Molecular Biology in Targeted Radionuclide Therapy Radiopharmaceutical Design
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 8752
Special Issue Editors
Interests: radiopharmacology; oncology imaging; amyloidosis
Special Issues, Collections and Topics in MDPI journals
Interests: thyroid; PET imaging; oncology diagnosis and therapy
Special Issues, Collections and Topics in MDPI journals
Interests: radiopharmaceuticals; radioactive tracers; nuclear medicine radiolabeling; new PET imaging radionuclides
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Targeted radionuclide therapy (TRT) can be defined by the delivery of radionuclides to a tumor-associated target, which may be present in the tumor cell itself or in the microenvironment. Apart from some exceptions, as in the case of 131I in differentiated thyroid cancer, radiation is delivered by a vector which recognizes a receptor or an antigen or is an element of a metabolic pathway.
The design of a radiopharmaceutical for TRT requires a multidisciplinary team involving biologist, radio chemist, radio pharmacologist, medical, and physical staff. After conjugation, usually by means of a bifunctional chelator, the compound may lose some affinity for the target. Great efforts have been made to select the more specific ligand and optimal labelling method in order to increase the specificity for the tumor tissue and the residence time to decrease the dose to normal tissues and critical organ subregions.
Molecular biology plays a fundamental role also in the field of nanosized particles loaded with radionuclides; specific coating may drive these particles towards the tumor, reducing the RES uptake.
Contributing papers to this Special Issue will present recent progress in the molecular approach to TRT of cancer, with emphasis on how to better design a radiopharmaceutical.
Dr. Carlo Aprile
Dr. Onelio Geatti
Dr. Lorenzo Lodola
Guest Editors
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Keywords
- molecular mechanisms
- radiopharmaceutical
- radionuclide therapy
- alpha emitters
- beta emitters
- radiobiology
- nuclear medicine