nutrients-logo

Journal Browser

Journal Browser

Nutrition Treatment for CKD (Chronic Kidney Disease) in the Present Day

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (5 March 2024) | Viewed by 1180

Special Issue Editors


E-Mail Website
Guest Editor
Division of Experimental Oncology, Urological Research Institute, IRCCS Ospedale San Raffaele, 20132 Milano, Italy
Interests: chronic kidney disease; cancer; onconephrology; nutritional treatment based with low- (LPD) and very-low-protein diet supplemented with amino acids (VLPD); exercise–diet interaction for health and chronic disease; body composition

E-Mail Website
Co-Guest Editor
Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
Interests: nephrology; renal; kidney transplantation; nephrotic syndrome

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) affects more than 10% of the general population worldwide. The prevalence of CKD increases with increasing age, especially above 65 years, aided by physiological age-related decline of kidney function. From the IIIb stage, the reduction of fluid and electrolyte homeostasis and the retention of toxins produce typical symptoms and changes of CKD. The alterations increase in the final stages of the disease, until renal replacement therapy is required. Nutritional status is known to deteriorate as chronic diseases such as CKD progress, and is a strong predictor for increased morbidity and mortality. The assessment of nutritional status should therefore be considered when patients begin education for nutritional treatment as part of their renal disease care, as well as for potential interventions regarding salt, potassium, phosphate and protein/energy intake assessments to avoid toxin accumulation and slow the progression of kidney disease. In the literature it is now clear that nutritional treatment based on low- (LPD) and very-low-protein diet supplemented with amino acids (VLPD) is useful and safe in CKD patients, and the benefits produced by the interaction with nutritional therapy and age-related diseases such as hypertension, diabetes and cancer are now well known (e.g., in blood pressure and metabolic status control, in preserving cellular mass and reducing asthenic symptoms). In fact, LPD and the VLPD interact with the therapy of patients and with their clinical condition, producing an additive effect and improving the prognosis. It is true for CKD, but it is enough: although physical activity is closely associated with nutrition and is considered essential for the prevention of malnutrition and disability, improved quality of life and the maintenance of physical performance in chronic diseases, exercise is rarely prescribed to CKD patients. However, LPD and VLPD, with or without physical activity, must be managed with care and experience: if protein restriction is not combined with adequate caloric intake, it produces malnutrition. This is especially true in cases of anorexia and catabolic conditions (e.g., in cancer patients). This Special Issue welcomes contributions from physicians and nutritionists focusing on nutritional support and dietary modification for patients with CKD, with special reference to the use of protein restriction for complex scenarios such as oncological conditions or advanced CKD in older adult patients, and to the synergic effect of LPD and VLPD with physical activity to improve nutritional status and clinical outcomes.

Dr. Arianna Bettiga
Dr. Domenico Giannese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CKD
  • chronic kidney disease
  • elderly
  • cancer
  • onconephrology
  • diet–drugs interaction
  • nutrition
  • diet
  • kidney
  • physical activity
  • nutritional status

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 613 KiB  
Article
Effects of a Personalized Diet on Nutritional Status and Renal Function Outcome in Nephrectomized Patients with Renal Cancer
by Francesco Trevisani, Fabiana Laurenti, Francesco Fiorio, Matteo Paccagnella, Matteo Floris, Umberto Capitanio, Michele Ghidini, Ornella Garrone, Andrea Abbona, Andrea Salonia, Francesco Montorsi and Arianna Bettiga
Nutrients 2024, 16(9), 1386; https://doi.org/10.3390/nu16091386 - 3 May 2024
Viewed by 861
Abstract
Nutritional therapy (NT) based on a controlled protein intake represents a cornerstone in managing chronic kidney disease (CKD). However, if a CKD patient is at the same time affected by cancer, oncologists and nutritionists tend to suggest a dietary regimen based on high [...] Read more.
Nutritional therapy (NT) based on a controlled protein intake represents a cornerstone in managing chronic kidney disease (CKD). However, if a CKD patient is at the same time affected by cancer, oncologists and nutritionists tend to suggest a dietary regimen based on high protein intake to avoid catabolism and malnutrition. International guidelines are not clear when we consider onco-nephrological patients and, as a consequence, no clinical shared strategy is currently applied in clinical practice. In particular, no precise nutritional management is established in nephrectomized patients for renal cell carcinoma (RCC), a specific oncological cohort of patients whose sudden kidney removal forces the remnant one to start a compensatory mechanism of adaptive hyperfiltration. Our study aimed to investigate the efficacy of a low–normal-protein high-calorie (LNPHC) diet based on a Mediterranean model in a consecutive cohort of nephrectomized RCC patients using an integrated nephrologist and nutritionist approach. A consecutive cohort of 40 nephrectomized RCC adult (age > 18) patients who were screened for malnutrition (malnutrition screening tool, MST < 2) were enrolled in a tertiary institution between 2020 and 2022 after signing a specific informed consent form. Each patient underwent an initial nephrological and nutritional evaluation and was subsequently subjected to a conventional CKD LNPHC diet integrated with aproteic foods (0.8 g/Kg/die: calories: 30–35 kcal per kg body weight/die) for a period of 6 months (±2 months). The diet was structured after considering eGFR (CKD-EPI 2021 creatinine formula), comorbidities, and nutritional status. MST, body mass index (BMI), phase angle (PA), fat mass percentage (FM%), fat-free mass index (FFMI), body cell mass index (BCMI), extracellular/intracellular water ratio (ECW/ICW), extracellular matrix/body cell mass ratio (ECM/BCM), waist/hip circumference ratio (WHC), lab test exams, and clinical variables were examined at baseline and after the study period. Our results clearly highlighted that the LNPHC diet was able to significantly improve several nutritional parameters, avoiding malnutrition and catabolism. In particular, the LNPHC diet preserved the BCM index (delta on median, ΔM + 0.3 kg/m2) and reduced the ECM/BCM ratio (ΔM − 0.03 *), with a significant reduction in the ECW/ICW ratio (ΔM − 0.02 *), all while increasing TBW (ΔM + 2.3% *). The LNPHC diet was able to preserve FFM while simultaneously depleting FM and, moreover, it led to a significant reduction in urea (ΔM − 11 mg/dL **). In conclusion, the LNPHC diet represents a new important therapeutic strategy that should be considered when treating onco-nephrological patients with solitary kidney due to renal cancer. Full article
Show Figures

Figure 1

Back to TopTop