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Animals
Special Issues
Therapeutics and Advanced Veterinary Care
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Therapeutics and Advanced Veterinary Care

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 13418

Special Issue Editor

Prof. Dr. Paul Mills

E-Mail Website
Guest Editor
School of Veterinary Science, The University of Queensland, Gatton 4343, Australia
Interests: veterinary pharmacology; veterinary education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human–animal bond develops over the life of a companion animal, and indeed, the companion animal is often considered a member of the family in many households. This attachment may therefore complicate decisions towards the end of the animal’s life, as to whether to prolong life (“where there is life, there is hope”) or to determine when quality of life has deteriorated to a point where euthanasia is the most humane option. Other factors further complicating these decisions are the challenge of assessing quality of life in different species, and the increasing therapeutic arsenal available to treat the many conditions associated with older age. This Special Issue will therefore focus on the therapeutics that may prolong life and/or enhance the quality of life to determine if and when intervention should be considered.

Prof. Dr. Paul Mills
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quality of life
  • euthanasia
  • age-related dysfunction
  • advanced care
  • veterinary ethics

Published Papers (2 papers)

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9 pages, 2607 KiB  
Article
Evaluation of a Tasteless Enrofloxacin Pharmaceutical Preparation for Cats. Naive Pooled-Sample Approach to Study Its Pharmacokinetics
by Lilia Gutierrez, Graciela Tapia, Eduardo Gutierrez and Hector Sumano
Animals 2021, 11(8), 2312; https://doi.org/10.3390/ani11082312 - 5 Aug 2021
Cited by 3 | Viewed by 2883
Abstract
Available pharmaceutical preparations of enrofloxacin injected SC or IM to cats are likely to cause adverse tissue reactions in the injection sites (pH of the drug preparations is ≥10.4). Tablets often induce abundant ptyalism and vomiting, casting doubt on the efficacy of the [...] Read more.
Available pharmaceutical preparations of enrofloxacin injected SC or IM to cats are likely to cause adverse tissue reactions in the injection sites (pH of the drug preparations is ≥10.4). Tablets often induce abundant ptyalism and vomiting, casting doubt on the efficacy of the drug administration maneuver. In addition, the reported oral bioavailability is very low. In this trial, the oral pharmacokinetics of dried alginate beads of enrofloxacin (DABE) administered by concealing them in the cat’s moist food or morsels, is described. A naïve polled sampling approach was chosen with fourteen adult healthy cats. Neither their housing nor their feeding habits were altered. A single pharmacokinetic profile was obtained with 5 samples per designated bleeding time, sampling each cat 2–3 times only. None of the cats rejected their medicated food or morsels. Plasma profile of enrofloxacin exhibited an AUC0–24 value of 12.4 µg·h/mL and an AUC0–∞ value of 19.2 µg·h/mL, which are comparatively greater than values previously referred for kittens. In contrast, λ and elimination t½ were almost identical (0.12 1/h and 6.1 h). Pharmacokinetics/pharmacodynamics ratios taking the breakpoint of Staphylococcus epidermidis as a surrogate (0.5 µg/mL), can be regarded as borderline or low, but perhaps adequate in cats, as higher concentrations may be linked to toxicity (AUC0–24/MIC = 24.8; Cmax/MIC = 4.6). Full article
(This article belongs to the Special Issue Therapeutics and Advanced Veterinary Care)
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16 pages, 307 KiB  
Commentary
Ethical Challenges Posed by Advanced Veterinary Care in Companion Animal Veterinary Practice
by Anne Quain, Michael P. Ward and Siobhan Mullan
Animals 2021, 11(11), 3010; https://doi.org/10.3390/ani11113010 - 20 Oct 2021
Cited by 19 | Viewed by 9330
Abstract
Advanced veterinary care (AVC) of companion animals may yield improved clinical outcomes, improved animal welfare, improved satisfaction of veterinary clients, improved satisfaction of veterinary team members, and increased practice profitability. However, it also raises ethical challenges. Yet, what counts as AVC is difficult [...] Read more.
Advanced veterinary care (AVC) of companion animals may yield improved clinical outcomes, improved animal welfare, improved satisfaction of veterinary clients, improved satisfaction of veterinary team members, and increased practice profitability. However, it also raises ethical challenges. Yet, what counts as AVC is difficult to pinpoint due to continuing advancements. We discuss some of the challenges in defining advanced veterinary care (AVC), particularly in relation to a standard of care (SOC). We then review key ethical challenges associated with AVC that have been identified in the veterinary ethics literature, including poor quality of life, dysthanasia and caregiver burden, financial cost and accessibility of veterinary care, conflicts of interest, and the absence of ethical review for some patients undergoing AVC. We suggest some strategies to address these concerns, including prospective ethical review utilising ethical frameworks and decision-making tools, the setting of humane end points, the role of regulatory bodies in limiting acceptable procedures, and the normalisation of quality-of-life scoring. We also suggest a role for retrospective ethical review in the form of ethics rounds and clinical auditing. Our discussion reenforces the need for a spectrum of veterinary care for companion animals. Full article
(This article belongs to the Special Issue Therapeutics and Advanced Veterinary Care)
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