Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon

Dear Colleagues,

This year marks the 25th anniversary of the publication of Professor Ho Jeong Kwon’s paper (PNAS, 95:3356, 1998), in which he reported a new inventory of biological tools using “depudecin’ as a pharmacologically active compound for the study of, and for medical intervention in, basic biological processes. This paper stimulated the interest of many researchers and physicians to explore the biological role of histone deacetylases in gene regulation.

The addition of depudecin to pharmacopoeia has the potential to contribute to both basic and clinical science; for instance, its novel structure has already contributed to the understanding of the enzymatic mechanisms of action of the deacetylases, and it may further have unique advantages for therapeutic purposes. The past 25 years have witnessed intense scientific efforts to discover new biomolecules for advancing biology and biomedical applications. Professor Kwon has been at the forefront of these innovative efforts, conducting pioneering research on some of the angiogenesis- and autophagy-regulating biomolecules such as terpestacin, curcumin, kaempferide, Rg3, sertraline, artemisinate, daptomycin, voacangine, crytotashinone, etc., as well as on the biological roles of the targets of these biomolecules and their translational applications in health and disease, providing insights into the “biomolecule-target-phenotype’ link in biology and translational applications.

This Special Issue aims to focus on the role of biomolecules and their impact on biology and translational applications. It will begin with a brief review of Professor Kwon’s contributions to this field, followed by original research articles and reviews on all aspects of the molecular mechanisms and functional actions of biomolecules and their applications in health and disease.

Dr. Eun-Woo Lee
Dr. Hye Jin Kang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• biomolecules
• cancer
• angiogenesis
• autophagy
• GPCRs
• translational applications
• target identification
• proximity-labeling
• molecular docking
• molecular probe
• molecular pharmacology