New Advances and Perspectives for Neonatal Brain Hypoxia

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neonatology".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 299

Special Issue Editor


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Guest Editor
Neonatal Intensive Care Unit, L'Archet University Hospital of Nice Côte d'Azur, Nice, France
Interests: epidemiology; neonatal critical care; hypoxic ischemic encephalopathy

Special Issue Information

Dear Colleagues,

Perinatal asphyxia and neonatal encephalopathy presumed hypoxic-ischemic stayed a frequent cause of death or disabilities around the world. Despite improvement of obstetrical and neonatal care, questions remain as to the underlying deleterious pathophysiological mechanisms, and how to improve the management and follow-up of these patients.

The current Special Issue “New Advances and Perspectives for Neonatal Brain Hypoxia” aims to comprehensively integrate the most topical trends in diagnosis and treatment of neonatal hypoxia encephalopathy to prompt recognition of the disease and prevention strategies. We welcome original articles or reviews reporting new experimental or clinical data and promoting the understanding of neonatal hypoxic encephalopathy. I look forward to your contributions to this exciting issue so that we can progress in this important field to improve neonatal brain outcomes.

Dr. Isabelle Guellec
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neonatal encephalopathy
  • perinatal asphyxia
  • outcome
  • perinatal care

Published Papers (1 paper)

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Research

10 pages, 493 KiB  
Article
The Impact of Time to Initiate Therapeutic Hypothermia on Short-Term Neurological Outcomes in Neonates with Hypoxic–Ischemic Encephalopathy
by Till Dresbach, Viktoria Rigoni, Anne Groteklaes, Thomas Hoehn, Anja Stein, Ursula Felderhoff-Mueser, Andreas Mueller and Hemmen Sabir
Children 2024, 11(6), 686; https://doi.org/10.3390/children11060686 - 4 Jun 2024
Abstract
Background: Therapeutic hypothermia is the standard treatment for neonates with hypoxic–ischemic encephalopathy. Preclinical evidence indicates that the time to initiate therapeutic hypothermia correlates with its therapeutic success. This study aims to explore whether there is a correlation between the early initiation of therapeutic [...] Read more.
Background: Therapeutic hypothermia is the standard treatment for neonates with hypoxic–ischemic encephalopathy. Preclinical evidence indicates that the time to initiate therapeutic hypothermia correlates with its therapeutic success. This study aims to explore whether there is a correlation between the early initiation of therapeutic hypothermia and improved short-term neurological outcomes in cooled asphyxiated newborns. Methods: A retrospective analysis was conducted, involving 68 neonates from two different neonatal intensive care units. The impact of time to initiate treatment, time to reach the target temperature, and time between initiation and target temperature was correlated with short-term outcomes on MRI. Results: We did not find a significant difference between outcomes regarding the time to start treatment and the time to achieve the target temperature. Interestingly, neonates with a poor outcome were treated on average earlier than neonates with a favorable outcome but required more time to reach the target temperature. Additionally, the study results did not support the hypothesis that a shorter time to initiate treatment would lead to shorter times to achieve the target temperature. Conclusion: Based on our findings, it is recommended to prioritize a thorough evaluation of neonatal encephalopathy before initiating therapeutic hypothermia. Early initiation of treatment should be balanced with the time required for precise assessment to ensure better outcomes. Full article
(This article belongs to the Special Issue New Advances and Perspectives for Neonatal Brain Hypoxia)
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