Signaling Molecules Involved in Gametes Development, Differentiation and Fertilization 2.0

Dear Colleagues,

The reproductive activity of a species is crucial to ensure its survival and genetic variability. Therefore, the production and differentiation of good-quality gametes, which are capable of fertilizing or being fertilized, are of primary importance. In contrast, there is a worrying decline in fertility worldwide, directly proportional to the increasing worsening of the quality of gametes. Thus, studies on the molecular mechanisms that regulate male and female gametogenesis are encouraged, not only to add new knowledge on the biological aspects of these differentiative processes but also to identify new potential markers of proper fertility and/or therapeutic targets on which to act to improve it.

This Special Issue aims to cover the physiological and pathological aspects of gamete production and differentiation at histological, cellular, and biomolecular levels. These include, but are not limited to, all aspects related to gamete function, including sperm and oocyte maturation, epididymal transit, fertilization, sperm motility, capacitation, and acrosome reaction. Papers focusing on the influence of environmental pollutants (endocrine-disrupting chemicals, microplastics, etc.), as well as metabolic disorders (overweight/obesity, diabetes), on gametes are also welcome to be submitted. Papers focusing on any vertebrate (including human) and non-vertebrate species will be accepted, as well as in vitro and ex vivo studies. This Special Issue welcomes research articles, case reports, short communications, letters, and review articles.

Prof. Dr. Sergio Minucci
Dr. Massimo Venditti
Guest Editors

Manuscript Submission Information

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• spermatogenesis
• oogenesis
• spermatozoa
• oocyte
• fertilization
• acrosome reaction
• fertility
• epidydimal transit
• endocrine disrupting chemicals
• testicular and ovarian cancer

• Signaling Molecules Involved in Gametes Development, Differentiation and Fertilization in International Journal of Molecular Sciences (9 articles)