims—a necessary and feasible methodological advance for vertebrate ichnology. Full article

It has long been hypothesized that some arthropod lineages transitioned to land by following an interstitial pathway through the spaces between sand grains. In recent years, various molecular phylogenetic analyses suggest a greater number of terrestrialization events within Arthropoda than previously hypothesized. The relative importance of an interstitial route to land is likely to have been underestimated because of biases in the fossil record and the choice of techniques used for collecting extant arthropods from sands and other types of mineral regolith (sediment with low organic content). A number of early-branching taxa are microarthropods that are common in mineral regolith, providing phyloecological evidence for an interstitial pathway onto land. Following interstitial terrestrialization, hexapods and early-branching arachnids may have remained minute and soft-bodied within mineral regolith until the Early Devonian, when organically rich soils developed on much of the land surface, resulting in increased food resources but also increased rates of predation. This led to defensive modifications and increases in surface abundance and body size, which would have all elevated the probability of fossilization. Full article

Background: The transition from fossil-derived polymer additives to renewable alternatives is essential to mitigate environmental persistence and ensure chemical safety within the plastics industry. This review provides a comprehensive overview of recent developments in bio-based functional additives and their integration into circular economy frameworks. Methods: Following PRISMA guidelines, a systematic literature search was conducted using the Scopus database for studies published between 2023 and 2026. Search terms targeted bio-based plasticizers, flame retardants, antioxidants, and compatibilizers. Studies were screened against predefined inclusion criteria, specifically focusing on experimental validation in polymer matrices, while data mining was employed to map emerging research fronts. Results: From an initial 996 records, 54 studies were selected after removing duplicates and ineligible articles. The findings highlight a paradigm shift from passive physical fillers toward active, multifunctional macromolecular agents. Recent literature demonstrates that targeted molecular interventions, such as phosphorylated lignin and biomimetic structures, can resolve trade-offs between ductility and thermal stability at low loadings (<5 wt%). Synthesis routes, performance outcomes, and end-of-life trajectories for each additive class are summarized. Conclusions: Bio-based additives have evolved from simple substitutes into strategic tools for the molecular programming of sustainable polymers. Although challenges regarding scalability and high-temperature processing persist, their integration into circular economy strategies establishes a clear roadmap for next-generation bioplastics. Full article

Fossils provide invaluable data for evolutionary studies in oceanic islands. The paleontological record of the Macaronesian archipelagos has been the target of many researchers for a long time, with a recent surge in interest in scientific research related to their paleontological heritage. In the Macaronesian Azores archipelago, the marine invertebrate fossil record from the warmest period of the Last Interglacial stage (also known as Marine Isotopic Stage 5e—MIS 5e) represents approximately 95.6% of the total species. In contrast, the MIS 5e marine vertebrate fossil record comprises only four reported species (2.2%), with marine algae accounting for the remaining 2.2% (four species). This study reports on—and adds to the paleobiodiversity of the MIS 5e deposits at Santa Maria Island (Azores Archipelago)—two marine mesopelagic lanternfishes, identified from their otoliths: Diaphus cf. holti Tåning, 1918, and Symbolophorus veranyi (Moreau, 1888). Finally, we offer a plausible explanation for the presence of mesopelagic fishes in the MIS 5e fossiliferous deposits of Santa Maria Island. Full article

Mesozoic tree ferns related to the extant Loxsomopsis, a relict and taxonomically isolated genus endemic to tropical South America, are exceedingly rare, making it difficult to trace its origin and evolution. Here, we describe a mid-Cretaceous fossil attributable to Loxsomopsis, Loxsomopsis minor sp. nov., based on two fertile pinnules preserved in Myanmar amber. The new species is assigned to the extant genus based on a suite of diagnostic features, including pinnate fertile segments with short lobes, marginal paraphysate sori, narrowly cyathiform to urceolate indusia, columnar and exserted receptacles, oblique sporangial annuli, and trilete spores. This discovery extends the fossil record of Loxsomopsis back to the Albian–Cenomanian and provides new evidence that the lineage—now restricted to tropical South America—was once more widespread. The occurrence of Loxsomopsis in the Myanmar amber biota is consistent with a Gondwanan affinity for this mid-Cretaceous forest ecosystem and suggests that the genus may have likely originated prior to the breakup of Pangaea. Full article

Background: Prostate cancer (PCa) arises from complex interactions among host genetics, androgen signaling, and microbial communities. Emerging genomic evidence supports the presence of microbial consortia within prostate tissue, suggesting that microbial genes, metabolites, and host–microbe interactions may contribute to chronic inflammation, oncogenic signaling, and therapeutic resistance. Methods: We conducted a narrative review using targeted searches of PubMed and Google Scholar for studies published between 2020 and 2025, complemented by selected mechanistic reports published in March 2026. Human studies and experimental research providing mechanistic insights into prostate models were prioritized. Due to the heterogeneous methodologies, evidence was synthesized qualitatively, with an emphasis on genomic and signaling perspectives. Results: Low-biomass microbial DNA is consistently detected in prostate tissue. Proteomic analyses of Corpora amylacea suggest a “fossil record” of past infections through sequestered microbial DNA and antimicrobial proteins, potentially priming tissue for long-term carcinogenic processes, although contamination remains a key limitation. Recurrent bacterial and viral signals, including Cutibacterium acnes, Escherichia coli, Pseudomonas, Acinetobacter, human papillomavirus, Epstein–Barr virus, and cytomegalovirus, appear to converge on a restricted set of tumor-relevant pathways, including TLR–NF-κB, MAPK, PI3K/AKT/mTOR, cGAS–STING, and p53/pRb disruption. These interactions may promote cytokine production, oxidative stress, DNA damage, epithelial–mesenchymal transition, extracellular matrix remodeling, immune evasion, and resistance to therapy. The gut–prostate axis further links intestinal dysbiosis and microbial metabolites with systemic IGF-1 signaling and castration resistance. Conclusions: Microbial genomic consortia in the prostate and gut may shape inflammatory, metabolic, and immune networks that influence PCa initiation and progression. However, most available data remain correlative and are limited by low-biomass sampling, contamination risk, and heterogeneous study designs. Future research should prioritize rigorous contamination control, longitudinal and prostate-specific mechanistic studies, and integrated multi-omic approaches to clarify causality and identify actionable microbial targets for prevention, diagnosis, and therapy. Full article

We report the discovery of a new palaeoscolecid worm specimen from the Bainiuchang area, southeastern Yunnan, China. The specimen exhibits a cylindrical body with annulations, each bearing two rows of Hadimopanella-type sclerites, along with plates, platelets, microplates, and implanted plates. These features are compatible with the diagnosis of the genus Wronascolex, and the specimen is tentatively assigned to Wronascolex sp. However, given the limited number and preservation of the available specimens, which preclude a detailed demonstration of the scleritome morphology for comparison with other palaeoscolecid worms, this assignment should be treated as tentative. This specimen may be the first record of a soft-bodied fossil from the Miaolingian Series (Wuliuan Stage) strata of southeastern Yunnan. Its taphonomic features—preservation as carbonaceous compressions accompanied by iron-rich films—are broadly consistent with Burgess Shale-type (BST) preservation. Whole-rock geochemical analysis of samples from the fossil-bearing interval yielded redox proxy values suggestive of suboxic to weakly reducing depositional conditions, broadly comparable to those reported from some BST deposits, such as the Mackenzie Mountains locality of Canada. However, these geochemical results are preliminary and based on a limited number of samples. Taken together, these observations suggest the possibility that the Bainiuchang area may host a BST Lagerstätte. Should this be confirmed, such a deposit would postdate the Chengjiang and Guanshan biotas (Cambrian Series 2, eastern Yunnan) and predate the Fulu biota, which is the only confirmed BST Lagerstätte in southeastern Yunnan to date. Furthermore, this discovery extends the known paleogeographic range of the genus Wronascolex southward to the southwestern margin of the South China Block. It also represents, to our knowledge, the first reported occurrence of soft-bodied fossil preservation in the Wuliuan Stage of Yunnan Province. Full article

Soldier beetle larvae are characterised by numerous very small setae on their body surface, giving them a velvety appearance and hydrophobic properties, and paired gland openings on the segments of the thorax and abdomen for defensive purposes. Only recently, such a larva has been recognised in Cretaceous amber. Previously, only two specimens from Baltic amber were known from the fossil record. This provides the impression that such larvae are rare. We report 45 new larval specimens from Eocene Baltic amber and Cretaceous Kachin amber (Myanmar), demonstrating that these fossils are, in fact, more common, but simply not reported. We use the expanded dataset (with fossil and extant larvae and adults, more than 300 specimens) to explore the ontogeny of soldier beetles by quantitatively comparing morphological aspects over time. It appears that there is no major loss in the morphology of adults and larvae. On the contrary, certain larvae known in the modern fauna, so-called pre-larvae, seem absent in the fossil record. Due to the pre-larvae, some modern soldier beetles have certain characteristics of hypermetamorphosis. This type of developmental pattern is also characterised by a distinct change in the direction of the developmental trajectory. However, such a change could not be identified in soldier beetles. Full article

Humans, and most other late Homo species, are characterized by large brains and bodies. However, the discovery of two small-brained Homo species—H. floresiensis and Homo naledi—has cast doubts on large brain size as a defining feature of our genus. We reevaluated brain and body size scaling using data for 225 extant primates and 16 fossil hominid taxa, including one of the most diminutive species in genus Homo, H. floresiensis. Brain and body size are tightly correlated in genus Homo, varying along a positively allometric slope (R² = 0.84, F(1,5) = 33, p < 0.01) that is significantly different from the slope characterizing extant primates (R² = 0.94, F(1,222) = 3294, p < 0.001). Both small-bodied Homo floresiensis and Homo naledi have endocranial volumes (ECVs) that are consistent with their body size given the scaling relationship that characterizes genus Homo. Paired ECV and body mass estimates demonstrate considerable overlap of brain:body size proportions across fossil hominid taxa. Earlier hominids, Ardipithecus ramidus and Australopithecus anamensis, are characterized by ancestral brain:body size scaling; we discuss the hypothesis that a fundamental biological shift ca. 3 Ma altered the trajectory of encephalization—potentially linked to changes in fetal growth and gestation in Pleistocene fossil hominids—and may be directly implicated in the evolution of complex symbolic behavior in our lineage. Full article

Binary-cycle geothermal plants are inherently limited by thermodynamics, forcing operators to reinject fluids at temperatures that are still valuable for direct heating. This process results in substantial exergetic waste. While prior research has examined efficiency at the level of individual plants, this study introduces a regional-scale framework to convert these facilities into multi-purpose energy hubs. The research focuses on Türkiye’s Western Anatolia Graben, a region with high geothermal activity that, paradoxically, remains dependent on fossil fuels. By combining meteorological records with operational plant data, we evaluated the existing housing stock of 983,277 residences across 14 districts and modeled the heating requirements for a targeted capacity of 468,719 residences that the proposed system can serve. The results indicate that the currently wasted thermal load in 10 specific districts, including key centers such as Sarayköy and Alaşehir, is sufficient to cover peak winter heating demands without fossil fuel backup. Although the infrastructure requires a significant initial investment of $4.51 billion, the project demonstrates long-term viability with a Levelized Cost of Heat (LCOH) of 62.94 USD/MWh and a payback period of 10.43 years. Beyond economic considerations, the system serves as a major decarbonization tool, capable of cutting residential CO₂ emissions by 1.7 million tons annually (a 47.7% reduction). These findings suggest that policy incentives should move away from electricity-only models toward integrated reservoir management to maximize resource efficiency. Full article