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29 pages, 4633 KB  
Article
Impact of Heat Waves on the Well-Being and Risks of Elderly People Living Alone: Case Study in Urban and Peri-Urban Dwellings in the Atlantic Climate of Spain
by Urtza Uriarte-Otazua, Zaloa Azkorra-Larrinaga, Miriam Varela-Alonso, Iñaki Gomez-Arriaran and Olatz Irulegi-Garmendia
Buildings 2025, 15(13), 2274; https://doi.org/10.3390/buildings15132274 - 28 Jun 2025
Viewed by 1614
Abstract
This study investigates the impact of heatwaves on the thermal comfort and well-being of elderly individuals living alone during heatwaves, focusing on two contrasting residential typologies in the Atlantic climate of Spain: a dense urban area and low-density peri-urban setting. A mixed-methods approach [...] Read more.
This study investigates the impact of heatwaves on the thermal comfort and well-being of elderly individuals living alone during heatwaves, focusing on two contrasting residential typologies in the Atlantic climate of Spain: a dense urban area and low-density peri-urban setting. A mixed-methods approach was used, combining in situ environmental monitoring, adaptive comfort modelling, and user-centred data from surveys and interviews based on the De Jong-Gierveld Loneliness Scale. The results show that both dwellings exceeded recommended indoor temperature thresholds during heatwaves, especially at night, contributing to sleep disturbance, cardiovascular stress, and emotional discomfort. Despite 85% of participants indicating that outdoor activities help them to mitigate not-wanted loneliness, architectural barriers often hinder such engagement. Over half reported having no balcony or terrace, which may have further intensified social isolation. Field data collected during 2022 summer heatwaves recorded maximum daytime temperatures of 30 °C and night-time peaks of 28.7 °C, exceeding the 25 °C threshold. The adaptive comfort evaluation classified both cases as Class 4 (severe discomfort). The urban dwelling showed consistent moderate discomfort (Category 3), likely due to poor ventilation and urban heat island effects. The peri-urban case, despite lacking the heat island influence, showed worse thermal conditions, especially during the day. Architectural barriers, poor thermal performance, and the lack of semi-outdoor spaces may exacerbate isolation among elderly people during extreme heat events. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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19 pages, 2107 KB  
Article
Integrating an Eco-Feedback Strategy to Enhance the Indoor Environmental Quality and Sleep Quality in Italian Bedrooms
by Michael T. Solomon, Laura Canale, Luca Stabile, Anderson D’Oliveira, Alexandro Andrade and Giorgio Buonanno
Buildings 2025, 15(13), 2269; https://doi.org/10.3390/buildings15132269 - 27 Jun 2025
Viewed by 572
Abstract
This study examines the short-term impact of an “eco-feedback” strategy, based on an awareness-raising information campaign and an experimental campaign, on indoor environmental quality (IEQ) parameters and sleep quality in Italian bedrooms. Forty-one participants from Cassino, Italy, monitored the IEQ in their bedroom [...] Read more.
This study examines the short-term impact of an “eco-feedback” strategy, based on an awareness-raising information campaign and an experimental campaign, on indoor environmental quality (IEQ) parameters and sleep quality in Italian bedrooms. Forty-one participants from Cassino, Italy, monitored the IEQ in their bedroom environments during the winter and spring seasons and assessed their sleep quality using the Groningen Sleep Quality Scale before and after receiving awareness-raising information. The experimental analysis revealed that, even if the IEQ and self-reported sleep quality before receiving the information were not representative of good sleep conditions (e.g., 94% of the volunteers slept in bedrooms with a median indoor CO2 concentration >800 ppm, the equivalent continuous sound pressure level was always >30 dB, and the self-reported sleep quality conditions were characteristic of disrupted sleep or intermediate sleep disturbance), the subjects were not able to obtain significant changes in IEQ parameters after the information campaign and that, consequently, no noticeable changes in sleep quality were obtained as well. The limited effectiveness of the eco-feedback strategy adopted in this study can be attributed to the fact that the proposed approach only led to behavioral changes characterized by a limited effect on the indoor environmental quality. This was mostly due to the period under investigation: as an example, the low nighttime outdoor temperatures did not allow for an improvement in the building ventilation during the night. Full article
(This article belongs to the Topic Sustainable Building Development and Promotion)
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21 pages, 9105 KB  
Article
Condensation Risk Under Different Window-Opening Behaviours in a Residential Building in Changsha During Plum Rains Season
by Yecong He, Miaomiao Liu, Zhigang Zhao, Sihui Li, Xiaofeng Zhang and Jifei Zhou
Buildings 2025, 15(9), 1536; https://doi.org/10.3390/buildings15091536 - 2 May 2025
Cited by 2 | Viewed by 1218
Abstract
Condensation assessment of a residential building in Changsha, China-located in the hot summer and cold winter climate zone-was conducted during the Plum Rain Season (PRS) using Energy Plus simulations and field measurements. Window-opening behaviour significantly influences indoor air quality and thermal comfort. This [...] Read more.
Condensation assessment of a residential building in Changsha, China-located in the hot summer and cold winter climate zone-was conducted during the Plum Rain Season (PRS) using Energy Plus simulations and field measurements. Window-opening behaviour significantly influences indoor air quality and thermal comfort. This study specifically examines how window-opening patterns, including opening duration and opening degree, affect interior surface condensation risk in a rural residential building during PRS. Results indicate that window operational status (open/closed) exerts a dominant influence on condensation risk, while varying window opening degrees during identical opening duration showed negligible differential impacts. Critical temporal patterns emerged: morning window openings during PRS should be avoided, whereas afternoon (15:00–18:00) and nighttime (18:00–06:00) ventilation proves advantageous. Optimisation analysis revealed that implementing combined afternoon and nighttime ventilation windows (15:00–18:00 + 18:00–06:00) achieved the lowest condensation risk of 0.112 among evaluated scenarios. Furthermore, monthly-adjusted window operation strategies yielded eight recommended ventilation modes, maintaining condensation risks below 0.11 and providing occupant-tailored solutions for Changsha’s PRS conditions. These findings establish evidence-based guidelines for moisture control through optimised window operation in climate-responsive building management. Full article
(This article belongs to the Special Issue Research on Ventilation and Airflow Distribution of Building Systems)
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16 pages, 2967 KB  
Article
Study on the Effect of Non-Uniform Ventilation on Energy and Plant Growth in a Greenhouse
by Ziteng Wang, Aiqun Bao, Jialei Li, Jinhong He, Kaiwen Wang, Xinke Wang and Xianpeng Sun
Horticulturae 2025, 11(2), 166; https://doi.org/10.3390/horticulturae11020166 - 5 Feb 2025
Viewed by 1699
Abstract
The progress of local environmental regulation in protected agriculture is sluggish, particularly concerning the local air supply, which poses a significant obstacle to greenhouse energy-saving research. This study establishes a test platform for local air supply in winter and summer by integrating design [...] Read more.
The progress of local environmental regulation in protected agriculture is sluggish, particularly concerning the local air supply, which poses a significant obstacle to greenhouse energy-saving research. This study establishes a test platform for local air supply in winter and summer by integrating design principles from human settlements’ supply air bag models with crop growth requirements. By utilizing a supply air bag to direct fresh air from the air conditioning system to specific areas within the greenhouse, non-uniform ventilation is created. Research has revealed that varying air supply levels in summer exerts a significant influence on environmental conditions, crop growth, and energy efficiency. Noticeable temperature stratification and cooling effects were observed within the conditioning greenhouse. The growth of lettuce was moderately enhanced, with mid-level local air supply demonstrating superior cooling effectiveness and range compared to the other two levels. Optimal control efficacy and energy conservation were achieved through mid-level local air supply. During daytime experiments in winter, this system did not have a significant impact on the greenhouse environment; however, during nighttime experiments, it consistently provided warming effects to maintain temperatures above the minimum requirement for lettuce growth. Therefore, utilizing air supply bags at secure specific positions and implementing targeted air supply methods within cultivation areas in greenhouses can facilitate the creation of suitable local environments for crop growth while achieving energy savings. Future research in this field could focus on further refining air supply bag models to enhance energy efficiency and local environmental control effects. Full article
(This article belongs to the Special Issue Latest Advances in Horticulture Production Equipment and Technology)
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12 pages, 1189 KB  
Article
Delirium Management Quality Improvement Project to Improve Awareness and Screening in a Medical ICU
by Hirsh Makhija, Kyle Digrande, Omar Awan, Russell G. Buhr, Rajan Saggar, Victoria Ramirez, Rainbow Tarumoto, Janelle M. Fine, Atul Malhotra, Dale M. Needham, Jennifer L. Martin and Biren B. Kamdar
Nurs. Rep. 2025, 15(1), 6; https://doi.org/10.3390/nursrep15010006 - 30 Dec 2024
Viewed by 2984
Abstract
Background/Objectives: Although delirium is common during critical illness, standard-of-care detection and prevention practices in real-world intensive care unit (ICU) settings remain inconsistent, often due to a lack of provider education. Despite availability for over 20 years of validated delirium screening tools such as [...] Read more.
Background/Objectives: Although delirium is common during critical illness, standard-of-care detection and prevention practices in real-world intensive care unit (ICU) settings remain inconsistent, often due to a lack of provider education. Despite availability for over 20 years of validated delirium screening tools such as the Confusion Assessment Method in the ICU (CAM-ICU), feasible and rigorous educational efforts continue to be needed to address persistent delirium standard-of-care practice gaps. Methods: Spanning an 8-month quality improvement project period, our single-ICU interdisciplinary effort involved delivery of CAM-ICU pocket cards to bedside nurses, and lectures by experienced champions that included a live delirium detection demonstration using the CAM-ICU, and a comprehensive discussion of evidence-based delirium prevention strategies (e.g., benzodiazepine avoidance). Subsequent engagement by health system leadership motivated the development of an electronic health record dataset to evaluate unit-level outcomes, including CAM-ICU documentation and benzodiazepine administration. Results: Using a dataset that spanned 9 pre- and 37 post-project months and included 3612 patients, 4470 admissions, and 33,913 patient days, we observed that delirium education was followed by a dramatic rise in CAM-ICU documentation, from <1% for daytime and nighttime shifts to peaks of 73% and 71%, respectively (p < 0.0001 for trend), and a fall in the proportion of mechanically ventilated patients ever receiving benzodiazepine infusions (69% to 41%; p < 0.0001). Conclusions: An interdisciplinary delirium project comprising rigorous lectures on standard-of-care practices can yield significant improvements in documentation and sedative administration. This approach can help ICUs jumpstart efforts to build awareness and address longstanding gaps in standard-of-care delirium practices. Full article
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6 pages, 194 KB  
Case Report
Successfully Anticipated Difficult Airway Management of a “Can Ventilate, but Cannot Intubate” Situation for Urgent Laparoscopic Appendectomy in a Patient with Duchenne Muscular Dystrophy
by Fabian P. Brunner, Philippe Neth and Alexander Kaserer
Reports 2024, 7(2), 47; https://doi.org/10.3390/reports7020047 - 14 Jun 2024
Viewed by 1822
Abstract
Background: Airway management in Duchenne patients can be challenging. We present a case of an anticipated difficult airway in a 24-year-old Duchenne patient that was managed by planning different suitable strategies based on the unanticipated difficult airway algorithm of the Difficult Airway Society [...] Read more.
Background: Airway management in Duchenne patients can be challenging. We present a case of an anticipated difficult airway in a 24-year-old Duchenne patient that was managed by planning different suitable strategies based on the unanticipated difficult airway algorithm of the Difficult Airway Society (DAS). Case presentation: The patient initially presented with appendicitis, requiring a laparoscopic appendectomy within 6 h. Due to the underlying condition and a known difficult airway, we anticipated potential airway problems and successfully managed the “can ventilate but cannot intubate” situation using the algorithm. The difficult airway was attributed to reduced mandibular mobility, limited inclination or reclination, a large tongue, prominent incisors, and a posteriorly positioned epiglottis. Despite thorough preparation and team briefing, we experienced three failed intubation attempts. Considering limited nighttime resources, the urgency of the surgery, the need for a tube for laparoscopy, and the risk of exacerbating airway issues, we made the decision to awaken the patient and wait for a second attempt after the epiglottis swelling had subsided. We used reversible, short-acting agents for induction, enabling us to continue with the algorithm within the allotted timeframe. In a second stage, we successfully performed fiberoptic-guided intubation via a supraglottic airway device using the Aintree intubation catheter, utilizing more favorable resources. Conclusions: For a patient with Duchenne muscular dystrophy and a difficult airway, advanced expertise is critical. Detailed anesthesia planning, clear team communication, and the use of reversible, short-acting agents are crucial. Adherence to the Difficult Airway Society guidelines is essential for safe airway management. Full article
26 pages, 8278 KB  
Article
Investigating Stagnant Air Conditions in Almaty: A WRF Modeling Approach
by Tatyana Dedova, Larissa Balakay, Edige Zakarin, Kairat Bostanbekov and Galymzhan Abdimanap
Atmosphere 2024, 15(6), 633; https://doi.org/10.3390/atmos15060633 - 24 May 2024
Cited by 4 | Viewed by 4112
Abstract
This study investigates stagnant atmospheric conditions in Almaty, Kazakhstan, a city nestled within a complex terrain. These conditions, characterized by weak local winds and inversion layers, trap pollutants within the city, particularly during winter. The Weather Research & Forecasting (WRF) model was employed [...] Read more.
This study investigates stagnant atmospheric conditions in Almaty, Kazakhstan, a city nestled within a complex terrain. These conditions, characterized by weak local winds and inversion layers, trap pollutants within the city, particularly during winter. The Weather Research & Forecasting (WRF) model was employed to simulate atmospheric conditions using Local Climate Zone data. Verification of the model’s accuracy was achieved through comparisons with data from weather stations and the Landsat-9 satellite. The model successfully reproduced the observed daily temperature variations and weak winds during the testing period (13–23 January 2023). Comparisons with radiosonde data revealed good agreement for morning temperature profiles, while underestimating the complexity of the evening atmospheric structure. The analysis focused on key air quality factors, revealing cyclical patterns of ground-level and elevated inversions linked to mountain-valley circulation. The model effectively captured anabatic and katabatic flows. The study further examined the urban heat island (UHI) using a virtual rural method. The UHI exhibited daily variations in size and temperature, with heat transported by prevailing winds and katabatic flows. Statistical analysis of temperature and wind patterns under unfavorable synoptic situations revealed poor ventilation in Almaty. Data from three Januaries (2022/2023/2024) were used to create maps showing average daytime and nighttime air temperatures, wind speed, and frequency of calm winds. Full article
(This article belongs to the Section Atmospheric Techniques, Instruments, and Modeling)
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16 pages, 4575 KB  
Article
Evaluation of Air Quality and Thermal Comfort in University Dormitories in China
by Yanpeng Wu, Xiaoyu Li, Sheng Zhao, Qianglong Wang, Shanxin Wang, Liyang Yu and Faming Wang
Atmosphere 2024, 15(5), 586; https://doi.org/10.3390/atmos15050586 - 11 May 2024
Cited by 2 | Viewed by 1974
Abstract
Most studies on Chinese dormitories are carried out in summer, while few focus on a transition season or winter. This study evaluated the air quality of a student dormitory in a university in the Beijing area by using a questionnaire survey and on-site [...] Read more.
Most studies on Chinese dormitories are carried out in summer, while few focus on a transition season or winter. This study evaluated the air quality of a student dormitory in a university in the Beijing area by using a questionnaire survey and on-site measurements. The CO2 concentration was used as an indoor air quality evaluation index to characterize the freshness of the air, and different window opening conditions in the dormitory were simulated, with corresponding improvement plans proposed. The results of this study revealed that the air quality and thermal comfort of the student dormitories during a transition season and winter fell short of expectations. According to the survey, students who opened their windows frequently had a better subjective perception of the air quality. However, due to the large temperature difference between day and night, more than 80% of the students felt too cold when opening the windows. For daytime conditions, the area of unilateral ventilation window opening should not be less than 0.39 m2, the area of bilateral ventilation window opening should not be less than 0.13 m2, and the time taken to close the windows and doors should not exceed the maximum ventilation interval. Empirical equations were fitted for nighttime conditions based on the CO2 concentration, number of people in the room, and window opening area, resulting in a reasonable window opening area of 0.349 m2~0.457 m2. In sum, this study assessed the air quality status within typical university dormitories across varying seasons, gaining a clear understanding of how different ventilation strategies and occupant densities influence air freshness and thermal comfort. Based on these insights, a practical and optimized window area recommendation was formulated to enhance the indoor environmental quality in these dormitories. Full article
(This article belongs to the Special Issue Contributions of Emission Inventory to Air Quality)
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31 pages, 8872 KB  
Article
Long-Term Analysis of Energy Consumption and Thermal Comfort in a Passivhaus Apartment in Spain
by Iñigo Rodríguez-Vidal, Rufino J. Hernández-Minguillón and Jorge Otaegi
Buildings 2024, 14(4), 878; https://doi.org/10.3390/buildings14040878 - 25 Mar 2024
Cited by 2 | Viewed by 3163
Abstract
This study presents a detailed analysis of thermal comfort and energy consumption in a Passivhaus-certified apartment in Bolueta Tower, Bilbao, Spain, over a period of three years (2020–2022). Utilizing a comprehensive, long-term monitoring approach, the research investigates the effectiveness of the Passivhaus standard [...] Read more.
This study presents a detailed analysis of thermal comfort and energy consumption in a Passivhaus-certified apartment in Bolueta Tower, Bilbao, Spain, over a period of three years (2020–2022). Utilizing a comprehensive, long-term monitoring approach, the research investigates the effectiveness of the Passivhaus standard in achieving both energy efficiency and occupant comfort in a temperate climate. Using calibrated data loggers to record indoor temperature, humidity, and CO2 levels were used alongside the collection of utility bills to assess energy consumption and thermal comfort, as well as IAQ, against several international standards. Significant issues with overheating were confirmed, in line with previous research. During the warmer months, indoor temperatures frequently exceeded the Passivhaus comfort threshold of 25 °C, reaching as high as 31.3 °C, particularly in the living room and bedroom. This resulted in discomfort during summer, with the percentage of hours above 25 °C reaching 23.21% in 2022. Nighttime temperatures often surpassed 24 °C, impacting sleep quality. Conversely, heating consumption was minimal, corroborating the building’s energy efficiency in colder months. The findings highlight a critical gap in the Passivhaus standard when applied in milder climates, where overheating becomes a significant issue. This study suggests the need for an integrated approach in sustainable building design, one that balances energy efficiency with adaptive strategies to mitigate overheating, such as improved natural ventilation and thermal mass. These insights contribute to the ongoing discourse on optimizing energy-efficient buildings for occupant comfort in various climatic conditions. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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22 pages, 5286 KB  
Article
An Investigation of the Energy-Saving Optimization Design of the Enclosure Structure in High-Altitude Office Buildings
by Wenjing Sun, Lixing Chen, Baimu Suolang and Kai Liu
Buildings 2024, 14(3), 645; https://doi.org/10.3390/buildings14030645 - 29 Feb 2024
Cited by 7 | Viewed by 2014
Abstract
Concerning the double carbon national strategy, the energy-saving renovation of old buildings has become one of the most important tasks of energy conservation and emission reduction in construction in China. There are many problems, such as high energy consumption, thermal environment, and poor [...] Read more.
Concerning the double carbon national strategy, the energy-saving renovation of old buildings has become one of the most important tasks of energy conservation and emission reduction in construction in China. There are many problems, such as high energy consumption, thermal environment, and poor thermal comfort. Taking Lhasa as an example, this study adopts field research, questionnaire interviews, on-site measurements, numerical simulations, and other methods to propose suitable energy-saving potential excavation points and thermal optimization strategies for office building envelopes in Lhasa through software simulation. Additionally, typical office buildings are selected to carry out the energy-saving renovation of envelopes with the goal of improving indoor thermal comfort to validate the feasibility of the energy-saving renovation strategies. The results show the following: (1) The measured and predicted thermal neutral temperatures of the office population in Lhasa are 16.5 °C and 18.9 °C, respectively. The 90% acceptable temperature range is from 16.10 °C to 21.77 °C, and the occupants of the office buildings in Lhasa have a higher tolerance for cold than predicted. (2) The passive measures adapted to Lhasa are prioritized in the order of passive solar energy, high-heat-capacity materials, and nighttime ventilation. (3) Through the optimization of the enclosure structure of existing office buildings, the improvement of the heat storage capacity of the outer enclosure structure, and the increase in the window opening area to increase natural ventilation, the indoor thermal comfort of the renovated buildings is effectively improved. Full article
(This article belongs to the Special Issue Indoor Environment and Thermal Comfort Performance of Buildings)
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43 pages, 11346 KB  
Article
Characterization of the Thermal Behavior of Semi-Exterior Laundry Spaces in an Overheating Passivhaus Residential Building in Bilbao, Spain
by Jorge Otaegi, Rufino J. Hernández-Minguillón and Iñigo Rodríguez-Vidal
Sustainability 2024, 16(2), 470; https://doi.org/10.3390/su16020470 - 5 Jan 2024
Cited by 3 | Viewed by 1942
Abstract
Overheating in buildings is a growing challenge in temperate climates, even in those where the traditional design focus was on protecting from cold and winter energy savings. This paper addresses a collateral problem that arose during the study of overheating in a residential [...] Read more.
Overheating in buildings is a growing challenge in temperate climates, even in those where the traditional design focus was on protecting from cold and winter energy savings. This paper addresses a collateral problem that arose during the study of overheating in a residential Passivhaus building in Bilbao, northern Spain. Specifically, the local climate of three laundry spaces was investigated, where high daytime and nighttime temperatures were recorded. An extensive monitoring campaign was carried out with different durations up to more than 21,000 h over four years, and the collected data were compared with outdoor climatic conditions. The results allowed for characterizing the thermal behavior of these semi-outdoor spaces and show the magnitude of the problem, quantifying it. Laundry spaces were confirmed to be hotter and dryer than the outdoor climate almost always. The mean average difference between the monitored rooms and the exterior was quantified to be around positive 5 °C during both daytime and nighttime. Extreme heat events were documented, with maximum temperatures above 50 °C and temperature differentials of up to 15.85 °C. In addition, this article comments on the impact of overheating these laundry spaces on the interior of the dwellings, pointing out the differences between the assumptions made during the design phase of the project and the observed or measured reality. Questions were raised about the possible implications of the peculiar performance of these semi-outdoor spaces on the mechanical heat recovery ventilation system (MHRV). The data presented in this article revealed and quantified a design flaw that went unnoticed by all agents involved in the planning, design, and construction of the 361-apartment project. The inability to predict the behavior of the studied spaces has had a negative impact on building performance during the summer months and has prevented the implementation of strategies that could have been beneficial in other periods. A thorough analysis of the thermal behavior of similar spaces becomes essential to prevent performance gaps in future projects and to inform adequate building modeling in the design stages. Full article
(This article belongs to the Section Green Building)
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28 pages, 9188 KB  
Article
Impact of Material Solutions and a Passive Sports Hall’s Use on Thermal Comfort
by Anna Dudzińska, Tomasz Kisilewicz and Ewelina Panasiuk
Energies 2023, 16(23), 7698; https://doi.org/10.3390/en16237698 - 21 Nov 2023
Cited by 1 | Viewed by 2269
Abstract
High outdoor temperatures and thermal gains due to solar radiation, which penetrates the interior of buildings as the climate warms up, pose a major challenge to maintaining thermal comfort in passive sports facilities. Superbly insulated and airtight envelopes, specific microclimatic requirements and very [...] Read more.
High outdoor temperatures and thermal gains due to solar radiation, which penetrates the interior of buildings as the climate warms up, pose a major challenge to maintaining thermal comfort in passive sports facilities. Superbly insulated and airtight envelopes, specific microclimatic requirements and very high user activity can easily lead to overheating and thermal imbalance during summer. This paper focuses on the influence of the varying thermal capacity of external walls and night-time cooling on thermal comfort in a passive sports hall building. Based on experimental studies of the thermal conditions in the building, a model of it was created in Design Builder. Through simulation, the program initially analysed the thermal conditions that arise under different envelope assemblies. Two different ways of cooling the building at night were then analysed: mechanical and natural. The results presented showed that in a well-insulated sports hall with a large volume, the type of wall material alone had only a limited influence on thermal comfort in summer. In contrast, night-time cooling in integration with the accumulation of cold in the building’s structural components had a significant impact on protection against overheating during the summer. The type of envelope material is even more important when night-time air exchange is high. Intensive natural ventilation is associated with the highest number of hours in the comfort range—28.1–32.4% more hours in relation to the variant without night ventilation. The use of mechanical ventilation, operating at night at maximum capacity, will result in an increase in the number of hours with air temperatures in the −0.5 < PMV < +0.5 range by only 14.1–21.3%. The high thermal mass of the envelope, combined with adequate ventilation, reduces the occurrence of very high indoor air temperatures, thus alleviating the nuisance of overheating. The maximum internal air temperature during the day is lower by 2.4–3.3 K, compared to the case when no night ventilation is used. Mechanical ventilation operating at its maximum capacity can reduce the maximum internal temperature by 1.2–1.6 K. Full article
(This article belongs to the Section J: Thermal Management)
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15 pages, 2118 KB  
Article
Activity in Group-Housed Home Cages of Mice as a Novel Preclinical Biomarker in Oncology Studies
by Stéphane Terry, Céline Gommet, Anne-Cécile Kerangueven, Mickaël Leguet, Vincent Thévenin, Mickaël Berthelot, Laurent Begoud, Fanny Windenberger and Pierre Lainee
Cancers 2023, 15(19), 4798; https://doi.org/10.3390/cancers15194798 - 29 Sep 2023
Cited by 2 | Viewed by 2547
Abstract
Background: Improving experimental conditions in preclinical animal research is a major challenge, both scientifically and ethically. Automated digital ventilated cages (DVC®) offer the advantage of continuous monitoring of animal activity in their home-cage. The potential utility of this technology remains understudied [...] Read more.
Background: Improving experimental conditions in preclinical animal research is a major challenge, both scientifically and ethically. Automated digital ventilated cages (DVC®) offer the advantage of continuous monitoring of animal activity in their home-cage. The potential utility of this technology remains understudied and deserves investigation in the field of oncology. Methods: Using the DVC® platform, we sought to determine if the continuous assessment of locomotor activity of mice in their home cages can serve as useful digital readout in the monitoring of animals treated with the reference oncology compounds cisplatin and cyclophosphamide. SCID mice of 14 weeks of age were housed in DVC® cages in groups of four and followed with standard and digital examination before and after treatment over a 17-day total period. Results: DVC® detected statistically significant effects of cisplatin on the activity of mice in the short and long term, as well as trends for cyclophosphamide. The activity differences between the vehicle- and chemotherapy-treated groups were especially marked during the nighttime, a period when animals are most active and staff are generally not available for regular checks. Standard clinical parameters, such as body weight change and clinical assessment during the day, provided additional and complementary information. Conclusion: The DVC® technology enabled the home cage monitoring of mice and non-invasive detection of animal activity disturbances. It can easily be integrated into a multimodal monitoring approach to better capture the different effects of oncology drugs on anti-tumor efficacy, toxicity, and safety and improve translation to clinical studies. Full article
(This article belongs to the Section Methods and Technologies Development)
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24 pages, 14664 KB  
Article
A Study on Modifying Campus Buildings to Improve Habitat Comfort—A Case Study of Tianjin University Campus
by Xinge Du, Guoyao Gao, Feng Gao and Zhihua Zhou
Sustainability 2023, 15(19), 14200; https://doi.org/10.3390/su151914200 - 26 Sep 2023
Cited by 4 | Viewed by 2525
Abstract
At present, the design and planning of teaching and living areas on university campuses are relatively straightforward but encounter problems, such as poor ventilation, low indoor air quality, and poor sound insulation. In this study, the teaching building and living area cluster at [...] Read more.
At present, the design and planning of teaching and living areas on university campuses are relatively straightforward but encounter problems, such as poor ventilation, low indoor air quality, and poor sound insulation. In this study, the teaching building and living area cluster at the Tianjin University campus were selected as the research objects. We verified the effectiveness of the simulation results before and after renovation through onsite testing. To improve ventilation, an atrium and patio were added to the teaching building, and the ventilation of the renovated building was studied. The indoor thermal environment intelligent control system regulates carbon dioxide (CO2) concentration and humidity in the teaching building and changes the thermal comfort of the teaching building. Limiting vehicle speeds near the teaching building and the living area cluster, using muffling materials and muffling equipment, and increasing greenery to reduce noise were factors we studied, considering whether they had a noise-reduction effect. It was found that the average number of air changes in the overall functional space of the first teaching building reaches 6.49 times/h, and the wind speed in the human activity region is below 1 m/s. When using a thermal environment intelligent control system, the indoor temperature throughout the year was within the thermal comfort range 81% of the time. The maximum noise around the teaching building during the daytime was 51.0 dB, the maximum noise at nighttime was 41.5 dB, and the maximum sound level on the facade of the living area cluster was 53 dB. The average noise-reduction rate was 22.63%, which exceeds the noise-reduction rate given in the above research literature. Full article
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8 pages, 644 KB  
Brief Report
The Safety of a High-Flow Nasal Cannula in Neuromuscular Disease Patients with Acute Respiratory Failure: A Retrospective Case-Series Study
by Federico Lionello, Francesco Lapia, Beatrice Molena, Andrea Padoan, Sara Lococo, Giovanna Arcaro, Gabriella Guarnieri and Andrea Vianello
J. Clin. Med. 2023, 12(18), 6061; https://doi.org/10.3390/jcm12186061 - 19 Sep 2023
Cited by 7 | Viewed by 3413
Abstract
(1) Background: Although Non-Invasive Ventilation (NIV) is effective in preventing mortality and endotracheal intubation in patients with Acute Respiratory Failure (ARF) linked to a neuromuscular disorder, its efficacy can be affected by patient intolerance. A High-Flow Nasal Cannula (HFNC) appears to have a [...] Read more.
(1) Background: Although Non-Invasive Ventilation (NIV) is effective in preventing mortality and endotracheal intubation in patients with Acute Respiratory Failure (ARF) linked to a neuromuscular disorder, its efficacy can be affected by patient intolerance. A High-Flow Nasal Cannula (HFNC) appears to have a significant advantage over NIV as far as patient tolerance is concerned. The aim of the study was to investigate HFNC’s safety profile in a group of consecutive Neuromuscular Disease (NMD) patients intolerant to NIV who were admitted to an Intermediate Respiratory Care Unit (IRCU) for ARF. (2) Methods: The clinical course of nine NMD patients intolerant to NIV and switched to HFNC was reported. HFNC was provided during daytime hours and NIV during the night-time to the NIV-intolerant patients. HFNC was utilized 24 h a day in those patients who were intolerant of even nocturnal NIV. (3) Results: HFNC was simple to use and it was well tolerated by all of the patients. Three out of nine patients experienced treatment failure, consisting of the need for ETI and/or death during their IRCU stay. The remaining 6 had a favorable outcome. Treatment failure was linked to the utilization of HFNC 24 h a day. (4) Conclusion: HFNC during the daytime hours, together with nocturnal NIV, seems to be a safe therapeutic approach for NMD patients with ARF. A round-the-clock use of HFNC tends to be linked to a high likelihood of failure. Full article
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