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Search Results (1,603)

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Keywords = health hazard evaluation

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21 pages, 2915 KB  
Article
Tissue-Specific Accumulation and Dietary Risk of Arsenic and Other Potentially Toxic Elements in Retail Meats
by Syed Sayyam Abbas, Syed Ali Musstjab Akber Shah Eqani, Ismat Nawaz, Mansoor A. Alghamdi, Ahmed S. Summan, Abdul Qadir, Shabbar Abbas, Iqra Rasheed, Syeda Maria Ali, Mustafa Nawaz Shafqat, Mohammed I. Orif, Heqing Shen and Nadeem Ali
J. Xenobiot. 2026, 16(3), 90; https://doi.org/10.3390/jox16030090 (registering DOI) - 21 May 2026
Viewed by 212
Abstract
Data on arsenic (As) and other potentially toxic elements (PTEs) in Pakistani retail meats are limited, constraining evidence-based dietary risk assessment and management. This study aimed to determine the concentrations and profiles of As and seven other PTEs (Cr, Ni, Mn, Pb, Cd, [...] Read more.
Data on arsenic (As) and other potentially toxic elements (PTEs) in Pakistani retail meats are limited, constraining evidence-based dietary risk assessment and management. This study aimed to determine the concentrations and profiles of As and seven other PTEs (Cr, Ni, Mn, Pb, Cd, Cu, Zn) in commonly consumed meats and to evaluate the associated non-carcinogenic health risks. Ninety-two paired liver and muscle samples from broiler chicken, goat (mutton), and beef cattle were collected from four cities across the Indus Plain and analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Dietary exposure was evaluated using estimated daily intake (EDI), target hazard quotient (THQ), and hazardous index (HI) under typical and high-consumption scenarios. Overall, Zn and Cu exhibited the highest concentrations, followed by Mn and Cr, whereas As, Pb, Ni, and Cd occurred at comparatively lower but environmentally relevant levels. Beef liver exhibited the highest contamination levels, exceeding FAO/WHO permissible limits for Pb, Cu, and Cd in up to 40% of samples. In contrast, mutton and beef muscle contained the highest As and Zn concentrations, while chicken muscle showed elevated Cr levels. Multivariate statistical analysis revealed three dominant co-variation patterns, suggesting potential contamination pathways: (i) geogenic groundwater sources enriched with As, Cr, and Ni; (ii) atmospheric and industrial dust inputs linked with Pb, Cd, and Mn; (iii) mineral-enriched feed additives potentially contributing to elevated Zn and Cu, particularly in poultry. Under high-consumption scenarios, THQ values for As, Cr, Cu, and Zn exceeded the safety threshold (THQ > 1), highlighting beef products as the dominant source of chronic dietary risk. Overall, the findings highlight pronounced tissue- and species-specific accumulation trends, and emphasizes the urgent need for stricter feed and water quality control measures to minimize dietary exposure to PTEs. Full article
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18 pages, 798 KB  
Article
Integrated Chinese and Western Medicine for Breast Cancer Patients with Depression—Association with Survival and Healthcare Utilization: A Nationwide Retrospective Cohort Study in Taiwan
by Chingying Liang, Yen-Chun Huang, Jiun-Liang Chen, Chi Wen Chen and Mingchih Chen
Healthcare 2026, 14(10), 1406; https://doi.org/10.3390/healthcare14101406 - 20 May 2026
Viewed by 142
Abstract
Background: Breast cancer (BC) survivors frequently experience depression, which is associated with poorer quality of life (QoL), increased healthcare utilization, and worse prognosis. Although traditional Chinese medicine (TCM) is commonly used as an adjunctive therapy among Chinese populations for cancer-related symptom relief [...] Read more.
Background: Breast cancer (BC) survivors frequently experience depression, which is associated with poorer quality of life (QoL), increased healthcare utilization, and worse prognosis. Although traditional Chinese medicine (TCM) is commonly used as an adjunctive therapy among Chinese populations for cancer-related symptom relief and supportive care, population-based evidence remains limited regarding whether integrated Chinese and Western medicine (ICWM) confers measurable benefits over Western medicine (WM) alone in terms of healthcare utilization and survival. Taiwan’s National Health Insurance (NHI) system offers a unique nationwide setting to address this gap because it reimburses patients for both WM and TCM services and captures care from a large number of TCM clinics across Taiwan, allowing evaluation of adjunctive TCM use in routine clinical practice at a scale rarely possible in prior studies. We used emergency department visits, hospitalization, and length of stay as pragmatic proxy indicators of patients’ daily functioning and disease burden. Leveraging a 10-year enrollment window (2004–2013) and up to 17 years of follow-up, we hypothesized that ICWM would be associated with a reduced risk of acute care events and lower healthcare expenditures compared with WM alone. This hypothesis was examined in a large cohort of breast cancer patients treated across nearly 4000 medical facilities nationwide, encompassing the entire Taiwanese population. Methods: A retrospective cohort study was performed to analyze Taiwan’s National Health Insurance Research Database and Cancer Registry. Women newly diagnosed with breast cancer between 2004 and 2013 who subsequently developed depression (≥3 outpatient diagnoses or 1 hospitalization) were followed until death or 31 December 2021. Patients receiving ≥30 cumulative days of TCM after diagnosis were classified as the ICWM group, whereas those receiving <30 days were classified as the WM group. Multivariable Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs) for all-cause mortality. Healthcare utilization, including emergency department visits, hospitalization, and medical expenditures, was analyzed on a per-person-year basis. Results: A total of 1193 patients were included, with 488 in the WM group and 705 in the ICWM group. Compared with WM users, ICWM users were younger, had lower body mass index, and were more likely to have stage 0–II disease. ICWM was associated with lower total, inpatient, and emergency healthcare expenditures per person-year, as well as fewer emergency visits per person-year, although outpatient and overall visits were higher. In stage-stratified multivariable analyses, ICWM was associated with lower all-cause mortality in both stage 0–II disease (aHR = 0.61, 95% CI: 0.39–0.94) and stage III–IV disease (aHR = 0.38, 95% CI: 0.21–0.67). Kaplan–Meier analyses likewise showed significantly better overall survival in the ICWM group in both early-stage and advanced-stage disease. Conclusions: In this nationwide retrospective cohort of breast cancer patients with depression, adjunctive ICWM was associated with better survival, lower acute care utilization, and lower healthcare expenditures compared with WM alone. However, because quality of life was not directly measured and the study was based on observational data, QoL-related interpretations should be made cautiously, with healthcare utilization outcomes viewed as indirect proxy indicators rather than direct evidence of improved daily QoL. Full article
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19 pages, 7199 KB  
Review
Research Trends in Microbial Remediation of Heavy Metal-Contaminated Soils: A Bibliometric Analysis
by Zhikang Guo, Mu Peng and Haibo Wang
Microorganisms 2026, 14(5), 1140; https://doi.org/10.3390/microorganisms14051140 - 17 May 2026
Viewed by 228
Abstract
Heavy metal contamination in soils threatens ecosystem stability, agricultural productivity, and human health due to its persistence, toxicity, and ecological risks. Microbial remediation has emerged as a sustainable and cost-effective strategy, but the knowledge structure and research trends in this field remain insufficiently [...] Read more.
Heavy metal contamination in soils threatens ecosystem stability, agricultural productivity, and human health due to its persistence, toxicity, and ecological risks. Microbial remediation has emerged as a sustainable and cost-effective strategy, but the knowledge structure and research trends in this field remain insufficiently summarized. This study conducted a bibliometric analysis of publications on microbial remediation of heavy metal-contaminated soils retrieved from the Web of Science Core Collection from 2000 to 2025. VOSviewer (version 1.6.20), CiteSpace (version 7.0.R0), and the bibliometrix package (version 4.5.0) were used to analyze publication trends, major contributors, influential journals, and keyword evolution. The results showed that the number of publications increased continuously, with rapid growth after 2020. China, India, and the United States were the leading contributors, while Poland, Spain, and the United States played important bridging roles in international collaboration. Ravi Naidu was the most cited author, and Journal of Hazardous Materials was the most productive journal. Keyword analysis revealed a shift from pollutant degradation and microbial screening toward plant–microbe synergistic remediation, co-contaminated soil treatment, microbial community responses, and ecological risk assessment. Future research should emphasize multi-omics-based mechanisms, long-term in situ applications, and integrated evaluation frameworks. Full article
(This article belongs to the Collection Biodegradation and Environmental Microbiomes)
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23 pages, 21519 KB  
Article
Bioaccumulation of Trace Elements in the Most Commercial Fish in the Southern Black Sea and Risk Estimates Related to Their Consumption
by Levent Bat, Süleyman Özdemir, Zekiye Birinci Özdemir and Ayşah Öztekin
Fishes 2026, 11(5), 295; https://doi.org/10.3390/fishes11050295 - 15 May 2026
Viewed by 210
Abstract
This study evaluates the accumulation of trace elements (Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Hg, and Pb) in the muscle tissues of six commercially important fish species (Scophthalmus maximus, Merlangius merlangus, Mullus ponticus, Trachurus mediterraneus [...] Read more.
This study evaluates the accumulation of trace elements (Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Hg, and Pb) in the muscle tissues of six commercially important fish species (Scophthalmus maximus, Merlangius merlangus, Mullus ponticus, Trachurus mediterraneus, Engraulis encrasicolus, and Sprattus sprattus) harvested from multiple locations across the Sinop and Samsun coasts of the southern Black Sea during the 2023–2025 fishing seasons to assess potential human health risks. Element concentrations were quantified using inductively coupled plasma mass spectrometry (ICP-MS) and compared against national and international food safety standards. Results indicated that essential elements, particularly Fe and Zn, exhibited the highest concentrations, while Co and potentially toxic elements (Cd, Pb, As, and Hg) remained at lower levels. Although significant geographical variations in accumulation were observed between sampling locations, inter-species differences were relatively minor. Human health risk assessments, including Estimated Daily Intake (EDI), Target Hazard Quotient (THQ), and Carcinogenic Risk (CR), revealed that all THQ values were well below 1, indicating no non-carcinogenic concerns. Furthermore, CR values for As, Cr, and Pb fell within the acceptable range (10−6 to 10−4) defined by the U.S. EPA. Consequently, fish consumption from these regions poses no unacceptable risk, though localized element elevations suggest a need for enhanced environmental monitoring of pollution sources. Full article
(This article belongs to the Special Issue Stress Ecology of Aquatic Animals)
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17 pages, 1002 KB  
Article
Acute Pediatric Health Risks from Elastomer Thermolysis—PAH Emission Scenarios at School Receptors Following an Industrial Tire Fire
by Kamil Pająk and Andrzej R. Reindl
Molecules 2026, 31(10), 1659; https://doi.org/10.3390/molecules31101659 - 14 May 2026
Viewed by 252
Abstract
Uncontrolled scrap tire fires represent high-intensity episodic emission events that pose severe toxicological threats to urban environments. This study employs atmospheric dispersion modelling to quantify the impact of a tire stockpile fire on a distal educational receptor, evaluating two distinct dynamic stages of [...] Read more.
Uncontrolled scrap tire fires represent high-intensity episodic emission events that pose severe toxicological threats to urban environments. This study employs atmospheric dispersion modelling to quantify the impact of a tire stockpile fire on a distal educational receptor, evaluating two distinct dynamic stages of the event: an initial high-intensity open flame scenario (E1, 4 h) and a prolonged smouldering/suppression scenario (E2, 6 h), induced by firefighting interventions. Results reveal extreme pollutant loading at the receptor site during E1, with PM10 and SO2 concentrations peaking at 23,766 μgm3 and 7821 μgm3 respectively, indicating an immediate risk of acute respiratory distress. The organic fraction was dominated by volatile organic compounds (VOCs) (8691 μgm3) and a ∑16 PAHs flux of 313.9 μgm3. Toxicological assessment identified Benzo[a]pyrene (BaP) as the primary driver of health hazards, contributing approximately 70% to the carcinogenic risk profile. A critical disparity was observed between Mutagenic Equivalency (MEQ) of 18.32 and Toxic Equivalency (TEQ) of 15.37, suggesting that standard monitoring significantly underestimates the biological threat to sensitive paediatric populations. These findings demonstrate that acute, oxygen-limited tire combustion creates a concentrated toxic slug of high-molecular-weight PAHs. The study underscores the necessity of integrating mutagenicity-based models into emergency response protocols to accurately safeguard vulnerable communities against the long-term toxicological legacy of elastomer thermolysis. Full article
(This article belongs to the Special Issue Modern Trends and Solutions in Analytical Chemistry in Poland)
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22 pages, 4171 KB  
Article
From Waste to Health: Landfill Biogas Recovery as a Strategy for Greenhouse Gas Mitigation and Public Health Co-Benefits in Brazil
by Estefane Caetano Nazzari, Gredson Keiff Souza, Fernanda Nayara Campos de Almeida, Anderson Rafael Igarashi, Alexandre Diorio, Djeine Cristina Schiavon Maia and Nehemias Curvelo Pereira
Int. J. Environ. Res. Public Health 2026, 23(5), 648; https://doi.org/10.3390/ijerph23050648 - 13 May 2026
Viewed by 170
Abstract
Biogas from municipal solid waste is a promising pathway for renewable energy production while mitigating environmental pollution and public health risks. In this study, biogas emissions from a sanitary landfill in Maringá, southern Brazil, were evaluated using three models (IPCC, LandGEM, and CETESB [...] Read more.
Biogas from municipal solid waste is a promising pathway for renewable energy production while mitigating environmental pollution and public health risks. In this study, biogas emissions from a sanitary landfill in Maringá, southern Brazil, were evaluated using three models (IPCC, LandGEM, and CETESB tool) to estimate methane generation and energy recovery potential. Experimental analysis revealed methane concentrations from 51.10 ± 8.89% to 57.06 ± 1.19% across collection drains, indicating favorable conditions for energy utilization. Methane generation was estimated under different scenarios, reaching up to 1.30 × 104 tonnes of CH4, with peak production projected over 25–26 years depending on the model. Beyond energetic relevance, controlled biogas recovery can substantially reduce methane emissions, a key precursor of tropospheric ozone, and limit hazardous trace gas release, improving air quality and reducing population exposure to harmful pollutants. These findings are particularly relevant in developing countries, where insufficient waste management infrastructure leads to uncontrolled emissions, posing elevated environmental and health risks. This study supports integrating landfill biogas recovery into waste management and climate strategies, contributing to Sustainable Development Goals related to clean energy (SDG 7), climate action (SDG 13), and health (SDG 3), demonstrating it as a scalable solution for sustainable urban development. Full article
(This article belongs to the Special Issue Energy Sector Pollution and Health Promotion)
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21 pages, 530 KB  
Review
Toxic Substances in Plastics, Micro- and Nanoplastics: Utilizing ATSDR’s Plastics-Related Toxicological Profile Tool and Mixtures Framework for Human Health Risk Assessment
by Custodio V. Muianga, Gregory M. Zarus, Katie Stallings, Gaston Casillas, Mohammad Shoeb, Kimberly Gehle, Mohammad Moiz Mumtaz and Christopher M. Reh
Toxics 2026, 14(5), 429; https://doi.org/10.3390/toxics14050429 - 13 May 2026
Viewed by 503
Abstract
The prevalence of plastics in the environment raises concerns about their complex and poorly understood effects on human health. Research continues to uncover more sources of exposure and wider ranges of plastics within the body. Adverse health effects have been observed in animals, [...] Read more.
The prevalence of plastics in the environment raises concerns about their complex and poorly understood effects on human health. Research continues to uncover more sources of exposure and wider ranges of plastics within the body. Adverse health effects have been observed in animals, but their relevance to humans remains unclear. To address the growing need for reliable toxicity assessment resources and tools to aid in the synthesis of findings and the identification of data gaps and needs, we have developed a data visualization tool to provide streamlined access to the evaluated data on the chemical impacts of plastics on human health. The Plastics-Related Toxicology Profiles Tool uses Tableau Public to organize the extracted chemical-specific information from ATSDR Toxicological Profiles, the United Nations Environmental Program’s 2023 Chemicals in Plastics Technical Report, and a literature review of relevant research in Google Scholar and PubMed. The tool organizes extracted data from 98 ATSDR Toxicological Profiles representing over 476 substances related to plastics production in 16 tabulated health outcome categories associated with plastics exposure. The chemicals are organized into four categories based on their role in plastics manufacturing. The top four health endpoints impacted by all listed substance profiles are respiratory, neurologic, hepatic, and developmental effects. More than 30% of the substance profiles affected these systems as well as other non-cancer endpoints involving the immunological, renal, and reproductive systems, as well as increased cancer risk in respiratory and hepatic systems. Most monomers negatively impact development and the respiratory system, and most metal additives affect the respiratory system. We explain how this data visualization tool combined with ATSDR’s framework for assessing health impacts from multiple chemicals could be applied to identify the target organs impacted by components of the common plastic polyvinyl chloride. Hazard quotients and index show low toxicity and health risk of components in the cured product. This data provide a valuable resource for prioritizing health risk assessments. Use of this interactive tool can enhance the ability of public health professionals to navigate the expanding literature, synthesize findings, and identify future health risk assessment and research priorities. Full article
(This article belongs to the Section Emerging Contaminants)
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18 pages, 2447 KB  
Article
Integrated Machine Learning and Health Risk Assessment for Groundwater Nitrate Contamination in Handan City, China
by Yuanchao Zhao, Jing Liu, Xiaokai Zhang, Qun Li and Jin Wu
Water 2026, 18(10), 1174; https://doi.org/10.3390/w18101174 - 13 May 2026
Viewed by 258
Abstract
Groundwater nitrate (NO3) pollution is a critical environmental challenge with direct implications for human health. In this work, we propose a comprehensive analytical framework that integrates multi-model intercomparison, interpretable machine learning techniques, and quantitative health risk evaluation to tackle the [...] Read more.
Groundwater nitrate (NO3) pollution is a critical environmental challenge with direct implications for human health. In this work, we propose a comprehensive analytical framework that integrates multi-model intercomparison, interpretable machine learning techniques, and quantitative health risk evaluation to tackle the pressing groundwater nitrate governance dilemmas in Handan City, a representative urban area in North China. Based on 157 groundwater samples and 17 hydrochemical parameters, comparative analysis of three state-of-the-art machine learning algorithms showed that the Light Gradient Boosting Machine (LightGBM) algorithm outperformed all counterparts, delivering the optimal predictive performance (R2 = 0.753, RMSE = 3.67). SHapley Additive exPlanations (SHAP) analysis identified F, Ca2+, Cl, K+, total hardness, and Mg2+ as dominant factors influencing groundwater NO3 concentrations, reflecting the combined effects of carbonate dissolution, nitrification, and anthropogenic inputs. Subsequently, we performed a health risk assessment based on the standard methodological framework issued by the United States Environmental Protection Agency (USEPA), and the results indicated that children were the most vulnerable group, with hazard quotient (HQ, a non-carcinogenic risk indicator) values reaching 1.07 in the western mountainous region, exceeding the safety threshold (HQ > 1). These findings clarify the pollution mechanisms and spatial heterogeneity, and provide targeted policy guidance for groundwater protection as well as the safeguarding of public health. Full article
(This article belongs to the Section Hydrogeology)
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17 pages, 2609 KB  
Article
Seasonal Trace Element Contamination and Health Risk Assessment of the Mediterranean Limpet (Patella caerulea) from the Southern Black Sea
by Oylum Gökkurt Baki
Life 2026, 16(5), 806; https://doi.org/10.3390/life16050806 (registering DOI) - 13 May 2026
Viewed by 183
Abstract
The Mediterranean limpet (Patella caerulea, Linnaeus, 1758) is a native species in Türkiye that is not yet a major commercial species but has potential for future commercialisation, particularly given the country’s substantial mollusc export market. This study aimed to evaluate seasonal [...] Read more.
The Mediterranean limpet (Patella caerulea, Linnaeus, 1758) is a native species in Türkiye that is not yet a major commercial species but has potential for future commercialisation, particularly given the country’s substantial mollusc export market. This study aimed to evaluate seasonal and station-level variation in trace-element burdens in P. caerulea collected from the Sinop inner harbour (southern Black Sea coast, Türkiye) and to assess the associated trace-element–related non-carcinogenic health risks under a precautionary consumption scenario. Spatial and seasonal variations in the concentrations of 10 trace elements (Mn, Fe, Co, Ni, Cu, Zn, Cd, Pb, Hg, and total As) were analysed in specimens collected seasonally from autumn 2022 to summer 2023. Permutational multivariate analysis of variance revealed that season was the primary factor influencing trace element concentration variability, accounting for 76.9% of the total variance, followed by station (11.2%) and the season × station interaction (7.2%). All elements varied significantly among seasons (Kruskal–Wallis, p < 0.001), with maxima in autumn and minima in winter. Spatial differences were significant only for Mn, Co, Pb, Zn, and Hg, indicating localised sources. A human health risk assessment was performed for 6-year-old children, 12-year-old children, and adults. Total target hazard quotient (TTHQ) values were <1 across all groups; however, Cd was the dominant contributor, with the highest value observed in children (max TTHQ = 0.94). TTHQ followed the seasonal contamination pattern, peaking in autumn. Even under the high-consumption scenario, TTHQ for P. caerulea from the Sinop inner harbour remained below the non-carcinogenic risk threshold. The strong seasonal signal supports its use in locally focused biomonitoring, while the health-risk assessment should be limited to the analysed trace elements and associated non-carcinogenic effects. Full article
(This article belongs to the Section Diversity and Ecology)
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13 pages, 2959 KB  
Article
Association Between Dietary Copper Intake and Incident Metabolic Syndrome in Chinese Adults: A Discrete-Time Hazard Model Analysis
by Zhongting Lu, Zhihong Wang, Jiguo Zhang, Lixin Hao, Boya Zhao, Liusen Wang, Huijun Wang and Hongru Jiang
Nutrients 2026, 18(10), 1539; https://doi.org/10.3390/nu18101539 - 12 May 2026
Viewed by 216
Abstract
Objective: The aim of this study was to examine the association between dietary copper intake and incident metabolic syndrome (MetS) in Chinese adults. Methods: Data were obtained from the China Health and Nutrition Survey (CHNS) in 2009, 2015, and 2018. A total of [...] Read more.
Objective: The aim of this study was to examine the association between dietary copper intake and incident metabolic syndrome (MetS) in Chinese adults. Methods: Data were obtained from the China Health and Nutrition Survey (CHNS) in 2009, 2015, and 2018. A total of 2418 adults aged 18–64 years who were free of MetS at baseline in 2009 were included. Person-period data were constructed, and discrete-time hazard models with a complementary log-log link were used to evaluate the associations of dietary copper intake with incident MetS and its components. Restricted cubic spline analysis (RCS) was used to assess the dose–response relationship. Results: After multivariable adjustment, compared with the lowest quartile (Q1) of dietary copper intake, the Q4 groups had a higher risks of incident MetS, with HR (95% CI) of 1.32 (1.06–1.65) (p = 0.014). When analyzed as a continuous variable, each 1 mg/1000 kcal increase in energy-adjusted dietary copper intake was associated with an approximately 27% higher risk of incident MetS (HR = 1.27, 95% CI: 1.03–1.53) (p = 0.023). RCS indicated a significant overall association without evidence of nonlinearity. Component analyses suggested that higher dietary copper intake might be associated with increased risks of reduced high-density lipoprotein cholesterol (HDL-C) and abdominal obesity. Sensitivity analyses were generally consistent with the main findings. Conclusions: Higher dietary copper intake was associated with an increased risk of incident MetS in Chinese adults. Component analyses suggested a more consistent association for reduced HDL-C, while an additional possible association was observed for abdominal obesity. Full article
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16 pages, 353 KB  
Systematic Review
Long-Acting Lipid-Lowering Injectables and Behavioral Moral Hazard: A Systematic Review of Adherence, Lifestyle Measurement, and Structural Evidence Gaps
by Carmen Marinela Cumpăt, Muthana Zouri, Nicoleta Zouri, Robert Daniel Negru, Andra Oancea and Bogdan Ionel Tamba
Healthcare 2026, 14(10), 1319; https://doi.org/10.3390/healthcare14101319 - 12 May 2026
Viewed by 183
Abstract
Background/Objectives: Long-acting lipid-lowering injectable therapies, including PCSK9 monoclonal antibodies, inclisiran, and selected glucagon-like peptide-1 receptor agonists, represent a structural innovation in chronic disease management. By reducing dosing frequency and embedding pharmacologic persistence within healthcare delivery systems, these therapies address persistent challenges of long-term [...] Read more.
Background/Objectives: Long-acting lipid-lowering injectable therapies, including PCSK9 monoclonal antibodies, inclisiran, and selected glucagon-like peptide-1 receptor agonists, represent a structural innovation in chronic disease management. By reducing dosing frequency and embedding pharmacologic persistence within healthcare delivery systems, these therapies address persistent challenges of long-term statin non-adherence. However, from a health economics perspective, such innovations may also alter incentive structures related to preventive behaviors. This study examines whether outcome measurement in the long-acting injectable literature reflects shifts in the balance between pharmacologic adherence and lifestyle-related prevention. Methods: A systematic review was conducted in accordance with PRISMA 2020 guidelines. Eligible studies included adult populations receiving PCSK9 monoclonal antibodies, inclisiran, or GLP-1 receptor agonists that reported pharmacologic adherence or persistence and/or lifestyle-related measures. Studies were categorized by therapy class and design. The prevalence of adherence and lifestyle outcome measurement was calculated, and a descriptive Measurement Asymmetry Index was defined as the difference between adherence measurement prevalence and lifestyle measurement prevalence. Results: Four studies met the inclusion criteria, comprising randomized controlled trials. Pharmacologic adherence or persistence was measured in all included studies (100%), whereas lifestyle-related outcomes were assessed in only one study (25%), limited to a GLP-1 receptor agonist trial. No study explicitly evaluated behavioral substitution, risk compensation, or changes in patient responsibility. The Measurement Asymmetry Index was 75 percentage points, indicating a pronounced imbalance between pharmacologic and behavioral outcome domains. Conclusions: The findings do not provide evidence of behavioral moral hazard at the individual level but reveal a structural asymmetry in how prevention is assessed within the injectable therapy evidence base. This pattern may reflect an emphasis on drug-attributable and measurable outcomes, with comparatively limited attention to lifestyle engagement. As long-acting therapies become more integrated into chronic disease management, incorporating standardized lifestyle metrics into cardiovascular research may be necessary to support a more balanced framework of preventive responsibility. Full article
(This article belongs to the Section Healthcare Quality, Patient Safety, and Self-care Management)
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33 pages, 1701 KB  
Article
Exploring Causes of Safety Barriers in Sri Lankan Construction Industry: A Survey
by Asela Weerakoon, David Thorpe, Amirhossein Heravi, Anirudh Atmakuru, Asoke Mehera and Subrata Chakraborty
Safety 2026, 12(3), 69; https://doi.org/10.3390/safety12030069 - 12 May 2026
Viewed by 145
Abstract
This study aims to identify key health and safety challenges and examine root causes while developing a conceptual framework to improve safety. Results of the study will be useful for policy makers, regulatory authorities, construction managers, safety professionals and researchers to improve regulations, [...] Read more.
This study aims to identify key health and safety challenges and examine root causes while developing a conceptual framework to improve safety. Results of the study will be useful for policy makers, regulatory authorities, construction managers, safety professionals and researchers to improve regulations, safety practices, training programs and policy development. The emerging construction industry in Sri Lanka is facing significant safety challenges for workers, including poor practices, inappropriate conduct, and negative attitudes. The construction industry was selected for this study due to its labor-intensive nature and its consistently high exposure to occupational hazards compared to other industrial sectors. The underlying root causes of these health and safety challenges remain unclear, primarily due to a lack of comprehensive government regulations, which are currently limited to the outdated Factories Ordinance of 1942. Sri Lanka was chosen as the focus of this study because of its rapidly expanding construction sector and outdated regulatory framework; it is also a representative of underdeveloped countries. Several studies have identified contributing factors such as outdated legislation, a shortage of qualified officers, poor attitudes, lack of funding, negligence, and limited awareness. To address this research gap, the safety aspects of the Sri Lankan construction industry have been examined, revealing emerging challenges such as poor safety practices, the presence of foreign workers, and the inadequate use of personal protective equipment (PPE) by staff. A deeper examination of these challenges indicates that sufficient safety budgets reflect leadership attitudes toward preventing injuries, and that targeted safety training for different roles can help mitigate these issues. Accordingly, a conceptual safety framework has been developed. A qualitative, semi-structured interview comprising both open- and closed-ended questions was conducted to gain insights from 26 experts (including engineers, architects, human resource personnel, safety officers, and managers) regarding workplace safety challenges. The interview data was thematically categorized based on the identified safety challenges using NVivo analysis, to determine their root causes and develop strategies to improve workplace safety. To evaluate the emotional tone of participants’ response, sentiment analysis was conducted. Results highlighted participants’ optimism when discussing proactive or successful safety measures, neutrality in objective assessments, and concern or dissatisfaction when addressing safety challenges and organizational shortcomings. Experts recommended that safety education should be introduced in universities and vocational institutes. Firms can incorporate safety training through toolbox talks and induction sessions, and they can allocate a safety budget in their contracts. The study suggests developing a certificate-level safety training module for the construction industry and provides fresh insights into the underlying causes of safety issues in the Sri Lankan construction sector. Furthermore, the study has implications for delivering a health and safety framework for project risk management in developing countries that face budget constraints and limited training and development opportunities for enhancing construction skill sets. Full article
(This article belongs to the Special Issue Safety Performance Assessment and Management in Construction)
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14 pages, 1131 KB  
Article
Simultaneous Determination of Aromatic Amines in Tattoo Ink by Gas Chromatography–Electron Ionization (GC-EI)–Mass Spectrometry (MS) and Tandem MS (MS/MS)
by Eunyoung Shin, Hyebeen Kim, Jihye Choi, Minjae Kang, Juhui Shin and Sangwon Cha
Molecules 2026, 31(10), 1623; https://doi.org/10.3390/molecules31101623 - 12 May 2026
Viewed by 297
Abstract
Aromatic amines (AAs) are potent carcinogens found in tattoo inks that pose significant health risks. Precise quantitative analysis is essential for safety. In this study, we developed and validated a robust method for the simultaneous quantification of 21 regulated AAs using both gas [...] Read more.
Aromatic amines (AAs) are potent carcinogens found in tattoo inks that pose significant health risks. Precise quantitative analysis is essential for safety. In this study, we developed and validated a robust method for the simultaneous quantification of 21 regulated AAs using both gas chromatography–electron ionization (GC-EI)–mass spectrometry (MS) and tandem MS (MS/MS). After optimizing separation conditions, MS-based selected ion monitoring (SIM) and MS/MS-based multiple reaction monitoring (MRM) were evaluated. While both methods were largely sufficient to ensure compliance with international safety thresholds, the MRM-based approach exhibited superior detection capability with comparable analytical accuracy and precision, providing a more effective tool for trace-level hazardous compound analysis. The developed MRM method was applied to eight commercial tattoo inks, identifying five AAs in five products. Notably, o-toluidine, o-anisidine, and 3,3′-dichlorobenzidine significantly exceeded the regulatory limit (5.0 mg/kg), particularly in green and yellow inks. The dual-capability GC-MS platform—combining high-performance MRM quantification with robust spectral confirmation—ensures the high throughput and analytical confidence necessary for regulatory compliance and public health protection. Full article
(This article belongs to the Special Issue Chromatography—The Ultimate Analytical Tool, 3rd Edition)
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20 pages, 1425 KB  
Systematic Review
Burden of Mental Health Outcomes and Job Burnout Among Coal Mine Workers and Synthesis of Intervention Measures: A Systematic Review & Meta-Analysis
by Indranil Saha, Joydeep Majumder, Bhavani Shankara Bagepally, Saibal Das, Manoj Kalita, Devaraja Munikrishnappa, Uday Mondal, Devi Das, Taneir Lubana Siddiqui, Neha Dahiya, Asim Saha and Amit Chakrabarti
Psychiatry Int. 2026, 7(3), 111; https://doi.org/10.3390/psychiatryint7030111 - 12 May 2026
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Abstract
Coal mining is a hazardous occupation that can adversely affect both the physical and mental health of workers. This study aimed to estimate the pooled prevalence of various mental health outcomes and job burnout among coal miners and to summarize available intervention strategies [...] Read more.
Coal mining is a hazardous occupation that can adversely affect both the physical and mental health of workers. This study aimed to estimate the pooled prevalence of various mental health outcomes and job burnout among coal miners and to summarize available intervention strategies addressing these conditions. A systematic search of scientific databases, including Scopus, Embase, PubMed and Cochrane Central, was conducted for studies published from 2000 onwards. The study protocol was registered in PROSPERO [CRD42024536144]. Methodological quality of the studies was evaluated using AXIS, ROBINS-I and RoB 2 tools. A random-effects model was applied to estimate pooled prevalences. Of the 14,048 studies identified, 34 studies were included, comprising a total of 38,996 coal miners. The pooled prevalence of job burnout was 53.75% (95% CI: 50.64–56.86%), while depressive symptoms were observed in 35.35% of coal miners (95% CI: 16.43–54.28%; I2 = 97.41%). The pooled prevalence estimates were calculated with substantial heterogeneity (I2 > 90%) and wide prediction intervals indicate considerable variability across studies. These findings should be interpreted with caution due to substantial heterogeneity across studies, which may limit the reliability of pooled estimates. A limited number of studies reported interventions, including an Integrated Approach of Yoga Therapy (IAYT) and peer-based mental health and suicide prevention programs with supervisor training, which demonstrated potential benefits; however, these findings are based on limited and methodologically heterogeneous evidence, and the overall certainty remains low. The findings highlight a substantial burden of mental health problems among coal miners and suggest important policy implications, particularly for integrating mental health screening into periodic occupational health assessments. Addressing personal, social, and work-related determinants through comprehensive workplace strategies may help improve mental well-being and support workforce sustainability in the mining sector. Full article
(This article belongs to the Section Mental Health)
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20 pages, 2553 KB  
Article
Wet Chemical Synthesis of Benzalkonium Chloride-Hectorite Composites: Structural Regulation and Enhanced Antibacterial/Antifungal Performance for Indoor High-Humidity Decorative Materials
by Changchun Liu, Feng Yang, Wenkang Zhang, Feiya Shi, Shirong Xu, Taotao Yu, Jin Cheng, Ruize Chen, Chen Fang, Guping Tang, Hong Sun and Kenji Ogino
Coatings 2026, 16(5), 579; https://doi.org/10.3390/coatings16050579 - 11 May 2026
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Abstract
To mitigate health hazards from pathogenic bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Aspergillus niger) as well as the coating mildew issue in high-humidity indoor environments, and to overcome the challenges of particle agglomeration and non-uniform distribution in [...] Read more.
To mitigate health hazards from pathogenic bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Aspergillus niger) as well as the coating mildew issue in high-humidity indoor environments, and to overcome the challenges of particle agglomeration and non-uniform distribution in conventional benzalkonium chloride (BAC)-clay composites, this study proposes a wet chemical strategy to prepare BAC-hectorite antimicrobial composites using synthetic hectorite as a high-performance carrier, which is superior to natural clays such as montmorillonite and kaolin in structural uniformity, ion-exchange efficiency, and dispersion stability. Characterization using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and Brunauer–Emmett–Teller (BET) analysis confirmed the successful intercalation of BAC cations into the hectorite interlayers through ion exchange. This resulted in a significant expansion of the interlayer spacing from 1.0–1.2 nm to 1.5–1.8 nm, a marked alleviation of particle agglomeration, and an optimized pore structure. A clear structure–activity relationship between preparation conditions, microstructure regulation, and antimicrobial performance is systematically established. Antibacterial tests revealed superior efficacy against Gram-positive bacteria; the composite exhibited an inhibition zone of 13.31 mm and a minimum inhibitory concentration (MIC) of 4 μg/mL against S. aureus, compared to 11.62 mm and 32 μg/mL against E. coli. Practical application tests demonstrated that at an ultralow addition level of 0.4%, incorporating this composite into latex paint achieved an antibacterial rate exceeding 99.9% against both pathogens. When added to putty powder, it yielded Grade 0 mold resistance with no observable growth. Furthermore, compounding with polypropylene (PP) increased the elongation at break to approximately 600%, simultaneously realizing antibacterial, antifungal, and toughening functions, thereby not only conferring antibacterial functionality but also significantly enhancing toughness—resolving the typical polymer embrittlement caused by traditional inorganic antibacterial fillers. Short-term evaluations confirm that this composite offers a stable structure, high-efficiency antimicrobial properties, and improved substrate mechanics at low loading levels. These findings provide technical support and experimental guidance for the functional upgrading of indoor decorative coatings, putties, and polymer materials used in high-humidity scenarios such as kitchens and bathrooms. Full article
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