New Techniques and Applications in Cancer Drug Discovery and Therapies

Dear Colleagues,

Malignant tumors remain a serious global public health issue, increasing in incidence and threatening human health. The causes of many cancer types are still unknown, and much remains to be explored in the field of cancer research. The past two decades have seen impressive advances in the life sciences field, with many new technologies emerging that play important roles in uncovering new molecular targets for cancer diagnosis and treatment. These technologies include multiple "Omics" techniques, such as genomics, transcriptomics, epigenomics, and metabolomics, as well as novel biological detection systems like nucleic acid aptamers and microfluidic chips. With these new tools, researchers can detect small molecules that are difficult to detect with traditional systems, as well as trace substances like circulating tumor cells, ctDNA, and cfDNA. Additionally, new experimental models have been introduced, including genetically modified animal models, PDX models, and organoid models, which can speed up the study of new drugs and therapies, including immune checkpoint inhibitors. This Special Issue welcomes original research articles and reviews focused on the multiple aspects of new technologies in cancer biology, with potential applications in cancer drug discovery, diagnosis, and treatment.

Please find below a list of potential sub-topics related to drug discovery and therapies:

1. Innovative techniques for researching molecular targets.
2. New models for studying cancer diagnosis and treatment.
3. Recent advancements in drug screening.
4. Medicinal chemistry approaches for cancer prevention, diagnosis, and treatment.
5. In silico techniques of drug–target interactions in assessing anti-cancer drugs.
6. Strategies for synthesizing and developing anti-cancer drugs based on their underlying biology and medicinal chemistry.
7. Development of novel molecules related to a specific target or target class for anti-cancer drugs.
8. Drug repositioning in cancer treatment.

Dr. Viswas Raja Solomon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• genomics
• transcriptomics
• epigenomics
• metabolomics
• in silico study
• cancer drug discovery
• diagnosis and therapy