Nuclear Receptors in Health and Diseases 2.0

Dear Colleagues,

Nuclear receptors (NRs) are a superfamily of transcription factors, which consist of 48 NRs in the human genome; 24 are ligand-dependent transcription factors. In general, NRs are crucial mediators of health and diseases. They can bind directly to DNA (sequence-specific promoter elements) to regulate the expression of target genes, thereby controlling metabolism, homeostasis, development, and reproduction. Recently, accumulating evidence has emerged suggesting that NRs are ideal pharmacological targets for drug discovery. As a consequence, NRs play a key role in maintaining health and treating multiple diseases.

I guest-edited an initial Special Issue on “Nuclear Receptors in Health and Diseases” in the IJMS in 2022–2023. Despite the global health crisis, 10 papers were published in this Special Issue, which have received, at this point in time, nearly 10,000 views. The impact factor of the IJMS increased dramatically in the previous year, to 6.2, and it is a Q1 as well as top journal in the fields of biochemistry and molecular biology.

This new Special Issue, “Nuclear Receptors in Health and Diseases 2.0”, provides an open access forum that aims to bring together a collection of review and original research articles addressing the functions of NRs in physiological and pathological states. To this end, we welcome contributions that could cover the roles of NRs and their essential signaling pathways as well as metabolic mechanisms in the context of health maintenance and disease pathogenesis. We look forward to providing an exciting resource on the various aspects of the action of NRs, from basic science to applied therapeutic approaches.

Dr. Pengfei Xu
Guest Editor

Manuscript Submission Information

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• nuclear receptors
• hormone receptors
• orphan receptors
• retinoid receptors
• PPARs
• PXR
• CAR
• LXRs
• FXR
• RORs
• RXRs
• ERs
• HNF4s
• health
• cancers
• metabolic diseases
• drug metabolism
• agonists and antagonists
• coactivators and corepressors

• Nuclear Receptors in Health and Diseases in International Journal of Molecular Sciences (12 articles)