Genetic Variants in Neurological and Psychiatric Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 4996
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Special Issue Information
Dear Colleagues,
Genetic susceptibility to multifactorial neurological and psychiatric diseases is one of the hottest topics in molecular biology and translational medicine. Indeed, improvements in diagnostics, as well as the findings of multicenter studies, are changing the perspectives of researchers. The overlapping symptoms of common disorders are now being explained as genetic risk factors, shared by patients with several psychiatric conditions (i.e., anxiety, depression, epilepsy).
In addition, genetic variants and single-nucleotide polymorphisms have been associated with immune-mediated diseases, leading to neuroinflammatory disorders, as well as to neurological dysfunctions. Meanwhile, through genome-wide studies, the scientific community is revealing the genetic architecture underlying high-impact neurodegenerative diseases, such as Alzheimer and Parkinson diseases, making individual genetic profiling a concrete opportunity to prevent or delay disease onset. Furthermore, the opportunity to identify variants associated with enzymes responsible for drug metabolism (i.e., cytochromes, monoamine oxidases, catechol-o-methyltransferases) is opening new landscapes in personalized therapy. All these outcomes allow the provision of the most effective treatment for each patient in terms of therapeutic molecule selection and dose adjustment.
This Special Issue welcomes every paper (i.e., original research article, systematic review, case report, short communication, and meta-analysis) representing a significant contribution in this research field.
Prof. Dr. Maria A. Mariggiò
Dr. Maria A. Bonifacio
Guest Editors
Manuscript Submission Information
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Keywords
- genetic variants
- polymorphisms
- genetic profile
- neurological diseases
- psychiatric disorders
- therapeutic drug monitoring (TDM)