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Advancements in Personalized Medicine: Integrating Genomic Insights and Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 29 June 2024 | Viewed by 445

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue delves into the forefront of personalized medicine, wherein the fusion of genomic insights with cutting-edge bio-molecular features will pave the way for innovative therapeutic strategies. Emphasizing the integration of genomic data, we invite contributions that spotlight the intricate molecular mechanisms underpinning personalized treatment approaches. From explorations of biomarkers to in-depth analyses of bio-molecular pathways, this issue aims to bridge the gap between genomic discoveries and their practical application in tailoring therapeutic interventions. We welcome submissions that showcase the synergy between clinical insights and rigorous bio-molecular experiments, encouraging more comprehensive understanding of personalized medicine’s evolving landscape.

Dr. Mariarosaria Boccellino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized medicine
  • genomic insights
  • therapeutic strategies
  • molecular profiling
  • precision medicine
  • molecular targets
  • precision oncology
  • genomic biomarkers

Published Papers (1 paper)

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Research

19 pages, 3165 KiB  
Article
Genomic Characterization of Preclinical Prostate Cancer Cell Line Models
by Erica L. Beatson, Emily N. Risdon, Giulia C. Napoli, Douglas K. Price, Cindy H. Chau and William D. Figg
Int. J. Mol. Sci. 2024, 25(11), 6111; https://doi.org/10.3390/ijms25116111 - 1 Jun 2024
Viewed by 181
Abstract
As we move into the era of precision medicine, the growing relevance of genetic alterations to prostate cancer (PCa) development and treatment demonstrates the importance of characterizing preclinical models at the genomic level. Our study investigated the genomic characterization of eight PCa cell [...] Read more.
As we move into the era of precision medicine, the growing relevance of genetic alterations to prostate cancer (PCa) development and treatment demonstrates the importance of characterizing preclinical models at the genomic level. Our study investigated the genomic characterization of eight PCa cell lines to understand which models are clinically relevant. We designed a custom AmpliSeq DNA gene panel that encompassed key molecular pathways targeting AR signaling, apoptosis, DNA damage repair, and PI3K/AKT/PTEN, in addition to tumor suppressor genes. We examined the relationship between cell line genomic alterations and therapeutic response. In addition, using DepMap’s Celligner tool, we identified which preclinical models are most representative of specific prostate cancer patient populations on cBioPortal. These data will help investigators understand the genetic differences in preclinical models of PCa and determine which ones are relevant for use in their translational research. Full article
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