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Keywords = multi-relaxation test

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19 pages, 1609 KB  
Article
Instance-Based Transfer Learning-Improved Battery State-of-Health Estimation with Self-Attention Mechanism
by Renjun He, Chunxiao Wang, Chun Yin, Shang Yang, Yifan Wang, Yuanpeng Fang, Kai Chen and Jiusi Zhang
Energies 2025, 18(21), 5672; https://doi.org/10.3390/en18215672 - 29 Oct 2025
Viewed by 191
Abstract
Batteries’ state-of-health (SOH) estimation has attracted appealing attention in energy industrial systems. In conventional data-driven methods, the lack of target data and different source data can also lead to poor model training effect. To tackle this problem, this paper combines the instance-based transfer [...] Read more.
Batteries’ state-of-health (SOH) estimation has attracted appealing attention in energy industrial systems. In conventional data-driven methods, the lack of target data and different source data can also lead to poor model training effect. To tackle this problem, this paper combines the instance-based transfer (ITL) and interpretable self-attention mechanism (SAM) to integrate the fitting ability of long short-term memory (LSTM), which can improve the SOH estimation performance. ITL re-weights the temporal instance of a training set to give more impact of target-like data, which can relax the independent and identical distribution (IID) assumption. SAM method can enhance the estimation performance by re-weighting the spatial features, and be interpreted by detailed visualization. During the model training, the pre-trained multi-layer LSTM model is fine-tuned by target data to make full use of target information. The proposed method has outperformed other compared algorithms in transfer tasks, and has tested in real-world cross-domain conditions datasets. Full article
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28 pages, 5293 KB  
Article
A QR-Enabled Multi-Participant Quiz System for Educational Settings with Configurable Timing
by Junjie Li, Wenyuan Bian, Yuan Diao, Tianji Zou, Xinqing Yang and Boqi Kang
Appl. Syst. Innov. 2025, 8(6), 158; https://doi.org/10.3390/asi8060158 - 22 Oct 2025
Viewed by 275
Abstract
An integrated QR-based identification and multi-participant quiz system is developed for classroom and competition scenarios. It reduces the check-in latency, removes fixed buzz-in timing, and lifts hardware-imposed limits on the participant count. On the software side, a MATLAB-R2022b-based module integrates the generation and [...] Read more.
An integrated QR-based identification and multi-participant quiz system is developed for classroom and competition scenarios. It reduces the check-in latency, removes fixed buzz-in timing, and lifts hardware-imposed limits on the participant count. On the software side, a MATLAB-R2022b-based module integrates the generation and recognition of linear barcodes and QR Codes, enabling fast, accurate acquisition of contestant information while reducing the latency and error risk of manual entry. On the hardware side, control circuits for compulsory and buzz-in modules are designed and simulated in Multisim-14.3. To accommodate diverse scenarios, the team-versus-team buzz-in mode is extended to support two- or three-member teams. Functional tests demonstrate the stable display of key states—including contestant identity, buzz-in priority group ID, and response duration. Compared with typical MCU-channel-based designs, the proposed system relaxes hardware-channel constraints, decoupling the participant count from fixed input channels. It also overcomes fixed-timing limitations by supporting scenario-dependent configuration. The Participant Information Registration subsystem achieved a mean accuracy of 86.7% and a mean per-sample computation time of 14 ms. The 0–99 s configurable timing aligns with question difficulty and instructional procedures. It enhances fairness, adaptability, and usability in formative assessments and competition-based learning. Full article
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17 pages, 661 KB  
Article
Adaptive Learning Control for Vehicle Systems with an Asymmetric Control Gain Matrix and Non-Uniform Trial Lengths
by Yangbo Tang, Zetao Chen and Hongjun Wu
Symmetry 2025, 17(8), 1203; https://doi.org/10.3390/sym17081203 - 29 Jul 2025
Viewed by 345
Abstract
Intelligent driving is a key technology in the field of automotive manufacturing due to its advantages in environmental protection, energy efficiency, and economy. However, since the intelligent driving model is an uncertain multi-input multi-output dynamic system, especially in an interactive environment, it faces [...] Read more.
Intelligent driving is a key technology in the field of automotive manufacturing due to its advantages in environmental protection, energy efficiency, and economy. However, since the intelligent driving model is an uncertain multi-input multi-output dynamic system, especially in an interactive environment, it faces uncertainties such as non-uniform trial lengths, unknown nonlinear parameters, and unknown control direction. In this paper, an adaptive iterative learning control method is proposed for vehicle systems with non-uniform trial lengths and asymmetric control gain matrices. Unlike the existing research on adaptive iterative learning for non-uniform test lengths, this paper assumes that the elements of the system’s control gain matrix are asymmetric. Therefore, the assumption made in traditional adaptive iterative learning methods that the control gain matrix of the system is known or real, symmetric, and positive definite (or negative definite) is relaxed. Finally, to prove the convergence of the system, a composite energy function is designed, and the effectiveness of the adaptive iterative learning method is verified using vehicle systems. This paper aims to address the challenges in intelligent driving control and decision-making caused by environmental and system uncertainties and provides a theoretical basis and technical support for intelligent driving, promoting the high-quality development of intelligent transportation. Full article
(This article belongs to the Special Issue Symmetry and Asymmetry in Intelligent Control and Computing)
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15 pages, 3980 KB  
Article
Four-Dimensional-Printed Woven Metamaterials for Vibration Reduction and Energy Absorption in Aircraft Landing Gear
by Xiong Wang, Changliang Lin, Liang Li, Yang Lu, Xizhe Zhu and Wenjie Wang
Materials 2025, 18(14), 3371; https://doi.org/10.3390/ma18143371 - 18 Jul 2025
Viewed by 696
Abstract
Addressing the urgent need for lightweight and reusable energy-absorbing materials in aviation impact resistance, this study introduces an innovative multi-directional braided metamaterial design enabled by 4D printing technology. This approach overcomes the dual challenges of intricate manufacturing processes and the limited functionality inherent [...] Read more.
Addressing the urgent need for lightweight and reusable energy-absorbing materials in aviation impact resistance, this study introduces an innovative multi-directional braided metamaterial design enabled by 4D printing technology. This approach overcomes the dual challenges of intricate manufacturing processes and the limited functionality inherent to traditional textile preforms. Six distinct braided structural units (types 1–6) were devised based on periodic trigonometric functions (Y = A sin(12πX)), and integrated with shape memory polylactic acid (SMP-PLA), thereby achieving a synergistic combination of topological architecture and adaptive response characteristics. Compression tests reveal that reducing strip density to 50–25% (as in types 1–3) markedly enhances energy absorption performance, achieving a maximum specific energy absorption of 3.3 J/g. Three-point bending tests further demonstrate that the yarn amplitude parameter A is inversely correlated with load-bearing capacity; for instance, the type 1 structure (A = 3) withstands a maximum load stress of 8 MPa, representing a 100% increase compared to the type 2 structure (A = 4.5). A multi-branch viscoelastic constitutive model elucidates the temperature-dependent stress relaxation behavior during the glass–rubber phase transition and clarifies the relaxation time conversion mechanism governed by the Williams–Landel–Ferry (WLF) and Arrhenius equations. Experimental results further confirm the shape memory effect, with the type 3 structure fully recovering its original shape within 3 s under thermal stimulation at 80 °C, thus addressing the non-reusability issue of conventional energy-absorbing structures. This work establishes a new paradigm for the design of impact-resistant aviation components, particularly in the context of anti-collision structures and reusable energy absorption systems for eVTOL aircraft. Future research should further investigate the regulation of multi-stimulus response behaviors and microstructural optimization to advance the engineering application of smart textile metamaterials in aviation protection systems. Full article
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23 pages, 6299 KB  
Article
Multi-Valve Coordinated Disturbance Rejection Control for an Intake Pressure System Using External Penalty Functions
by Louyue Zhang, Duoqi Shi, Chao Zhai, Zhihong Dan, Hehong Zhang, Xi Wang and Gaoxi Xiao
Actuators 2025, 14(7), 334; https://doi.org/10.3390/act14070334 - 2 Jul 2025
Viewed by 434
Abstract
Altitude test facilities for aero-engines employ multi-chamber, multi-valve intake systems that require effective decoupling and strong disturbance rejection during transient tests. This paper proposes a coordinated active disturbance rejection control (ADRC) scheme based on external penalty functions. The chamber pressure safety limit is [...] Read more.
Altitude test facilities for aero-engines employ multi-chamber, multi-valve intake systems that require effective decoupling and strong disturbance rejection during transient tests. This paper proposes a coordinated active disturbance rejection control (ADRC) scheme based on external penalty functions. The chamber pressure safety limit is formulated as an inequality-constrained optimization problem, and an exponential penalty together with a gradient based algorithm is designed for dynamic constraint relaxation, with guaranteed global convergence. A coordination term is then integrated into a distributed ADRC framework to yield a multi-valve coordinated ADRC controller, whose asymptotic stability is established via Lyapunov theory. Hardware-in-the-loop simulations using MATLAB/Simulink and a PLC demonstrate that, under ±3 kPa pressure constraints, the maximum engine inlet pressure error is 1.782 kPa (77.1% lower than PID control), and under an 80 kg/s2 flow-rate disturbance, valve oscillations decrease from ±27% to ±5%. These results confirm the superior disturbance rejection and decoupling performance of the proposed method. Full article
(This article belongs to the Special Issue Actuation and Robust Control Technologies for Aerospace Applications)
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12 pages, 949 KB  
Article
Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy
by Mustafa Koyun and Kemal Niyazi Arda
Diagnostics 2025, 15(13), 1634; https://doi.org/10.3390/diagnostics15131634 - 26 Jun 2025
Viewed by 691
Abstract
Background/Objectives: T2 mapping is a quantitative magnetic resonance imaging (MRI) technique that provides information about tissue water content and molecular mobility. This study aimed to evaluate the diagnostic utility of T2 mapping in assessing sacroiliitis associated with spondyloarthropathy (SpA). Methods: A prospective study [...] Read more.
Background/Objectives: T2 mapping is a quantitative magnetic resonance imaging (MRI) technique that provides information about tissue water content and molecular mobility. This study aimed to evaluate the diagnostic utility of T2 mapping in assessing sacroiliitis associated with spondyloarthropathy (SpA). Methods: A prospective study examined a total of 56 participants, comprising 31 SpA patients (n = 31) and 25 healthy controls (n = 25), who underwent sacroiliac joint MRI between August 2018 and August 2020. T2 mapping images were generated using multi-echo turbo spin echo (TSE) sequence, and quantitative T2 relaxation times were measured from bone and cartilage regions. Statistical analysis employed appropriate parametric and non-parametric tests with significance set at p < 0.05. Results: The mean T2 relaxation time measured from the areas with osteitis of SpA patients (100.23 ± 7.41 ms; 95% CI: 97.51–102.95) was significantly higher than that of the control group in normal bone (69.44 ± 4.37 ms; 95% CI: 67.64–71.24), and this difference was found to be statistically significant (p < 0.001). No significant difference was observed between cartilage T2 relaxation times in SpA patients and controls (p > 0.05). Conclusions: T2 mapping serves as a valuable quantitative imaging biomarker for diagnosing sacroiliitis associated with SpA, particularly by detecting bone marrow edema. The technique shows promise for objective disease assessment, though larger studies are needed to establish standardized reference values for T2 relaxation times in osteitis to enhance diagnostic accuracy and facilitate treatment monitoring. Full article
(This article belongs to the Special Issue Advances in Musculoskeletal Imaging: From Diagnosis to Treatment)
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18 pages, 3371 KB  
Article
Evaluating Parameter Value Identification Methods for Modeling of Nonlinear Stress Relaxation in Polyethylene
by Furui Shi and P.-Y. Ben Jar
Materials 2025, 18(13), 2960; https://doi.org/10.3390/ma18132960 - 23 Jun 2025
Viewed by 381
Abstract
Viscous properties play a major role in the time-dependent deformation behavior of polymers and have long been characterized using spring-dashpot models. However, such models face a bottleneck of having multiple sets of model parameter values that can all be used to simulate the [...] Read more.
Viscous properties play a major role in the time-dependent deformation behavior of polymers and have long been characterized using spring-dashpot models. However, such models face a bottleneck of having multiple sets of model parameter values that can all be used to simulate the same deformation behavior. As a result, these model parameters have not been widely used to quantify the viscous properties. In this study, a newly developed multi-relaxation-recovery test was used to obtain the variation in stress response to deformation of polyethylene (PE) and its pipes during relaxation, revealing the complexity of PE’s nonlinear viscous stress response to deformation. Using a three-branch spring-dashpot model with two Eyring’s dashpots, this study shows the possibility of determining the model parameter values using four different analysis methods, namely, the mode method, peak-point method, highest-frequency method, and best-five-fits method. Model parameter values from these methods are compared and discussed in this paper, to reach the conclusion that the best-five-fits method provides the most reliable and relatively unique set of model parameter values for characterizing the mechanical performance of PE and its pipes. The best-five-fits method is expected to enable the use of the model parameters to quantify PE’s viscous properties so that PE’s load-carrying performance can be properly characterized, even for long-term applications. Full article
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22 pages, 376 KB  
Article
Impact of a Single Virtual Reality Relaxation Session on Mental-Health Outcomes in Frontline Workers on Duty During the COVID-19 Pandemic: A Preliminary Study
by Sara Faria, Sílvia Monteiro Fonseca, António Marques and Cristina Queirós
Healthcare 2025, 13(12), 1434; https://doi.org/10.3390/healthcare13121434 - 16 Jun 2025
Cited by 1 | Viewed by 1867
Abstract
Background/Objectives: The COVID-19 pandemic affected frontline workers’ mental health, including healthcare workers, firefighters, and police officers, increasing the need for effective interventions. This study focuses on the pandemic’s psychological impact, perceived stress, depression/anxiety symptoms, and resilience, examining if a brief virtual reality [...] Read more.
Background/Objectives: The COVID-19 pandemic affected frontline workers’ mental health, including healthcare workers, firefighters, and police officers, increasing the need for effective interventions. This study focuses on the pandemic’s psychological impact, perceived stress, depression/anxiety symptoms, and resilience, examining if a brief virtual reality (VR)–based relaxation session could reduce psychological symptoms. Methods: In this preliminary study with data collected in 2025 from frontline workers who had served during the acute phase of the COVID-19 pandemic, 54 frontline workers completed a baseline assessment of the perceived psychological impact of COVID-19 pandemic, general perceived well-being, perceived stress (PSS-4), anxiety/depression (PHQ-4) and resilience (RS-25). Each participant then engaged in a 10-min immersive VR relaxation session featuring a calming 360° nature environment with audio guidance, after which questionnaires were re-administered. Paired samples t-tests and repeated-measures ANOVA evaluated pre-/post-session differences, and a hierarchical multiple linear regression model tested predictors of the change in stress. Results: Pre-session results showed moderate perceived stress and resilience and low depression/anxiety. Occupation groups varied in baseline stress, mostly reporting negative pandemic psychological effects. After VR, significantly perceived well-being increased, and stress decreased, whereas depression/anxiety changes were nonsignificant. Repeated-measures ANOVA revealed a main effect of time on stress (p = 0.003) without occupation-by-time interaction (p = 0.246), indicating all occupational groups benefited similarly from the VR session. Hierarchical regression indicated baseline depression and higher perceived pandemic-related harm independently predicted greater stress reduction, whereas resilience and baseline anxiety showed no statistically significant results. Conclusions: A single VR relaxation session lowered perceived stress among frontline workers, particularly those reporting higher baseline depression or pandemic-related burden. Limitations include the absence of a control group. Results support VR-based interventions as feasible, rapidly deployable tools for high-stress settings. Future research should assess longer-term outcomes, compare VR to alternative interventions, and consider multi-session protocols. Full article
(This article belongs to the Special Issue Depression, Anxiety and Emotional Problems Among Healthcare Workers)
16 pages, 4569 KB  
Article
Characterization of Polycarbonate and Glass-Filled Polycarbonate Using Multi-Relaxation Test—Role of Glass Fiber on Viscous Behavior of Matrix in Fiber Composites
by Jingchao Wang and P.-Y. Ben Jar
Polymers 2025, 17(11), 1469; https://doi.org/10.3390/polym17111469 - 26 May 2025
Viewed by 753
Abstract
The work presented here describes an approach that separates the viscous stress from the quasi-static counterpart for polycarbonate (PC) and its short glass fiber composite (GF-PC), with the aim to characterize the influence of short glass fiber on the viscous behavior of PC [...] Read more.
The work presented here describes an approach that separates the viscous stress from the quasi-static counterpart for polycarbonate (PC) and its short glass fiber composite (GF-PC), with the aim to characterize the influence of short glass fiber on the viscous behavior of PC as the matrix of GF-PC. A multi-relaxation (MR) test was used for the mechanical testing and a three-branch spring–dashpot model for the data analysis, using a genetic algorithm to establish 100 sets of fitting parameter values that enabled the three-branch model to regenerate the measured stress decay during relaxation. Using the spring modulus Kv,s of the short-term branch in the three-branch model, two groups for these fitting parameter values were established as a function of specimen displacement (named stroke) of GF-PC, one of which shows a trend that is similar to the trend of the corresponding fitting parameters for the pure PC, and thus is believed to reflect the influence of glass fiber on the PC matrix of GF-PC. The study concludes that the short glass fiber increases the short-term viscous stress, but its role on the long-term viscous stress is marginal. Full article
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22 pages, 8071 KB  
Article
Reliability Modeling and Verification of Locking Mechanisms Based on Failure Mechanisms
by Ping Qian, Tianying Tu, Wenhua Chen, Fan Yang, Chi Chen and Yucheng Zhu
Actuators 2025, 14(5), 205; https://doi.org/10.3390/act14050205 - 23 Apr 2025
Viewed by 749
Abstract
The locking mechanism is crucial for the reliable connection and disconnection of electrical connectors. Aiming at the lack of theoretical support for the reliability evaluation in long-term storage, a comprehensive multi-theory modeling method is proposed to solve unlocking failure and related performance-evaluation problems. [...] Read more.
The locking mechanism is crucial for the reliable connection and disconnection of electrical connectors. Aiming at the lack of theoretical support for the reliability evaluation in long-term storage, a comprehensive multi-theory modeling method is proposed to solve unlocking failure and related performance-evaluation problems. An analysis reveals that metal-crystal dislocation glide, causing pull-rod deformation and spring stress relaxation, is the main cause of unlocking failure. Based on Hertz’s contact theory, a locking-state mechanical model is established. Integrating the crystal dislocation-slip theory, an accelerated degradation trajectory model considering design parameters is developed to characterize the friction between the pull rod and steel ball and the spring’s elastic-force degradation. Finally, the model is verified using the unlocking-force accelerated test data. It offers a theoretical basis for the reliability evaluation and design of locking mechanisms in long-term storage environments. Full article
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21 pages, 2351 KB  
Article
Security-Constrained Multi-Stage Robust Dynamic Economic Dispatch with Bulk Storage
by Li Dai, Renshi Ye, Dahai You and Xianggen Yin
Energies 2025, 18(5), 1073; https://doi.org/10.3390/en18051073 - 22 Feb 2025
Cited by 1 | Viewed by 798
Abstract
As wind penetration rates continue to increase, the main challenge faced by operators is how to schedule flexible resources, such as traditional generation and storage, in the future to ensure the safe and stable operation of power grids under multiple uncertainties. In this [...] Read more.
As wind penetration rates continue to increase, the main challenge faced by operators is how to schedule flexible resources, such as traditional generation and storage, in the future to ensure the safe and stable operation of power grids under multiple uncertainties. In this paper, a security-constrained multi-stage robust dynamic economic dispatch model with storage (SMRDEDS) is proposed to address multiple uncertainties of wind power outputs and N-1 contingencies. Compared to the traditional two-stage robust dynamic economic dispatch model, the proposed multi-stage dispatch model yields sequential operation decisions with uncertainties revealed gradually over time. What is more, a combined two-stage Benders’ decomposition and relaxed approximation–robust dual dynamic programming (RA-RDDP) is proposed to handle the computational issue of multi-stage problems due to large-scale post-contingency constraints and the convergence issue of the stochastic dual dynamic programming (SDDP) algorithm. First, a two-stage Benders’ decomposition algorithm is applied to relax the SMRDEDS model into a master problem and sub-problem. The master problem determines the generator output and storage charge and discharge, and the sub-problem determines the total generation and storage reserve capacity to cover all the generator N-1 contingencies. Second, a relaxed approximation–RDDP algorithm is proposed to solve the multi-stage framework problem. Compared to the traditional SDDP algorithm and RDDP algorithm, the proposed RA-RDDP algorithm uses the inner relaxed approximation and outer approximation methods to approximate the upper and lower bounds of the future cost-to-go function, which overcomes the convergence issue of the traditional SDDP algorithm and solution efficiency of the RDDP algorithm. We tested the proposed algorithm on the IEEE-3 bus, IEEE-118 bus, and the German power system. The simulation results verify the effectiveness of the proposed model and proposed algorithm. Full article
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22 pages, 2107 KB  
Article
Feedback Tracking Constraint Relaxation Algorithm for Constrained Multi-Objective Optimization
by Yuling Lai, Junming Chen, Yile Chen, Hui Zeng and Jialin Cai
Mathematics 2025, 13(4), 629; https://doi.org/10.3390/math13040629 - 14 Feb 2025
Cited by 2 | Viewed by 914
Abstract
In practical applications, constrained multi-objective optimization problems (CMOPs) often fail to achieve the desired results when dealing with CMOPs with different characteristics. Therefore, to address this drawback, we designed a constraint multi-objective evolutionary algorithm based on feedback tracking constraint relaxation, referred to as [...] Read more.
In practical applications, constrained multi-objective optimization problems (CMOPs) often fail to achieve the desired results when dealing with CMOPs with different characteristics. Therefore, to address this drawback, we designed a constraint multi-objective evolutionary algorithm based on feedback tracking constraint relaxation, referred to as CMOEA-FTR. The entire search process of the algorithm is divided into two stages: In the first stage, the constraint boundaries are adaptively adjusted based on the feedback information from the population solutions, guiding the boundary solutions towards neighboring solutions and tracking high-quality solutions to obtain the complete feasible region, thereby promoting the population to approach the unconstrained Pareto front (UPF). The obtained feasible solutions are stored in an archive and continuously updated to promote the diversity and convergence of the population. In the second stage, the scaling of constraint boundaries is stopped, and a new dominance criterion is established to obtain high-quality parents, thereby achieving the complete constrained Pareto front (CPF). Additionally, we customized an elite mating pool selection, an archive updating strategy, and an elite environmental selection truncation mechanism to maintain a balance between diversity and convergence. To validate the performance of CMOEA-FTR, we conducted comparative experiments on 44 benchmark test problems and 16 real-world application cases. The statistical IGD and HV metrics indicate that CMOEA-FTR outperforms seven other CMOEAs. Full article
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25 pages, 789 KB  
Article
Two-Stage Archive Evolutionary Algorithm for Constrained Multi-Objective Optimization
by Kai Zhang, Siyuan Zhao, Hui Zeng and Junming Chen
Mathematics 2025, 13(3), 470; https://doi.org/10.3390/math13030470 - 31 Jan 2025
Cited by 3 | Viewed by 1918
Abstract
The core issue in handling constrained multi-objective optimization problems (CMOP) is how to maintain a balance between objectives and constraints. However, existing constrained multi-objective evolutionary algorithms (CMOEAs) often fail to achieve the desired performance when confronted with complex feasible regions. Building upon this [...] Read more.
The core issue in handling constrained multi-objective optimization problems (CMOP) is how to maintain a balance between objectives and constraints. However, existing constrained multi-objective evolutionary algorithms (CMOEAs) often fail to achieve the desired performance when confronted with complex feasible regions. Building upon this theoretical foundation, a two-stage archive-based constrained multi-objective evolutionary algorithm (CMOEA-TA) based on genetic algorithms (GA) is proposed. In CMOEA-TA, First stage: The archive appropriately relaxes constraints based on the proportion of feasible solutions and constraint violations, compelling the population to explore more search space. Second stage: Sharing valuable information between the archive and the population, while embedding constraint dominance principles to enhance the feasibility of solutions. In addition an angle-based selection strategy was used to select more valuable solutions to increase the diversity of the population. To verify its effectiveness, CMOEA-TA was tested on 54 CMOPs in 4 benchmark suites and 7 state-of-the-art algorithms were compared. The experimental results show that it is far superior to seven competitors in inverse generation distance (IGD) and hypervolume (HV) metrics. Full article
(This article belongs to the Section E: Applied Mathematics)
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13 pages, 3729 KB  
Article
Quasi-Static Mechanical Biomimetics Evaluation of Car Crash Dummy Skin
by Yurun Li, Zhixin Liu, Cuiru Sun, Xiaoya Zheng, Guorui Du, Xiaoshuang Wang, Songchen Wang and Weidong Liu
Biomimetics 2024, 9(12), 762; https://doi.org/10.3390/biomimetics9120762 - 15 Dec 2024
Viewed by 1314
Abstract
Accurate replication of soft tissue properties is essential for the development of car crash test dummy skin to ensure the precision of biomechanical injury data. However, the intricacy of multi-layer soft tissue poses challenges in standardizing the development and testing of dummy skin [...] Read more.
Accurate replication of soft tissue properties is essential for the development of car crash test dummy skin to ensure the precision of biomechanical injury data. However, the intricacy of multi-layer soft tissue poses challenges in standardizing the development and testing of dummy skin materials to emulate soft tissue properties. This study presents a comprehensive testing and analysis of the compressive mechanical properties of both single and multi-layered soft tissues and car crash dummy skin materials, aiming to enhance the biofidelity of dummy skin. We presented one-term Ogden hyperelastic models and generalized Maxwell viscoelastic models for single-layer and multi-layer soft tissues, as well as dummy skin materials. The comparative analysis results indicate that the existing dummy skin material fails to fully consider the strain-rate-dependent characteristic of soft tissue. Furthermore, dummy skin materials exhibited ~3 times shorter relaxation times and ~2–3 times lower stress decay rates compared to soft tissues, suggesting a less viscous nature. This study provides an accurate representation of the mechanics of soft tissue and dummy skin under quasi-static compressive loading. The findings are instrumental for the development of novel bionic skin materials or structures to more precisely replicate the biomechanical properties of soft tissues, thereby enhancing the accuracy and reliability of car crash test dummies. Full article
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11 pages, 7411 KB  
Article
Small Molecule Inhibitors of Mycobacterium tuberculosis Topoisomerase I Identified by Machine Learning and In Vitro Assays
by Somaia Haque Chadni, Matthew A. Young, Pedro Igorra, Md Anisur Rahman Bhuiyan, Victor Kenyon and Yuk-Ching Tse-Dinh
Int. J. Mol. Sci. 2024, 25(22), 12265; https://doi.org/10.3390/ijms252212265 - 15 Nov 2024
Cited by 1 | Viewed by 1952
Abstract
Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading infectious cause of death globally. The treatment of patients becomes much more difficult for the increasingly common multi-drug resistant TB. Topoisomerase I is essential for the viability of M. tuberculosis and has been validated [...] Read more.
Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading infectious cause of death globally. The treatment of patients becomes much more difficult for the increasingly common multi-drug resistant TB. Topoisomerase I is essential for the viability of M. tuberculosis and has been validated as a new target for the discovery of novel treatment against TB resistant to the currently available drugs. Virtual high-throughput screening based on machine learning was used in this study to identify small molecules that target the binding site of divalent ion near the catalytic tyrosine of M. tuberculosis topoisomerase I. From the virtual screening of more than 2 million commercially available compounds, 96 compounds were selected for testing in topoisomerase I relaxation activity assay. The top hit that has IC50 of 7 µM was further investigated. Commercially available analogs of the top hit were purchased and tested with the in vitro enzyme assay to gain further insights into the molecular scaffold required for topoisomerase inhibition. Results from this project demonstrated that novel small molecule inhibitors of bacterial topoisomerase I can be identified starting with the machine-learning-based virtual screening approach. Full article
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