DNA Molecular Engineering-Based Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 803

Special Issue Editor


E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
Interests: DNA dynamic nanotechnology; DNA self-assembly nanostructure; artificial cell; single-molecule imaging; bioanalysis

Special Issue Information

Dear Colleagues,

Bioanalysis of important biotargets offers an effective means to understand the operational mechanisms of spatiotemporal biological systems. There is an urgent need to develop novel biosensors and bioanalysis strategies with high sensitivity, high precision, and high intelligence through molecular engineering design. Benefitting from the obvious advantages of DNA molecules, such as the predictability of DNA hybridizations and the scaling-up ability of DNA strand displacement reactions, DNA nanotechnology provides a flexible and programmable platform for molecular engineering. Through rational molecular design, DNA molecules can be constructed into a series of DNA reaction networks and DNA nanostructures with specific functions involving molecular computing, logic control, mechanical motion and intelligent signal transduction. By combining DNA molecular engineering with biosensing strategies, numerous DNA molecular engineering-based biosensors have been reported in recent years and have showed great potential in bioapplications. However, due to the complexity of biological systems, there are still some challenges when designing DNA molecular engineering-based biosensors. With the development of biology and biomedicine, more and more important biological targets should be detected and various bioenvironments should be considered. In addition, we hope that our sensors will continue to become more sensitive, more selective, cheaper, smaller, and easy to use.

This Special Issue aims to gather original articles and reviews showing research advances, molecular design, innovative applications, new challenges and future perspectives regarding DNA molecular engineering-based biosensors.

If you would be interested in submitting a contribution, or if you have any questions, please contact me.

Dr. Yifan Lyu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • DNA nanotechnology
  • molecular diagnosis
  • bioimaging
  • bioanalysis
  • functional nucleic acid
  • aptamers

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

24 pages, 13029 KiB  
Review
DNA-Based Molecular Machines: Controlling Mechanisms and Biosensing Applications
by Chunran Ma, Shiquan Li, Yuqi Zeng and Yifan Lyu
Biosensors 2024, 14(5), 236; https://doi.org/10.3390/bios14050236 - 8 May 2024
Viewed by 646
Abstract
The rise of DNA nanotechnology has driven the development of DNA-based molecular machines, which are capable of performing specific operations and tasks at the nanoscale. Benefitting from the programmability of DNA molecules and the predictability of DNA hybridization and strand displacement, DNA-based molecular [...] Read more.
The rise of DNA nanotechnology has driven the development of DNA-based molecular machines, which are capable of performing specific operations and tasks at the nanoscale. Benefitting from the programmability of DNA molecules and the predictability of DNA hybridization and strand displacement, DNA-based molecular machines can be designed with various structures and dynamic behaviors and have been implemented for wide applications in the field of biosensing due to their unique advantages. This review summarizes the reported controlling mechanisms of DNA-based molecular machines and introduces biosensing applications of DNA-based molecular machines in amplified detection, multiplex detection, real-time monitoring, spatial recognition detection, and single-molecule detection of biomarkers. The challenges and future directions of DNA-based molecular machines in biosensing are also discussed. Full article
(This article belongs to the Special Issue DNA Molecular Engineering-Based Biosensors)
Show Figures

Figure 1

Back to TopTop