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Osteoarthritis Biomarkers, Diagnosis and Treatments

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 May 2024) | Viewed by 253

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Guest Editor
Department of Rheumatology, Translational Medicine Research Platform, PRIMMO, Regional Hospital of Orleans, 45067 Orleans, France
Interests: osteoporosis; cartilage; arthrose
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For several decades, osteoarthritis (OA) has remained the most common cause of disability in older adults. To date, clinicians face often difficulties assisting their patients as no registered disease-modifying OA drugs exist, and only symptomatic treatments are available. In fact, multiple joint tissues are involved in OA pathophysiology; cartilage was often the focus of research and long thought to play a primary role. However, although cartilage is usually impaired, it is an aneural tissue and pain would be more related to synovium and subchondral bones.

The relationship between osteoarthritis, cartilage degeneration and bone is strong and complex. Research on the mechanisms of osteoarthritis can help us to determine the molecular biology, biochemical, and biomechanical mechanisms involved in the degeneration, repair and regeneration of joints. New targets and compounds for these targets are currently under investigation.

This Special Issue aims to focus on the most recent research conducted in the domain of molecular mechanisms that impact OA repair and treatments. Experimental studies, as well as clinical submissions with biomolecular experiments, are within the scope of our Special Issue and are welcomed for submission, in particular (1) disease-modifying OA drugs, (2) advanced cell treatments for osteoarthritis, (3) changes in cells’ biological mechanisms resulting from osteoarthritis; (4) osteoarthritis and chemical and biomolecular engineering.

All authors are invited to send their research related to the topic of our Special Issue, including both original and review articles, to be assessed and included in the peer review process of our journal.

Dr. Hechmi Toumi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • degenerative joint disease
  • biomarkers
  • diagnosis
  • treatments

Published Papers (1 paper)

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Research

16 pages, 23556 KiB  
Article
The Therapeutic Potential of Intra-Articular Injection of Synthetic Deer Antler Peptides in a Rat Model of Knee Osteoarthritis
by Yu-Chou Hung, Li-Jin Chen, Jen-Hung Wang, Tsung-Jung Ho, Guo-Fang Tseng and Hao-Ping Chen
Int. J. Mol. Sci. 2024, 25(11), 6041; https://doi.org/10.3390/ijms25116041 - 30 May 2024
Abstract
Synthetic deer antler peptides (TSKYR, TSK, and YR) stimulate the proliferation of human chondrocytes and osteoblasts and increase the chondrocyte content of collagen and glycosamino-glycan in vitro. This study investigated the peptide mixture’s pain relief and chondroprotective effect in a rat model of [...] Read more.
Synthetic deer antler peptides (TSKYR, TSK, and YR) stimulate the proliferation of human chondrocytes and osteoblasts and increase the chondrocyte content of collagen and glycosamino-glycan in vitro. This study investigated the peptide mixture’s pain relief and chondroprotective effect in a rat model of collagenase-induced osteoarthritis. Thirty-six adult male Sprague–Dawley rats were divided into three groups: control (saline), positive control (hyaluronic acid), and ex-perimental (peptides). Intra-articular collagenase injections were administered on days 1 and 4 to induce osteoarthritis in the left knees of the rats. Two injections of saline, hyaluronic acid, or the peptides were injected into the same knees of each corresponding group at the beginning of week one and two, respectively. Joint swelling, arthritic pain, and histopathological changes were evaluated. Injection of the peptides significantly reduced arthritic pain compared to the control group, as evidenced by the closer-to-normal weight-bearing and paw withdrawal threshold test results. Histological analyses showed reduced cartilage matrix loss and improved total cartilage degeneration score in the experimental versus the control group. Our findings suggest that intra-articular injection of synthetic deer antler peptides is a promising treatment for osteoarthritis. Full article
(This article belongs to the Special Issue Osteoarthritis Biomarkers, Diagnosis and Treatments)
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