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Biomedicines
Special Issues
Research Advances in Kidney Diseases and Sepsis
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Research Advances in Kidney Diseases and Sepsis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 596

Special Issue Editor

Dr. Eiichi Sato

E-Mail Website
Guest Editor
Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Matsudo, Chiba, Japan
Interests: sepsis; acute kidney injury; chronic kidney disease; hemodialysis therapy; diabetic nephropathy; aquaporin 2
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sepsis and kidney diseases have a strong interrelationship, as they mutually increase the risk of one another. Kidney disease can contribute to the development of sepsis, particularly in individuals undergoing dialysis who possess a vascular access site such as a catheter, graft or fistula beneath their skin and within a blood vessel. This access point provides an avenue for pathogens to directly enter the bloodstream. Furthermore, chronic kidney disease can compromise the immune system's functionality, thereby elevating susceptibility to severe infections. Additionally, certain medications utilized post-kidney transplant surgery (such as anti-rejection drugs) may weaken the immune response. Infections can arise from kidney stones and potentially disseminate throughout the body, leading to sepsis. Sepsis can lead to systemic dysfunction, resulting in multi-organ failure, often initiating with renal impairment. Hypotension may ensue, leading to compromised perfusion of oxygen and nutrients to the kidneys. Additionally, intravascular coagulation can impede renal oxygenation. It is estimated that sepsis accounts for approximately one-third to one-half of cases involving acute kidney injury.

This Special Issue of Biomedicines will focus on sepsis and kidney disease via articles or reviews dealing with pathophysiology, diagnosis, biomarkers and treatment are welcome.

Dr. Eiichi Sato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sepsis
  • acute kidney injury
  • dialysis
  • kidney failure
  • immune system

Published Papers (1 paper)

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Research

10 pages, 2902 KiB  
Article
Ubiquitin-Specific Protease 18 in Chronic Kidney Disease—Another Emerging Biomarker to Consider?
by Paulina Dziamałek-Macioszczyk, Agata Winiarska, Anna Pawłowska, Jan Macioszczyk, Paweł Wojtacha and Tomasz Stompór
Biomedicines 2024, 12(5), 1073; https://doi.org/10.3390/biomedicines12051073 - 13 May 2024
Viewed by 478
Abstract
Ubiquitin-specific protease 18 (USP18) is a protein recognized for its dual enzymatic and non-enzymatic nature. It is involved in many physiological processes like the cell cycle and cell signaling. It also suppresses heart muscle remodeling upon an increase in the afterload. The role [...] Read more.
Ubiquitin-specific protease 18 (USP18) is a protein recognized for its dual enzymatic and non-enzymatic nature. It is involved in many physiological processes like the cell cycle and cell signaling. It also suppresses heart muscle remodeling upon an increase in the afterload. The role of USP18 in kidney pathology remains unknown. The objective of the study was to assess the relationship between serum and urine USP18 levels, the factors contributing to cardiovascular risk, and the markers of kidney disease activity at different stages of chronic kidney disease (CKD). One hundred participants, aged between 24 and 85 years (mean 53.1 ± 17.1 years), were included. Five groups (n = 20 each) were recruited according to their renal status (healthy individuals, patients with proteinuric glomerulonephritis, patients with non-proteinuric CKD, patients who were treated with hemodialysis, and kidney transplant recipients). The measurements of serum and urine USP18 levels were performed using ELISA. The median serum USP18 level was the highest in healthy participants (1143.0 pg/mL) and kidney transplant recipients (856.6 pg/mL), whereas, in individuals with different forms of CKD, it fitted within the range of 402.1–471.9 pg/mL. Urinary USP18 reached the highest level in the group of CKD patients not yet on dialysis (303.3 pg/mL). Only in this group did it correlate with serum creatinine and urea concentrations. Our results suggest the inhibition of cardioprotective USP18 signaling when kidney function is impaired. Moreover, an increased level of urinary USP18 may indicate chronic tubular damage. Full article
(This article belongs to the Special Issue Research Advances in Kidney Diseases and Sepsis)
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