Novel Therapeutic Targets and Management in Pediatric Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 567

Special Issue Editor


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Guest Editor
Department of Pediatrics, Borsod-Abaúj-Zemplén County Central Hospital and University Teaching Hospital, Budapest, Hungary
Interests: pediatric brain tumor; ewing-sarcoma; neuroblastoma; ATRT; glioma; predisposition syndrome
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Special Issue Information

Dear Colleagues,

The treatment of pediatric malignancies has reached a milestone in recent years. The wide use of modern diagnostic methods provides a deeper insight into the molecular background of pediatric solid tumors and leukemias, which facilitates a better prognostic estimation for individual tumors and also enables the use of targeted therapy in certain cases. The introduction of treatment modalities applying immunological aspects of leukemias and solid tumor provides the long-term control of tumor growth and a better survival. Newer approaches of targeted and immunotherapy will hopefully fundamentally change the treatment of pediatric malignancies by the marginalization of conventional chemotherapy with an increased burden of long-term side effects. The application of modern molecular technics may promote the early recognition of predisposition syndromes, patients then undergoing a subsequent regular follow-up, helping an early diagnosis and better survival of pediatric malignancies in certain cases.

This Special Issue aims to provide an overview of the recent advances in predisposition syndromes, targeted treatment, and immunotherapy in the field of pediatric hematology and oncology.

Dr. Péter Hauser
Guest Editor

Manuscript Submission Information

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Keywords

  • pediatric tumor
  • pediatric brain tumor
  • bone tumor
  • neuroblastoma
  • targeted treatment
  • immunotherapy
  • predisposition syndrome

Published Papers (1 paper)

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Research

17 pages, 7570 KiB  
Article
Hu14.18K.322A Causes Direct Cell Cytotoxicity and Synergizes with Induction Chemotherapy in High-Risk Neuroblastoma
by Maria Thomas, Thu Hien Nguyen, Jenny Drnevich, Amber M. D’Souza, Pedro A. de Alarcon and Manu Gnanamony
Cancers 2024, 16(11), 2064; https://doi.org/10.3390/cancers16112064 - 30 May 2024
Viewed by 199
Abstract
The disialoganglioside, GD2, is a promising therapeutic target due to its overexpression in certain tumors, particularly neuroblastoma (NB), with limited expression in normal tissues. Despite progress, the intricate mechanisms of action and the full spectrum of the direct cellular responses to anti-GD2 antibodies [...] Read more.
The disialoganglioside, GD2, is a promising therapeutic target due to its overexpression in certain tumors, particularly neuroblastoma (NB), with limited expression in normal tissues. Despite progress, the intricate mechanisms of action and the full spectrum of the direct cellular responses to anti-GD2 antibodies remain incompletely understood. In this study, we examined the direct cytotoxic effects of the humanized anti-GD2 antibody hu14.18K322A (hu14) on NB cell lines, by exploring the associated cell-death pathways. Additionally, we assessed the synergy between hu14 and conventional induction chemotherapy drugs. Our results revealed that hu14 treatment induced direct cytotoxic effects in CHLA15 and SK-N-BE1 cell lines, with a pronounced impact on proliferation and colony formation. Apoptosis emerged as the predominant cell-death pathway triggered by hu14. Furthermore, we saw a reduction in GD2 surface expression in response to hu14 treatment. Hu14 demonstrated synergy with induction chemotherapy drugs with alterations in GD2 expression. Our comprehensive investigation provides valuable insights into the multifaceted effects of hu14 on NB cells, shedding light on its direct cytotoxicity, cell-death pathways, and interactions with induction chemotherapy drugs. This study contributes to the evolving understanding of anti-GD2 antibody therapy and its potential synergies with conventional treatments in the context of NB. Full article
(This article belongs to the Special Issue Novel Therapeutic Targets and Management in Pediatric Cancer)
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