Advancing Cancer Research by Exploring the Tissue Engineering Toolbox

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1925

Special Issue Editor


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Guest Editor
Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, Dublin, Ireland
Interests: tumour microenvironment; 3D in vitro models; neuroblastoma

Special Issue Information

Dear Colleagues,

Cancer research requires physiologically relevant experimental 3D in vitro models to advance our understanding of tumour biology, pathogenesis, and drug response at the tissue level. The native tumour microenvironment (TME) consists of cancerous and non-cancerous cells surrounded by an extracellular matrix. We can reconstruct relevant TME in 3D in vitro using tissue engineering and a biomaterial development toolbox, physical sciences, and additive manufacturing with appropriately sourced and propagated human cells, which retain the fundamental genetic and epigenetic landscape. This Special Issue will explore the growing body of evidence supporting these models' experimental value.

We look forward to receiving your contributions, whether they be in the form of an article or a review on the topic.

Dr. Olga Piskareva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • biomaterials
  • tumour microenvironment
  • extracellular matrix
  • biomechanics
  • functional materials
  • 3D in vitro models
  • organoids
  • cancer cell signalling
  • metastasis
  • organ/tumour-on-chip

Published Papers (1 paper)

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Review

19 pages, 2044 KiB  
Review
Utilizing 3D Models to Unravel the Dynamics of Myeloma Plasma Cells’ Escape from the Bone Marrow Microenvironment
by Stefaan W. Verbruggen, Ciara L. Freeman and Fiona E. Freeman
Cancers 2024, 16(5), 889; https://doi.org/10.3390/cancers16050889 - 22 Feb 2024
Viewed by 1484
Abstract
Recent therapeutic advancements have markedly increased the survival rates of individuals with multiple myeloma (MM), doubling survival compared to pre-2000 estimates. This progress, driven by highly effective novel agents, suggests a growing population of MM survivors exceeding the 10-year mark post-diagnosis. However, contemporary [...] Read more.
Recent therapeutic advancements have markedly increased the survival rates of individuals with multiple myeloma (MM), doubling survival compared to pre-2000 estimates. This progress, driven by highly effective novel agents, suggests a growing population of MM survivors exceeding the 10-year mark post-diagnosis. However, contemporary clinical observations indicate potential trends toward more aggressive relapse phenotypes, characterized by extramedullary disease and dominant proliferative clones, despite these highly effective treatments. To build upon these advances, it is crucial to develop models of MM evolution, particularly focusing on understanding the biological mechanisms behind its development outside the bone marrow. This comprehensive understanding is essential to devising innovative treatment strategies. This review emphasizes the role of 3D models, specifically addressing the bone marrow microenvironment and development of extramedullary sites. It explores the current state-of-the-art in MM modelling, highlighting challenges in replicating the disease’s complexity. Recognizing the unique demand for accurate models, the discussion underscores the potential impact of these advanced 3D models on understanding and combating this heterogeneous and still incurable disease. Full article
(This article belongs to the Special Issue Advancing Cancer Research by Exploring the Tissue Engineering Toolbox)
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