Host Immune Responses in the Control of Leishmania Infection and New Forms of Therapy for Tegumentary Leishmaniasis

Dear Colleagues,

Immunologic responses in the different clinical forms of leishmaniasis vary considerably depending the species of leishmania, genotypic differences intraspecies, and clinical forms of the diseases (including visceral, cutaneous, mucosal, disseminated leishmaniasis, and diffuse cutaneous leishmaniasis). Moreover, about 20% of healthy subjects who reside in endemic areas have evidence of leishmania infection, but do not develop any disease. These individuals are considered to have asymptomatic or subclinical (SC) infection. There is a gap in the understanding of how some subjects control leishmanial infection, while in others the parasites proliferate and consequently develop disease. Additionally, it is not clear why parasites are easily detectable infections caused by some leishmania species such as Leishmania Viannia guyanensis and are scarce in diseases caused by L. braziliensis, as well as why parasites persist in macrophages despite the presence of the Th1 immune response. In American tegumentary leishmaniasis caused by L. braziliensis infection, macrophages produce reactive oxygen species and nitric oxide but have a limited ability to kill leishmania. In contrast, macrophages from subjects with SC infection are less permissive to leishmania penetration and kill parasites, even in the absence of a Th1 immune response. In subjects cured of CL, the ability to control leishmanial infection is restored and, despite the observation of a poor immune response in peripheral blood, there is a strong DTH to leishmania antigens. In mice, resident memory T cells, together with macrophages, control a new infection, but this subject has not been studied in humans.

Treatment failure in tegumentary leishmaniasis is on the rise and chemotherapy associated with immunostimulants or drugs that down-modulate inflammatory responses can enhance the cure rate and decrease the healing time of ulcers.   

The focus of this Special Issue is to show how the immune response controls or facilitates parasite multiplication in human cells and the use of immunotherapy and chemotherapy in the treatment of tegumentary leishmaniasis.

Prof. Dr. Edgar Carvalho
Prof. Dr. Walderez Ornelas Dutra
Guest Editors

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• leishmania killing
• macrophages
• dermal memory T cells
• subclinical leishmania infection
• cutaneous leishmaniasis

Title: The role of senescent CD8+ T cells in the pathogenesis of dis-seminated leishmaniasis
Author: CARDOSO
Highlights: Disseminated Leishmaniasis; CD8+T cells; senescent.