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Cancers
Special Issues
Clinical Research on the Relationship between Diet and Cancer Development
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Clinical Research on the Relationship between Diet and Cancer Development

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 366

Special Issue Editor

Dr. Zsuzsanna Németh

E-Mail Website
Guest Editor
Department of Internal Medicine and Oncology, Semmelweis University, Koranyi S. u 2/a, 1083 Budapest, Hungary
Interests: cancer prevention; complementary therapies; molecular biology

Special Issue Information

Dear Colleagues,

This Special Issue aims to collect clinical trial articles focusing on dietary pattern and cancer survival. It is already well-known that the risk of developing cancer can be significantly reduced by 40% with an appropriate lifestyle, including diet. It is also known that an imbalance of vitamins and micro-nutrients can directly affect the metabolism and, through epigenetic alterations, gene transcription, which then can lead to metabolic changes and cancer formation. Obesity and metabolic syndrome are both related to improper or deficient dietary patterns, which have been shown to increase the chance of developing tumors.

Dietary questionnaires and diet diaries are the most commonly used forms of recall of dietary patterns, but recall bias is a possibility. A more reliable and scientific-evidence-based form is clinical trials. We therefore request studies that discuss the relationship between dietary pattern and metabolic changes that may explain the beneficial effect on cancer formation and survival.

Dr. Zsuzsanna Németh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • nutrition
  • complementary therapy
  • vitamins, minerals
  • micro-nutrients
  • survival
  • cancer

Published Papers (1 paper)

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Review

20 pages, 1390 KiB  
Review
Spontaneous Tumor Regression and Reversion: Insights and Associations with Reduced Dietary Phosphate
by Ronald B. Brown
Cancers 2024, 16(11), 2126; https://doi.org/10.3390/cancers16112126 - 3 Jun 2024
Viewed by 143
Abstract
Tumors that spontaneously shrink from unknown causes in tumor regression, and that return to normal cells in tumor reversion, are phenomena with the potential to contribute new knowledge and novel therapies for cancer patient survival. Tumorigenesis is associated with dysregulated phosphate metabolism and [...] Read more.
Tumors that spontaneously shrink from unknown causes in tumor regression, and that return to normal cells in tumor reversion, are phenomena with the potential to contribute new knowledge and novel therapies for cancer patient survival. Tumorigenesis is associated with dysregulated phosphate metabolism and an increased transport of phosphate into tumor cells, potentially mediated by phosphate overload from excessive dietary phosphate intake, a significant problem in Western societies. This paper proposes that reduced dietary phosphate overload and reregulated phosphate metabolism may reverse an imbalance of kinases and phosphatases in cell signaling and cellular proliferation, thereby activating autophagy in tumor regression and reversion. Dietary phosphate can also be reduced by sickness-associated anorexia, fasting-mimicking diets, and other diets low in phosphate, all of which have been associated with tumor regression. Tumor reversion has also been demonstrated by transplanting cancer cells into a healthy microenvironment, plausibly associated with normal cellular phosphate concentrations. Evidence also suggests that the sequestration and containment of excessive phosphate within encapsulated tumors is protective in cancer patients, preventing the release of potentially lethal amounts of phosphate into the general circulation. Reducing dietary phosphate overload has the potential to provide a novel, safe, and effective reversion therapy for cancer patients, and further research is warranted. Full article
(This article belongs to the Special Issue Clinical Research on the Relationship between Diet and Cancer Development)
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