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New Advances in Platelet Biology and Functions: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 1442

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Special Issue Information

Dear Colleagues,

Platelets, best known as the primary mediators of hemostasis and thrombosis, are a critical component of blood vessel walls. As secretory cells, platelets can release multiple substances from storage granules and membrane vesicles, such as biomediators, influencing both physiological and pathophysiological processes. Conversely, platelets can uptake plasma and cellular components, influencing platelet responsiveness. The analysis of platelet function through the development of powerful imaging techniques, as well as the identification of cells and new molecules that regulate their activation and aggregation within vessels, is instrumental in order to better understand the mechanisms through which platelets protect or damage organisms. These analyses provide useful information for studying the pathogenesis of many disease states.

This Special Issue of the International Journal of Molecular Sciences, titled “New Advances in Platelet Biology and Functions”, will focus on the recent advances in platelet function research, such as platelet action or the release of substances or micro-particles containing platelet miRNA, enzymes, proteins, and small molecules with roles in healthy conditions and as drivers of immunity, inflammation, angiogenesis, and tumor growth. Contributions on these and related topics are welcome, including original research and reviews. We particularly welcome submissions from postdocs, PhD students, and young researchers.

Dr. Isabella Russo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • platelet microparticles
  • thrombosis
  • inflammation
  • oxidative stress
  • antiplatelet drug
  • signal transduction
  • immunity
  • tumor growth

Published Papers (2 papers)

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28 pages, 9412 KiB  
Article
Deciphering Abnormal Platelet Subpopulations in COVID-19, Sepsis and Systemic Lupus Erythematosus through Machine Learning and Single-Cell Transcriptomics
by Xinru Qiu, Meera G Nair, Lukasz Jaroszewski and Adam Godzik
Int. J. Mol. Sci. 2024, 25(11), 5941; https://doi.org/10.3390/ijms25115941 - 29 May 2024
Viewed by 131
Abstract
This study focuses on understanding the transcriptional heterogeneity of activated platelets and its impact on diseases such as sepsis, COVID-19, and systemic lupus erythematosus (SLE). Recognizing the limited knowledge in this area, our research aims to dissect the complex transcriptional profiles of activated [...] Read more.
This study focuses on understanding the transcriptional heterogeneity of activated platelets and its impact on diseases such as sepsis, COVID-19, and systemic lupus erythematosus (SLE). Recognizing the limited knowledge in this area, our research aims to dissect the complex transcriptional profiles of activated platelets to aid in developing targeted therapies for abnormal and pathogenic platelet subtypes. We analyzed single-cell transcriptional profiles from 47,977 platelets derived from 413 samples of patients with these diseases, utilizing Deep Neural Network (DNN) and eXtreme Gradient Boosting (XGB) to distinguish transcriptomic signatures predictive of fatal or survival outcomes. Our approach included source data annotations and platelet markers, along with SingleR and Seurat for comprehensive profiling. Additionally, we employed Uniform Manifold Approximation and Projection (UMAP) for effective dimensionality reduction and visualization, aiding in the identification of various platelet subtypes and their relation to disease severity and patient outcomes. Our results highlighted distinct platelet subpopulations that correlate with disease severity, revealing that changes in platelet transcription patterns can intensify endotheliopathy, increasing the risk of coagulation in fatal cases. Moreover, these changes may impact lymphocyte function, indicating a more extensive role for platelets in inflammatory and immune responses. This study identifies crucial biomarkers of platelet heterogeneity in serious health conditions, paving the way for innovative therapeutic approaches targeting platelet activation, which could improve patient outcomes in diseases characterized by altered platelet function. Full article
(This article belongs to the Special Issue New Advances in Platelet Biology and Functions: 2nd Edition)
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15 pages, 1948 KiB  
Article
Association between Platelet-Derived Growth Factor Receptor Alpha Gene Polymorphisms and Platelet-Rich Plasma’s Efficiency in Treating Lateral Elbow Tendinopathy—A Prospective Cohort Study
by Alicja Jarosz, Anna Balcerzyk-Matić, Joanna Iwanicka, Tomasz Iwanicki, Tomasz Nowak, Karol Szyluk, Marcin Kalita, Sylwia Górczyńska-Kosiorz, Wojciech Kania and Paweł Niemiec
Int. J. Mol. Sci. 2024, 25(8), 4266; https://doi.org/10.3390/ijms25084266 - 12 Apr 2024
Viewed by 527
Abstract
Individual differences in the response to platelet-rich plasma (PRP) therapy can be observed among patients. The genetic background may be the cause of this variability. The current study focused on the impact of genetic variants on the effectiveness of PRP. The aim of [...] Read more.
Individual differences in the response to platelet-rich plasma (PRP) therapy can be observed among patients. The genetic background may be the cause of this variability. The current study focused on the impact of genetic variants on the effectiveness of PRP. The aim of the present study was to analyze the impact of single nucleotide polymorphisms (SNP) of the platelet-derived growth factor receptor alpha (PDGFRA) gene on the effectiveness of treating lateral elbow tendinopathy (LET) with PRP. The treatment’s efficacy was analyzed over time (2, 4, 8, 12, 24, 52 and 104 weeks after the PRP injection) on 107 patients using patient-reported outcome measures (PROM) and achievement of a minimal clinically important difference (MCID). Four SNPs of the PDGFRA gene (rs7668190, rs6554164, rs869978 and rs1316926) were genotyped using the TaqMan assay method. Patients with the AA genotypes of the rs7668190 and the rs1316926 polymorphisms, as well as carriers of the T allele of rs6554164 showed greater effectiveness of PRP therapy than carriers of other genotypes. Moreover, the studied SNPs influenced the platelets’ parameters both in whole blood and in PRP. These results showed that PDGFRA gene polymorphisms affect the effectiveness of PRP treatment. Genotyping the rs6554164 and the rs1316926 SNPs may be considered for use in individualized patient selection for PRP therapy. Full article
(This article belongs to the Special Issue New Advances in Platelet Biology and Functions: 2nd Edition)
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