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Molecular Aspects of Cartilage Biology
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Molecular Aspects of Cartilage Biology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 385

Special Issue Editor

Dr. Michela Geminiani

E-Mail Website
Guest Editor
1. Department of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy
2. SienabioACTIVE, University of Siena, Via A. Moro, 53100 Siena, Italy
Interests: rare disease; osteoarticular disorders; antioxidant; inflammation

Special Issue Information

Dear Colleagues,

Articular cartilage, which is a highly specialized tissue, consists mainly of a dense extracellular matrix (ECM) comprising type II collagen fibers, proteoglycans, and water; this is alongside the dispersal of its distinctive cell type, chondrocytes, within the ECM. Chondrocytes play a crucial role in maintaining the cartilage matrix by producing and releasing collagen, proteoglycans, and the enzymes involved in cartilage metabolism. The metabolic function of chondrocytes is governed by the mechanical stress experienced by the tissue.

This Special Issue aims to explore cutting-edge advancements in Cartilage Biology, shedding light on the latest research, methodologies, and breakthroughs regarding the structure, function, and regeneration of cartilage tissues. We welcome contributions encompassing molecular mechanisms, chondrocytes interactions, and translational approaches that enhance our comprehension of cartilage-related disorders and potential therapeutic interventions.

Dr. Michela Geminiani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cartilage biology
  • tissue regeneration
  • molecular mechanisms
  • chondrocytes
  • cartilage disorders
  • therapeutic interventions
  • biomaterials

Published Papers (1 paper)

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Review

13 pages, 1695 KiB  
Review
Prg4-Expressing Chondroprogenitor Cells in the Superficial Zone of Articular Cartilage
by Nadezda Ignatyeva, Nikita Gavrilov, Peter S. Timashev and Ekaterina V. Medvedeva
Int. J. Mol. Sci. 2024, 25(11), 5605; https://doi.org/10.3390/ijms25115605 - 21 May 2024
Viewed by 270
Abstract
Joint-resident chondrogenic precursor cells have become a significant therapeutic option due to the lack of regenerative capacity in articular cartilage. Progenitor cells are located in the superficial zone of the articular cartilage, producing lubricin/Prg4 to decrease friction of cartilage surfaces during joint movement. [...] Read more.
Joint-resident chondrogenic precursor cells have become a significant therapeutic option due to the lack of regenerative capacity in articular cartilage. Progenitor cells are located in the superficial zone of the articular cartilage, producing lubricin/Prg4 to decrease friction of cartilage surfaces during joint movement. Prg4-positive progenitors are crucial in maintaining the joint’s structure and functionality. The disappearance of progenitor cells leads to changes in articular hyaline cartilage over time, subchondral bone abnormalities, and the formation of ectopic ossification. Genetic labeling cell technology has been the main tool used to characterize Prg4-expressing progenitor cells of articular cartilage in vivo through drug injection at different time points. This technology allows for the determination of the origin of progenitor cells and the tracking of their progeny during joint development and cartilage damage. We endeavored to highlight the currently known information about the Prg4-producing cell population in the joint to underline the significance of the role of these cells in the development of articular cartilage and its homeostasis. This review focuses on superficial progenitors in the joint, how they contribute to postnatal articular cartilage formation, their capacity for regeneration, and the consequences of Prg4 deficiency in these cells. We have accumulated information about the Prg4+ cell population of articular cartilage obtained through various elegantly designed experiments using transgenic technologies to identify potential opportunities for further research. Full article
(This article belongs to the Special Issue Molecular Aspects of Cartilage Biology)
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