Search Results (22,550)

The adoption of digital technologies (DTs) in the workplace has emerged as a core driver of organizational effectiveness, and many studies have explored the intrinsic connection between the two. However, due to the wide range of subdivisions of employee performance, existing studies present inconsistent research conclusions on the implementation effects of DTs and lack a systematic review of their impact on employee psychology and behavior for large sample data. To address this issue, employing a random-effects model and a psychometric meta-analysis approach based on subgroup and meta-regression analyses, this study examines 106 empirical studies, comprising 119 effect sizes. The findings reveal that DTs exhibit a “double-edged sword” effect. On the bright side, DTs significantly enhance task performance, innovation performance, employee engagement, job satisfaction, and job efficacy. On the dark side, DTs aggravate service sabotage, withdrawal behavior, job burnout, and work anxiety and have a suppressive effect on job well-being, while their influence on turnover intention is non-significant. Furthermore, this study identifies the moderating effects of industry characteristics, technology usage types, and demographic factors on the relationships between DTs and behavioral and psychological outcomes. The research conclusions help clarify the logical relationship between DTs and employee psychology and behavior and provide explanations for the differentiated research conclusions of previous studies. This study provides information for scientific management decisions regarding DTs in the workplace. Full article

This study introduces a novel approach to optimal Service Level Agreement (SLA) tier selection in online services by incorporating client-side obsolescence factors into effective SLA planning. We analyze a comprehensive dataset of 600 million records collected over four years, focusing on the lifecycle patterns of browsers published into the iPhone and Samsung ecosystems. Using Gaussian Process Regression with a Matérn kernel and exponential decay models, we model browser version adoption and decline rates, accounting for data sparsity and noise. Our methodology includes a centroid-based filtering technique and a quadratic decay term to mitigate bot-related anomalies. Results indicate distinct browser delivery refresh cycles for both ecosystems, with iPhone browsers showing peaks at 22 and 42 days, while Samsung devices exhibit peaks at 44 and 70 days. We quantify the support duration required to achieve various SLA tiers as follows: for 99.9% coverage, iPhone and Samsung browsers require 254 and 255 days of support, respectively; for 99.99%, 360 and 556 days; and for 99.999%, 471 and 672 days. These findings enable more accurate and effective SLA calculations, facilitating cost-efficient service planning considering the full service delivery and consumption pipeline. Our approach provides a data-driven framework for balancing aggressive upgrade requirements against generous legacy support, optimizing both security and performance within given cost boundaries. Full article

Type III interferons (IFN-λ) are the most recently identified members of the interferon family, distantly related to type I interferons and members of the interleukin-10 (IL-10). Unlike type I interferons, which have broadly distributed cellular receptors, IFN-λ signals through a heterodimeric receptor complex with primary expression on epithelial cells. This restricted receptor distribution makes IFN-λ a favorable candidate for therapeutic and antiviral applications with reduced side effects. In this review, we describe the molecular structure, signaling mechanisms, and the role of IFN-λ in the innate immunity of epithelial tissue, which are its primary sites of action. Moreover, this review will summarize and critically examine the antiviral potential of IFN-λ based on all published clinical trials conducted for the treatment of COVID-19, and hepatitis B, C and D virus. Furthermore, this review suggests IFN-λ as a promising therapeutic recombinant protein, with special emphasis on its potential for production using alternative expression and advanced drug delivery systems. To emphasize its potential as a therapeutic intervention, the design and engineering of recombinant IFN-λ will be presented, with a focus on its lower side-effect profile compared to Type I interferons. Full article

The purpose of this paper is to comprehensively review the research progress of nattokinase in lowering blood lipid, including its source, structure and physicochemical properties, mechanisms of functions, clinical research status, and safety considerations, so as to provide reference for further research on the application of nattokinase in the treatment of dyslipidemia. Natto is a traditional Japanese fermented food, which is made from soybeans fermented by Bacillus natto. During the fermentation process, natto will produce a variety of biologically active substances, including nattokinase. Nattokinase (NK) is a serine protease with stable enzyme activity and good freeze–thaw tolerance, which exerts lipid-lowering and anti-atherosclerotic effects by activating hormone-sensitive lipase (HSL), inhibiting hydroxymethylglutaryl monoacyl coenzyme A reductase (HMG-CoA reductase), and enhancing lipoprotein lipase (LPL) activity. Large-scale clinical trials have confirmed that nattokinase significantly improves the lipid profile and reduces the atherosclerotic plaque area and intima-media thickness with a favorable safety profile. Compared with traditional lipid-lowering drugs (e.g., statins and fibrates), nattokinase has a multifaceted lipid-lowering mechanism and lower risk of side effects, which makes it suitable for patients intolerant of traditional drugs; when combined with natural products such as statins, fibrates, red yeast, and lifestyle interventions, it can play a synergistic role and further reduce the risk of cardiovascular disease. There are various types of nattokinase preparations on the market, and consumers should choose regular products with high activity and purity, and pay attention to their safety and applicable population. Full article

Wood-based membranes have garnered increasing attention due to their structural advantages and durability in the efficient treatment of oily kitchen wastewater. However, conventional fabrication methods often rely on toxic chemicals or synthetic processes, generating secondary pollutants and suffering from fouling, which reduces performance and increases resource loss. In this study, an innovative bilayer membrane was developed from balsa wood by combining a hydrophilic longitudinal layer for water transport with a polydimethylsiloxane (PDMS)-impregnated carbonized transverse layer to enhance hydrophobicity, resulting in increased separation efficiency and a reduction in fouling by 98.38%. The results show a high permeation flux of 1176.86 Lm^–2 h^–1 and a separation efficiency of 98.60%, maintaining low fouling resistance (<3%) over 20 cycles. Mechanical tests revealed a tensile strength of 10.92 MPa and a fracture elongation of 10.42%, ensuring robust mechanical properties. Wettability measurements indicate a 144° contact angle and a 7° sliding angle with water on the carbonized side, and a 163.7° contact angle with oil underwater and a 5° sliding angle on the hydrophilic side, demonstrating excellent selective wettability. This study demonstrates the potential of carbonized wood-based membranes as a sustainable, effective alternative for large-scale wastewater treatment. Full article

As a novel energy-saving and maneuvering device for ships, the gate rudder system (GRS) functions similarly to an accelerating duct. While providing additional thrust, its independently controllable rudder blades on either side of the propeller also enhance ship maneuverability. The GRS was first fully implemented on a container ship in Japan, demonstrating improved propulsion efficiency, fuel savings, and excellent performance in maneuvering, noise, and vibration reduction. In recent years, extensive research has been conducted on the hydrodynamic performance, acoustic characteristics, and energy-saving effects of the GRS. However, certain gaps remain in the research, such as a lack of systematic studies on optimal GRS design in the publicly available literature. Only Ahmet Yusuf Gurkan has investigated the sensitivity of propulsion performance to parameters such as rudder angle, rudder X-shift, rudder tip skewness, and blade tip chord ratio. Therefore, this study employs the JBC benchmark vessel and adopts a coupled CFD-CAESES approach to develop a matching optimization design for the GRS. The influence of geometric parameters—including GRS airfoil camber, maximum camber position, chord length, thickness, distance from the leading edge to the propeller plane, and the gap between the GRS and propeller blades—on ship propulsion performance is investigated. The sensitivity of these design variables to propulsion performance is analyzed, and the optimal GRS design is selected to predict and evaluate its energy-saving effects. This research establishes a rapid and comprehensive CFD-based optimization methodology for GRS matching design. The findings indicate that the gap between the GRS and propeller, the distance from the GRS to the stern, and the airfoil camber of the GRS significantly contribute to various performance responses. After GRS installation, the viscous pressure resistance of the JBC ship decreases, resulting in an 8.05% energy-saving effect at the designated speed. Full article

As part of the substantial public discourse surrounding the distribution and use of mifepristone, which is used with misoprostol to facilitate drug-induced abortions, claims comparing the safety of this regimen to that of common pharmaceuticals have emerged and proliferated. Offered in forums ranging from social media to the Supreme Court, these claims have so gained public acceptance that they are now echoed without scrutiny and, at times, reference. Yet the simplistic slogan that “mifepristone is safer than Tylenol”, though easily disseminated, defies both an intuitive understanding of how we evaluate drug safety and our norms and regulations for doing so. Indeed, if such an assertion was attributable to the manufacturer, it would precipitate a reprimand by the FDA given the lack of specific, controlled, and head-to-head evidence rightly required for its support. To the extent that these claims persist, however, including among the outputs of medical societies, abortion centers, clinical researchers, and government officials, and to the extent that they aim to inform both individual and public decision-making, it is critical that the evidence offered for their support be thoroughly explored. Such examination reveals these claims to be wholly unfounded, offering deficient and disingenuous representations of safety for any of the drugs compared. Full article

The effectiveness and uses of chitosan nanoparticles (CNPs) in drug delivery systems are examined in this work. Important results include the improved drug encapsulating efficiency: CNPs showed up to 90% encapsulation for different therapeutic agents. Furthermore, the research shows that CNPs provide extended-release patterns, greatly enhancing medication bioavailability especially for hydrophobic compounds. One interesting outcome was the greater drug stability in acidic surroundings, which are common in the stomach, where CNPs turn into a gel and later inflate in the intestine where the drug is released. Moreover, CNPs showed a 2–3-fold improvement in the absorption of encapsulated pharmaceuticals relative to traditional formulations, therefore indicating their capacity to overcome the problems of low oral bioavailability. These nanoparticles’ pH-sensitive character produced a 50–70% increase in drug release at certain pH values, hence maximizing therapeutic results. Significantly less systemic toxicity was seen in the in vivo tests, and at therapeutic dosages there were no noted side effects. Histological study confirmed the biocompatibility and non-toxicity of CNPs, therefore attesting their fit for long-term usage. These results highlight the great potential of CNPs in providing effective, focused, continuous drug release, hence improving therapeutic effectiveness and patient compliance. Full article

Pelton turbines are susceptible to hydro-abrasive erosion from sediment-laden flows, resulting in a progressive loss of efficiency. Typical defect classes can be derived from the analysis of such damage observed in hydropower plants. A systematic strategy was developed to investigate the effect of locally damaged Pelton runners on the efficiency in laboratory tests using a model turbine. For this purpose, nine identical runners were fabricated and machined with an increasing size, depth, or number of different artificial defect types, such as splitter, rounded or sharp-edged, defects at the cutout, defects in the bucket base, and added ripples on the bucket sides. The processing steps, the efficiency measurement, and the extracted slopes of the efficiency drops are discussed in detail. The main findings are that the efficiency losses due to the various defects increase in a good approximation linearly with the machining depth and that the individual defect types can be superimposed. Defects at the splitter, bucket base, and bucket side dominate the losses at partial load of the turbine, while those at the cutout dominate at full load. Based on the results of this measurement campaign, power plant operators can estimate the magnitude of efficiency losses in their plant. Full article

This paper presents the modified arithmetic optimization algorithm (MAOA), a swift and effective optimization algorithm specifically designed for electromagnetic applications. Its primary advantage is its ability to avoid local minima by striking a balance between global exploration and local exploitation searches. This equilibrium is maintained through three key improvements: an enhanced initialization process, a distinctive guidance mechanism for steering searches, and an additional learning phase to refine newly found solutions. This process innovation significantly boosts MAOA’s performance in addressing both constrained and unconstrained optimization challenges. In this study, MAOA is applied to optimize the spacing and current amplitude of linear antenna array (LAA) elements, with the goal of minimizing peak side lobe level (PSLL), close-in side lobe level (CSLL), and overall side lobe level (SLL), both with and without constraints on first null beamwidth (FNBW), as well as null positioning with SLL minimization. Ten designs, comprising 10 and 20 antenna elements of LAA and one 14-element circular antenna array (CAA), showcase MAOA’s proficiency in antenna array pattern synthesis. Optimizing element positions results in a PSLL of −21.28 dB, a CSLL of −34.50 dB, and a null depth of −89.00 dB, while optimizing current amplitude achieves a PSLL of −24.32 dB, a CSLL of −29.73 dB, and a null depth of −77.60 dB across various antenna designs. Simulation results reveal that MAOA significantly surpasses traditional uniform linear arrays (ULA) and established optimization techniques. Its superiority is further confirmed through a Wilcoxon rank-sum and Friedman test. Full article

Uniformity in material coating is not only essential for ensuring durability and long-term reliability but also for reducing costs, optimizing resources, and maintaining high-quality standards in industrial applications. Zinc phosphate is notable for coating steel surfaces due to its excellent corrosion resistance and adhesion properties in various industries. This study investigates the optimal flow rate of a diaphragm pump for achieving the effective and uniform coating of a steel cylinder. The coating uniformity was assessed using Scanning Electron Microscopy (SEM), focusing on layer thickness and elemental composition. A range of flow rates was analyzed to determine their influence on coating quality and regularity, with Energy-Dispersive Spectroscopy (EDS) revealing the distribution and homogeneity of the applied layer. The results identified a flow rate of 30 L/min as optimal with a thickness of 3.6 µm of coating on both sample sides, as it minimized surface defects and ensured consistent thickness across the cylinder. This study provides valuable insights for optimizing industrial coating processes, contributing to improved efficiency and reduced resource waste. Full article

With the rapid development of the national economy, the construction of super high-rise buildings, long-span bridges, high-speed railways, and transmission towers has become increasingly common. It is also more frequent to build structures on karst foundations, which imposes higher demands on foundation engineering, especially pile foundations. To study the influence of the roughness factor (RF) on the bearing characteristics of rock-socketed pile, model pile load tests were conducted with different RF values (0.0, 0.1, 0.2, and 0.3) to reveal the failure modes of the test pile, analyze the characteristics of the load–displacement curves and the axial force and resistance exertion law of the pile, and discuss the influence of the RF on the ultimate bearing capacity of the test pile. Based on the load transfer law of test piles, a load transfer model considering the relative pile–soil displacement and the shear dilatancy effect of pile–rock is established to analyze its load transfer characteristics. The results show that the failure mode of the test pile is splitting failure. The load–displacement curves are upward concave and slowly varying. The pile side resistance and the pile tip resistance mainly bear the load on the pile top. As the load on the pile top increases, the pile tip resistance gradually comes into play, and when the ultimate load is reached, the pile tip resistance bears 72.12% to 79.22% of the upper load. The pile side resistance is mainly borne by the rock-socketed section, and the pile side resistance increases sharply after entering the rock layer, but it decreases slightly with increasing depth, and the peak point is located in the range of 1.25D below the soil–rock interface. Increasing the roughness of the pile can greatly improve the ultimate bearing capacity. In this study, the ultimate bearing capacity of the test pile shows a trend of increasing and then decreasing with the gradual increase in RF from 0.0 to 0.3, and the optimal RF is 0.2. The load transfer model of pile–soil relative displacement and pile–rock shear dilatancy effect, as well as the pile tip load calculation model, were established. The calculation results were compared with the test results and engineering measured data, respectively, and they are in good agreement. Full article

In recent years, extreme natural disasters, such as typhoons, have become increasingly frequent, leading to persistent power outages in urban distribution grids. These outages pose significant challenges to the stability of urban power supply systems. With the growing number of electric vehicle (EV) users and the expanding EV industry, and considering the potential of EVs as flexible load storage resources, this paper proposes a post-disaster power supply restoration strategy that takes into account the potential of coordinated scheduling of EVs and mobile energy storage. First, a compression method based on the Minkowski addition is proposed for the EV cluster model in charging stations, which establishes an EV dispatchable model. Second, the spatiotemporal matrix of failure rates for distribution network elements is calculated using the Batts wind field model, enabling the generation of distribution network failure scenarios under typhoon conditions. Finally, the power supply restoration strategy of multi-source coordination with the participation of EV cluster and mobile storage is formulated with the objective of minimizing the loss of the distribution network side. Simulation results demonstrate that the proposed strategy effectively utilizes the load storage potential of EVs and mobile energy storage, enhances recovery performance, ensures cost-effectiveness, and explicitly solves the islanding operation stability problem. Full article

In order to control the stability of tunnel surrounding rock, reduce the construction cost, and improve the construction schedule, the deformation behavior and instability mechanisms of tunnel surrounding rock are studied by numerical simulation and field monitoring methods according to the engineering characteristics of the fractured slate zone under construction of Longshu Tunnel in the central Yunnan water diversion project. The results show that step excavation technology can effectively control the deformation of the tunnel surrounding rock. The deformation range of the top and bottom of the tunnel is 32 mm~35 mm, the deformation range of the left shoulder is 25 mm~28 mm, and the deformation range of the right shoulder is 26 mm~29 mm. The stability range of the tunnel surrounding rock is about 25 m away from the palm surface, and the concentrated stress on both sides of the tunnel is at a low level. Full article

Background/Objectives: Cluster headache (CH) is a debilitating primary headache disorder characterized by severe unilateral pain attacks. Chronic CH (CCH) poses significant treatment challenges, especially in refractory cases. Neuromodulation, including repetitive transcranial magnetic stimulation (rTMS), offers a potential alternative; however, evidence for its efficacy in CCH is lacking. Methods: A randomized, double-blind, placebo-controlled, crossover pilot study was conducted. Eligibility criteria included patients with refractory CCH (rCCH), who were then randomized to receive two treatment sequences: A, rTMS followed by sham stimulation, or B, sham followed by rTMS, separated by a one-month washout, with a follow-up period of 3 months. The primary endpoint was to analyze efficacy by assessing the change in the number of attacks per week (APW). Secondary endpoints included treatment tolerability and changes in intensity, duration, and use of rescue medication. The trial was registered with ClinicalTrials.gov (NCT06917144). Results: Eight patients were enrolled and randomized with a 50% probability of assignment to either treatment arm. Despite this, five patients were allocated to sequence A and three to sequence B. Three patients completed the entire study; five received treatment with rTMS and six with sham. The APW change during rTMS showed a change of (mean ± SD) +2.2 (10.8) attacks per week (p = 0.672). Two patients achieved complete remission during the rTMS phase, though symptoms returned by the washout period. In comparison with sham, the difference was also not statistically significant. No significant changes were observed in secondary endpoints. Side effects (two cases) were mild and transient. Conclusions: This pilot study suggests that rTMS may provide clinical benefits for rCCH in selected cases, though its effects seem transient. Adherence to treatment remains a critical challenge. Full article