Journal of Personalized Medicine

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Special Issue Information

Dear Colleagues,

Stroke management has advanced considerably in recent decades, although there remain opportunities to further enhance outcomes via personalized and precision medicine approaches. Some key points in the background and history of this topic are as follows: the heterogeneity of stroke, personalized medicine, the Human Genome Project, advances in imaging, biomarkers, and omics technologies, wearables and telemedicine, AI and machine learning techniques. Recent studies have provided proof-of-concept for elements of precision stroke care while highlighting the need for further research and translation into standard clinical practice.

We look forward to contributions that showcase the immense potential to enhance the standard of care and outcomes across the many facets of stroke management via emerging precision and personalized medicine approaches.

This Special Issue seeks to showcase high-quality research focused on personalized and precision medicine approaches across the spectrum of stroke management, from rapid and accurate diagnostics to targeted therapies and tailored rehabilitation plans. We welcome original research as well as review articles that synthesize the state of the art in using patient-specific biomarkers, genetics, and other factors to achieve optimal outcomes in stroke care.

Potential topics of interest include, but are not limited to, the following:

Precision diagnostics for ischemic vs. haemorrhagic stroke;
Imaging and biomarkers to identify salvageable tissue;
Genomics and stroke risk prediction;
Pharmacogenomics to predict drug efficacy/side effects;
Personalized selection of thrombolytic and neuroprotective agents;
Targeted rehabilitation programs based on functional deficits;
Wearables and telemedicine for individualized post-stroke monitoring;
Machine learning applications in tailored stroke management.

This Special Issue aims to spotlight innovations in precision medicine to address the heterogeneity inherent in stroke populations. We hope to assemble a body of work that captures the state of the art in this field while inspiring further advancements towards truly personalized stroke care.

Dr. Wenjun Tu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

stroke
personalized medicine
diagnostic
therapy and rehabilitation

Published Papers (2 papers)

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Research

Jump to: Review

11 pages, 273 KiB

Open AccessArticle

Association between Height and Functional Outcomes of Patients 6 Months after a Stroke: A Multicenter Prospective Observational Cohort Study

by Nae Yoon Kang, Sung-Hwa Ko, Yong-Il Shin, Ji Hong Min, Mi Sook Yun, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Gyung-Jae Oh, Yang Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Yun-Hee Kim and Won Hyuk Chang

J. Pers. Med. 2024, 14(6), 610; https://doi.org/10.3390/jpm14060610 - 7 Jun 2024

Viewed by 137

Abstract

Many physical factors influence post-stroke functional outcomes. However, few studies have examined the influence of height on these outcomes. Here, data from the Korean Stroke Cohort for Functioning and Rehabilitation were used and patients’ height was categorized into three groups: short (lower 25%), middle (middle 50%), and tall (upper 25%). Differences in the modified Rankin scale (mRS), functional ambulatory category (FAC), and Korean-translated version of the Modified Barthel Index (K-MBI) scores were analyzed for each group at 6 months post-stroke. A subgroup analysis was conducted based on the initial Fugl-Meyer Assessment (FMA) score. We analyzed functional outcomes in 5296 patients at 6 months post-stroke, adjusting for age and body mass index. The short-height group exhibited higher mRS scores (1.88 ± 0.043), lower FAC scores (3.74 ± 0.045), and lower K-MBI scores (82.83 ± 0.748) than the other height groups (p < 0.05). In the subgroup analysis, except for the very severe FMA group, the short-height group also exhibited worse outcomes in terms of mRS, FAC, and K-MBI scores (p < 0.05). Taken together, the short-height group exhibited worse outcomes related to disability, gait function, and ADLs at 6 months post-stroke. Full article

(This article belongs to the Special Issue Stroke Management—Personalized Diagnostic, Therapy and Rehabilitation)

Review

Jump to: Research

16 pages, 1432 KiB

Open AccessReview

Sexual Functioning and Sexual Health in Female Patients following Stroke: A Scoping Review with Implications for Rehabilitation

by Desirèe Latella, Alessandro Grimaldi and Rocco Salvatore Calabrò

J. Pers. Med. 2024, 14(3), 267; https://doi.org/10.3390/jpm14030267 - 29 Feb 2024

Viewed by 939

Abstract

The impact of stroke on the sexual functioning of female survivors can arise from direct neurological effects or be triggered indirectly through various psychophysiological processes. Although an increasing number of publications exist, the topic of sexuality remains seldom discussed in the stroke literature, even though patients have expressed a need for sexual rehabilitation services. A literature review on sexual functioning in post-stroke females examining existing rehabilitation programs addressing patients’ sexuality and exploring the perspectives of nurses and caregivers on sexual issues constitutes a novel approach. Therefore, we conducted a scoping review to better investigate this hot topic. Studies were identified by searching Scopus, PubMed, Web of Science, Cochrane Library, PsychINFO, and Embase databases. Current data indicates substantial connections between stroke and female sexual dysfunction (SD), including factors like desire/libido, sexual satisfaction, and sexual intercourse. Some intervention programs have been created to provide specific guidance to healthcare professionals in addressing patients’ requirements for sexual recovery, although their adequacy remains uncertain. However, to date, there are neither specific rehabilitation programs for post-stroke female SD nor healthcare personnel trained to deal with post-stroke sexual issues adequately and efficiently. The incorporation of sexual rehabilitation into the overall rehabilitation process for stroke patients is crucial, ideally within an interdisciplinary framework. Despite being a fundamental aspect of post-stroke women’s lives, sexuality remains taboo. Full article

(This article belongs to the Special Issue Stroke Management—Personalized Diagnostic, Therapy and Rehabilitation)

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