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33 Results Found

  • Article
  • Open Access
12 Citations
2,950 Views
11 Pages

Non-mass Breast Lesions: Could Multimodal Ultrasound Imaging Be Helpful for Their Diagnosis?

  • Wenjuan Guo,
  • Tong Wang,
  • Fan Li,
  • Chao Jia,
  • Siqi Zheng,
  • Xuemei Zhang and
  • Min Bai

23 November 2022

Objective: To develop a prediction model for discriminating malignant from benign breast non-mass-like lesions (NMLs) using conventional ultrasound (US), strain elastography (SE) of US elastography and contrast-enhanced ultrasound (CEUS). Methods: A...

  • Article
  • Open Access
330 Views
16 Pages

Multimodal Deep Learning-Based Classification of Breast Non-Mass Lesions Using Gray Scale and Color Doppler Ultrasound

  • Tianjiao Wang,
  • Qingli Zhu,
  • Tianxiang Yu,
  • Denis Leonov,
  • Xinran Shi,
  • Zhuhuang Zhou,
  • Ke Lv,
  • Mengsu Xiao and
  • Jianchu Li

22 November 2025

Objectives: To propose a multimodal deep learning method for the classification of benign and malignant breast non-mass lesions (NMLs) using grayscale and color Doppler ultrasound and to compare the performance of multi-modality and single-modality b...

  • Article
  • Open Access
1 Citations
2,739 Views
12 Pages

Prognostic Molecular Biomarkers in Breast Cancer Lesions with Non-Mass Enhancement on MR

  • Mei-Lin Wang,
  • Yu-Pin Chang,
  • Chen-Hao Wu,
  • Chuan-Han Chen,
  • Mein-Kai Gueng,
  • Yi-Ying Wu and
  • Jyh-Wen Chai

Clustered ring enhancement (CRE) is a new lexicon for non-mass enhancement (NME) of breast MR in the 5th BIRADS, indicating a high suspicion of malignancy. We wonder if the presence of CRE correlates with expression of prognostic molecular biomarkers...

  • Article
  • Open Access
1,642 Views
11 Pages

DWI in the Differentiation of Malignant and Benign Breast Lesions Presenting with Non-Mass Enhancement on CE-MRI

  • Iva Perić,
  • Boris Brkljačić,
  • Tade Tadić,
  • Kristian Jerković,
  • Krešimir Dolić,
  • Matija Borić and
  • Marija Ćavar

25 December 2024

Objectives: This study aimed to investigate whether the apparent diffusion coefficient (ADC) maps values of breast lesions presenting as non-mass enhancement (NME) on MRI could predict benign or malignant pathohistological findings. Materials and Met...

  • Article
  • Open Access
10 Citations
4,572 Views
13 Pages

Idiopathic Granulomatous Mastitis or Breast Cancer? A Comparative MRI Study in Patients Presenting with Non-Mass Enhancement

  • Fatma Nur Soylu Boy,
  • Gul Esen Icten,
  • Yasemin Kayadibi,
  • Iksan Tasdelen and
  • Dolunay Alver

Objective: To compare and determine discriminative magnetic resonance imaging (MRI) findings of idiopathic granulomatous mastitis (IGM) and breast cancer (BC) that present as non-mass enhancement. Materials and Methods: This retrospective study inclu...

  • Article
  • Open Access
1 Citations
2,062 Views
10 Pages

The aim of this study was to evaluate the clinical utility of ultrasound (US) with magnetic resonance imaging (MRI) virtual navigation in a novel prone position for MRI-detected incidental breast lesions. Between June 2016 and June 2020, 30 consecuti...

  • Article
  • Open Access
9 Citations
2,890 Views
10 Pages

Contrast-Enhanced Mammography-Guided Biopsy: Preliminary Results of a Single-Center Retrospective Experience

  • Matteo Sammarra,
  • Claudia Lucia Piccolo,
  • Marina Sarli,
  • Rita Stefanucci,
  • Manuela Tommasiello,
  • Paolo Orsaria,
  • Vittorio Altomare and
  • Bruno Beomonte Zobel

6 February 2024

Background: CEM-guided breast biopsy is an advanced diagnostic procedure that takes advantage of the ability of CEM to enhance suspicious breast lesions. The aim pf this paper is to describe a single-center retrospective experience on CEM-guided brea...

  • Article
  • Open Access
934 Views
9 Pages

Contrast-Enhanced Mammography as a Functional Biomarker in Breast Cancer: Correlation of Enhancement Patterns with Ki-67 and Histological Grade

  • Marina Balbino,
  • Manuela Montatore,
  • Federica Masino,
  • Antonietta Ancona,
  • Francesca Anna Carpagnano,
  • Giulia Capuano,
  • Riccardo Guglielmi and
  • Giuseppe Guglielmi

17 September 2025

Background: Contrast-Enhanced Spectral Mammography (CESM) combines anatomical and functional imaging, showing promise in breast cancer diagnosis. Despite well-established lesion detection accuracy, few studies have investigated the link between CESM...

  • Article
  • Open Access
496 Views
14 Pages

Multimodal Imaging of Ductal Carcinoma In Situ: A Single-Center Study of 75 Cases

  • Fabrizio Urraro,
  • Nicoletta Giordano,
  • Vittorio Patanè,
  • Maria Chiara Brunese,
  • Carlo Varelli,
  • Carolina Russo,
  • Luca Brunese and
  • Salvatore Cappabianca

27 October 2025

Introduction: Ductal carcinoma in situ (DCIS) is a non-invasive precursor of breast cancer, usually detected on mammography as clustered microcalcifications. Many cases, however, lack calcifications and require complementary imaging. This study aimed...

  • Article
  • Open Access
2,173 Views
15 Pages

Digital Mammography (DM) vs. Dynamic Contrast Enhancement-Magnetic Resonance Imaging (DCE-MRI) in Microcalcifications Assessment: A Radiological–Pathological Comparison

  • Federica Cicciarelli,
  • Elisa Guiducci,
  • Francesca Galati,
  • Giuliana Moffa,
  • Paolo Ricci,
  • Federica Pediconi and
  • Veronica Rizzo

The aim of this study was to compare the characteristics of breast microcalcification on digital mammography (DM) with the histological and molecular subtypes of breast cancer and to identify the predictive value of DM and dynamic contrast-enhanced m...

  • Article
  • Open Access
2 Citations
1,463 Views
12 Pages

Lesion Conspicuity in Contrast-Enhanced Mammography: A Retrospective Analysis of Tumor Characteristics

  • Chiara Bellini,
  • Tommaso Susini,
  • Kassandra Toncelli,
  • Martina Pandolfi,
  • Giuliano Migliaro,
  • Francesca Pugliese,
  • Bianca Vanzi,
  • Ludovica Incardona,
  • Giulia Bicchierai and
  • Federica di Naro
  • + 5 authors

3 February 2025

Background/Objectives: The aim of this study is to evaluate the impact of tumor characteristics on lesion conspicuity in contrast-enhanced mammography (CEM) and identify factors associated with different levels of conspicuity. Methods: In this retros...

  • Review
  • Open Access
1 Citations
1,880 Views
27 Pages

Unsupervised Learning Techniques for Breast Lesion Segmentation on MRI Images: Are We Ready for Automation?

  • Marina Fedon Vocaturo,
  • Luisa Altabella,
  • Giuseppe Cardano,
  • Stefania Montemezzi and
  • Carlo Cavedon

24 February 2025

In the era of precision medicine, increasing importance is given to machine learning (ML) applications. In breast cancer, advanced analyses, such as the radiomic process, characterise tumours and predict therapy responses. Breast magnetic resonance i...

  • Article
  • Open Access
1 Citations
2,209 Views
15 Pages

14 August 2023

Diffusion-weighted imaging (DWI) utilizing maximum-intensity projection (MIP) was suggested as a cost-effective alternative tool without the risk of gadolinium-based contrast agents. The purpose of this study was to investigate whether DWI MIPs playe...

  • Article
  • Open Access
1,542 Views
14 Pages

Distinguishing Low Expression Levels of Human Epidermal Growth Factor Receptor 2 in Breast Cancer: Insights from Qualitative and Quantitative Magnetic Resonance Imaging Analysis

  • Yiyuan Shen,
  • Xu Zhang,
  • Jinlong Zheng,
  • Simin Wang,
  • Jie Ding,
  • Shiyun Sun,
  • Qianming Bai,
  • Caixia Fu,
  • Junlong Wang and
  • Jing Gong
  • + 2 authors

Background: The discovery of novel antibody–drug conjugates for low-expression human epidermal growth factor receptor 2 (HER2-low) breast cancer highlights the inadequacy of the conventional binary classification of HER2 status as either negati...

  • Article
  • Open Access
682 Views
15 Pages

Quantitative Volumetric Analysis Using 3D Ultrasound Tomography for Breast Mass Characterization

  • Maria L. Anzola,
  • David Alberico,
  • Joyce Yip,
  • James Wiskin,
  • Bilal Malik,
  • Raluca Dinu,
  • Belinda Curpen,
  • Michael L. Oelze and
  • Gregory J. Czarnota

30 September 2025

Breast cancer detection remains a significant challenge, with traditional mammography presenting barriers such as discomfort, radiation exposure, high false-positive rates, and financial burden. Moreover, younger women frequently fall outside routine...

  • Article
  • Open Access
311 Views
16 Pages

Suspicion for Sarcoma: Clinical Presentation, Multi-Modality Imaging Evaluation, and Ultrasound Artificial Intelligence-Based Decision Support

  • Nikki A. Mehran,
  • Emily Rooney,
  • Harsh Shah,
  • Tamar Gomolin,
  • Nebras Zeizafoun,
  • Dayna Williams,
  • Laurie R. Margolies and
  • Christine Chen

11 November 2025

Background/Objective: This study aims to better characterize the clinical presentation, histology, and imaging features of breast sarcomas on mammography, ultrasound, and MRI, in addition to analyzing the effectiveness of AI DS in detecting breast sa...

  • Article
  • Open Access
8 Citations
3,610 Views
12 Pages

24 February 2023

No studies have evaluated whether any clinicopathological or imaging characteristics of breast papillary lesions are associated with pathological nipple discharge (PND). We analyzed 301 surgically confirmed papillary breast lesions diagnosed between...

  • Case Report
  • Open Access
782 Views
9 Pages

20 September 2025

Introduction: Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion characterized by stromal myofibroblast proliferation forming slit-like pseudoangiomatous spaces. Although most frequently diagnosed in premenopausal women, it has al...

  • Article
  • Open Access
708 Views
10 Pages

Morpho-Functional and Biochemical Characterization of Adrenal Masses in a Heterogeneous Cancer Population

  • Rosaria Meucci,
  • Antonio Stigliano,
  • Giuseppe Campagna,
  • Francesco Garaci,
  • Tommaso Pintus,
  • Guido Roberto and
  • Alberto Signore

3 September 2025

Background/Objectives: The aim of this retrospective study is to analyze the prevalence of adrenal masses in patients with different types of tumors who performed [18F]FDG PET/CT. Method: Eighty-eight patients who performed [18F]FDG PET/CT from 2019...

  • Article
  • Open Access
5 Citations
3,004 Views
7 Pages

25 October 2019

Background and Objectives: Accurate breast tumor sizing is very important in treatment planning; as a result, ultrasound (US) plays an important role in diagnosing breast masses, due to its non-magnified image and its availability. The continuous cha...

  • Article
  • Open Access
14 Citations
6,701 Views
20 Pages

A Novel Computer-Aided-Diagnosis System for Breast Ultrasound Images Based on BI-RADS Categories

  • Yi-Wei Chang,
  • Yun-Ru Chen,
  • Chien-Chuan Ko,
  • Wei-Yang Lin and
  • Keng-Pei Lin

6 March 2020

The breast ultrasound is not only one of major devices for breast tissue imaging, but also one of important methods in breast tumor screening. It is non-radiative, non-invasive, harmless, simple, and low cost screening. The American College of Radiol...

  • Article
  • Open Access
2 Citations
779 Views
14 Pages

29 July 2025

Purpose: This study aimed to develop a predictive nomogram integrating AI-based BI-RADS lexicons and lesion-to-nipple distance (LND) ultrasound features to differentiate mass-type ductal carcinoma in situ (DCIS) from invasive ductal carcinoma (IDC) v...

  • Case Report
  • Open Access
1,374 Views
7 Pages

A Rare Case of Non-Hodgkin B-Cell Lymphoma Following Invasive Lobular Carcinoma of the Breast: A Case Report

  • Elisa Bertulla,
  • Raquel Diaz,
  • Matteo Mascherini,
  • Marco Casaccia,
  • Francesca Depaoli,
  • Letizia Cuniolo,
  • Chiara Cornacchia,
  • Cecilia Margarino,
  • Federica Murelli and
  • Simonetta Franchelli
  • + 5 authors

The association between breast cancer and non-Hodgkin lymphoma of the spleen is extremely rare, with very few cases documented in the medical literature. We present the case of a 39-year-old woman in good health but with a family history of breast ca...

  • Interesting Images
  • Open Access
2 Citations
1,114 Views
9 Pages

Neuroendocrine Tumor Metastases to the Breast Mimic Breast Primary Carcinoma: Mammography and Multimodality US Assessment in Challenging Differential Diagnosis

  • Francesco Marcello Aricò,
  • Antonio Portaluri,
  • Francesca Catanzariti,
  • Elvira Condorelli,
  • Demetrio Aricò,
  • Mariagiovanna Zagami,
  • Emilia Magliolo,
  • Sara Monforte and
  • Maria Adele Marino

Metastases to the breast from non-mammary malignancies are rare, accounting for 0.1–5% of all breast malignancies. Neuroendocrine tumors (NETs) rarely metastasize to the breast. PET-CT somatostatin receptor imaging plays a pivotal role in the s...

  • Article
  • Open Access
1 Citations
1,510 Views
12 Pages

Evaluation of Hologic LOCalizer™ RFID Tags for Preoperative Localization of Breast Lesions: A Single-Center Experience

  • Charlotte Munday,
  • Anmol Malhotra,
  • Sawsan Taif,
  • Adeola Omotade,
  • Arathi Menon and
  • Kefah Mokbel

Background: The increasing detection of non-palpable breast lesions necessitates accurate preoperative localization to ensure complete excision while preserving healthy tissue and optimizing cosmetic outcomes. Traditional wire-guided localization (WL...

  • Article
  • Open Access
3 Citations
1,696 Views
13 Pages

Abbreviated breast magnetic resonance imaging (AB-MRI) has emerged as a supplementary screening tool, though protocols have not been standardized. The purpose of this study was to compare the diagnostic performance of modified and classic AB-MRI and...

  • Article
  • Open Access
6 Citations
2,935 Views
17 Pages

Radiomics in Breast Imaging: Future Development

  • Alessandra Panico,
  • Gianluca Gatta,
  • Antonio Salvia,
  • Graziella Di Grezia,
  • Noemi Fico and
  • Vincenzo Cuccurullo

Breast cancer is the most common and most commonly diagnosed non-skin cancer in women. There are several risk factors related to habits and heredity, and screening is essential to reduce the incidence of mortality. Thanks to screening and increased a...

  • Article
  • Open Access
23 Citations
3,708 Views
21 Pages

14 June 2022

Background: This study aimed to identify optimal combinations between feature selection methods and machine-learning classifiers for predicting the metabolic response of individual metastatic breast cancer lesions, based on clinical variables and rad...

  • Article
  • Open Access
8 Citations
3,726 Views
11 Pages

Contribution of Outpatient Ultrasound Transvaginal Biopsy and Puncture in the Diagnosis and Treatment of Pelvic Lesions: A Bicenter Study

  • Irene Pelayo-Delgado,
  • Javier Sancho,
  • Mar Pelayo,
  • Virginia Corraliza,
  • Belen Perez-Mies,
  • Cristina Del Valle,
  • Leopoldo Abarca,
  • Maria Jesus Pablos,
  • Carmen Martin-Gromaz and
  • Juan Ramón Pérez-Vidal
  • + 4 authors

Background: The use of transvaginal ultrasound guided biopsy and puncture of pelvic lesions is a minimally invasive technique that allows for accurate diagnosis. It has many advantages compared to other more invasive (lower complication rate) or non-...

  • Article
  • Open Access
1,426 Views
15 Pages

Purpose: Routine surveillance chest CT is not recommended by current guidelines; however, its use has been increasing with improved accessibility. This study aimed to evaluate the utility of surveillance contrast-enhanced chest computed tomography (C...

  • Article
  • Open Access
1 Citations
2,609 Views
12 Pages

18 May 2022

Breast cancer with liver metastasis (BCLM) frequently cause hepatic failure owing to extensive liver metastasis compared to other cancers; however, there are no clinicopathologic or radiologic parameters for estimating BCLM prognosis. We analyzed the...

  • Article
  • Open Access
1 Citations
1,806 Views
16 Pages

An Innovative Non-Linear Prediction Model for Clinical Benefit in Women with Newly Diagnosed Breast Cancer Using Baseline FDG-PET/CT and Clinical Data

  • Ken Kudura,
  • Nando Ritz,
  • Arnoud J. Templeton,
  • Tim Kutzker,
  • Martin H. K. Hoffmann,
  • Kwadwo Antwi,
  • Daniel R. Zwahlen,
  • Michael C. Kreissl and
  • Robert Foerster

20 November 2023

Objectives: We aimed to develop a novel non-linear statistical model integrating primary tumor features on baseline [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), molecular subtype, and clinical data for treat...

  • Article
  • Open Access
593 Views
12 Pages

Can PSMA-Targeting Radiopharmaceuticals Be Useful for Detecting Brain Metastasis of Various Tumors Using Positron Emission Tomography?

  • Esra Arslan,
  • Nurhan Ergül,
  • Rahime Şahin,
  • Ediz Beyhan,
  • Özge Erol Fenercioğlu,
  • Yeşim Karagöz,
  • Arzu Algün Gedik,
  • Yakup Bozkaya and
  • Tevfik Fikret Çermik

22 September 2025

Objective: The high expression of prostate-specific membrane antigen (PSMA) associated with neovascularization in non-prostatic malignant tumors and metastatic lesions has been documented in many studies. By taking advantage of the absence of PSMA-re...