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820 Results Found

  • Review
  • Open Access
734 Views
15 Pages

Differential Characteristics and Comparison Between Long-COVID Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

  • Mariya Ivanovska,
  • Maysam Salim Homadi,
  • Gergana Angelova,
  • Hristo Taskov and
  • Marianna Murdjeva

17 November 2025

Long-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are disabling diseases characterised by ongoing fatigue, post-exertional malaise, cognitive impairment, and autonomic dysfunction. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ty...

  • Article
  • Open Access
2 Citations
2,933 Views
11 Pages

Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome

  • Laszlo Zavori,
  • Tihamer Molnar,
  • Reka Varnai,
  • Andrea Kanizsai,
  • Lajos Nagy,
  • Bence Vadkerti,
  • Balazs Szirmay,
  • Attila Schwarcz and
  • Peter Csecsei

19 February 2023

Long-COVID syndrome is associated with high healthcare costs, but its pathophysiology is not yet fully understood. Inflammation, renal impairment or disturbance of the NO system emerge as potential pathogenetic factors. We aimed to investigate the re...

  • Article
  • Open Access
22 Citations
3,995 Views
8 Pages

Alteration of Inflammatory Parameters and Psychological Post-Traumatic Syndrome in Long-COVID Patients

  • Irma Clemente,
  • Gaia Sinatti,
  • Antonio Cirella,
  • Silvano Junior Santini and
  • Clara Balsano

The aim of our study is to evaluate the correlation between the psychological status of patients recovered from SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection (long-COVID patients) and their inflammatory status. Three months a...

  • Article
  • Open Access
14 Citations
3,871 Views
15 Pages

Pain and Clinical Presentation: A Cross-Sectional Study of Patients with New-Onset Chronic Pain in Long-COVID-19 Syndrome

  • Andrés Calvache-Mateo,
  • Laura López-López,
  • Javier Martín-Núñez,
  • Alejandro Heredia-Ciuró,
  • María Granados-Santiago,
  • Araceli Ortiz-Rubio and
  • Marie Carmen Valenza

The aim of this study was to evaluate the characteristics of pain (i.e., pain intensity, pain interference, clinical presentation) in Long-COVID-19 patients and compare the location of pain between successfully recovered COVID-19 patients and healthy...

  • Article
  • Open Access
9 Citations
2,964 Views
13 Pages

Changes in Physical Activity and the Occurrence of Specific Symptoms of “Long-COVID Syndrome” in Men Aged 18–25

  • Anna Sojka,
  • Mariusz Machniak,
  • Waldemar Andrzejewski,
  • Aureliusz Kosendiak and
  • Agnieszka Chwałczyńska

The aim of this study was to assess the occurrence of non-specific symptoms of “long-COVID syndrome” depending on the physical activity undertaken resulting from the imposed forms of study (distance learning–contact learning); 136 m...

  • Article
  • Open Access
2,101 Views
12 Pages

Evaluation of Long-COVID Syndrome in a Cohort of Patients with Endometriosis or Adenomyosis

  • Anjeza Xholli,
  • Isabella Perugi,
  • Francesca Cremonini,
  • Ambrogio Pietro Londero and
  • Angelo Cagnacci

8 March 2025

Background: Long-COVID is characterized by the persistency of COVID-19 symptoms beyond 12 weeks, and it is probably consequent to immune dysregulation induced by SARS-CoV-2 infection. Immune dysregulation is associated with and probably involved in t...

  • Review
  • Open Access
988 Views
26 Pages

Long-Term Complications of Multisystem Inflammatory Syndrome in Children and Adults Post-COVID-19: A Systematic Review

  • Sanish Varghese,
  • Ibrahim Al-Hassani,
  • Ubaida Al-Aani,
  • Noor J. Rob,
  • Sara Al-Mannai,
  • Aayami Jaguri,
  • Reel A. Yousif,
  • Aisha Al-Mulla,
  • Fathima F. Palayangal and
  • Sa’ad Laws
  • + 2 authors

3 November 2025

The SARS-CoV-2 pandemic has posed global medical challenges due to its ability to affect multiple organ systems. Among the post-COVID-19 complications, multisystem inflammatory syndrome has emerged as a severe condition affecting both children (MIS-C...

  • Review
  • Open Access
9 Citations
4,337 Views
22 Pages

Pathogenic Connections in Post-COVID Conditions: What Do We Know in the Large Unknown? A Narrative Review

  • Celina Silvia Stafie,
  • Sorina Mihaela Solomon,
  • Irina-Georgeta Sufaru,
  • Maria Manaila,
  • Ingrid Ioana Stafie,
  • Gabriela Melinte,
  • Bianca Simionescu and
  • Letitia Leustean

30 July 2022

The coronavirus 2019 (COVID-19) disease has long-term effects, known as post-COVID conditions (PCC) or long-COVID. Post-COVID-19 syndrome is defined by signs and symptoms that occur during or after severe acute respiratory syndrome coronavirus 2 (SAR...

  • Review
  • Open Access
3 Citations
3,305 Views
11 Pages

SGLT2 Inhibitors in Long COVID Syndrome: Is There a Potential Role?

  • Paul Zimmermann,
  • Harald Sourij,
  • Felix Aberer,
  • Sian Rilstone,
  • Janis Schierbauer and
  • Othmar Moser

The coronavirus disease (COVID)-19 has turned into a pandemic causing a global public health crisis. While acute COVID-19 mainly affects the respiratory system and can cause acute respiratory distress syndrome, an association with persistent inflamma...

  • Article
  • Open Access
51 Citations
6,070 Views
13 Pages

Long-COVID Clinical Features and Risk Factors: A Retrospective Analysis of Patients from the STOP-COVID Registry of the PoLoCOV Study

  • Michał Chudzik,
  • Mateusz Babicki,
  • Joanna Kapusta,
  • Żaneta Kałuzińska-Kołat,
  • Damian Kołat,
  • Piotr Jankowski and
  • Agnieszka Mastalerz-Migas

11 August 2022

Despite recovering from the acute phase of coronavirus disease (COVID-19), many patients report continuing symptoms that most commonly include fatigue, cough, neurologic problems, hair loss, headache, and musculoskeletal pain, a condition termed long...

  • Case Report
  • Open Access
1,590 Views
14 Pages

Ocular and Neurological Sequelae in Long COVID: Dry Eye, Asthenopia, Sleep Disorders, Asthenia, and Restless Legs Syndrome—A Case Report with Literature Review

  • Mario Troisi,
  • Salvatore Troisi,
  • Livio Vitiello,
  • Diego Strianese,
  • Carlo Bellucci,
  • Michele Rinaldi,
  • Luca D’Andrea and
  • Ciro Costagliola

14 August 2025

This case report presents a unique constellation of symptoms—including dry eye disease, visual and general asthenia, sleep disturbances, and restless legs syndrome—in a patient with a recent history of coronavirus disease 2019 (COVID-19)...

  • Review
  • Open Access
33 Citations
3,981 Views
18 Pages

The Psychiatric Consequences of Long-COVID: A Scoping Review

  • Gaia Sampogna,
  • Matteo Di Vincenzo,
  • Vincenzo Giallonardo,
  • Francesco Perris,
  • Antonio Volpicelli,
  • Valeria Del Vecchio,
  • Mario Luciano and
  • Andrea Fiorillo

26 October 2022

The COVID-19 pandemic has represented a new form of traumatic event, affecting the general population worldwide and causing severe disruption of daily routine. A new urgent concern is related to the burden associated with COVID-19 symptoms that persi...

  • Review
  • Open Access
58 Citations
20,774 Views
17 Pages

11 December 2020

An increasing number of young and previously fit and healthy people who did not require hospitalisation continue to have symptoms months after mild cases of COVID-19. Rehabilitation clinics are already offering cognitive behavioural therapy (CBT) as...

  • Case Report
  • Open Access
4 Citations
10,153 Views
9 Pages

9 February 2024

mRNA COVID-19 vaccines have been reported as protecting against COVID-19 and reducing its severity, and we have recognized post-vaccination symptoms recently. This research investigates the clinical trajectories of ocular disorders in a 51-year-old f...

  • Article
  • Open Access
29 Citations
14,436 Views
11 Pages

Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis

  • Abhigan Babu Shrestha,
  • Aashna Mehta,
  • Pashupati Pokharel,
  • Aakash Mishra,
  • Lukash Adhikari,
  • Sajina Shrestha,
  • Randhir Sagar Yadav,
  • Surakshya Khanal,
  • Ranjit Sah and
  • Behdin Nowrouzi-Kia
  • + 2 authors

(1) Background: Long COVID syndrome is a significant cause of morbidity in COVID-19 patients who remain symptomatic with varied clinical presentations beyond three weeks. Furthermore, the relevance of considering cardiovascular outcomes in post-COVID...

  • Review
  • Open Access
126 Citations
19,344 Views
19 Pages

The majority of people infected with SARS-CoV-2 fully recovered within a few weeks. However, a considerable number of patients of different ages still suffer from long-lasting problems similar to the multi-organ damage in its acute phase of infection...

  • Case Report
  • Open Access
9 Citations
2,731 Views
14 Pages

Severe Course of COVID-19 and Long-COVID-19 in Children: Difficulties in Diagnosis

  • Elena Vasichkina,
  • Olga Kofeynikova,
  • Svetlana Fetisova,
  • Anastasia Y. Starshinova,
  • Elizaveta Sheyanova,
  • Tatiana Vershinina,
  • Anton Ryzhkov,
  • Aleksey Skripnik,
  • Daria Alekseeva and
  • Elizaveta Nechaeva
  • + 4 authors

14 March 2023

The question of COVID-19 and long-COVID-19 course in children remains unsolved. This infection in children, which is associated with COVID-19, can vary from asymptomatic to systemic damage of various systems. Multisystem inflammatory syndrome in chil...

  • Article
  • Open Access
12 Citations
2,821 Views
12 Pages

Predictive Factors and ACE-2 Gene Polymorphisms in Susceptibility to Long COVID-19 Syndrome

  • David Varillas-Delgado,
  • Carmen Jimenez-Antona,
  • Angel Lizcano-Alvarez,
  • Roberto Cano-de-la-Cuerda,
  • Alberto Molero-Sanchez and
  • Sofia Laguarta-Val

24 November 2023

Long COVID-19 syndrome is present in 5–10% of patients infected with SARS-CoV-2, and there is still little information on the predisposing factors that lead to its development. The purpose of the study was to evaluate the predictive factors in...

  • Review
  • Open Access
11 Citations
6,638 Views
14 Pages

The Growing Understanding of the Pituitary Implication in the Pathogenesis of Long COVID-19 Syndrome: A Narrative Review

  • Ach Taieb,
  • Ben Haj Slama Nassim,
  • Gorchane Asma,
  • Methnani Jabeur,
  • Saad Ghada and
  • Ben Abdelkrim Asma

14 February 2024

Long COVID-19, also known as post-acute sequelae of SARS-CoV-2 infection, is a condition where individuals who have recovered from the acute phase of COVID-19 continue to experience a range of symptoms for weeks or even months afterward. While it was...

  • Review
  • Open Access
1,024 Views
12 Pages

Changes in the Gut Microbiota of Patients After SARS-CoV-2 Infection: What Do We Know?

  • Isabel de Souza Andrade Arruda,
  • Caio da Silva Cavalcante,
  • Rebeca Siqueira Rubens,
  • Larissa Nava Pinto de Faria Castro,
  • Yanna Karla de Medeiros Nóbrega and
  • Tanise Vendruscolo Dalmolin

COVID-19 can cause long-term symptoms, such as a post-infection syndrome, known as Long-COVID. Among the symptoms present during this period, the most reported are gastrointestinal symptoms. This study discusses the effects of changes in the gut micr...

  • Article
  • Open Access
2 Citations
3,144 Views
12 Pages

Exercise Intolerance Is Associated with Cardiovascular Dysfunction in Long COVID-19 Syndrome

  • Angelos Vontetsianos,
  • Nikolaos Chynkiamis,
  • Maria Ioanna Gounaridi,
  • Christina Anagnostopoulou,
  • Christiana Lekka,
  • Stavroula Zaneli,
  • Nektarios Anagnostopoulos,
  • Evangelos Oikonomou,
  • Manolis Vavuranakis and
  • Nikoletta Rovina
  • + 4 authors

16 July 2024

Background/Objectives: Cardiorespiratory complications are commonly reported among patients with long COVID-19 syndrome. However, their effects on exercise capacity remain inconclusive. We investigated the impact of long COVID-19 on exercise toleranc...

  • Review
  • Open Access
28 Citations
5,753 Views
20 Pages

Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications

  • Maha F. Alenazy,
  • Haya I. Aljohar,
  • Ashwag R. Alruwaili,
  • Maha H. Daghestani,
  • Mona A. Alonazi,
  • Ranyah S. Labban,
  • Afaf K. El-Ansary and
  • Hanan A. Balto

27 September 2022

Increasing numbers of patients who recover from COVID-19 report lasting symptoms, such as fatigue, muscle weakness, dementia, and insomnia, known collectively as post-acute COVID syndrome or long COVID. These lasting symptoms have been examined in di...

  • Article
  • Open Access
3 Citations
1,833 Views
11 Pages

Differences of Disabling Symptoms between Previously Hospitalized or Non-Hospitalized Currently Working Long-COVID Survivors One Year after Infection: A Descriptive Study

  • Laura López-López,
  • Andrés Calvache-Mateo,
  • Araceli Ortiz-Rubio,
  • María Granados-Santiago,
  • Alejandro Heredia-Ciuró,
  • Javier Martín-Núñez and
  • Marie Carmen Valenza

16 August 2023

This study aimed to describe the presence of disabling symptoms in currently working Long-COVID survivors by comparing the hospitalized and non-hospitalized one year after infection. Patients with Long-COVID syndrome (LCS) that have been infected by...

  • Review
  • Open Access
4 Citations
4,809 Views
19 Pages

SARS-CoV-2 Spike Protein and Long COVID—Part 1: Impact of Spike Protein in Pathophysiological Mechanisms of Long COVID Syndrome

  • Bruno Pereira de Melo,
  • Jhéssica Adriane Mello da Silva,
  • Mariana Alves Rodrigues,
  • Julys da Fonseca Palmeira,
  • Felipe Saldanha-Araujo,
  • Gustavo Adolfo Argañaraz and
  • Enrique Roberto Argañaraz

25 April 2025

SARS-CoV-2 infection has resulted in more than 700 million cases and nearly 7 million deaths worldwide. Although vaccination efforts have effectively reduced mortality and transmission rates, a significant proportion of recovered patients—up to...

  • Review
  • Open Access
321 Citations
32,397 Views
14 Pages

26 April 2021

Background and Objectives: Long COVID defines a series of chronic symptoms that patients may experience after resolution of acute COVID-19. Early reports from studies with patients with long COVID suggests a constellation of symptoms with similaritie...

  • Article
  • Open Access
14 Citations
7,126 Views
12 Pages

Utility of Serum Ferritin for Predicting Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Patients with Long COVID

  • Yukichika Yamamoto,
  • Yuki Otsuka,
  • Kazuki Tokumasu,
  • Naruhiko Sunada,
  • Yasuhiro Nakano,
  • Hiroyuki Honda,
  • Yasue Sakurada,
  • Toru Hasegawa,
  • Hideharu Hagiya and
  • Fumio Otsuka

18 July 2023

Objective: The most common symptom of post-acute coronavirus disease 2019 (COVID-19) is fatigue, and it potentially leads to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, a specific prognosticator is lacking. We aimed to eluci...

  • Opinion
  • Open Access
8 Citations
17,062 Views
18 Pages

Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID

  • Douglas B. Kell,
  • Muhammed Asad Khan,
  • Binita Kane,
  • Gregory Y. H. Lip and
  • Etheresia Pretorius

31 January 2024

Postural orthostatic tachycardia syndrome (POTS) is a common accompaniment of a variety of chronic, inflammatory diseases, including long COVID, as are small, insoluble, ‘fibrinaloid’ microclots. We here develop the argument, with accompa...

  • Article
  • Open Access
17 Citations
3,897 Views
17 Pages

11 February 2023

Symptoms of long COVID-19 syndrome (long COVID-19) are reported by 80% of convalescents up to several months after contracting the coronavirus-19 disease (COVID-19). The study aimed to assess the frequency and correlations of long COVID symptoms with...

  • Article
  • Open Access
15 Citations
4,048 Views
12 Pages

Assessing the Quality of Life, Coping Strategies, Anxiety and Depression Levels in Patients with Long-COVID-19 Syndrome: A Six-Month Follow-Up Study

  • Adrian Vasile Bota,
  • Felix Bratosin,
  • Iulia Bogdan,
  • Susa Septimiu-Radu,
  • Adrian Cosmin Ilie,
  • Sonia-Roxana Burtic,
  • David Vladut Razvan,
  • Raluca Tudor,
  • Mirela Florica Indries and
  • Andrei Nicolae Csep
  • + 3 authors

11 January 2024

This longitudinal study investigates the psychosocial effects of long-COVID Syndrome, a domain still not extensively researched. It specifically evaluates the quality of life, coping mechanisms, anxiety and depression levels in COVID-19 survivors, di...

  • Article
  • Open Access
53 Citations
18,689 Views
18 Pages

24 December 2021

Background and Objectives: Symptoms and hemodynamic findings during orthostatic stress have been reported in both long-haul COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but little work has directly compared patients from...

  • Review
  • Open Access
9 Citations
8,581 Views
23 Pages

21 May 2024

Myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS), and long COVID are complex, multisystemic and long-term disabling conditions characterized by debilitating post-exertional malaise and other core symptoms related to immune d...

  • Article
  • Open Access
5 Citations
3,842 Views
18 Pages

Association of Mediterranean Diet with Cardiovascular Risk Factors and with Metabolic Syndrome in Subjects with Long COVID: BioICOPER Study

  • Nuria Suárez-Moreno,
  • Leticia Gómez-Sánchez,
  • Alicia Navarro-Caceres,
  • Silvia Arroyo-Romero,
  • Andrea Domínguez-Martín,
  • Cristina Lugones-Sánchez,
  • Olaya Tamayo-Morales,
  • Susana González-Sánchez,
  • Ana B. Castro-Rivero and
  • Emiliano Rodríguez-Sánchez
  • + 3 authors

12 February 2025

Background. Long COVID has been associated with increased cardiovascular risk and chronic low-grade inflammation, raising concerns about its long-term metabolic consequences. Given that the Mediterranean diet (MD) has shown beneficial effects on card...

  • Article
  • Open Access
12 Citations
4,751 Views
15 Pages

Effects of Aerobic Exercise Therapy through Nordic Walking Program in Lactate Concentrations, Fatigue and Quality-of-Life in Patients with Long-COVID Syndrome: A Non-Randomized Parallel Controlled Trial

  • Sofía Laguarta-Val,
  • David Varillas-Delgado,
  • Ángel Lizcano-Álvarez,
  • Alberto Molero-Sánchez,
  • Alberto Melian-Ortiz,
  • Roberto Cano-de-la-Cuerda and
  • Carmen Jiménez-Antona

11 February 2024

Background: Long-COVID syndrome comprises a variety of signs and symptoms that develop during or after infection with COVID-19 which may affect the physical capabilities. However, there is a lack of studies investigating the effects of Long-COVID syn...

  • Article
  • Open Access
12 Citations
4,048 Views
13 Pages

The Interactive Effects of Post-Traumatic Stress Symptoms and Breathlessness on Fatigue Severity in Post-COVID-19 Syndrome

  • Sari Harenwall,
  • Suzanne Heywood-Everett,
  • Rebecca Henderson,
  • Joanne Smith,
  • Rachel McEnery and
  • Amy R. Bland

21 October 2022

Background: Post-traumatic stress symptoms (PTSS) and breathlessness have been well documented in the acute phase of COVID-19 as well as in Post-COVID-19 Syndrome (PCS), commonly known as Long-COVID. The present study aimed to explore whether PTSS an...

  • Article
  • Open Access
783 Views
15 Pages

Impaired Peripheral Blood Mononuclear Cell (PBMC) Mitochondrial Respiration Is Associated with Mortality and Long COVID Syndrome Severity in COVID-19 Patients

  • Anne-Laure Charles,
  • Léa Debrut,
  • Walid Oulehri,
  • Véronique Vincent,
  • Héloise Delagreverie,
  • Pauline Asael,
  • Marianne Riou,
  • Margherita Giannini,
  • Alain Meyer and
  • Bernard Geny

24 October 2025

COVID-19 is a public health issue with a significant mortality rate and potential long-lasting disabling symptoms responsible for the long-COVID syndrome. Mitochondrial dysfunction is a key mechanism but whether peripheral blood mononuclear cell (PBM...

  • Article
  • Open Access
1 Citations
3,538 Views
21 Pages

Comparing DNA Methylation Landscapes in Peripheral Blood from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Patients

  • Katie Peppercorn,
  • Sayan Sharma,
  • Christina D. Edgar,
  • Peter A. Stockwell,
  • Euan J. Rodger,
  • Aniruddha Chatterjee and
  • Warren P. Tate

Post-viral conditions, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC), share > 95% of their symptoms, but the connection between disturbances in their underlying molecular biology is unclear. This study investigate...

  • Article
  • Open Access
1 Citations
5,016 Views
17 Pages

The Use of Heart Rate Variability-Biofeedback (HRV-BF) as an Adjunctive Intervention in Chronic Fatigue Syndrome (CSF/ME) in Long COVID: Results of a Phase II Controlled Feasibility Trial

  • Giulia Cossu,
  • Goce Kalcev,
  • Diego Primavera,
  • Stefano Lorrai,
  • Alessandra Perra,
  • Alessia Galetti,
  • Roberto Demontis,
  • Enzo Tramontano,
  • Fabrizio Bert and
  • Roberta Montisci
  • + 6 authors

29 July 2025

Background: Emerging evidence indicates that some individuals recovering from COVID-19 develop persistent symptoms, including fatigue, pain, cognitive difficulties, and psychological distress, commonly known as Long COVID. These symptoms often overla...

  • Review
  • Open Access
1 Citations
2,522 Views
26 Pages

17 September 2025

Although Gulf War Illness (GWI), fibromyalgia (FM), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID have distinct origins, in this article we have reviewed evidence that these disorders comprise a group of so-called low-ene...

  • Systematic Review
  • Open Access
23 Citations
6,993 Views
14 Pages

Impact of Pre-Infection COVID-19 Vaccination on the Incidence and Severity of Post-COVID Syndrome: A Systematic Review and Meta-Analysis

  • Milena Adina Man,
  • Daniela Rosca,
  • Felix Bratosin,
  • Ovidiu Fira-Mladinescu,
  • Adrian Cosmin Ilie,
  • Sonia-Roxana Burtic,
  • Ariadna Petronela Fildan,
  • Camelia Melania Fizedean,
  • Adelina Maria Jianu and
  • Rodica Anamaria Negrean
  • + 1 author

12 February 2024

This systematic review critically evaluated the impact of a pre-infection COVID-19 vaccination on the incidence and severity of post-COVID-19 syndrome and aimed to assess the potential protective effect across different vaccines and patient demograph...

  • Article
  • Open Access
6 Citations
7,117 Views
14 Pages

Insulin Resistance in Long COVID-19 Syndrome

  • Dana Emilia Man,
  • Minodora Andor,
  • Valentina Buda,
  • Nilima Rajpal Kundnani,
  • Daniel Marius Duda-Seiman,
  • Laura Maria Craciun,
  • Marioara Nicula Neagu,
  • Iulia-Stefania Carlogea and
  • Simona-Ruxanda Dragan

28 August 2024

Background: The COVID-19 pandemic has caused severe health issues worldwide and contributed to huge financial losses. Key comorbidities linked to an increased risk of severe COVID-19 and higher mortality rates include cardio-metabolic disorders such...

  • Review
  • Open Access
14 Citations
8,087 Views
12 Pages

22 December 2022

Long Covid can affect anyone who has previously had acute COVID-19. The root causes of this syndrome are still unknown, and no effective therapeutics are available. This complex syndrome, with a wide array of symptoms, is still evolving. Given the di...

  • Article
  • Open Access
13 Citations
3,745 Views
10 Pages

COVID-19, Long COVID Syndrome, and Mental Health Sequelae in a Mexican Population

  • Jesús Maximiliano Granados Villalpando,
  • Humberto Azuara Forcelledo,
  • Jorge Luis Ble Castillo,
  • Alejandro Jiménez Sastré,
  • Isela Esther Juárez Rojop,
  • Viridiana Olvera Hernández,
  • Fernando Enrique Mayans Canabal and
  • Crystell Guadalupe Guzmán Priego

The COVID-19 pandemic is currently a worldwide threat and concern, not only because of COVID-19 itself but its sequelae. The aim of this study was to evaluate whether a relation between COVID-19, Long COVID, and the prevalence of mental health disord...

  • Article
  • Open Access
40 Citations
9,151 Views
9 Pages

Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID

  • Kazuki Tokumasu,
  • Hiroyuki Honda,
  • Naruhiko Sunada,
  • Yasue Sakurada,
  • Yui Matsuda,
  • Koichiro Yamamoto,
  • Yasuhiro Nakano,
  • Toru Hasegawa,
  • Yukichika Yamamoto and
  • Yuki Otsuka
  • + 4 authors

25 June 2022

Background and Objectives: COVID-19 can be serious not only in the acute phase but also after the acute phase and some patients develop ME/CFS. There have been few studies on patients with long COVID in whom ME/CFS was diagnosed by physicians based o...

  • Review
  • Open Access
40 Citations
8,020 Views
21 Pages

Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review

  • Joht Singh Chandan,
  • Kirsty R. Brown,
  • Nikita Simms-Williams,
  • Nasir Z. Bashir,
  • Jenny Camaradou,
  • Dominic Heining,
  • Grace M. Turner,
  • Samantha Cruz Rivera,
  • Richard Hotham and
  • Sonica Minhas
  • + 11 authors

Background: Post-viral syndromes (PVS), including Long COVID, are symptoms sustained from weeks to years following an acute viral infection. Non-pharmacological treatments for these symptoms are poorly understood. This review summarises the evidence...

  • Article
  • Open Access
59 Citations
17,508 Views
17 Pages

Long COVID: Association of Functional Autoantibodies against G-Protein-Coupled Receptors with an Impaired Retinal Microcirculation

  • Charlotte Szewczykowski,
  • Christian Mardin,
  • Marianna Lucio,
  • Gerd Wallukat,
  • Jakob Hoffmanns,
  • Thora Schröder,
  • Franziska Raith,
  • Lennart Rogge,
  • Felix Heltmann and
  • Michael Moritz
  • + 12 authors

Long COVID (LC) describes the clinical phenotype of symptoms after infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnostic and therapeutic options are limited, as the pathomechanism of LC is elusive. As the number...

  • Article
  • Open Access
6 Citations
5,058 Views
21 Pages

A substantial fraction of the 15% with double-jointedness or hypermobility have the traditionally ascertained joint-skeletal, cutaneous, and cardiovascular symptoms of connective tissue dysplasia and its particular manifestation as Ehlers–Danlo...

  • Review
  • Open Access
13 Citations
3,870 Views
18 Pages

Dynamics of the Microbiota and Its Relationship with Post-COVID-19 Syndrome

  • Nidia Carolina Moreno-Corona,
  • Orestes López-Ortega,
  • Cesar Augusto Pérez-Martínez,
  • Macario Martínez-Castillo,
  • Luis Adrián De Jesús-González,
  • Guadalupe León-Reyes and
  • Moisés León-Juárez

1 October 2023

Coronavirus disease (COVID-19) is an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can be asymptomatic or present with multiple organ dysfunction. Many infected individuals have chronic alterations associated...

  • Editorial
  • Open Access
3 Citations
2,172 Views
4 Pages

What Do We Know Today about Long COVID? Nursing Care for a New Clinical Syndrome

  • Rosa M. Cárdaba-García,
  • Carlos Durantez-Fernández,
  • Lucía Pérez Pérez,
  • María Ángeles Barba-Pérez and
  • Elena Olea

Persistent COVID, long COVID, long-effects, long-term effects or chronic COVID are all names of a new syndrome caused by a set of multi-organ symptoms that appear after having been infected with SARS-CoV-2 [...]

  • Review
  • Open Access
14 Citations
5,273 Views
17 Pages

Neuroimmunological Effect of Vitamin D on Neuropsychiatric Long COVID Syndrome: A Review

  • Ting-Bin Chen,
  • Ching-Mao Chang,
  • Cheng-Chia Yang,
  • I-Ju Tsai,
  • Cheng-Yu Wei,
  • Hao-Wen Yang and
  • Chun-Pai Yang

30 August 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19). COVID-19 is now recognized as a multiorgan disease with a broad spectrum of manifestations. A substantial proportion of in...

  • Review
  • Open Access
5 Citations
3,063 Views
21 Pages

Long COVID Syndrome: A Narrative Review on Burden of Age and Vaccination

  • Panaiotis Finamore,
  • Elena Arena,
  • Domenica Lupoi,
  • Luisa Savito,
  • Francesca Di Nunzio,
  • Michela Furbatto,
  • Silvano Dragonieri,
  • Raffaele Antonelli Incalzi and
  • Simone Scarlata

13 August 2024

Background/Objective: The COVID-19 pandemic has led to the emergence of post-acute COVID-19 syndrome, also known as long COVID, which presents a significant challenge due to its varied symptoms and unpredictable course, particularly in older adults....

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