Functional Neuro-Oncology—Volume II

Dear Colleagues,

There is increasing evidence to support the notion that the nervous system plays a pivotal role in the progression of brain neoplasms, both primary and metastatic. Specifically, we know that the progression of glial tumors is driven by neuronal activity, mediated through secreted growth factors along with direct synaptic communication. Similarly, the influence of tumor cells on the modulation of the structural and electrical activity of brain circuits has also been demonstrated. This line of evidence has bearings on our understanding of the underpinnings of tumor progression and response to treatment, as well as brain plasticity and the therapeutic implications. Together, this has culminated in the rise in functional neuro-oncology as a specialist subset of neuro-oncology. The adoption of a functional approach to the management of brain tumors has improved our ability to achieve maximally safe tumor resection, elucidated several functional brain networks affected by tumors, and offered insight into the mechanism of brain tumor progression. However, this knowledge has also given rise to additional questions, concerning the role of the nervous system in the initiation of intrinsic brain tumors, the contribution of this interaction to the development of tumor-related epilepsy and strategies to mitigate it, the effect of various therapies on this interaction, and identifying opportunities for more effective therapeutic intervention. A more comprehensive understanding of this interplay can also be leveraged to improve cognitive rehabilitation. This Special Issue will highlight the latest developments in the field of functional neuro-oncology, with a particular focus on further elaborating on our mechanistic understanding and therapeutic opportunities.

Dr. Alireza Mansouri
Guest Editor

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• brain mapping
• functional imaging
• tractography
• awake mapping
• neuro-oncology