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Cells
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Charming Micro-Insights into Health and Diseases
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Charming Micro-Insights into Health and Diseases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 454

Special Issue Editor

Prof. Dr. Alexander E. Kalyuzhny

E-Mail Website
Guest Editor
Neuroscience, UMN Twin Cities, 6-145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
Interests: investigating the mechanisms underlying the constitutive induced heteromerization of opioid receptors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The 3rd International Online Conference on Cells: Charming Micro-Insights into Health and Diseases (Cells2025) (https://sciforum.net/event/CELLS2025) was organized by the MDPI open access journal Cells (Impact Factor 6.0) and will be held online from 25 to 27 March 2025. This conference aims to provide leading scientists working in the field with an online platform on which to share their latest research and engage in exciting discussions. The main topics of the conference are as follows:

  •     Cellular pathology of cancers;
  •     Neural cell biology;
  •     Cellular antivirus immune responses;
  •     Cell therapies;
  •     Cellular signaling;
  •     Cell research in animal models;
  •     Cellular metabolism;
  •     Protein quality control;
  •     Proteasomal degradation and autophagy.

This Special Issue intends to collect the extended and expanded versions of Proceedings papers from the conference. All conference participants will be granted a 10% discount on Article Processing Charges (APCs).

Prof. Dr. Alexander E. Kalyuzhny
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular pathology of cancers
  • neural cell biology
  • cellular antivirus immune responses
  • cell therapies
  • cellular signaling
  • cell research in animal models
  • cellular metabolism
  • protein quality control
  • proteasomal degradation and autophagy

Published Papers (1 paper)

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Research

12 pages, 2056 KiB  
Communication
NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light–Chain Kinase (ERK/MLCK) Pathway
by Jie Tao, Jinghua Cheng, Ying Shi, Benqiang Li, Pan Tang, Jiajie Jiao and Huili Liu
Cells 2024, 13(11), 913; https://doi.org/10.3390/cells13110913 - 25 May 2024
Viewed by 270
Abstract
Porcine astrovirus (PAstV) has a potential zoonotic risk, with a high proportion of co-infection occurring with porcine epidemic diarrhea virus (PEDV) and other diarrheal pathogens. Despite its high prevalence, the cellular mechanism of PAstV pathogenesis is ill–defined. Previous proteomics [...] Read more.
Porcine astrovirus (PAstV) has a potential zoonotic risk, with a high proportion of co-infection occurring with porcine epidemic diarrhea virus (PEDV) and other diarrheal pathogens. Despite its high prevalence, the cellular mechanism of PAstV pathogenesis is ill–defined. Previous proteomics analyses have revealed that the differentially expressed protein NOD–like receptor X1 (NLRX1) located in the mitochondria participates in several important antiviral signaling pathways in PAstV–4 infection, which are closely related to mitophagy. In this study, we confirmed that PAstV–4 infection significantly up-regulated NLRX1 and mitophagy in Caco–2 cells, while the silencing of NLRX1 or the treatment of mitophagy inhibitor 3–MA inhibited PAstV–4 replication. Additionally, PAstV–4 infection triggered the activation of the extracellular regulated protein kinases/ myosin light-chain kinase (ERK/MLCK) pathway, followed by the down-regulation of tight–junction proteins (occludin and ZO–1) as well as MUC–2 expression. The silencing of NLRX1 or the treatment of 3–MA inhibited myosin light-chain (MLC) phosphorylation and up-regulated occludin and ZO–1 proteins. Treatment of the ERK inhibitor PD98059 also inhibited MLC phosphorylation, while MLCK inhibitor ML-7 mitigated the down-regulation of mucosa-related protein expression induced by PAstV–4 infection. Yet, adding PD98059 or ML–7 did not affect NLRX1 expression. In summary, this study preliminarily explains that NLRX1 plays an important role in the disruption of intestinal mucosal function triggered by PAstV–4 infection via the ERK/MLC pathway. It will be helpful for further antiviral drug target screening and disease therapy. Full article
(This article belongs to the Special Issue Charming Micro-Insights into Health and Diseases)
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