Zinc in Health and Disease Conditions II

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (25 May 2024) | Viewed by 353

Special Issue Editor


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Guest Editor
Department(s) of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108-2792, USA
Interests: acid-sensing ion channel; zinc; glucose; patch-clamp recording; stroke; drug addiction; brain injury
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Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of the Special Issue “Zinc in Health and Disease Conditions”.

Zinc, the second most prevalent trace element in the body, functions as a signaling molecule that regulates a variety of physiological activities. Evidence from both basic and clinical studies suggests the importance of zinc homeostasis in physiological condition and disease states. For example, zinc, via the modulation of a variety of targets, is critical for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation and inhibition may cause seizures. However, the relationship between zinc signaling and disease states is complex, as both extracellular and intracellular zinc can produce either protective or detrimental effects. This Special Issue welcomes studies that provide functional (cellular and molecular) evidence on the involvement of zinc in physiology, pathology or pharmacology, as well as those exploring the potential of targeting biomolecules associated with zinc signaling or homeostasis as a therapeutic strategy. Original manuscripts and reviews focused on any aspects of zinc are also encouraged.

Dr. Xiang-Ping Chu
Guest Editor

Manuscript Submission Information

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Keywords

  • zinc
  • physiology
  • disease
  • regulation/modulation
  • function
  • pathology

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Published Papers (1 paper)

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Review

22 pages, 1292 KiB  
Review
Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters
by Ana Cirovic, Aleksandar Cirovic, Supabhorn Yimthiang, David A. Vesey and Soisungwan Satarug
Biomolecules 2024, 14(6), 650; https://doi.org/10.3390/biom14060650 (registering DOI) - 31 May 2024
Abstract
Zinc (Zn) is the second most abundant metal in the human body and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from the diet by specialized transport proteins, which unfortunately [...] Read more.
Zinc (Zn) is the second most abundant metal in the human body and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from the diet by specialized transport proteins, which unfortunately also provide an entry route for the toxic metal pollutant cadmium (Cd). The intestinal absorption of Zn depends on the composition of food that is consumed, firstly the amount of Zn itself and then the quantity of other food constituents such as phytate, protein, and calcium (Ca). In cells, Zn is involved in the regulation of intermediary metabolism, gene expression, cell growth, differentiation, apoptosis, and antioxidant defense mechanisms. The cellular influx, efflux, subcellular compartmentalization, and trafficking of Zn are coordinated by transporter proteins, solute-linked carriers 30A and 39A (SLC30A and SLC39A), known as the ZnT and Zrt/Irt-like protein (ZIP). Because of its chemical similarity with Zn and Ca, Cd disrupts the physiological functions of both. The concurrent induction of a Zn efflux transporter ZnT1 (SLC30A1) and metallothionein by Cd disrupts the homeostasis and reduces the bioavailability of Zn. The present review highlights the increased mortality and the severity of various diseases among Cd-exposed persons and the roles of Zn and other transport proteins in the manifestation of Cd cytotoxicity. Special emphasis is given to Zn intake levels that may lower the risk of vision loss and bone fracture associated with Cd exposure. The difficult challenge of determining a permissible intake level of Cd is discussed in relation to the recommended dietary Zn intake levels. Full article
(This article belongs to the Special Issue Zinc in Health and Disease Conditions II)
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