The Multiple Roles of Glutathione-Dependent Enzymes: A Themed Issue in Honor of Prof. Bengt Mannervik
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Enzymology".
Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 325
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue of Biomolecules on the "The multiple roles of glutathione-dependent enzymes" is to honor the vast contribution of Professor Bengt Mannervik to this field. Bengt has had an extraordinarily productive and influential career, publishing in excess of 500 peer-reviewed research papers that have been cited more than 45,000 times. Bengt’s main area of interest has been in the glutathione transferase enzymes, where he was the first to recognize the class structure of the cytosolic glutathione transferase family of proteins and he has been a major contributor to our knowledge of their structure and function. In addition, Bengt has made many valuable contributions to our understanding of other glutathione-dependent enzymes such as thiol transferase, glyoxalase, and glutathione reductase. In recent years, Bengt has used GSTs as exemplars to provide novel insights into protein engineering and directed evolution. Having supervised more than 60 PhD scholars from around the world and having hosted several International “glutathione transferase” conferences, Bengt is widely recognized as the world’s most prominent authority in this field.
Before his “retirement”, Bengt held the Karin and Herbert Jacobsson Professorship of Biochemistry at Uppsala University, originally held by Nobel Prize Laureate Arne Tiselius, arguably the most prestigious chair in Sweden. Bengt is currently a Senior Professor at Stockholm University and an Adjunct Professor at The Scripps Research Institute, La Jolla, CA, USA.
Glutathione is a unique molecule which is utilized by a range of glutathione-dependent enzymes. These enzymes have been shown to contribute to an extraordinary array of metabolic and cellular processes including redox regulation, detoxification of xenobiotics and endogenous toxicants, intermediary metabolism of amino acids, steroid hormone production, gene regulation, inflammation, and the modulation of ion channels. This series of papers explores the diverse roles that glutathione-dependent enzymes play in living cells and represents a fitting tribute to Bengt’s past and continuing contributions to the field.
We are pleased to invite you to contribute an original research article or a review to this Special Issue that explores the diverse roles that glutathione-dependent enzymes play in living cells and how they can be manipulated in biotechnological and therapeutic settings.
The scope of this Special Issue includes investigations of the function, structure, and regulation of enzymes that bind and utilize glutathione, including but not limited to glutathione transferases; glutathione peroxidases; glutathione reductase; the glyoxalases, glutaredoxins, and enzymes that synthesize and breakdown glutathione; and CLIC proteins and glutathione conjugate transporters.
Prof. Dr. Philip G. Board
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- glutathione transferase
- glutathione peroxidase
- glutathione reductase
- glyoxalases
- glutaredoxins
- glutamate-cysteine ligase
- glutathione synthetase
- CHAC1 and g-glutamyl cyclotransferases
- CLIC proteins
- glutathione conjugate transporters
