PSMA PET/CT in Prostate Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 930

Special Issue Editor


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Guest Editor
Department of Urology, Chris O’Brien Lifehouse, Sydney, NSW 2050, Australia
Interests: PSMA PET; prostate cancer; prostatic obstruction

Special Issue Information

Dear Colleagues,

The introduction of PSMA PET/CT into clinical use has had a major impact on our management of prostate cancer. Its initial utilization was in the identification of disease in biochemical recurrence and, shortly after that, it became recognized as a superior tool in primary staging at diagnosis. The potential roles of PSMA PET/CT continue to expand and there is growing data to demonstrate its utility in the assessment of local disease. As such, there are emerging data that demonstrate its utility in diagnosis, active surveillance, and as a biomarker. This novel imaging has also paved the way for a therapeutic option and the exponential growth of interest in theranostics.

We are pleased to invite you to contribute manuscripts that provide emerging or mature data on how PSMA PET/CT has influenced prostate cancer management in your institution or systematically evaluate the research experience in specific applications of PSMA PET/CT. The aim of this Special Issue is to create a collection of papers that define the use of this novel form of imaging in urological clinical practice.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Diagnosis
  • Staging
  • Re-staging
  • Predictive disease states
  • Imaging biomarker

I look forward to receiving your contributions.

Dr. Henry Hyunshik Woo
Guest Editor

Manuscript Submission Information

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Keywords

  • prostate cancer
  • staging
  • diagnosis
  • radical prostatectomy
  • biochemical recurrence

Published Papers (1 paper)

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Research

19 pages, 4691 KiB  
Article
From Despair to Hope: First Arabic Experience of 177Lu-PSMA and 161Tb-PSMA Therapy for Metastatic Castration-Resistant Prostate Cancer
by Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Deya’ Aldeen Sweedat, Stephan Maus, Ula Al-Rasheed, Samer Salah, Fadi Khriesh, Diyaa Juaidi, Dina Abu Dayek, Feras Istatieh, Farah Anwar, Aisha Asrawi, Alaa Abufara, Mohammad Al-Rwashdeh, Ramiz Abu-Hijlih, Baha’ Sharaf, Rami Ghanem, Hikmat Abdel-Razeq and Asem Mansour
Cancers 2024, 16(11), 1974; https://doi.org/10.3390/cancers16111974 - 23 May 2024
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Abstract
The objective of this retrospective study is to assess the effectiveness and safety of two beta-emitting prostate-specific membrane antigen (PSMA) radioligands, [177Lu]Lu and [161Tb]Tb, in heavily treated patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 148 cycles of beta-emitting [...] Read more.
The objective of this retrospective study is to assess the effectiveness and safety of two beta-emitting prostate-specific membrane antigen (PSMA) radioligands, [177Lu]Lu and [161Tb]Tb, in heavily treated patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 148 cycles of beta-emitting PSMA radioligand therapy were given to 53 patients at a specialized cancer care center in Amman, Jordan. This treatment was offered following the exhaustion of all prior treatment modalities. Approximately half of the cases (n = 26) demonstrated an initial partial response to PSMA radioligand therapy. Moreover, roughly one-fourth of the patients (n = 13) exhibited a sustained satisfactory biochemical response, which qualified them to receive a total of six PSMA radioligand therapy cycles and maintain continued follow-up for additional treatment cycles. This was reflected by an adequate prostate-specific antigen (PSA) decline and a concomitant partial response evident on [68Ga]Ga-PSMA positron emission tomography/computed tomography imaging. A minority of patients (n= 18; 34%) experienced side effects. Generally, these were low-grade and self-limiting toxicities. This study endorses previous research evidence about PSMA radioligand therapy’s safety and efficacy. It also provides the first clinical insight from patients of Arab ethnicity. This should facilitate and promote further evidence, both regionally and internationally. Full article
(This article belongs to the Special Issue PSMA PET/CT in Prostate Cancer)
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