Modulation of Transcription: Imag(in)ing a Fundamental Mechanism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 1379
Special Issue Editor
Special Issue Information
Dear Colleagues,
Transcription of DNA into RNA is a key step in the complex process of gene expression, and it is crucial to all living organisms. Conversion of the nucleotide information into a final functional product is therefore strictly regulated through a variety of sophisticated mechanisms that underlie such phenomena as cell differentiation, development, response to external conditions and much more. Any step in the gene expression pathway may be controlled, from its initiation to protein stability. Transcription factors, gene regulatory elements and epigenetic mechanisms constitute only the tip of the iceberg of the molecular mediators involved in this network.
Enormous progress has been achieved in understanding the fundamentals of transcription modulation. However, the majority of the current information is mainly derived from biochemical and biomolecular approaches. In recent years, the potential of imaging techniques has expanded to include high-resolution technologies and the possibility to localize and follow various processes in real time, among which include numerous steps of gene expression regulation.
Hence, the aim of this Special Issue is to improve our current understanding in the field of transcription modulation, with particular attention to imaging approaches. Original articles, up-to-date reviews and perspectives addressing this topic are welcomed.
Also, we would like to acknowledge Dr. Claudio Casali (https://orcid.org/0000-0001-8002-8262)'s input on the development of this Special Issue.
Dr. Marco Biggiogera
Guest Editor
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