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Children
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Adverse Neonatal Outcomes in Perinatal Periods: Risk Factors, Screening and...
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Adverse Neonatal Outcomes in Perinatal Periods: Risk Factors, Screening and Treatment

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neonatology".

Deadline for manuscript submissions: 5 July 2024 | Viewed by 1630

Special Issue Editors

Dr. Noa Ofek-Shlomai

E-Mail Website
Guest Editor
Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel
Interests: neonatology; growth and nutrition in very low birth weight infants; sedation in the NICU; renal failure in the NICU; microbiom
Dr. Smadar Eventov-Friedman

E-Mail Website
Guest Editor
Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel
Interests: neonatology; congenital CMV infection; nutrition and breast milk in preterm infants

Special Issue Information

Dear Colleagues,

Preterm birth affects approximately 15 million infants each year, and accounts for around 11% of live births worldwide. While modern neonatology has improved survival rates in the smallest and sickest infants, these infants are susceptible to a wide range of long-term adverse outcomes. Long term consequences may include impairments in the respiratory and cardiovascular systems (bronchopulmonary dysplasia and right heart failure), chronic kidney disease, sub-optimal growth and feeding issues, short bowel syndrome, late-life cardiometabolic disease and psychological and psychosocial long-lasting issues.

In terms of cognitive and neurodevelopmental impairment including vision and hearing impairments, preterm infants are at an increased risk of developmental delays, intellectual disabilities, learning difficulties, and behavioral disorders.

A multidisciplinary collaboration and holistic approach to extremely preterm infants may allow better follow-up and improve long term outcomes.

Dr. Noa Ofek-Shlomai
Dr. Smadar Eventov-Friedman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prematurity
  • very low birth weight
  • neurodevelopmental impairment
  • adverse outcome

Published Papers (2 papers)

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Research

11 pages, 2855 KiB  
Article
Study of Correlation between Fetal Bowel Dilation and Congenital Gastrointestinal Malformation
by Yi Jiang, Weipeng Wang, Weihua Pan, Wenjie Wu, Dan Zhu and Jun Wang
Children 2024, 11(6), 670; https://doi.org/10.3390/children11060670 (registering DOI) - 31 May 2024
Abstract
Background: Ultrasound serves as a valuable tool for the early detection of fetal bowel dilatation, yet the correlation between fetal bowel dilatation and gastrointestinal malformations remains to be further investigated. This study aims to explore the relationship by conducting a follow-up and analysis [...] Read more.
Background: Ultrasound serves as a valuable tool for the early detection of fetal bowel dilatation, yet the correlation between fetal bowel dilatation and gastrointestinal malformations remains to be further investigated. This study aims to explore the relationship by conducting a follow-up and analysis of fetuses with bowel dilation. Methods: A retrospective analysis was conducted on 113 fetuses with bowel dilatation at our center from July 2014 to December 2019. The location and degree of bowel dilatation were analyzed. ROC curves were constructed based on the diameter of the bowel and its ratio to fetal gestational age. Results: In total, 40 of 41 cases (97.6%) with upper gastrointestinal dilatation (double-bubble sign) and 46 of 72 cases (63.9%) with lower gastrointestinal dilatation were diagnosed with gastrointestinal malformations postnatally. The AUC of the dilatation diameter was 0.854 with a cutoff value of 18.05 mm in patients with lower gastrointestinal dilatation. The ratio of the diameter to gestational age (D/GA) showed a higher AUC of 0.906 with a cutoff value of 0.4931. Conclusions: The presence of the double-bubble sign in fetuses indicates a close association with duodenal obstruction. The risk of gastrointestinal malformations increases when the bowel diameter exceeds 18.05 mm, particularly when the D/GA surpasses 0.4931. Full article
(This article belongs to the Special Issue Adverse Neonatal Outcomes in Perinatal Periods: Risk Factors, Screening and Treatment)
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9 pages, 908 KiB  
Article
The Most Valuable Predictive Factors for Bronchopulmonary Dysplasia in Very Preterm Infants
by Wenwen Chen, Zhenhai Zhang, Liping Xu and Chao Chen
Children 2023, 10(8), 1373; https://doi.org/10.3390/children10081373 - 11 Aug 2023
Viewed by 1298
Abstract
Introduction: It is urgent to make a rapid screening of infants at the highest risk for bronchopulmonary dysplasia (BPD) via some succinct postnatal biomarkers, such as Ureaplasma Urealyticum (UU) infection and chest radiograph images. Methods: A retrospective study was performed. Moderate [...] Read more.
Introduction: It is urgent to make a rapid screening of infants at the highest risk for bronchopulmonary dysplasia (BPD) via some succinct postnatal biomarkers, such as Ureaplasma Urealyticum (UU) infection and chest radiograph images. Methods: A retrospective study was performed. Moderate to severe BPD or death was set as the main outcome. The association between putative variables and the main outcome were assessed by bivariate analyses and logistic regression. Results: A total of 134 infants were enrolled. Bivariate analyses showed the gestational age, birth weight, appearances of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies on chest radiographic images, a ductal diameter ≥1.5 mm and whether UU infection was associated with BPD. After adjustment by logistic regression, the risk of BPD with gestational age, sex and specific chest-radiographic manifestations remained significant. Conclusions: Chest radiograph images (appearance of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies) could provide a quick prediction of developing BPD in clinical practice, in addition to gestational age and sex. UU infection was not an independent risk factor for BPD. Full article
(This article belongs to the Special Issue Adverse Neonatal Outcomes in Perinatal Periods: Risk Factors, Screening and Treatment)
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