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Novel Therapeutic Strategies for Neurodegenerative Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 2234

Special Issue Editor


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Guest Editor
Associate Professor of Physiology, Department of Biomedical Sciences, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece
Interests: Alzheimer’s disease; mild cognitive impairment; cerebrospinal fluid; beta amyloid; neurodegenerative diseases; neurodegeneration; cognition disorders; event-related potentials; evoked potentials
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Special Issue Information

Dear Colleagues,

Neurodegenerative diseases, including Alzheimer's disease, Frontotemporal dementia, Parkinson's disease and Amyotrophic lateral sclerosis, are each characterized by progressive degeneration and loss of specific subsets of neurons that lead to declines in brain function such as cognition and locomotor control. Despite intense research into Alzheimer’s disease (AD) and other dementias, there is no drug that effectively intervenes in the pathogenesis of the disease. Dementia and other neurodegenerative diseases that affect memory, cognition, and behavior are public health priorities throughout the developed world.

IJMS has organized a series of Special Issues to highlight the latest advancements in this area of science in order to be at the forefront of different fields of research. This editorial initiative of particular relevance, led by Professor Vasileios Papaliagkas, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Neurodegenerative Disease.

The present Special Issue, entitled “Novel Therapeutic Strategies for Neurodegenerative Disease”, aims to present recent research developments on drugs or other innovative therapeutic strategies for treating AD and related dementias to those involved in this field and the wider community. We welcome contributions from original articles, reviews and case reports which focus on topics within this field.

Dr. Vasileios Papaliagkas
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • neurodegenerative diseases
  • Alzheimer’s disease
  • Parkinson’s disease
  • therapy

Published Papers (1 paper)

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Review

14 pages, 638 KiB  
Review
GLP-1 Receptor Agonists: A New Treatment in Parkinson’s Disease
by Kallirhoe Kalinderi, Vasileios Papaliagkas and Liana Fidani
Int. J. Mol. Sci. 2024, 25(7), 3812; https://doi.org/10.3390/ijms25073812 - 29 Mar 2024
Cited by 1 | Viewed by 2032
Abstract
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Recent data highlight similarities between neurodegenerative diseases, including PD and type 2 diabetes mellitus (T2DM), suggesting a crucial interplay between the gut–brain axis. Glucagon-like peptide-1 receptor (GLP-1R) agonists, known for their use [...] Read more.
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Recent data highlight similarities between neurodegenerative diseases, including PD and type 2 diabetes mellitus (T2DM), suggesting a crucial interplay between the gut–brain axis. Glucagon-like peptide-1 receptor (GLP-1R) agonists, known for their use in T2DM treatment, are currently extensively studied as novel PD modifying agents. For this narrative review article, we searched PubMed and Scopus databases for peer-reviewed research, review articles and clinical trials regarding GLP-1R agonists and PD published in the English language with no time restrictions. We also screened the references of the selected articles for possible additional articles in order to include most of the key recent evidence. Many data on animal models and preclinical studies show that GLP1-R agonists can restore dopamine levels, inhibit dopaminergic loss, attenuate neuronal degeneration and alleviate motor and non-motor features of PD. Evidence from clinical studies is also very promising, enhancing the possibility of adding GLP1-R agonists to the current armamentarium of drugs available for PD treatment. Full article
(This article belongs to the Special Issue Novel Therapeutic Strategies for Neurodegenerative Disease)
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